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The map label for this gene is pabB [H]

Identifier: 145299250

GI number: 145299250

Start: 2422973

End: 2424352

Strand: Direct

Name: pabB [H]

Synonym: ASA_2293

Alternate gene names: 145299250

Gene position: 2422973-2424352 (Clockwise)

Preceding gene: 145299248

Following gene: 145299251

Centisome position: 51.53

GC content: 61.09

Gene sequence:

>1380_bases
ATGAAACCAACTCTTCATATCCACCACTTTGATCACCAGACAGCGCTGCATGCGTTGTTTGCCCGTCTGCATCATCAGCC
CTGGGCCATGTTGCTCGAATCGGCCGGCCCGCAGGGAGCGGACAACCGCTTTGACATCATCAGCGCCGACCCGCTGGCAA
CCCTGCAGACAGAGGGGCCACTGACCTGGATAACCCGGGGCGAACAGTGTCTGTCGTTTGACACGGATCCCCTGACCCTG
CTGGCACAATGGCAACGTGATCTGCTGGGCGAGAAAGCACCGCACTGTGACGAATTGCCTTTTATTGGCGGCGCCCTCGG
GCTGTTTGGCTATGATCTTGGCCGTCGCTTCGAGCGATTGCCGACACTGGCCGCGCAGGATGTGTCCGTGCCGGACATGG
CAGTCGGCATCTATGACTGGGCCCTGCTGCGCAACGTAGCAAGCGGCACCTGGCAGCTGGTGCATTGGGGTGATGAAGCA
GGCCTCCATCGCCGGCTGCAGTGGCTGGCCGCACAGCACGAGATGCCAACACCGCCATTTGCCCTGCAGAGCGAGTGGCG
CAGCAACATGAGCCGCGCCGAGTACGGCGAGAAATTTGCGCGAGTACAGGCTTACCTGAGTGCCGGGGACTGTTATCAAA
TCAACCTGACCCAGCGCTTCAGCGCCGCCTATTGCGGCGATGAGTGGCAGGCTTATCAGGTGTTGTCCCGCGCCAACCGG
GCTCCGTTTTCGGCCTTTGTTCGCCTGCCGCAGAGCGCCATTCTAAGCCTCTCCCCCGAGCGGTTTCTGCTGCTTGATGA
TCGCCATATCGAAACCAAGCCCATCAAGGGTACCCGCCCCCGACTTGCCGATCCGCAGCAAGATCAGGCCAGCGCCCTCG
AGCTGGCTGGCGCCGACAAGGACAGATCAGAGAATCTGATGATCGTGGATCTGCTGCGCAACGATATCGGCAGGGTGAGC
CGTCCTAGCTCCGTCAGCGTGCCCAGCCTGTTTGCCGTGGAGTCGTTCCCGGCGGTGCATCATCTGGTGTCCACCATCCA
CGGCGAGCTGGATAACCGCTGGCAGGCGGTGGATCTGCTGCGCGCCTGTTTCCCGGGCGGTTCCATCACCGGCGCCCCCA
AGATCAGGGCCATGGAGATCATTGAGGAGCTGGAGCCCCAGCGCCGCAACGCTTACTGTGGCAGTATCGGCTATCTGAGC
CAGCATGGCCGGATGGACACCAGCATCTGCATTCGCACTCTGATTGCGGCAGACCGCCAACTACACTGCTGGGCCGGGGG
GGGAATCATTGCCGACTCCGATGTGGACAGTGAATATCAGGAAACCTATGACAAGGTGGCCCGCATACTGCCGTTGCTGG
AGACGCTGAAAAGCCGATAA

Upstream 100 bases:

>100_bases
CAACGGCGTGTTTGTTCTAAAAATTCCGATGCCTATGATACGCTTGCCCCCCCATACCGGCTAGGGAGCAGGGTGCAAAC
TGTTGCCTGTGTAACAAAAA

Downstream 100 bases:

>100_bases
GCTGAGAAGTTGAGAAGTTGAGAAGTTGAGAAGTTGAGAAGTTGAGAAGTTGACAGAATGGATAACGGAGTGACCATGAA
AGAGACCCCAGCGCAGGATT

Product: para-aminobenzoate synthase, component I

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKPTLHIHHFDHQTALHALFARLHHQPWAMLLESAGPQGADNRFDIISADPLATLQTEGPLTWITRGEQCLSFDTDPLTL
LAQWQRDLLGEKAPHCDELPFIGGALGLFGYDLGRRFERLPTLAAQDVSVPDMAVGIYDWALLRNVASGTWQLVHWGDEA
GLHRRLQWLAAQHEMPTPPFALQSEWRSNMSRAEYGEKFARVQAYLSAGDCYQINLTQRFSAAYCGDEWQAYQVLSRANR
APFSAFVRLPQSAILSLSPERFLLLDDRHIETKPIKGTRPRLADPQQDQASALELAGADKDRSENLMIVDLLRNDIGRVS
RPSSVSVPSLFAVESFPAVHHLVSTIHGELDNRWQAVDLLRACFPGGSITGAPKIRAMEIIEELEPQRRNAYCGSIGYLS
QHGRMDTSICIRTLIAADRQLHCWAGGGIIADSDVDSEYQETYDKVARILPLLETLKSR

Sequences:

>Translated_459_residues
MKPTLHIHHFDHQTALHALFARLHHQPWAMLLESAGPQGADNRFDIISADPLATLQTEGPLTWITRGEQCLSFDTDPLTL
LAQWQRDLLGEKAPHCDELPFIGGALGLFGYDLGRRFERLPTLAAQDVSVPDMAVGIYDWALLRNVASGTWQLVHWGDEA
GLHRRLQWLAAQHEMPTPPFALQSEWRSNMSRAEYGEKFARVQAYLSAGDCYQINLTQRFSAAYCGDEWQAYQVLSRANR
APFSAFVRLPQSAILSLSPERFLLLDDRHIETKPIKGTRPRLADPQQDQASALELAGADKDRSENLMIVDLLRNDIGRVS
RPSSVSVPSLFAVESFPAVHHLVSTIHGELDNRWQAVDLLRACFPGGSITGAPKIRAMEIIEELEPQRRNAYCGSIGYLS
QHGRMDTSICIRTLIAADRQLHCWAGGGIIADSDVDSEYQETYDKVARILPLLETLKSR
>Mature_459_residues
MKPTLHIHHFDHQTALHALFARLHHQPWAMLLESAGPQGADNRFDIISADPLATLQTEGPLTWITRGEQCLSFDTDPLTL
LAQWQRDLLGEKAPHCDELPFIGGALGLFGYDLGRRFERLPTLAAQDVSVPDMAVGIYDWALLRNVASGTWQLVHWGDEA
GLHRRLQWLAAQHEMPTPPFALQSEWRSNMSRAEYGEKFARVQAYLSAGDCYQINLTQRFSAAYCGDEWQAYQVLSRANR
APFSAFVRLPQSAILSLSPERFLLLDDRHIETKPIKGTRPRLADPQQDQASALELAGADKDRSENLMIVDLLRNDIGRVS
RPSSVSVPSLFAVESFPAVHHLVSTIHGELDNRWQAVDLLRACFPGGSITGAPKIRAMEIIEELEPQRRNAYCGSIGYLS
QHGRMDTSICIRTLIAADRQLHCWAGGGIIADSDVDSEYQETYDKVARILPLLETLKSR

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=442, Percent_Identity=59.9547511312217, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1787518, Length=367, Percent_Identity=34.0599455040872, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786809, Length=197, Percent_Identity=26.9035532994924, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082077, Length=204, Percent_Identity=28.4313725490196, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=439, Percent_Identity=32.1184510250569, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324361, Length=395, Percent_Identity=27.8481012658228, Blast_Score=142, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 51404; Mature: 51404

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTLHIHHFDHQTALHALFARLHHQPWAMLLESAGPQGADNRFDIISADPLATLQTEGP
CCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCC
LTWITRGEQCLSFDTDPLTLLAQWQRDLLGEKAPHCDELPFIGGALGLFGYDLGRRFERL
EEEEECCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
PTLAAQDVSVPDMAVGIYDWALLRNVASGTWQLVHWGDEAGLHRRLQWLAAQHEMPTPPF
CCHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCH
ALQSEWRSNMSRAEYGEKFARVQAYLSAGDCYQINLTQRFSAAYCGDEWQAYQVLSRANR
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHCCC
APFSAFVRLPQSAILSLSPERFLLLDDRHIETKPIKGTRPRLADPQQDQASALELAGADK
CCHHHHHHCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
DRSENLMIVDLLRNDIGRVSRPSSVSVPSLFAVESFPAVHHLVSTIHGELDNRWQAVDLL
CCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RACFPGGSITGAPKIRAMEIIEELEPQRRNAYCGSIGYLSQHGRMDTSICIRTLIAADRQ
HHHCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCE
LHCWAGGGIIADSDVDSEYQETYDKVARILPLLETLKSR
EEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPTLHIHHFDHQTALHALFARLHHQPWAMLLESAGPQGADNRFDIISADPLATLQTEGP
CCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCC
LTWITRGEQCLSFDTDPLTLLAQWQRDLLGEKAPHCDELPFIGGALGLFGYDLGRRFERL
EEEEECCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
PTLAAQDVSVPDMAVGIYDWALLRNVASGTWQLVHWGDEAGLHRRLQWLAAQHEMPTPPF
CCHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCH
ALQSEWRSNMSRAEYGEKFARVQAYLSAGDCYQINLTQRFSAAYCGDEWQAYQVLSRANR
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHCCC
APFSAFVRLPQSAILSLSPERFLLLDDRHIETKPIKGTRPRLADPQQDQASALELAGADK
CCHHHHHHCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
DRSENLMIVDLLRNDIGRVSRPSSVSVPSLFAVESFPAVHHLVSTIHGELDNRWQAVDLL
CCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RACFPGGSITGAPKIRAMEIIEELEPQRRNAYCGSIGYLSQHGRMDTSICIRTLIAADRQ
HHHCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCE
LHCWAGGGIIADSDVDSEYQETYDKVARILPLLETLKSR
EEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6330050; 9097040; 9278503; 7896119; 2251281; 7592344 [H]