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The map label for this gene is hemC [H]

Identifier: 145300736

GI number: 145300736

Start: 4161818

End: 4162765

Strand: Direct

Name: hemC [H]

Synonym: ASA_3875

Alternate gene names: 145300736

Gene position: 4161818-4162765 (Clockwise)

Preceding gene: 145300733

Following gene: 145300737

Centisome position: 88.5

GC content: 64.03

Gene sequence:

>948_bases
ATGAAACAACTGATTGATATGGCAGCCCGAACCCTGAAAATTGCCACTCGCAAGAGCCCATTGGCCCTGTGGCAGGCCAA
CTTCGTCAAAGACCGGCTGGAAGCCCTGTACCCCGAGTTGCAGGTCGAGCTGGTGCCCATGAGCACTCAGGGTGACAAGA
TCCTGGATACCCCTCTCGCCAAAGTGGGTGGCAAGGGGTTGTTCGTCAAGGAGCTGGAAACCGCCATGCTGGAGGGCCGC
GCCGACATCGCCGTCCACTCCATGAAGGATGTGCCGGTGGAGTTCCCGGAAGGGCTGGGCCTGCACACCATCTGTGAGCG
CGAAGATCCGCGCGATGCCTTCGTTTCCAACCGTTTCAGCCAGATAGAAGCACTGCCGCAGGGCGCCGTGGTCGGCACCT
CCAGCCTGCGCCGTCAGTGTCAACTGCGGGCCGCCCGCCCGGATCTGGTGATCCGCGACCTGCGTGGCAACGTCAATACC
CGTCTCGCCAAGCTGGATGCCGGTGAATATGACGCCATCATTCTTGCCGCCGCCGGCCTGAAGCGTCTGGAGATGGCACA
TCGCATCACCGCCTTCATCGAGCCGGAGCAGAGCCTGCCTGCCAACGGTCAGGGTGCGGTCGGCATCGAATGCCGCCTCG
ACGATCACGAGCTGCACACCCTGTTGGCACCGCTGGAGCACGCCGAGACCCGGATACGGGTGCTGACCGAGCGAGCCATG
AACCGCGCCCTGCAAGGGGGCTGTCAGGTCCCTATTGGCGCCTACGCTCTGGTACAGGGGGATGAGGTCTGGTTGCGCGG
TCTGGTGGGCAGCCCGGATGGCAGTCAGGTGATCCACGACGAGATCCGCGGTCCGCTGGCAGACGGTGAGGCCCTCGGTC
ACACCCTGGCCCAGCGTCTGCTGGCGGCTGGTGCCGACGTTATCCTGGCCGAGGTCTACCGGGCATGA

Upstream 100 bases:

>100_bases
AAAATCATTTTCAGCAGCCCTTTTTGAGCTTGGCCCCGCTTTTGCTGGCTGCGCCATGAAAGCCCCTGCAAAGGGTGGTA
AGATCGTTTTCCTTCTAAAG

Downstream 100 bases:

>100_bases
TACCCCTGGTGGTGCGCCCGGCCGCTCAGGCCGCCGAGCTGGTGCAACTGCTGCGCCAGCACGGCCACGCACCGCTCTGC
TGTCCACTGCTTGAAACGGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKQLIDMAARTLKIATRKSPLALWQANFVKDRLEALYPELQVELVPMSTQGDKILDTPLAKVGGKGLFVKELETAMLEGR
ADIAVHSMKDVPVEFPEGLGLHTICEREDPRDAFVSNRFSQIEALPQGAVVGTSSLRRQCQLRAARPDLVIRDLRGNVNT
RLAKLDAGEYDAIILAAAGLKRLEMAHRITAFIEPEQSLPANGQGAVGIECRLDDHELHTLLAPLEHAETRIRVLTERAM
NRALQGGCQVPIGAYALVQGDEVWLRGLVGSPDGSQVIHDEIRGPLADGEALGHTLAQRLLAAGADVILAEVYRA

Sequences:

>Translated_315_residues
MKQLIDMAARTLKIATRKSPLALWQANFVKDRLEALYPELQVELVPMSTQGDKILDTPLAKVGGKGLFVKELETAMLEGR
ADIAVHSMKDVPVEFPEGLGLHTICEREDPRDAFVSNRFSQIEALPQGAVVGTSSLRRQCQLRAARPDLVIRDLRGNVNT
RLAKLDAGEYDAIILAAAGLKRLEMAHRITAFIEPEQSLPANGQGAVGIECRLDDHELHTLLAPLEHAETRIRVLTERAM
NRALQGGCQVPIGAYALVQGDEVWLRGLVGSPDGSQVIHDEIRGPLADGEALGHTLAQRLLAAGADVILAEVYRA
>Mature_315_residues
MKQLIDMAARTLKIATRKSPLALWQANFVKDRLEALYPELQVELVPMSTQGDKILDTPLAKVGGKGLFVKELETAMLEGR
ADIAVHSMKDVPVEFPEGLGLHTICEREDPRDAFVSNRFSQIEALPQGAVVGTSSLRRQCQLRAARPDLVIRDLRGNVNT
RLAKLDAGEYDAIILAAAGLKRLEMAHRITAFIEPEQSLPANGQGAVGIECRLDDHELHTLLAPLEHAETRIRVLTERAM
NRALQGGCQVPIGAYALVQGDEVWLRGLVGSPDGSQVIHDEIRGPLADGEALGHTLAQRLLAAGADVILAEVYRA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=42.042042042042, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI20149500, Length=333, Percent_Identity=42.042042042042, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=70.0325732899023, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.9408099688474, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI20130425, Length=287, Percent_Identity=41.1149825783972, Blast_Score=215, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34316; Mature: 34316

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLIDMAARTLKIATRKSPLALWQANFVKDRLEALYPELQVELVPMSTQGDKILDTPLA
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCHH
KVGGKGLFVKELETAMLEGRADIAVHSMKDVPVEFPEGLGLHTICEREDPRDAFVSNRFS
HHCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHH
QIEALPQGAVVGTSSLRRQCQLRAARPDLVIRDLRGNVNTRLAKLDAGEYDAIILAAAGL
HHHHCCCCCEECCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEEHHCH
KRLEMAHRITAFIEPEQSLPANGQGAVGIECRLDDHELHTLLAPLEHAETRIRVLTERAM
HHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
NRALQGGCQVPIGAYALVQGDEVWLRGLVGSPDGSQVIHDEIRGPLADGEALGHTLAQRL
HHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
LAAGADVILAEVYRA
HHCCHHHHHHHHHCC
>Mature Secondary Structure
MKQLIDMAARTLKIATRKSPLALWQANFVKDRLEALYPELQVELVPMSTQGDKILDTPLA
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCHH
KVGGKGLFVKELETAMLEGRADIAVHSMKDVPVEFPEGLGLHTICEREDPRDAFVSNRFS
HHCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHH
QIEALPQGAVVGTSSLRRQCQLRAARPDLVIRDLRGNVNTRLAKLDAGEYDAIILAAAGL
HHHHCCCCCEECCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEEHHCH
KRLEMAHRITAFIEPEQSLPANGQGAVGIECRLDDHELHTLLAPLEHAETRIRVLTERAM
HHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
NRALQGGCQVPIGAYALVQGDEVWLRGLVGSPDGSQVIHDEIRGPLADGEALGHTLAQRL
HHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
LAAGADVILAEVYRA
HHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA