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The map label for this gene is mprA [H]

Identifier: 145296603

GI number: 145296603

Start: 2773154

End: 2773876

Strand: Reverse

Name: mprA [H]

Synonym: cgR_2511

Alternate gene names: 145296603

Gene position: 2773876-2773154 (Counterclockwise)

Preceding gene: 145296604

Following gene: 145296602

Centisome position: 83.7

GC content: 53.39

Gene sequence:

>723_bases
ATGGAAGAGATGAAAATGGACAACCAGTCTGATGGACAAATCCGCGTACTCGTCGTTGATGACGAGCCAAACATTGTTGA
GCTGCTCACCGTAAGCCTTAAATTCCAAGGCTTCGCAGTGATGACCGCCAATGATGGCAATGAAGCCCTGAAGATTGCTC
GTGAATTCCGTCCAGATGCTTACATCCTTGACGTGATGATGCCAGGCATGGATGGTTTTGAGCTGCTCACCAAGCTGCGT
AGTGAAGGCCTTGACAGCCCAGTTCTGTACCTCACCGCAAAGGATGCCGTGGAGCACCGCATCCACGGACTGACCATCGG
CGCTGACGACTACGTGACCAAGCCTTTCTCCCTGGAAGAAGTAATCACCCGCCTGCGCGTGATTCTTCGTCGCGGTGGAG
CAGTTGAAGAAGACACCTCAACTTCCCTGCAGTACGCAGACCTCACCCTCAACGATGAAACCCACGAGGTCACCAAGGCT
GGCGAACTGATCGATCTTTCCCCAACCGAATTCAACCTCCTGCGCTACCTCATGCTCAACGCTGAAGTTGTGCTGTCCAA
GGCAAAGATCCTGGATAACGTATGGCACTACGATTTCGGTGGCGACGGCAATGTCGTGGAATCCTACATCTCCTACCTAC
GTCGCAAGGTGGACACCCAAGAGCCACAGCTGATCCAGACTGTTCGTGGCGTTGGATACGTTCTGCGCACCCCACGTAAC
TAA

Upstream 100 bases:

>100_bases
AATTTCAACTCTTTCAGTACATTCACAGTTAGTATTCAGTGGTGTTGAAGTTCCAGGGTGTTCACTAGTGAGAAGTTAAT
TATTCCGCCAATGGATACCA

Downstream 100 bases:

>100_bases
TTTCTCCTATGGAAAACCCTTATGTTGCTGCGCTCGATGACGAAAACCAAGAAGTCGGCGTAAAAAAAGAAGCAGAAAAA
GAACCTGAAATAGGCCCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MEEMKMDNQSDGQIRVLVVDDEPNIVELLTVSLKFQGFAVMTANDGNEALKIAREFRPDAYILDVMMPGMDGFELLTKLR
SEGLDSPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRLRVILRRGGAVEEDTSTSLQYADLTLNDETHEVTKA
GELIDLSPTEFNLLRYLMLNAEVVLSKAKILDNVWHYDFGGDGNVVESYISYLRRKVDTQEPQLIQTVRGVGYVLRTPRN

Sequences:

>Translated_240_residues
MEEMKMDNQSDGQIRVLVVDDEPNIVELLTVSLKFQGFAVMTANDGNEALKIAREFRPDAYILDVMMPGMDGFELLTKLR
SEGLDSPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRLRVILRRGGAVEEDTSTSLQYADLTLNDETHEVTKA
GELIDLSPTEFNLLRYLMLNAEVVLSKAKILDNVWHYDFGGDGNVVESYISYLRRKVDTQEPQLIQTVRGVGYVLRTPRN
>Mature_240_residues
MEEMKMDNQSDGQIRVLVVDDEPNIVELLTVSLKFQGFAVMTANDGNEALKIAREFRPDAYILDVMMPGMDGFELLTKLR
SEGLDSPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRLRVILRRGGAVEEDTSTSLQYADLTLNDETHEVTKA
GELIDLSPTEFNLLRYLMLNAEVVLSKAKILDNVWHYDFGGDGNVVESYISYLRRKVDTQEPQLIQTVRGVGYVLRTPRN

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=39.8230088495575, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=36.4035087719298, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=37.8378378378378, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=35.2941176470588, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788394, Length=236, Percent_Identity=33.8983050847458, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.219730941704, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.8385650224215, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.6363636363636, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.2105263157895, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788550, Length=177, Percent_Identity=32.2033898305085, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.0748898678414, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=28.755364806867, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1790437, Length=126, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788713, Length=158, Percent_Identity=31.6455696202532, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=127, Percent_Identity=36.2204724409449, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27070; Mature: 27070

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEMKMDNQSDGQIRVLVVDDEPNIVELLTVSLKFQGFAVMTANDGNEALKIAREFRPDA
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCEEEEEECCCHHHHHHHHHHCCCE
YILDVMMPGMDGFELLTKLRSEGLDSPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEE
EEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCEEEECCCCCCCCCCCHHH
VITRLRVILRRGGAVEEDTSTSLQYADLTLNDETHEVTKAGELIDLSPTEFNLLRYLMLN
HHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCEEECCCCHHHHHHHHHHH
AEVVLSKAKILDNVWHYDFGGDGNVVESYISYLRRKVDTQEPQLIQTVRGVGYVLRTPRN
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCC
>Mature Secondary Structure
MEEMKMDNQSDGQIRVLVVDDEPNIVELLTVSLKFQGFAVMTANDGNEALKIAREFRPDA
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCEEEEEECCCHHHHHHHHHHCCCE
YILDVMMPGMDGFELLTKLRSEGLDSPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEE
EEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCEEEECCCCCCCCCCCHHH
VITRLRVILRRGGAVEEDTSTSLQYADLTLNDETHEVTKAGELIDLSPTEFNLLRYLMLN
HHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCEEECCCCHHHHHHHHHHH
AEVVLSKAKILDNVWHYDFGGDGNVVESYISYLRRKVDTQEPQLIQTVRGVGYVLRTPRN
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA