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The map label for this gene is pgl [H]

Identifier: 145295701

GI number: 145295701

Start: 1810300

End: 1811007

Strand: Direct

Name: pgl [H]

Synonym: cgR_1628

Alternate gene names: 145295701

Gene position: 1810300-1811007 (Clockwise)

Preceding gene: 145295700

Following gene: 145295736

Centisome position: 54.62

GC content: 54.94

Gene sequence:

>708_bases
ATGGTTGATGTAGTACGCGCACGCGATACTGAAGATTTGGTTGCACAGGCTGCCTCCAAATTCATTGAGGTTGTTGAAGC
AGCAACTGCCAATAATGGCACCGCACAGGTAGTGCTCACCGGTGGTGGCGCCGGCATCAAGTTGCTGGAAAAGCTCAGCG
TTGATGCGGCTGACCTTGCCTGGGATCGCATTCATGTGTTCTTCGGCGATGAGCGCAATGTCCCTGTCAGTGATTCTGAG
TCCAATGAGGGCCAGGCTCGTGAGGCACTGTTGTCCAAGGTTTCTATCCCTGAAGCCAACATTCACGGATATGGTCTCGG
CGACGTAGATCTTGCAGAGGCAGCCCGCGCTTACGAAGCTGTGTTGGATGAATTCGCACCAAACGGCTTTGATCTTCACC
TGCTCGGCATGGGTGGCGAAGGCCATATCAACTCCCTGTTCCCTCACACCGATGCAGTCAAGGAGACCTCCGCAAAGGTC
ATCGCGGTGTTTGATTCCCCTAAGCCTCCTTCAGAGCGTGCAACTCTAACCCTTCCTGCGGTTCACTCCGCAAAGCGGGT
GTGGTTGCTGGTTTCTGGTGCGGAGAAGGCTGAGGCAGCTGCGGCGATCGTCAACGGTGAGCCTGCTGTTGAGTGGCCTG
CTGCTGGAGCTACCGGATCTGAGGAAACGGTATTGTTCTTGGCTGATGATGCTGCAGGAAATCTCTAA

Upstream 100 bases:

>100_bases
GAGGAGCTTCGCCACATGGATCCAGATTTGGGCTACCAGCACGCACTATCCGGCTTGTCCAGCGTCAAGCTGGAAACCGT
CTAAGGAGAAATACAACACT

Downstream 100 bases:

>100_bases
GCAGCGCCAGCTCTAACAAGAAGCTTTAACTAGAAGCTCTAACGAAAAGCACTAACAAACTAATCCGGGTGCGAACCTTC
ATCTGAATCGATGGAGGTTC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MVDVVRARDTEDLVAQAASKFIEVVEAATANNGTAQVVLTGGGAGIKLLEKLSVDAADLAWDRIHVFFGDERNVPVSDSE
SNEGQAREALLSKVSIPEANIHGYGLGDVDLAEAARAYEAVLDEFAPNGFDLHLLGMGGEGHINSLFPHTDAVKETSAKV
IAVFDSPKPPSERATLTLPAVHSAKRVWLLVSGAEKAEAAAAIVNGEPAVEWPAAGATGSEETVLFLADDAAGNL

Sequences:

>Translated_235_residues
MVDVVRARDTEDLVAQAASKFIEVVEAATANNGTAQVVLTGGGAGIKLLEKLSVDAADLAWDRIHVFFGDERNVPVSDSE
SNEGQAREALLSKVSIPEANIHGYGLGDVDLAEAARAYEAVLDEFAPNGFDLHLLGMGGEGHINSLFPHTDAVKETSAKV
IAVFDSPKPPSERATLTLPAVHSAKRVWLLVSGAEKAEAAAAIVNGEPAVEWPAAGATGSEETVLFLADDAAGNL
>Mature_235_residues
MVDVVRARDTEDLVAQAASKFIEVVEAATANNGTAQVVLTGGGAGIKLLEKLSVDAADLAWDRIHVFFGDERNVPVSDSE
SNEGQAREALLSKVSIPEANIHGYGLGDVDLAEAARAYEAVLDEFAPNGFDLHLLGMGGEGHINSLFPHTDAVKETSAKV
IAVFDSPKPPSERATLTLPAVHSAKRVWLLVSGAEKAEAAAAIVNGEPAVEWPAAGATGSEETVLFLADDAAGNL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=215, Percent_Identity=31.6279069767442, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI6912586, Length=173, Percent_Identity=35.8381502890173, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115533058, Length=234, Percent_Identity=32.0512820512821, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI115533060, Length=234, Percent_Identity=32.0512820512821, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321957, Length=214, Percent_Identity=31.7757009345794, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321687, Length=212, Percent_Identity=32.0754716981132, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324362, Length=211, Percent_Identity=33.175355450237, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319918, Length=208, Percent_Identity=34.6153846153846, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24641119, Length=234, Percent_Identity=31.6239316239316, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 24492; Mature: 24492

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVVRARDTEDLVAQAASKFIEVVEAATANNGTAQVVLTGGGAGIKLLEKLSVDAADLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCHHHCC
WDRIHVFFGDERNVPVSDSESNEGQAREALLSKVSIPEANIHGYGLGDVDLAEAARAYEA
EEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
VLDEFAPNGFDLHLLGMGGEGHINSLFPHTDAVKETSAKVIAVFDSPKPPSERATLTLPA
HHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCEEEEECC
VHSAKRVWLLVSGAEKAEAAAAIVNGEPAVEWPAAGATGSEETVLFLADDAAGNL
CCCCCEEEEEEECCCCHHHEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MVDVVRARDTEDLVAQAASKFIEVVEAATANNGTAQVVLTGGGAGIKLLEKLSVDAADLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCHHHCC
WDRIHVFFGDERNVPVSDSESNEGQAREALLSKVSIPEANIHGYGLGDVDLAEAARAYEA
EEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
VLDEFAPNGFDLHLLGMGGEGHINSLFPHTDAVKETSAKVIAVFDSPKPPSERATLTLPA
HHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCEEEEECC
VHSAKRVWLLVSGAEKAEAAAAIVNGEPAVEWPAAGATGSEETVLFLADDAAGNL
CCCCCEEEEEEECCCCHHHEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]