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The map label for this gene is tetR [H]

Identifier: 145296068

GI number: 145296068

Start: 2187631

End: 2188206

Strand: Direct

Name: tetR [H]

Synonym: cgR_1990

Alternate gene names: 145296068

Gene position: 2187631-2188206 (Clockwise)

Preceding gene: 145296065

Following gene: 145296069

Centisome position: 66.01

GC content: 49.31

Gene sequence:

>576_bases
ATGCTGGCAATTGTGCAGCTATCTAAAGAATCTATTATTGGGGCAGCCGTTTCGATCCTGAGCGAGTTCGGTTTGTCGGA
TATGACCATGCGTCGCGTCGCAAAGCAATTAAATGTCGCGCCGGGCGCGCTGTATTGGCATTTTAAAAATAAGCAGGAGC
TTATCGACGCCACCTCACGCCATCTCCTGGCGCCTATCTTGGGGCGCAACGACGAGCAGCGAGCAAGCATTTCCGCGCAG
GAAACGTGCGCAGAAATGCGTTCACTGATGATGCAAACCAAAGATGGTGCGGAAGTCATCAGTGCCGCACTGAGTAATCA
GCAATTGCGCCAAGAATTGGAATCACTCATTTCTGACTCTCTCAAGGAACCTAATGAGATTGGCGCTTTTACACTGCTGC
ATTTTGTGGTGGGTGCAGTATTAACAGAACAAACTCAGCTGCAGATGCAAAAGTTCACGGCTGGCGCGGAAGATGACACA
CAAGAAAACCCTGCCGATGCGAACTTTGAGGAGAGATTCAATCAAGGATTAGAAATCATTCTGGTGGGTCTAGACGCGCT
TGGGCATATAAGATAG

Upstream 100 bases:

>100_bases
ATCATCGACATGCTCCGGAAAACTTAAAAATTCCCGGACGGTTCACGCAGATTACCCTAGCAAAGCAATCTAGCTGACGA
GCCAATTTAGTCCTGTCATT

Downstream 100 bases:

>100_bases
CGTTCTATGACATCAACGACTGAGCACTCGTACCAAGTTTGGCCTGGACATGCTTATCCTTTGGGTTCAACCTATGACGG
TGCTGGAACGAACTTCGCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MLAIVQLSKESIIGAAVSILSEFGLSDMTMRRVAKQLNVAPGALYWHFKNKQELIDATSRHLLAPILGRNDEQRASISAQ
ETCAEMRSLMMQTKDGAEVISAALSNQQLRQELESLISDSLKEPNEIGAFTLLHFVVGAVLTEQTQLQMQKFTAGAEDDT
QENPADANFEERFNQGLEIILVGLDALGHIR

Sequences:

>Translated_191_residues
MLAIVQLSKESIIGAAVSILSEFGLSDMTMRRVAKQLNVAPGALYWHFKNKQELIDATSRHLLAPILGRNDEQRASISAQ
ETCAEMRSLMMQTKDGAEVISAALSNQQLRQELESLISDSLKEPNEIGAFTLLHFVVGAVLTEQTQLQMQKFTAGAEDDT
QENPADANFEERFNQGLEIILVGLDALGHIR
>Mature_191_residues
MLAIVQLSKESIIGAAVSILSEFGLSDMTMRRVAKQLNVAPGALYWHFKNKQELIDATSRHLLAPILGRNDEQRASISAQ
ETCAEMRSLMMQTKDGAEVISAALSNQQLRQELESLISDSLKEPNEIGAFTLLHFVVGAVLTEQTQLQMQKFTAGAEDDT
QENPADANFEERFNQGLEIILVGLDALGHIR

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 21053; Mature: 21053

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAIVQLSKESIIGAAVSILSEFGLSDMTMRRVAKQLNVAPGALYWHFKNKQELIDATSR
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
HLLAPILGRNDEQRASISAQETCAEMRSLMMQTKDGAEVISAALSNQQLRQELESLISDS
HHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LKEPNEIGAFTLLHFVVGAVLTEQTQLQMQKFTAGAEDDTQENPADANFEERFNQGLEII
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCEEE
LVGLDALGHIR
EEHHHHHCCCC
>Mature Secondary Structure
MLAIVQLSKESIIGAAVSILSEFGLSDMTMRRVAKQLNVAPGALYWHFKNKQELIDATSR
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
HLLAPILGRNDEQRASISAQETCAEMRSLMMQTKDGAEVISAALSNQQLRQELESLISDS
HHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LKEPNEIGAFTLLHFVVGAVLTEQTQLQMQKFTAGAEDDTQENPADANFEERFNQGLEII
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCEEE
LVGLDALGHIR
EEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527; 3208760 [H]