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The map label for this gene is surA [H]

Identifier: 145300233

GI number: 145300233

Start: 3622320

End: 3623618

Strand: Direct

Name: surA [H]

Synonym: ASA_3348

Alternate gene names: 145300233

Gene position: 3622320-3623618 (Clockwise)

Preceding gene: 145300232

Following gene: 145300234

Centisome position: 77.03

GC content: 61.66

Gene sequence:

>1299_bases
ATGAAGAAGACGTTGATTTCCCTGCTGACTGCAGGCCTGTTCGGAGCCATGAGTCAGGGGGCCTTCGCCGCCCCCGAGCT
GATGGACAAGGTGCTTGCCGTGGTCAACAAGGACGTGGTGCTGGCCAGCCAGCAGGAAGCCCTGGTACAGAAAGTCAAAA
GCTCTGCCCAGGAGAGCGGCCAGTCCCTGCCCGATGATGCCACCCTGCGCAAGCAGGCGCTGGATCGCCTGATCCAGGAG
AGCCTGCAACTGCAACTGGCGGATCGCCAGGGCCTGAAGATCAGCGACACCCAGCTGGAGCAAGCCATCCAGAGCATAGC
CGCCGACAACAAGATGACCCTGGATCAGCTGCGAGCCCAACTGGCCCGCGAAGGCCTGACCTATGCCCAGTATCGGGAAG
AGGTGCGCCGCGAGATCCTGATGAACGAAGTGCGCCGCAACCAGGTGCGCCGTCGCATCAATATCTCCGATCAGGAGGTC
AAGCAGGTGGTGGATATCCTCGCCAAGCAGGGCCAGCAGCAACAGCAGTACCATGTCGGCCATATCCAGATTGCCCTGCC
TGACAACCCGAGCGCCGAGCAGCTCAACGCCGCCAAGAGTAAGATAGAGCGCATCCTGGCTGCCCTGAAACAGGGCGCCG
ACTTCCGCAAGCTGGCCATTGCCGAGAGTAATGGTCCCAAGGCACTGGAAGGGGGCGACTGGAGCTGGATGAGCCCGCAA
GAGATGCCGACCCTGATGGCCGAAGCGGTACAAGGCGCAGCCAAGGGTGACATAGTGGGCCCGCTGCGCTCTGGCGCCGG
TCTGCACATCGTCAAGGTGTTCGATGCCAAGGGTCAGCAGCAGGTGCTGCAGACCGAGGTAAAAGCACGCCACATACTGA
TCAAGCCTTCCATCATCCTCAGCGAAGAGAAAGCCAAGGGCATGCTGGATGGCATACTGCACGACATCAAGAGCGGCAAG
GCGACCTTCGCCAGTCTGGCGGAAAAATACTCCGAAGATCCGGGCTCTGCGGTGCAGGGCGGCGAGCTGGGCTGGTCTGA
TCCCAACGTCTATGTGCCGGAGTTCCGCGACATGGTCAACCGCCTCAAGCCGGGTGAGCTGAGCGCCCCCTTCCGTACTA
CCCACGGCTGGCACATAGTGCAGCTGGAAGAGCGTCGCAGCCAGGATGCCACCAGCAAGGCCCAGGAGCAGCGTGCCTAT
CAGCTCATCTTCAACCGCCGCTTCACCGAAGAGTCCCAGGCGTGGCTGGATGAGCTGCGTGACGAGGCCTACATCCAGAT
TGAAGGCGCCGGCAGCTGA

Upstream 100 bases:

>100_bases
CTCCAAGGGCACCTCCCTGGATACCGAAGCACTGCCTTACATTCGTCCGTTTAACCTGCGAGACCAATAACCGGTCTGGC
AAACGCCTTGAGAGATGGAT

Downstream 100 bases:

>100_bases
TGAGCTGTCGTCGTCTCGCCATTACGCCGGGTGAGCCCGCCGGAATAGGCCCGGATCTGGTGCTGCAGATAGCCCAGCAG
GATTGGCCCCACCAGCTGGT

Product: chaperone surA

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase surA; PPIase surA; Rotamase surA [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKKTLISLLTAGLFGAMSQGAFAAPELMDKVLAVVNKDVVLASQQEALVQKVKSSAQESGQSLPDDATLRKQALDRLIQE
SLQLQLADRQGLKISDTQLEQAIQSIAADNKMTLDQLRAQLAREGLTYAQYREEVRREILMNEVRRNQVRRRINISDQEV
KQVVDILAKQGQQQQQYHVGHIQIALPDNPSAEQLNAAKSKIERILAALKQGADFRKLAIAESNGPKALEGGDWSWMSPQ
EMPTLMAEAVQGAAKGDIVGPLRSGAGLHIVKVFDAKGQQQVLQTEVKARHILIKPSIILSEEKAKGMLDGILHDIKSGK
ATFASLAEKYSEDPGSAVQGGELGWSDPNVYVPEFRDMVNRLKPGELSAPFRTTHGWHIVQLEERRSQDATSKAQEQRAY
QLIFNRRFTEESQAWLDELRDEAYIQIEGAGS

Sequences:

>Translated_432_residues
MKKTLISLLTAGLFGAMSQGAFAAPELMDKVLAVVNKDVVLASQQEALVQKVKSSAQESGQSLPDDATLRKQALDRLIQE
SLQLQLADRQGLKISDTQLEQAIQSIAADNKMTLDQLRAQLAREGLTYAQYREEVRREILMNEVRRNQVRRRINISDQEV
KQVVDILAKQGQQQQQYHVGHIQIALPDNPSAEQLNAAKSKIERILAALKQGADFRKLAIAESNGPKALEGGDWSWMSPQ
EMPTLMAEAVQGAAKGDIVGPLRSGAGLHIVKVFDAKGQQQVLQTEVKARHILIKPSIILSEEKAKGMLDGILHDIKSGK
ATFASLAEKYSEDPGSAVQGGELGWSDPNVYVPEFRDMVNRLKPGELSAPFRTTHGWHIVQLEERRSQDATSKAQEQRAY
QLIFNRRFTEESQAWLDELRDEAYIQIEGAGS
>Mature_432_residues
MKKTLISLLTAGLFGAMSQGAFAAPELMDKVLAVVNKDVVLASQQEALVQKVKSSAQESGQSLPDDATLRKQALDRLIQE
SLQLQLADRQGLKISDTQLEQAIQSIAADNKMTLDQLRAQLAREGLTYAQYREEVRREILMNEVRRNQVRRRINISDQEV
KQVVDILAKQGQQQQQYHVGHIQIALPDNPSAEQLNAAKSKIERILAALKQGADFRKLAIAESNGPKALEGGDWSWMSPQ
EMPTLMAEAVQGAAKGDIVGPLRSGAGLHIVKVFDAKGQQQVLQTEVKARHILIKPSIILSEEKAKGMLDGILHDIKSGK
ATFASLAEKYSEDPGSAVQGGELGWSDPNVYVPEFRDMVNRLKPGELSAPFRTTHGWHIVQLEERRSQDATSKAQEQRAY
QLIFNRRFTEESQAWLDELRDEAYIQIEGAGS

Specific function: Chaperone involved in the correct folding and assembly of outer membrane proteins. It recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm. Note=Is capable of associating with the outer membrane (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PpiC domains [H]

Homologues:

Organism=Escherichia coli, GI1786238, Length=412, Percent_Identity=48.3009708737864, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR023034
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 47904; Mature: 47904

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTLISLLTAGLFGAMSQGAFAAPELMDKVLAVVNKDVVLASQQEALVQKVKSSAQESG
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHEECHHHHHHHHHHHHHHHCC
QSLPDDATLRKQALDRLIQESLQLQLADRQGLKISDTQLEQAIQSIAADNKMTLDQLRAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
LAREGLTYAQYREEVRREILMNEVRRNQVRRRINISDQEVKQVVDILAKQGQQQQQYHVG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCC
HIQIALPDNPSAEQLNAAKSKIERILAALKQGADFRKLAIAESNGPKALEGGDWSWMSPQ
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCCCCHH
EMPTLMAEAVQGAAKGDIVGPLRSGAGLHIVKVFDAKGQQQVLQTEVKARHILIKPSIIL
HHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHEEEECCCCEE
SEEKAKGMLDGILHDIKSGKATFASLAEKYSEDPGSAVQGGELGWSDPNVYVPEFRDMVN
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCHHHHHHH
RLKPGELSAPFRTTHGWHIVQLEERRSQDATSKAQEQRAYQLIFNRRFTEESQAWLDELR
HCCCCCCCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
DEAYIQIEGAGS
CCEEEEEECCCC
>Mature Secondary Structure
MKKTLISLLTAGLFGAMSQGAFAAPELMDKVLAVVNKDVVLASQQEALVQKVKSSAQESG
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHEECHHHHHHHHHHHHHHHCC
QSLPDDATLRKQALDRLIQESLQLQLADRQGLKISDTQLEQAIQSIAADNKMTLDQLRAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
LAREGLTYAQYREEVRREILMNEVRRNQVRRRINISDQEVKQVVDILAKQGQQQQQYHVG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCC
HIQIALPDNPSAEQLNAAKSKIERILAALKQGADFRKLAIAESNGPKALEGGDWSWMSPQ
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCCCCHH
EMPTLMAEAVQGAAKGDIVGPLRSGAGLHIVKVFDAKGQQQVLQTEVKARHILIKPSIIL
HHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHEEEECCCCEE
SEEKAKGMLDGILHDIKSGKATFASLAEKYSEDPGSAVQGGELGWSDPNVYVPEFRDMVN
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCHHHHHHH
RLKPGELSAPFRTTHGWHIVQLEERRSQDATSKAQEQRAYQLIFNRRFTEESQAWLDELR
HCCCCCCCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
DEAYIQIEGAGS
CCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]