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The map label for this gene is hemX [H]

Identifier: 145300738

GI number: 145300738

Start: 4163493

End: 4164542

Strand: Direct

Name: hemX [H]

Synonym: ASA_3877

Alternate gene names: 145300738

Gene position: 4163493-4164542 (Clockwise)

Preceding gene: 145300737

Following gene: 145300739

Centisome position: 88.54

GC content: 59.81

Gene sequence:

>1050_bases
ATGACTGAACAACAAGAATCCCAGGTCAAGCCCCAGCCGACCGCCGTGGTCAATGGCGGCAAGAGCCGCTCCGGCGTTCT
GCTGGGTGGCGTTGCCATACTGCTGGCCCTCGGCCTGACTGGCGGTCTCTACCTGCATGGCCACCAGAGCGCCGTGGCCC
AGCAGGGGGAACTGGATCAGCTCAAGCAGCAACTGGCCGAGGCCATGAACAAGCTGGATCAGAGCAACAGCAAGGATAGC
GAGCAACTGAGTGCGCTGGGCAAAACCCAGCAGCAACTGCAAGAAGAGCTCAAGGGTCTGCAGAATCGGGTGCTGGATCT
CAACGACAAGCGTCCCAACGACTGGATGCTGGCCGAATCCGAATACCTGGTACGCATGGCGGGCCGCAAGTTGTGGCTGG
AACATGACCTCATCTCCGCCATTACCTTGCTTGGCAATGCCGACGAGCGGATCAAGGCGCTCAACGATCCCAGCCTGATG
CCCATTCGCAAGGCGCTGGCGGAAGACATAGCCCAGCTCAAGGGGATGCCGCGCATCGACCGTGAAGGATTGACTCTGAA
ACTGGCCGCCCTCTCTGACCAGATAGAGCTGTTGCCCCTCTCCACCGTCAGCATGCCGGAAGCCAAGACCGAGCCGGATC
AAGCCGTCAGCACCAATCCGGACGAGTGGGAAAGCAACCTGAAGAAGAACTGGGTCAAGTTCACCGAGAACTTCATCACC
ATACGTCGCCGCGATGGCGCCGTGGAAGCCCTGCTCTCCCCGCAGCAGGAGATCTTCCTGCGCGAAAACCTCAAGACCAA
GCTGCTGCAAGCCCAGCTCGCCGTCTACCGCGAGCAGCAGGCACTGTATGACGACAGCCTGGAGAAGGCACAGCGCTGGC
TGACCCAGTATTTCGATACCGACAACAGCGCCACTCACTACATGCAGTCCGAGCTGGACAAGCTCAAGAGCGAGCAGATC
CAGTTCACCTATCCGGATCGCTTCAAGACCCAAGCCATGCTGGAAGAGGTGCTGACCGAGCGCCTGCAACGCATTCTGGC
CAGCAACTGA

Upstream 100 bases:

>100_bases
TGGCCGACATGGCCAAGATGGCGGGCTTTACCCATATCACGATTGCCCAGGGTGCATCCAACCAGGCCCTGACGGCCGCT
CTGGAACTGAGGAAGATGGA

Downstream 100 bases:

>100_bases
GGAGGGCACCATGATTCGTCTGATTGTTCTGGTGGCCGTGATGATAGCCGGGCTGATGTTTGGCCCTGAAGCATCCGGCA
ACAAGGGGTATGTGCTGATC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTEQQESQVKPQPTAVVNGGKSRSGVLLGGVAILLALGLTGGLYLHGHQSAVAQQGELDQLKQQLAEAMNKLDQSNSKDS
EQLSALGKTQQQLQEELKGLQNRVLDLNDKRPNDWMLAESEYLVRMAGRKLWLEHDLISAITLLGNADERIKALNDPSLM
PIRKALAEDIAQLKGMPRIDREGLTLKLAALSDQIELLPLSTVSMPEAKTEPDQAVSTNPDEWESNLKKNWVKFTENFIT
IRRRDGAVEALLSPQQEIFLRENLKTKLLQAQLAVYREQQALYDDSLEKAQRWLTQYFDTDNSATHYMQSELDKLKSEQI
QFTYPDRFKTQAMLEEVLTERLQRILASN

