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The map label for this gene is pdhA [H]

Identifier: 138896775

GI number: 138896775

Start: 3240012

End: 3241109

Strand: Reverse

Name: pdhA [H]

Synonym: GTNG_3138

Alternate gene names: 138896775

Gene position: 3241109-3240012 (Counterclockwise)

Preceding gene: 138896776

Following gene: 138896774

Centisome position: 91.29

GC content: 56.38

Gene sequence:

>1098_bases
ATGATGGGAGGGGATCGCATGTTTGATCCAAAGGAGCTGCCCGTCGAGATGGTGCAAATTCTTGACGAAAACGGGAATGG
GGATGAGGCGAAAATCGCGGCGTTTTCCGATGAGTGGCTGCTCGATGCCTACCGAGCGATGCGGCGGGCACGCGTTGTCG
ATGAGCGGCTGCTGCGCATGCAGCGGCAAGGGCGGATTGGTACATATGCGCCATTTAGCGGCCAAGAGGCAGCCCAAATC
GGCAGCGTCCTTGCGCTTCAAAAAGATGACTGGATTTTCCCGAGCTATCGCGAAGTGGCGGTCTGTTTGACGCACGGCAT
GCCGCTCGAGCAGTTTTTCCATTACGTGCGCGGCCGCCTGTCAGGGAAGAGGATGCCAGAAGAACTGAACATTTTCCCGA
CACAAATTATCATCGCTGCGCAGACACTGCATGCAGTTGGCTGCGCGTGGGCAACAAAATTGAAAGGCGAATCGCATGTG
TCGGTCGCCTATTTCGGCGACGGGGCGACGTCGGAAGGAGATTTTCATGAAGCAATGAATTTTGCCGCGGTGTACAACGT
GCCGGTCATCTTTTTCTGCCAAAACAACCAGTATGCGATTAGCGTCCCATACGCGAAACAGACGGCGAGCCGGACGATCG
CGCAAAAAGCGCTCGCTTATGGGATGAAGGGGGTGCTGGTCGATGGCAACGATGTGTTGGCCGTCTATGAAACGATGAAA
CAGGCGGTCGAGGCGGCGCGTCGCGGAGAGGGGCCAATGTTGATTGAGGCGCTCACGTATCGGCTCGGGCCGCACACAAC
CGCTGATGACCCAACGAAATACCGTCATCCGGAAGAAGTGGAAACATGGCGGAGGAAAGATCCGCTTCACCGCTTGCGGG
TGTTGCTTGAGCGGCGCGGGCTGTGGACGGATGCGAAAGAAGAGGAGTTCGTTGCCAAAGTGAACGAGGAAGTGACAGCC
GCGTACGAGGCGGCTGTCGCCAGTGAGTCCGGTTCGATTGCGGATGTGTTTGATTATGTGTACAGCGAGGCGCCGAAGTT
GCTCGCCGAGCAAAAAGAAGAAGTGATACGGCGAAAGCAAGCGAAAGAGGTGAAATGA

Upstream 100 bases:

>100_bases
ATTATTTGGAGAATCCGGAACTGTTGCTGCTGGATGTGCGGTAGGCGGCCGTTAGTTCACTTTCGTTTTGTGAACCGAAT
AAGACTGTGAGTCGCAAAAA

Downstream 100 bases:

>100_bases
GATGGCGGAATTAACGATGATCGAAGCAATCAATGAAGCGATGCGCCAGGAGATGGAGCGTAATTCGCGCGTCATCGTGC
TTGGAGAAGATGTCGGCGAA

Product: pyruvate dehydrogenase E1 (lipoamide) subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MMGGDRMFDPKELPVEMVQILDENGNGDEAKIAAFSDEWLLDAYRAMRRARVVDERLLRMQRQGRIGTYAPFSGQEAAQI
GSVLALQKDDWIFPSYREVAVCLTHGMPLEQFFHYVRGRLSGKRMPEELNIFPTQIIIAAQTLHAVGCAWATKLKGESHV
SVAYFGDGATSEGDFHEAMNFAAVYNVPVIFFCQNNQYAISVPYAKQTASRTIAQKALAYGMKGVLVDGNDVLAVYETMK
QAVEAARRGEGPMLIEALTYRLGPHTTADDPTKYRHPEEVETWRRKDPLHRLRVLLERRGLWTDAKEEEFVAKVNEEVTA
AYEAAVASESGSIADVFDYVYSEAPKLLAEQKEEVIRRKQAKEVK

Sequences:

>Translated_365_residues
MMGGDRMFDPKELPVEMVQILDENGNGDEAKIAAFSDEWLLDAYRAMRRARVVDERLLRMQRQGRIGTYAPFSGQEAAQI
GSVLALQKDDWIFPSYREVAVCLTHGMPLEQFFHYVRGRLSGKRMPEELNIFPTQIIIAAQTLHAVGCAWATKLKGESHV
SVAYFGDGATSEGDFHEAMNFAAVYNVPVIFFCQNNQYAISVPYAKQTASRTIAQKALAYGMKGVLVDGNDVLAVYETMK
QAVEAARRGEGPMLIEALTYRLGPHTTADDPTKYRHPEEVETWRRKDPLHRLRVLLERRGLWTDAKEEEFVAKVNEEVTA
AYEAAVASESGSIADVFDYVYSEAPKLLAEQKEEVIRRKQAKEVK
>Mature_365_residues
MMGGDRMFDPKELPVEMVQILDENGNGDEAKIAAFSDEWLLDAYRAMRRARVVDERLLRMQRQGRIGTYAPFSGQEAAQI
GSVLALQKDDWIFPSYREVAVCLTHGMPLEQFFHYVRGRLSGKRMPEELNIFPTQIIIAAQTLHAVGCAWATKLKGESHV
SVAYFGDGATSEGDFHEAMNFAAVYNVPVIFFCQNNQYAISVPYAKQTASRTIAQKALAYGMKGVLVDGNDVLAVYETMK
QAVEAARRGEGPMLIEALTYRLGPHTTADDPTKYRHPEEVETWRRKDPLHRLRVLLERRGLWTDAKEEEFVAKVNEEVTA
AYEAAVASESGSIADVFDYVYSEAPKLLAEQKEEVIRRKQAKEVK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=357, Percent_Identity=36.4145658263305, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI258645172, Length=357, Percent_Identity=36.4145658263305, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI4885543, Length=311, Percent_Identity=29.2604501607717, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4505685, Length=314, Percent_Identity=28.0254777070064, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI291084742, Length=314, Percent_Identity=28.0254777070064, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI291084744, Length=321, Percent_Identity=27.1028037383178, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI291084757, Length=308, Percent_Identity=26.9480519480519, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI86563357, Length=339, Percent_Identity=40.117994100295, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI86563355, Length=339, Percent_Identity=40.117994100295, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17536047, Length=311, Percent_Identity=27.9742765273312, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564172, Length=296, Percent_Identity=28.3783783783784, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=334, Percent_Identity=28.1437125748503, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355903, Length=361, Percent_Identity=35.4570637119114, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24639746, Length=286, Percent_Identity=30.4195804195804, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24639744, Length=286, Percent_Identity=30.4195804195804, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI28571106, Length=286, Percent_Identity=30.4195804195804, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24639740, Length=286, Percent_Identity=30.4195804195804, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639748, Length=230, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41105; Mature: 41105

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGGDRMFDPKELPVEMVQILDENGNGDEAKIAAFSDEWLLDAYRAMRRARVVDERLLRM
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QRQGRIGTYAPFSGQEAAQIGSVLALQKDDWIFPSYREVAVCLTHGMPLEQFFHYVRGRL
HHCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
SGKRMPEELNIFPTQIIIAAQTLHAVGCAWATKLKGESHVSVAYFGDGATSEGDFHEAMN
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHH
FAAVYNVPVIFFCQNNQYAISVPYAKQTASRTIAQKALAYGMKGVLVDGNDVLAVYETMK
HHEEECCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHH
QAVEAARRGEGPMLIEALTYRLGPHTTADDPTKYRHPEEVETWRRKDPLHRLRVLLERRG
HHHHHHHCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCC
LWTDAKEEEFVAKVNEEVTAAYEAAVASESGSIADVFDYVYSEAPKLLAEQKEEVIRRKQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEVK
HHCCC
>Mature Secondary Structure
MMGGDRMFDPKELPVEMVQILDENGNGDEAKIAAFSDEWLLDAYRAMRRARVVDERLLRM
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QRQGRIGTYAPFSGQEAAQIGSVLALQKDDWIFPSYREVAVCLTHGMPLEQFFHYVRGRL
HHCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
SGKRMPEELNIFPTQIIIAAQTLHAVGCAWATKLKGESHVSVAYFGDGATSEGDFHEAMN
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHH
FAAVYNVPVIFFCQNNQYAISVPYAKQTASRTIAQKALAYGMKGVLVDGNDVLAVYETMK
HHEEECCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHH
QAVEAARRGEGPMLIEALTYRLGPHTTADDPTKYRHPEEVETWRRKDPLHRLRVLLERRG
HHHHHHHCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCC
LWTDAKEEEFVAKVNEEVTAAYEAAVASESGSIADVFDYVYSEAPKLLAEQKEEVIRRKQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEVK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA