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The map label for this gene is theD [H]

Identifier: 145295597

GI number: 145295597

Start: 1684148

End: 1686439

Strand: Reverse

Name: theD [H]

Synonym: cgR_1524

Alternate gene names: 145295597

Gene position: 1686439-1684148 (Counterclockwise)

Preceding gene: 145295598

Following gene: 145295596

Centisome position: 50.89

GC content: 57.11

Gene sequence:

>2292_bases
GTGACTGATTTTTCTTTGTATCTGGTCACCGATCCCGTTTTGGGTGGCGGGCCAGAAAAAGTAGCTGGAATTGTTGACAG
CGCAATTTCCGGCGGAGTTTCTGTGGTGCAGCTGCGCGATAAGAACTCAGGCGTGGAAGATGTTCGTGCGGCAGCGAAGG
AGCTGAAAGAACTCTGCGATGCTCGCGGGGTGGCGCTTGTTGTCAACGATTACTTAGATATCGCCGTTGAGCTGGGTCTT
CACCTGCACATTGGTCAAGGCGATACACCTTATACGCAAGCACGGGAGCTGCTTCCAGCTCATCTTGAATTGGGTTTGAG
CATTGAAAACCTGGATCAATTGCATGCTGTGATCGCGCAGTGCGCCGAGACTGGTGTGGCATTGCCCGATGTGATTGGCA
TTGGTCCGGTGGCCTCTACTGCGACCAAACCAGATGCGGCACCCGCATTGGGTGTGGAAGGCATCGCTGAGATCGCCGCT
GTAGCTCAAGACCACGGCATCGCATCAGTAGCTATTGGAGGCGTTGGTCTACGCAACGCGGCCGAACTCGCTGCTACGCC
CATCGACGGTCTGTGCGTGGTCTCTGAAATCATGACCGCCGCCAATCCAGCAGCTGCGGCAACTCGCCTGCGGACTGCTT
TTCAACCTACTTTCTCGCCTGAAACTCAAACTGAACTCTCTCAAACAGAACTCCAAGGAGCTTTCGTGAATTCGCCTTCT
GCCCCACGTGTGTTGTCTATTGCAGGCACTGATCCCACAGGTGGTGCAGGTATTCAGGCTGATCTGAAGTCCATTGCAGC
AGGTGGCGGCTACGGCATGTGCATTGTAACCTCGCTGGTCGCGCAAAACACCCACGGCGTCAACACGATCCACACCCCAC
CCTTGACCTTTTTGGAAGAACAGCTGGAAGCGGTCTTTTCCGACGTCACCGTCGATGCCATCAAGCTCGGCATGTTGGGC
TCTGCCGACACCGTCGATCTGGTGGCTTCGTGGCTTGGCTCCCACGAGCACGGTCCCGTGGTGCTTGATCCCGTCATGAT
CGCCACCAGCGGTGATCGCCTACTGGATGCGAGCGCTGAAGAATCGCTGCGCCGCCTAGCCGTGCACGTCGATGTGGTCA
CCCCGAATATTCCCGAACTTGCCGTGTTGTGCGACAGTGCTCCTGCCATCACCATGGATGAGGCCATTGCTCAGGCTCAA
GGATTTGCGCGGACTCATGACACCATCGTCATTGTCAAGGGTGGACATCTGACTGGCACGCTTGCTGATAACGCTGTCGT
GCGTCCCGACGGCTCGGTGTTCCAGGTGGAAAACCTGCGTGTCAACACCACCAACTCCCATGGCACAGGCTGTTCGCTCT
CTGCGTCACTTGCCACCAGGATCGCCGCCGGCGAAAGCGTGGAAAAAGCCCTCGAGTGGTCCACGCGTTGGCTCAACGAG
GCGCTCCGCCACGCCGATCACTTGGCTGTAGGTACTGGAAACGGCCCTGTCGACCACGGTCACCTGGCACGACGCATGAC
CCACGCGGCGGAAACCACTCCCTGGGCACACCTTCGGGCTCCGCGCCTAGACGGCGCCACCGCGGCAAGTTTCACCACAC
CCTCCACGGTAAAAAGCCCAGCTCCACGCATCGAACCTGCCGGGCCTTTCACGCGCGCACTGTGGGAGGCAAGTGGCGAA
ATCATCGCGGGCATCAACAGTTCTGATTTCATCACTATGCTTGGCGACGGCACCCTCCGGCGCCCAGAGTTCGATTTCTA
CATCGACCAAGACGCCCAATACCTCGCCCAATATTCCCGAGCATTGGCACGACTCTCTTCGATCGCACCTGATTCACACG
CACAAATCGAATGGGCTCAAAGCGCTGCAGAATGCCTGGTCGTGGAAGCCGAACTGCACCGCTCTTATATGACAGGAAAA
GAAGTCTCCGCACCATCACACATCACGATGGCCTATACCGACTTCCTCATCGCACGCACCTACACTGAGGACTACGTCTG
CGGTGTGGCGGCCGTACTGCCGTGCTACTGGCTTTACGCAGAGATCGGATTGATGCTGGCTGAACAAAACCACGACGAGC
ACCCCTACAAGGACTGGCTCAACACTTACTCCGGTGAAGAATTCATCGCTGGAACCCGTGCGGCTATCGCACGTCTAGAA
AAGGCTCTAGAAAATGCGGGTGCTGAACAACGCGTCGATGCTGCTCGAGCATTCTTGAGCGCCTCTGTCCATGAACGCGA
GTTCTTTGATCAGGCAACTCGCCATGGTTGGACAATGGTTGGATCTAGCTAA

Upstream 100 bases:

>100_bases
GCGCCAGGCAGCTTTGCGGTGGCGTTTATTGATGCGCTTTATGACGTGGATGCCCAGGCTGTGGCCTCGTTGGTTGATGT
GCGAGAGGCCTGAAAAGTAC

Downstream 100 bases:

>100_bases
ACCTGATCTCACTGCGCGCCGGGCCATCTCTGTCAATTAGGAGGTGGCCCGGCGCGCTTTTGCAGCTGTGGGGTTGGGCT
GGGGGCAAGTGTTCATGTAG

Product: multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGL
HLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAA
VAQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS
APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLG
SADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQ
GFARTHDTIVIVKGGHLTGTLADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE
ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGE
IIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGK
EVSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE
KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS

Sequences:

>Translated_763_residues
MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGL
HLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAA
VAQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS
APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLG
SADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQ
GFARTHDTIVIVKGGHLTGTLADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE
ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGE
IIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGK
EVSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE
KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS
>Mature_762_residues
TDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGLH
LHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAV
AQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPSA
PRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLGS
ADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQG
FARTHDTIVIVKGGHLTGTLADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNEA
LRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGEI
IAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGKE
VSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLEK
ALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thiaminase-2 family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=44.1860465116279, Blast_Score=193, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6325378, Length=506, Percent_Identity=25.8893280632411, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6324517, Length=391, Percent_Identity=32.4808184143223, Blast_Score=138, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324997, Length=397, Percent_Identity=31.4861460957179, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6325042, Length=258, Percent_Identity=29.0697674418605, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR016084
- InterPro:   IPR013749
- InterPro:   IPR004399
- InterPro:   IPR004305
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF08543 Phos_pyr_kin; PF03070 TENA_THI-4; PF02581 TMP-TENI [H]

EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 80472; Mature: 80341

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCD
CCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHC
ARGVALVVNDYLDIAVELGLHLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQ
CCCEEEEEHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
CAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAVAQDHGIASVAIGGVGLRNA
HHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCH
AELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS
HHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEE
CCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QLEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCEEEEECCCCCCCCHHH
ESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGT
HHHHHHEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEE
LADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE
ECCCEEECCCCCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSP
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCCCCCCCCCCCC
APRIEPAGPFTRALWEASGEIIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSR
CCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHH
ALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGKEVSAPSHITMAYTDFLIART
HHHHHHHCCCCCCCHHHHHHHHHHEEEEHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
YTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
TDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCD
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHC
ARGVALVVNDYLDIAVELGLHLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQ
CCCEEEEEHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
CAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAVAQDHGIASVAIGGVGLRNA
HHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCH
AELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS
HHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEE
CCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QLEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCEEEEECCCCCCCCHHH
ESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGT
HHHHHHEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEE
LADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE
ECCCEEECCCCCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSP
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCCCCCCCCCCCC
APRIEPAGPFTRALWEASGEIIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSR
CCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHH
ALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGKEVSAPSHITMAYTDFLIART
HHHHHHHCCCCCCCHHHHHHHHHHEEEEHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
YTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]