Sequences:

>Translated_349_residues
MTEQQESQVKPQPTAVVNGGKSRSGVLLGGVAILLALGLTGGLYLHGHQSAVAQQGELDQLKQQLAEAMNKLDQSNSKDS
EQLSALGKTQQQLQEELKGLQNRVLDLNDKRPNDWMLAESEYLVRMAGRKLWLEHDLISAITLLGNADERIKALNDPSLM
PIRKALAEDIAQLKGMPRIDREGLTLKLAALSDQIELLPLSTVSMPEAKTEPDQAVSTNPDEWESNLKKNWVKFTENFIT
IRRRDGAVEALLSPQQEIFLRENLKTKLLQAQLAVYREQQALYDDSLEKAQRWLTQYFDTDNSATHYMQSELDKLKSEQI
QFTYPDRFKTQAMLEEVLTERLQRILASN
>Mature_348_residues
TEQQESQVKPQPTAVVNGGKSRSGVLLGGVAILLALGLTGGLYLHGHQSAVAQQGELDQLKQQLAEAMNKLDQSNSKDSE
QLSALGKTQQQLQEELKGLQNRVLDLNDKRPNDWMLAESEYLVRMAGRKLWLEHDLISAITLLGNADERIKALNDPSLMP
IRKALAEDIAQLKGMPRIDREGLTLKLAALSDQIELLPLSTVSMPEAKTEPDQAVSTNPDEWESNLKKNWVKFTENFITI
RRRDGAVEALLSPQQEIFLRENLKTKLLQAQLAVYREQQALYDDSLEKAQRWLTQYFDTDNSATHYMQSELDKLKSEQIQ
FTYPDRFKTQAMLEEVLTERLQRILASN

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=345, Percent_Identity=36.8115942028986, Blast_Score=216, Evalue=1e-57,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 39466; Mature: 39335

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQQESQVKPQPTAVVNGGKSRSGVLLGGVAILLALGLTGGLYLHGHQSAVAQQGELDQ
CCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHH
LKQQLAEAMNKLDQSNSKDSEQLSALGKTQQQLQEELKGLQNRVLDLNDKRPNDWMLAES
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHH
EYLVRMAGRKLWLEHDLISAITLLGNADERIKALNDPSLMPIRKALAEDIAQLKGMPRID
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC
REGLTLKLAALSDQIELLPLSTVSMPEAKTEPDQAVSTNPDEWESNLKKNWVKFTENFIT
CCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
IRRRDGAVEALLSPQQEIFLRENLKTKLLQAQLAVYREQQALYDDSLEKAQRWLTQYFDT
EECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DNSATHYMQSELDKLKSEQIQFTYPDRFKTQAMLEEVLTERLQRILASN
CCCHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEQQESQVKPQPTAVVNGGKSRSGVLLGGVAILLALGLTGGLYLHGHQSAVAQQGELDQ
CCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHH
LKQQLAEAMNKLDQSNSKDSEQLSALGKTQQQLQEELKGLQNRVLDLNDKRPNDWMLAES
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHH
EYLVRMAGRKLWLEHDLISAITLLGNADERIKALNDPSLMPIRKALAEDIAQLKGMPRID
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC
REGLTLKLAALSDQIELLPLSTVSMPEAKTEPDQAVSTNPDEWESNLKKNWVKFTENFIT
CCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
IRRRDGAVEALLSPQQEIFLRENLKTKLLQAQLAVYREQQALYDDSLEKAQRWLTQYFDT
EECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DNSATHYMQSELDKLKSEQIQFTYPDRFKTQAMLEEVLTERLQRILASN
CCCHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]