Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 145296600

GI number: 145296600

Start: 2769761

End: 2771032

Strand: Direct

Name: bioA [H]

Synonym: cgR_2508

Alternate gene names: 145296600

Gene position: 2769761-2771032 (Clockwise)

Preceding gene: 145296597

Following gene: 145296601

Centisome position: 83.57

GC content: 55.27

Gene sequence:

>1272_bases
ATGGAAAACCCCAGCTTGCGCGAGCTTGATCACCGAAACATCTGGCACCCGTATGCCGCGCCGGGCGTGCGCAACAGACT
CGTCACCAACACTGATGGGGTGTTCTTGACGCTGGAAGATGGCAGCACCGTGATTGACGCGATGAGCTCCTGGTGGTCGG
CAATTCATGGACACGGACACCCCCGACTGAAAGCTGCCGCCCAAAAACAAATCGACACCATGAGTCACGTCATGTTCGGC
GGACTAACCCACGAGCCCGCCATTAAGCTCACCCACAAACTCCTCAATCTCACTGGCAATGCCTTTGACCACGTCTTTTA
TTCCGATTCGGGCTCGGTCTCGGTGGAGGTCGCCATCAAAATGGCACTGCAGGCCTCCAAAGGACAAGGCCACCCGGAAC
GCACAAAACTCCTCACCTGGCGGTCCGGCTACCACGGAGACACATTCACCGCGATGAGCGTGTGCGACCCAGAAAATGGC
ATGCATAGCCTCTGGAAAGGCACACTCCCCGAGCAGATTTTCGCCCCCGCCCCACCAGTTCGGGGGTCATCGCCGCAGGC
AATTTCCGAGTACCTGCACAGCATGGAATTGCTTATCGACGAGACCGTCTCCGCAATCATCATCGAACCGATCGTCCAAG
GCGCTGGAGGCATGCGCTTTCACGATGTCGCACTCATTGAAGGAGTCGCGGCACTGTGCAAGAAGCACGATCGTTTCTTG
ATCGTCGATGAAATTGCCACCGGTTTCGGCCGCACCGGTGAACTATTTGCCACGTTAAGCAATGGCGTACAACCAGACAT
CATGTGTGTGGGCAAGGCCCTCACCGGTGGATTCATGTCTTTTGCCGCCACTGTATGCACGGACAAGGTGGCTCAATTGA
TCAGTACCCCAGAAGGCGGAGGTGTGCTGATGCATGGCCCCACCTTTATGGCTAATCCTCTGGCCTGTGAGGTTTCGCAC
GCTTCGCTAGAAATCATTGAGACCGGCATGTGGCAGAAACAGGTTAAAAAAATCGAAGCCGAACTTATCGCAGGCCTTTC
CCCACTTCGATGTATTCCAGGAGTTGCCGATGTCCGGGTTCTCGGCGCGATTGGCGTCATCGAAATGGAACAAAATGTCA
ATGTCGAAGAAGCCACTCAGGCTGCATTAGATCACGGTGTGTGGATCCGCCCCTTTGGACGCTTGCTCTATGTCATGCCC
CCATATATCACCACGTCAGAGCAATGCGCACAGATCTGCGCCGCGCTTCATGCTGCAGTTAAAGGAAAATAA

Upstream 100 bases:

>100_bases
AAAGCTGCGGCAATGAAAAACACTTAGTGCCAAAAATTGAACACTGTTCAATTAACCTATTACACTGCACATATGCAACC
AAACCAAGTGACGGAGGAAA

Downstream 100 bases:

>100_bases
ACCATGCCATTTTTATTTGTCAGCGGCACCGGAACCGGGGTTGGAAAGACCTTCTCCACAGCCGTTTTGGTTCGTTACTT
AGCCGATCAAGGACACGATG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MENPSLRELDHRNIWHPYAAPGVRNRLVTNTDGVFLTLEDGSTVIDAMSSWWSAIHGHGHPRLKAAAQKQIDTMSHVMFG
GLTHEPAIKLTHKLLNLTGNAFDHVFYSDSGSVSVEVAIKMALQASKGQGHPERTKLLTWRSGYHGDTFTAMSVCDPENG
MHSLWKGTLPEQIFAPAPPVRGSSPQAISEYLHSMELLIDETVSAIIIEPIVQGAGGMRFHDVALIEGVAALCKKHDRFL
IVDEIATGFGRTGELFATLSNGVQPDIMCVGKALTGGFMSFAATVCTDKVAQLISTPEGGGVLMHGPTFMANPLACEVSH
ASLEIIETGMWQKQVKKIEAELIAGLSPLRCIPGVADVRVLGAIGVIEMEQNVNVEEATQAALDHGVWIRPFGRLLYVMP
PYITTSEQCAQICAALHAAVKGK

Sequences:

>Translated_423_residues
MENPSLRELDHRNIWHPYAAPGVRNRLVTNTDGVFLTLEDGSTVIDAMSSWWSAIHGHGHPRLKAAAQKQIDTMSHVMFG
GLTHEPAIKLTHKLLNLTGNAFDHVFYSDSGSVSVEVAIKMALQASKGQGHPERTKLLTWRSGYHGDTFTAMSVCDPENG
MHSLWKGTLPEQIFAPAPPVRGSSPQAISEYLHSMELLIDETVSAIIIEPIVQGAGGMRFHDVALIEGVAALCKKHDRFL
IVDEIATGFGRTGELFATLSNGVQPDIMCVGKALTGGFMSFAATVCTDKVAQLISTPEGGGVLMHGPTFMANPLACEVSH
ASLEIIETGMWQKQVKKIEAELIAGLSPLRCIPGVADVRVLGAIGVIEMEQNVNVEEATQAALDHGVWIRPFGRLLYVMP
PYITTSEQCAQICAALHAAVKGK
>Mature_423_residues
MENPSLRELDHRNIWHPYAAPGVRNRLVTNTDGVFLTLEDGSTVIDAMSSWWSAIHGHGHPRLKAAAQKQIDTMSHVMFG
GLTHEPAIKLTHKLLNLTGNAFDHVFYSDSGSVSVEVAIKMALQASKGQGHPERTKLLTWRSGYHGDTFTAMSVCDPENG
MHSLWKGTLPEQIFAPAPPVRGSSPQAISEYLHSMELLIDETVSAIIIEPIVQGAGGMRFHDVALIEGVAALCKKHDRFL
IVDEIATGFGRTGELFATLSNGVQPDIMCVGKALTGGFMSFAATVCTDKVAQLISTPEGGGVLMHGPTFMANPLACEVSH
ASLEIIETGMWQKQVKKIEAELIAGLSPLRCIPGVADVRVLGAIGVIEMEQNVNVEEATQAALDHGVWIRPFGRLLYVMP
PYITTSEQCAQICAALHAAVKGK

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=28.2051282051282, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI13994255, Length=363, Percent_Identity=26.4462809917355, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI284507298, Length=217, Percent_Identity=31.7972350230415, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI37574042, Length=403, Percent_Identity=22.8287841191067, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=23.3595800524934, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=51.5513126491647, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1788044, Length=383, Percent_Identity=31.0704960835509, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789759, Length=290, Percent_Identity=31.7241379310345, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789016, Length=415, Percent_Identity=28.433734939759, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI145693181, Length=405, Percent_Identity=28.8888888888889, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787560, Length=347, Percent_Identity=29.971181556196, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=397, Percent_Identity=27.9596977329975, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=218, Percent_Identity=33.4862385321101, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=426, Percent_Identity=26.056338028169, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=23.0232558139535, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=42.7631578947368, Blast_Score=342, Evalue=5e-95,
Organism=Saccharomyces cerevisiae, GI6323470, Length=391, Percent_Identity=28.6445012787724, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=308, Percent_Identity=28.8961038961039, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21357415, Length=398, Percent_Identity=28.894472361809, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574759, Length=387, Percent_Identity=26.3565891472868, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161085790, Length=387, Percent_Identity=26.3565891472868, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21356575, Length=366, Percent_Identity=24.3169398907104, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 45671; Mature: 45671

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENPSLRELDHRNIWHPYAAPGVRNRLVTNTDGVFLTLEDGSTVIDAMSSWWSAIHGHGH
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
PRLKAAAQKQIDTMSHVMFGGLTHEPAIKLTHKLLNLTGNAFDHVFYSDSGSVSVEVAIK
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCEEEEEEEE
MALQASKGQGHPERTKLLTWRSGYHGDTFTAMSVCDPENGMHSLWKGTLPEQIFAPAPPV
EHHHHCCCCCCCCHHEEEEECCCCCCCCEEEEEECCCCCCHHHHHCCCCCHHHCCCCCCC
RGSSPQAISEYLHSMELLIDETVSAIIIEPIVQGAGGMRFHDVALIEGVAALCKKHDRFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCEE
IVDEIATGFGRTGELFATLSNGVQPDIMCVGKALTGGFMSFAATVCTDKVAQLISTPEGG
EEEHHHHCCCCCCHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GVLMHGPTFMANPLACEVSHASLEIIETGMWQKQVKKIEAELIAGLSPLRCIPGVADVRV
EEEEECCCCCCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHH
LGAIGVIEMEQNVNVEEATQAALDHGVWIRPFGRLLYVMPPYITTSEQCAQICAALHAAV
HHHCCEEEECCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHH
KGK
CCC
>Mature Secondary Structure
MENPSLRELDHRNIWHPYAAPGVRNRLVTNTDGVFLTLEDGSTVIDAMSSWWSAIHGHGH
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
PRLKAAAQKQIDTMSHVMFGGLTHEPAIKLTHKLLNLTGNAFDHVFYSDSGSVSVEVAIK
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCEEEEEEEE
MALQASKGQGHPERTKLLTWRSGYHGDTFTAMSVCDPENGMHSLWKGTLPEQIFAPAPPV
EHHHHCCCCCCCCHHEEEEECCCCCCCCEEEEEECCCCCCHHHHHCCCCCHHHCCCCCCC
RGSSPQAISEYLHSMELLIDETVSAIIIEPIVQGAGGMRFHDVALIEGVAALCKKHDRFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCEE
IVDEIATGFGRTGELFATLSNGVQPDIMCVGKALTGGFMSFAATVCTDKVAQLISTPEGG
EEEHHHHCCCCCCHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GVLMHGPTFMANPLACEVSHASLEIIETGMWQKQVKKIEAELIAGLSPLRCIPGVADVRV
EEEEECCCCCCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHH
LGAIGVIEMEQNVNVEEATQAALDHGVWIRPFGRLLYVMPPYITTSEQCAQICAALHAAV
HHHCCEEEECCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHH
KGK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8161820; 12948626 [H]