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The map label for this gene is phoR [H]

Identifier: 145296602

GI number: 145296602

Start: 2771688

End: 2773145

Strand: Reverse

Name: phoR [H]

Synonym: cgR_2510

Alternate gene names: 145296602

Gene position: 2773145-2771688 (Counterclockwise)

Preceding gene: 145296603

Following gene: 145296599

Centisome position: 83.68

GC content: 55.9

Gene sequence:

>1458_bases
ATGGAAAACCCTTATGTTGCTGCGCTCGATGACGAAAACCAAGAAGTCGGCGTAAAAAAAGAAGCAGAAAAAGAACCTGA
AATAGGCCCCATTCGAGCTGCCGGACGAGCCATACCGCTGCGCACCCGCATCATTTTGATCGTGGTGGGTATCGCCGGGC
TTGGTTTGCTAGTCAACGCGGTTGCTGTCTCCAGCCTCATGCGTGAAGTTTCCTATACCCGCATGGATCAAGAGCTAGAG
ACTTCGATGGGGACGTGGGCGCATAACGTTGAGCTGTTTAATTTCGATGGGGTCCGCCAAGGACCGCCCAGCGATTATTA
CGTGGCCAAGGTTTTTCCGGACGGATCCAGCATCATCTTTAACGATGCACAATCGGCACCCGATCTAGCTGAAACCACCA
TCGGTACTGGTCCACACACTGTGGATGCTGCTAGCGGTTCTGCCTCCAACACTCCGTGGCGTGTGATGGCGGAAAAGAAC
GGTGACATTATCACCGTGGTGGGTAAAAGCATGGGGCGTGAAACAAACCTGCTGTACCGATTGGTGATGGTGCAGATGAT
CATCGGCGCGCTGATTCTGGTTGCTATTTTGATTACTTCACTCTTCCTAGTCAGACGCTCGTTGCGGCCGTTGAGAGAAG
TTGAAGAGACCGCCACCAGGATTGCGGGCGGTGATTTGGATCGACGTGTCCCGCAGTGGCCAATGACCACAGAAGTCGGA
CAGCTGTCGAATGCCCTCAATATCATGTTGGAGCAGCTCCAAGCCTCAATTCTGACCGCCCAGCAAAAAGAAGCTCAGAT
GCGCCGATTCGTTGGCGACGCCTCCCACGAGCTCCGCACACCACTGACCTCTGTGAAGGGCTTCACCGAGCTGTATTCAT
CAGGTGCAACAGATGATGCCAACTGGGTCATGTCCAAGATCGGTGGCGAAGCCCAACGCATGAGTGTGCTCGTGGAAGAC
CTCCTGTCACTGACGCGTGCCGAAGGCCAGCAAATGGAGAAGCACCGCGTTGACGTGCTGGAACTCGCCTTGGCAGTACG
CGGATCAATGCGCGCAGCCTGGCCAGATCGCACCGTGAACGTGTCCAATAAAGCCGCGTCCATTCCAGTTGTTGAAGGCG
ACCCAACCCGCCTCCACCAAGTGCTTACCAACTTGGTTGCCAACGGACTCAACCACGGCGGACCGGACGCGGAAGTCAGC
ATTGAGATCAACACCGATGGGCAAAACGTGAAGATTCTCGTGGCAGACAACGGTGTCGGAATGTCTGAAGAAGATGCCCA
GCACATCTTCGAGCGTTTCTACCGCGCTGATTCCTCCCGCTCACGCGCATCCGGCGGATCGGGCCTCGGCCTTGCGATCA
CGAAATCCCTGGTCGAAGGCCACGGCGGCACAGTCACCGTCGACAGCGTGCAAGGCGAAGGCACGGTGTTCACGATCACC
TTGCCGGCGGTTTCTTAA

Upstream 100 bases:

>100_bases
CCTACCTACGTCGCAAGGTGGACACCCAAGAGCCACAGCTGATCCAGACTGTTCGTGGCGTTGGATACGTTCTGCGCACC
CCACGTAACTAATTTCTCCT

Downstream 100 bases:

>100_bases
AGGCATCAAGGGCCGGAAAAGATTGCTTTTCGACGAACCCCTCCACCCGTGACAACCCTTCCGGCAAAGCTCCCCAAAAG
GGCACGCCGGTGACTCTCTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MENPYVAALDDENQEVGVKKEAEKEPEIGPIRAAGRAIPLRTRIILIVVGIAGLGLLVNAVAVSSLMREVSYTRMDQELE
TSMGTWAHNVELFNFDGVRQGPPSDYYVAKVFPDGSSIIFNDAQSAPDLAETTIGTGPHTVDAASGSASNTPWRVMAEKN
GDIITVVGKSMGRETNLLYRLVMVQMIIGALILVAILITSLFLVRRSLRPLREVEETATRIAGGDLDRRVPQWPMTTEVG
QLSNALNIMLEQLQASILTAQQKEAQMRRFVGDASHELRTPLTSVKGFTELYSSGATDDANWVMSKIGGEAQRMSVLVED
LLSLTRAEGQQMEKHRVDVLELALAVRGSMRAAWPDRTVNVSNKAASIPVVEGDPTRLHQVLTNLVANGLNHGGPDAEVS
IEINTDGQNVKILVADNGVGMSEEDAQHIFERFYRADSSRSRASGGSGLGLAITKSLVEGHGGTVTVDSVQGEGTVFTIT
LPAVS

Sequences:

>Translated_485_residues
MENPYVAALDDENQEVGVKKEAEKEPEIGPIRAAGRAIPLRTRIILIVVGIAGLGLLVNAVAVSSLMREVSYTRMDQELE
TSMGTWAHNVELFNFDGVRQGPPSDYYVAKVFPDGSSIIFNDAQSAPDLAETTIGTGPHTVDAASGSASNTPWRVMAEKN
GDIITVVGKSMGRETNLLYRLVMVQMIIGALILVAILITSLFLVRRSLRPLREVEETATRIAGGDLDRRVPQWPMTTEVG
QLSNALNIMLEQLQASILTAQQKEAQMRRFVGDASHELRTPLTSVKGFTELYSSGATDDANWVMSKIGGEAQRMSVLVED
LLSLTRAEGQQMEKHRVDVLELALAVRGSMRAAWPDRTVNVSNKAASIPVVEGDPTRLHQVLTNLVANGLNHGGPDAEVS
IEINTDGQNVKILVADNGVGMSEEDAQHIFERFYRADSSRSRASGGSGLGLAITKSLVEGHGGTVTVDSVQGEGTVFTIT
LPAVS
>Mature_485_residues
MENPYVAALDDENQEVGVKKEAEKEPEIGPIRAAGRAIPLRTRIILIVVGIAGLGLLVNAVAVSSLMREVSYTRMDQELE
TSMGTWAHNVELFNFDGVRQGPPSDYYVAKVFPDGSSIIFNDAQSAPDLAETTIGTGPHTVDAASGSASNTPWRVMAEKN
GDIITVVGKSMGRETNLLYRLVMVQMIIGALILVAILITSLFLVRRSLRPLREVEETATRIAGGDLDRRVPQWPMTTEVG
QLSNALNIMLEQLQASILTAQQKEAQMRRFVGDASHELRTPLTSVKGFTELYSSGATDDANWVMSKIGGEAQRMSVLVED
LLSLTRAEGQQMEKHRVDVLELALAVRGSMRAAWPDRTVNVSNKAASIPVVEGDPTRLHQVLTNLVANGLNHGGPDAEVS
IEINTDGQNVKILVADNGVGMSEEDAQHIFERFYRADSSRSRASGGSGLGLAITKSLVEGHGGTVTVDSVQGEGTVFTIT
LPAVS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=315, Percent_Identity=32.6984126984127, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=32.6164874551971, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=32.034632034632, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790346, Length=280, Percent_Identity=31.4285714285714, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1787894, Length=317, Percent_Identity=29.6529968454259, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789149, Length=343, Percent_Identity=29.4460641399417, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788713, Length=279, Percent_Identity=29.0322580645161, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=28.6919831223629, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=27.2, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=31.1740890688259, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=322, Percent_Identity=26.3975155279503, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=29.0178571428571, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790861, Length=255, Percent_Identity=28.2352941176471, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=28.3842794759825, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789403, Length=458, Percent_Identity=25.1091703056769, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=25.9701492537313, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789808, Length=295, Percent_Identity=26.1016949152542, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790300, Length=269, Percent_Identity=28.996282527881, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=233, Percent_Identity=25.7510729613734, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=28.0405405405405, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52267; Mature: 52267

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENPYVAALDDENQEVGVKKEAEKEPEIGPIRAAGRAIPLRTRIILIVVGIAGLGLLVNA
CCCCEEEEECCCCCCCCCCCHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VAVSSLMREVSYTRMDQELETSMGTWAHNVELFNFDGVRQGPPSDYYVAKVFPDGSSIIF
HHHHHHHHHHHHHHHHHHHHHHHCCCEECEEEEECCCCCCCCCCCEEEEEEECCCCEEEE
NDAQSAPDLAETTIGTGPHTVDAASGSASNTPWRVMAEKNGDIITVVGKSMGRETNLLYR
ECCCCCCCHHHHCCCCCCCEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHH
LVMVQMIIGALILVAILITSLFLVRRSLRPLREVEETATRIAGGDLDRRVPQWPMTTEVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHH
QLSNALNIMLEQLQASILTAQQKEAQMRRFVGDASHELRTPLTSVKGFTELYSSGATDDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCCCHH
NWVMSKIGGEAQRMSVLVEDLLSLTRAEGQQMEKHRVDVLELALAVRGSMRAAWPDRTVN
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
VSNKAASIPVVEGDPTRLHQVLTNLVANGLNHGGPDAEVSIEINTDGQNVKILVADNGVG
CCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEECCCCC
MSEEDAQHIFERFYRADSSRSRASGGSGLGLAITKSLVEGHGGTVTVDSVQGEGTVFTIT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEE
LPAVS
ECCCC
>Mature Secondary Structure
MENPYVAALDDENQEVGVKKEAEKEPEIGPIRAAGRAIPLRTRIILIVVGIAGLGLLVNA
CCCCEEEEECCCCCCCCCCCHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VAVSSLMREVSYTRMDQELETSMGTWAHNVELFNFDGVRQGPPSDYYVAKVFPDGSSIIF
HHHHHHHHHHHHHHHHHHHHHHHCCCEECEEEEECCCCCCCCCCCEEEEEEECCCCEEEE
NDAQSAPDLAETTIGTGPHTVDAASGSASNTPWRVMAEKNGDIITVVGKSMGRETNLLYR
ECCCCCCCHHHHCCCCCCCEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHH
LVMVQMIIGALILVAILITSLFLVRRSLRPLREVEETATRIAGGDLDRRVPQWPMTTEVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHH
QLSNALNIMLEQLQASILTAQQKEAQMRRFVGDASHELRTPLTSVKGFTELYSSGATDDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCCCHH
NWVMSKIGGEAQRMSVLVEDLLSLTRAEGQQMEKHRVDVLELALAVRGSMRAAWPDRTVN
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
VSNKAASIPVVEGDPTRLHQVLTNLVANGLNHGGPDAEVSIEINTDGQNVKILVADNGVG
CCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEECCCCC
MSEEDAQHIFERFYRADSSRSRASGGSGLGLAITKSLVEGHGGTVTVDSVQGEGTVFTIT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEE
LPAVS
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]