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The map label for this gene is pdhB [H]

Identifier: 138896774

GI number: 138896774

Start: 3239033

End: 3240010

Strand: Reverse

Name: pdhB [H]

Synonym: GTNG_3137

Alternate gene names: 138896774

Gene position: 3240010-3239033 (Counterclockwise)

Preceding gene: 138896775

Following gene: 138896773

Centisome position: 91.26

GC content: 59.1

Gene sequence:

>978_bases
ATGGCGGAATTAACGATGATCGAAGCAATCAATGAAGCGATGCGCCAGGAGATGGAGCGTAATTCGCGCGTCATCGTGCT
TGGAGAAGATGTCGGCGAAAACGGCGGCGTCTTCCGGGCGACGGACGGGCTGCTTGAGCAGTTTGGCTCCGGGCGCGTGT
TTGATACACCGCTGGCTGAATCCGGCATTATCGGCACGTCGATCGGATTGGCAATCAATGGTATGCGGCCGATTGCCGAG
ATCCAGTTTCTTGGGTTTGTGTACCAAGCGATGGACCAGCTCGCCGCGCAGGCGGCGCGCATCCGCTTCCGCTCCGGCGG
TCGGTTTTCATGCCCGATCGTCGTGCGCAGCCCATACGGTGGTGGGGTACGGACGCCAGAGCTGCACTCTGATGCGTTGG
AGGCGCTGTTTACCCATTCGCCTGGCTTAAAAGTCGTCATGCCGTCCAATCCGTACGATGCAAAAGGGCTGTTGATTTCC
GCCATTCGTGACGATGATCCGGTGCTGTTTTTCGAGCCGATGAAGCTGTACCGGGCGTTCCGTATGGAAGTGCCGGAAGA
ACCTTACACGATTCCGCTCGGCCAGGCGCGCATCGTGAAGGAGGGTGACGATGTAACGATTCTCACATGGGGGGCGACGG
TGCCGCTTGTCGCGAAACTCGCCGACGAGATGCGAATGAGAGGCGTTGACGCGGAAGTAATCGACCTGCGCTGTCTCCAG
CCGCTCGATATCGACACGATCATTGCCTCCGTCGAAAAAACAGGGCGGGTGATGATCGTCCATGAAGCGGTAAAAACGAG
CGGGTTTGGCGCGGAAGTGGCGGCGCTCATCAGCGAGCGGGCGCTCTTTTCCCTTTCGGCCCCAATCGTGCGCATCGCCG
GTTACGATACGCCATACCCGGTGCCGTCGGTCGAGGACGACTGGTTGCCCAACCCTGCCCGCATTGTGGAAGGAATCGAG
ACGTTGATGCGCTACTAA

Upstream 100 bases:

>100_bases
GCGGATGTGTTTGATTATGTGTACAGCGAGGCGCCGAAGTTGCTCGCCGAGCAAAAAGAAGAAGTGATACGGCGAAAGCA
AGCGAAAGAGGTGAAATGAG

Downstream 100 bases:

>100_bases
TCAAAACATGCCGCACGGCGTGCTCGACAATTGAAAGGGGAATGGTGCGGCTGTTGTATCCCAGTGATAAGGGGGAGAAC
GATGAACGTGTACGAATCAC

Product: pyruvate dehydrogenase E1 (lipoamide) subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAELTMIEAINEAMRQEMERNSRVIVLGEDVGENGGVFRATDGLLEQFGSGRVFDTPLAESGIIGTSIGLAINGMRPIAE
IQFLGFVYQAMDQLAAQAARIRFRSGGRFSCPIVVRSPYGGGVRTPELHSDALEALFTHSPGLKVVMPSNPYDAKGLLIS
AIRDDDPVLFFEPMKLYRAFRMEVPEEPYTIPLGQARIVKEGDDVTILTWGATVPLVAKLADEMRMRGVDAEVIDLRCLQ
PLDIDTIIASVEKTGRVMIVHEAVKTSGFGAEVAALISERALFSLSAPIVRIAGYDTPYPVPSVEDDWLPNPARIVEGIE
TLMRY

Sequences:

>Translated_325_residues
MAELTMIEAINEAMRQEMERNSRVIVLGEDVGENGGVFRATDGLLEQFGSGRVFDTPLAESGIIGTSIGLAINGMRPIAE
IQFLGFVYQAMDQLAAQAARIRFRSGGRFSCPIVVRSPYGGGVRTPELHSDALEALFTHSPGLKVVMPSNPYDAKGLLIS
AIRDDDPVLFFEPMKLYRAFRMEVPEEPYTIPLGQARIVKEGDDVTILTWGATVPLVAKLADEMRMRGVDAEVIDLRCLQ
PLDIDTIIASVEKTGRVMIVHEAVKTSGFGAEVAALISERALFSLSAPIVRIAGYDTPYPVPSVEDDWLPNPARIVEGIE
TLMRY
>Mature_324_residues
AELTMIEAINEAMRQEMERNSRVIVLGEDVGENGGVFRATDGLLEQFGSGRVFDTPLAESGIIGTSIGLAINGMRPIAEI
QFLGFVYQAMDQLAAQAARIRFRSGGRFSCPIVVRSPYGGGVRTPELHSDALEALFTHSPGLKVVMPSNPYDAKGLLISA
IRDDDPVLFFEPMKLYRAFRMEVPEEPYTIPLGQARIVKEGDDVTILTWGATVPLVAKLADEMRMRGVDAEVIDLRCLQP
LDIDTIIASVEKTGRVMIVHEAVKTSGFGAEVAALISERALFSLSAPIVRIAGYDTPYPVPSVEDDWLPNPARIVEGIET
LMRY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=43.3846153846154, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=43.3846153846154, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=37.3088685015291, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=35.1681957186544, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=44.9230769230769, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17538422, Length=322, Percent_Identity=38.8198757763975, Blast_Score=234, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=37.3088685015291, Blast_Score=220, Evalue=3e-58,
Organism=Drosophila melanogaster, GI160714828, Length=324, Percent_Identity=43.8271604938272, Blast_Score=276, Evalue=9e-75,
Organism=Drosophila melanogaster, GI160714832, Length=324, Percent_Identity=43.8271604938272, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21358145, Length=321, Percent_Identity=38.006230529595, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24650940, Length=321, Percent_Identity=38.006230529595, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=37.3626373626374, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=37.3626373626374, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35556; Mature: 35424

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELTMIEAINEAMRQEMERNSRVIVLGEDVGENGGVFRATDGLLEQFGSGRVFDTPLAE
CCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEECHHHHHHHCCCCEEECCCCC
SGIIGTSIGLAINGMRPIAEIQFLGFVYQAMDQLAAQAARIRFRSGGRFSCPIVVRSPYG
CCCCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECEEEEECCCC
GGVRTPELHSDALEALFTHSPGLKVVMPSNPYDAKGLLISAIRDDDPVLFFEPMKLYRAF
CCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCEEEECHHHHHHHH
RMEVPEEPYTIPLGQARIVKEGDDVTILTWGATVPLVAKLADEMRMRGVDAEVIDLRCLQ
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECC
PLDIDTIIASVEKTGRVMIVHEAVKTSGFGAEVAALISERALFSLSAPIVRIAGYDTPYP
CCCHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
VPSVEDDWLPNPARIVEGIETLMRY
CCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AELTMIEAINEAMRQEMERNSRVIVLGEDVGENGGVFRATDGLLEQFGSGRVFDTPLAE
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEECHHHHHHHCCCCEEECCCCC
SGIIGTSIGLAINGMRPIAEIQFLGFVYQAMDQLAAQAARIRFRSGGRFSCPIVVRSPYG
CCCCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECEEEEECCCC
GGVRTPELHSDALEALFTHSPGLKVVMPSNPYDAKGLLISAIRDDDPVLFFEPMKLYRAF
CCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCEEEECHHHHHHHH
RMEVPEEPYTIPLGQARIVKEGDDVTILTWGATVPLVAKLADEMRMRGVDAEVIDLRCLQ
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECC
PLDIDTIIASVEKTGRVMIVHEAVKTSGFGAEVAALISERALFSLSAPIVRIAGYDTPYP
CCCHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
VPSVEDDWLPNPARIVEGIETLMRY
CCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]