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The map label for this gene is pdxA [H]

Identifier: 145300234

GI number: 145300234

Start: 3623618

End: 3624613

Strand: Direct

Name: pdxA [H]

Synonym: ASA_3349

Alternate gene names: 145300234

Gene position: 3623618-3624613 (Clockwise)

Preceding gene: 145300233

Following gene: 145300235

Centisome position: 77.06

GC content: 62.55

Gene sequence:

>996_bases
ATGAGCTGTCGTCGTCTCGCCATTACGCCGGGTGAGCCCGCCGGAATAGGCCCGGATCTGGTGCTGCAGATAGCCCAGCA
GGATTGGCCCCACCAGCTGGTGGTGATCGCCGATCCTGCCCTGATGCTCGAACGGGCCGCCCTGCTGGGGCTGCCCATCG
AGCTGGAACCCTATGATGCAAAGGCCCCTGCCCAGCCGCAGCAGGCGGGTACCCTGAGCATCTGTCCACTCAGCCTCGGC
GCCCCCGTGGTGCCGGGTGAGCTGAACGAGGGCAACGGCGCCTATGTGCTGGCCACCCTGCAGCGCGCCTGTGACGGCAA
CCTCAGCGGTGAATTTGCCGCCGTGGTAACCGGGCCGGTGCACAAGGGGATCATCAATCAGGCGGGCGTGTCATTCAGTG
GTCATACCGAGTTCTTCGCACAGCAGTCAGGCACCGCCGACGTGGTGATGCTGCTGGCGACCGAAGGCTTGCGGGTGGCG
CTGGCGACCACCCATATCCCGCTCGCCTACGTGGCCATGGCCATCACGGAGGATCGCCTCGGCAAGGTGATCCGCATTCT
GGATGCGGATCTCAAAACCAAGTTTGGCATCGCCAAGCCCCGGATTTACGTCTGCGGCCTCAATCCCCACGCCGGGGAAG
GGGGTCATCTCGGCCGTGAAGAGATTGACGTGATCGAACCCGCCCTGGCCAGCTTGTGCCAGGAGGGTATCGATCTGGTC
GGCCCGCTGCCGGCCGATACCCTGTTCCAGGACAAATACCTCAAGGATGCGGATGCGGTACTCGCCATGTACCACGACCA
GGGGCTGCCCGTGCTCAAATACAAGGGGTTCGGCAGTTCGGTCAATATCACCCTTGGACTTCCTTTCATCCGCACTTCGG
TGGATCACGGCACTGCGCTGGATCTGGCAGGCAAGAGCCTGGCGGACCCGGGCAGCCTGATCACCGCGATTAACCACGCC
ATCAAGATGGTAGAGAAAAAAAGATATGAGCAGTAA

Upstream 100 bases:

>100_bases
ATCAGCTCATCTTCAACCGCCGCTTCACCGAAGAGTCCCAGGCGTGGCTGGATGAGCTGCGTGACGAGGCCTACATCCAG
ATTGAAGGCGCCGGCAGCTG

Downstream 100 bases:

>100_bases
GGTGCAGAGCAACAAGGTGCACATGGGTCACACGGCCCGTAAGCGTTTCGGTCAGAACTTCTTGCATGACCGCTATGTGA
TCGATCAGATAGTGGCCGCC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSCRRLAITPGEPAGIGPDLVLQIAQQDWPHQLVVIADPALMLERAALLGLPIELEPYDAKAPAQPQQAGTLSICPLSLG
APVVPGELNEGNGAYVLATLQRACDGNLSGEFAAVVTGPVHKGIINQAGVSFSGHTEFFAQQSGTADVVMLLATEGLRVA
LATTHIPLAYVAMAITEDRLGKVIRILDADLKTKFGIAKPRIYVCGLNPHAGEGGHLGREEIDVIEPALASLCQEGIDLV
GPLPADTLFQDKYLKDADAVLAMYHDQGLPVLKYKGFGSSVNITLGLPFIRTSVDHGTALDLAGKSLADPGSLITAINHA
IKMVEKKRYEQ

Sequences:

>Translated_331_residues
MSCRRLAITPGEPAGIGPDLVLQIAQQDWPHQLVVIADPALMLERAALLGLPIELEPYDAKAPAQPQQAGTLSICPLSLG
APVVPGELNEGNGAYVLATLQRACDGNLSGEFAAVVTGPVHKGIINQAGVSFSGHTEFFAQQSGTADVVMLLATEGLRVA
LATTHIPLAYVAMAITEDRLGKVIRILDADLKTKFGIAKPRIYVCGLNPHAGEGGHLGREEIDVIEPALASLCQEGIDLV
GPLPADTLFQDKYLKDADAVLAMYHDQGLPVLKYKGFGSSVNITLGLPFIRTSVDHGTALDLAGKSLADPGSLITAINHA
IKMVEKKRYEQ
>Mature_330_residues
SCRRLAITPGEPAGIGPDLVLQIAQQDWPHQLVVIADPALMLERAALLGLPIELEPYDAKAPAQPQQAGTLSICPLSLGA
PVVPGELNEGNGAYVLATLQRACDGNLSGEFAAVVTGPVHKGIINQAGVSFSGHTEFFAQQSGTADVVMLLATEGLRVAL
ATTHIPLAYVAMAITEDRLGKVIRILDADLKTKFGIAKPRIYVCGLNPHAGEGGHLGREEIDVIEPALASLCQEGIDLVG
PLPADTLFQDKYLKDADAVLAMYHDQGLPVLKYKGFGSSVNITLGLPFIRTSVDHGTALDLAGKSLADPGSLITAINHAI
KMVEKKRYEQ

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=324, Percent_Identity=67.5925925925926, Blast_Score=442, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34974; Mature: 34843

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCRRLAITPGEPAGIGPDLVLQIAQQDWPHQLVVIADPALMLERAALLGLPIELEPYDA
CCCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCEEECCCCC
KAPAQPQQAGTLSICPLSLGAPVVPGELNEGNGAYVLATLQRACDGNLSGEFAAVVTGPV
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEEECCH
HKGIINQAGVSFSGHTEFFAQQSGTADVVMLLATEGLRVALATTHIPLAYVAMAITEDRL
HHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
GKVIRILDADLKTKFGIAKPRIYVCGLNPHAGEGGHLGREEIDVIEPALASLCQEGIDLV
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GPLPADTLFQDKYLKDADAVLAMYHDQGLPVLKYKGFGSSVNITLGLPFIRTSVDHGTAL
CCCCCHHHHHHHHHCCHHHEEEEEECCCCCEEEECCCCCEEEEEEECCHHEECCCCCCEE
DLAGKSLADPGSLITAINHAIKMVEKKRYEQ
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SCRRLAITPGEPAGIGPDLVLQIAQQDWPHQLVVIADPALMLERAALLGLPIELEPYDA
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCEEECCCCC
KAPAQPQQAGTLSICPLSLGAPVVPGELNEGNGAYVLATLQRACDGNLSGEFAAVVTGPV
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEEECCH
HKGIINQAGVSFSGHTEFFAQQSGTADVVMLLATEGLRVALATTHIPLAYVAMAITEDRL
HHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
GKVIRILDADLKTKFGIAKPRIYVCGLNPHAGEGGHLGREEIDVIEPALASLCQEGIDLV
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GPLPADTLFQDKYLKDADAVLAMYHDQGLPVLKYKGFGSSVNITLGLPFIRTSVDHGTAL
CCCCCHHHHHHHHHCCHHHEEEEEECCCCCEEEECCCCCEEEEEEECCHHEECCCCCCEE
DLAGKSLADPGSLITAINHAIKMVEKKRYEQ
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA