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The map label for this gene is hemD [H]

Identifier: 145300737

GI number: 145300737

Start: 4162762

End: 4163496

Strand: Direct

Name: hemD [H]

Synonym: ASA_3876

Alternate gene names: 145300737

Gene position: 4162762-4163496 (Clockwise)

Preceding gene: 145300736

Following gene: 145300738

Centisome position: 88.52

GC content: 63.4

Gene sequence:

>735_bases
ATGATACCCCTGGTGGTGCGCCCGGCCGCTCAGGCCGCCGAGCTGGTGCAACTGCTGCGCCAGCACGGCCACGCACCGCT
CTGCTGTCCACTGCTTGAAACGGCAGCGGGCAGCGAACTCCCCCGCCTGCCCGAACTGCTGCCCCAGGCTGACATCGTCA
TCGCAGTCAGCGTGCATGCAGTTCATTTCACTCATCATTTTCTGTTGCAAACTGGTCAGACCTGGCCAAGTATTGACTAC
TTTGCGGTCGGCCAGGCCAGCGCGGATGCCTTCGCCGACGTCGGTATAGAGGCGAGCTGCCCTGACGATCCCCGTAGCGA
AGGGCTGCTGGCCCTGCCCGCCCTGCAACAGGTGAGCGGCAAGCGGGTATTGATACTCAGAGGCAACGGGGGCCGGGATC
TTATCGCCCGGACGCTGGCCTCACGCGGTGCTCTGGTGCACTATTGTGCGGCCTATGAGCGCCACTACCCCGAACTCGAC
GGGGACACATTGACTCGCCATTGGCAGGCAGCCGGGCTCGACAGCCTGCTCATTACCAGTGGTGAACTGTTGCAACGGCT
GCTGGAGCTGGTGCCAGGCCAGCAGCAGCCCTGGCTTTATGACCGCCTCTTGGTGGTGCCCAGCCCCCGCGTGGCCGACA
TGGCCAAGATGGCGGGCTTTACCCATATCACGATTGCCCAGGGTGCATCCAACCAGGCCCTGACGGCCGCTCTGGAACTG
AGGAAGATGGAATGA

Upstream 100 bases:

>100_bases
TCCGCGGTCCGCTGGCAGACGGTGAGGCCCTCGGTCACACCCTGGCCCAGCGTCTGCTGGCGGCTGGTGCCGACGTTATC
CTGGCCGAGGTCTACCGGGC

Downstream 100 bases:

>100_bases
CTGAACAACAAGAATCCCAGGTCAAGCCCCAGCCGACCGCCGTGGTCAATGGCGGCAAGAGCCGCTCCGGCGTTCTGCTG
GGTGGCGTTGCCATACTGCT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MIPLVVRPAAQAAELVQLLRQHGHAPLCCPLLETAAGSELPRLPELLPQADIVIAVSVHAVHFTHHFLLQTGQTWPSIDY
FAVGQASADAFADVGIEASCPDDPRSEGLLALPALQQVSGKRVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPELD
GDTLTRHWQAAGLDSLLITSGELLQRLLELVPGQQQPWLYDRLLVVPSPRVADMAKMAGFTHITIAQGASNQALTAALEL
RKME

Sequences:

>Translated_244_residues
MIPLVVRPAAQAAELVQLLRQHGHAPLCCPLLETAAGSELPRLPELLPQADIVIAVSVHAVHFTHHFLLQTGQTWPSIDY
FAVGQASADAFADVGIEASCPDDPRSEGLLALPALQQVSGKRVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPELD
GDTLTRHWQAAGLDSLLITSGELLQRLLELVPGQQQPWLYDRLLVVPSPRVADMAKMAGFTHITIAQGASNQALTAALEL
RKME
>Mature_244_residues
MIPLVVRPAAQAAELVQLLRQHGHAPLCCPLLETAAGSELPRLPELLPQADIVIAVSVHAVHFTHHFLLQTGQTWPSIDY
FAVGQASADAFADVGIEASCPDDPRSEGLLALPALQQVSGKRVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPELD
GDTLTRHWQAAGLDSLLITSGELLQRLLELVPGQQQPWLYDRLLVVPSPRVADMAKMAGFTHITIAQGASNQALTAALEL
RKME

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=246, Percent_Identity=41.869918699187, Blast_Score=162, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 26418; Mature: 26418

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLVVRPAAQAAELVQLLRQHGHAPLCCPLLETAAGSELPRLPELLPQADIVIAVSVHA
CCCEEECCHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCHHHHCCCCCEEEEEEEHH
VHFTHHFLLQTGQTWPSIDYFAVGQASADAFADVGIEASCPDDPRSEGLLALPALQQVSG
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHCCC
KRVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPELDGDTLTRHWQAAGLDSLLITS
CEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHEECC
GELLQRLLELVPGQQQPWLYDRLLVVPSPRVADMAKMAGFTHITIAQGASNQALTAALEL
HHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
RKME
HCCC
>Mature Secondary Structure
MIPLVVRPAAQAAELVQLLRQHGHAPLCCPLLETAAGSELPRLPELLPQADIVIAVSVHA
CCCEEECCHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCHHHHCCCCCEEEEEEEHH
VHFTHHFLLQTGQTWPSIDYFAVGQASADAFADVGIEASCPDDPRSEGLLALPALQQVSG
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHCCC
KRVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPELDGDTLTRHWQAAGLDSLLITS
CEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHEECC
GELLQRLLELVPGQQQPWLYDRLLVVPSPRVADMAKMAGFTHITIAQGASNQALTAALEL
HHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
RKME
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]