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The map label for this gene is degU [H]

Identifier: 138896712

GI number: 138896712

Start: 3169884

End: 3170561

Strand: Reverse

Name: degU [H]

Synonym: GTNG_3075

Alternate gene names: 138896712

Gene position: 3170561-3169884 (Counterclockwise)

Preceding gene: 138896713

Following gene: 138896711

Centisome position: 89.3

GC content: 47.35

Gene sequence:

>678_bases
ATGACAACACGCATTGCCATTATTGATGACCACCAACTGTTCCGTGAAGGTATCAAACGTATTTTAGAGTTTGATGGTGA
TTTTGAAGTCGTGGCCGAAGGGAGCGATGGACGCGAAGCTCTTTCGATCGTTGAAGAGCATCGCCCAGATTTGGTGTTGA
TGGATATTAACATGCCAGACACGAACGGGGTTGAGGCGACAAAACAGCTGATTGAGACGTATCCTGATACGAAAGTTGTC
GTCTTATCGATCCATGATGATGAAAACTATGTCATGCGCGCCTTGCAAACGGGGGCAACCGGGTATTTGCTTAAAGAAAT
GGATGCCGACACGCTCATTGAAGCAGTGAGAATTGTCGCTGAAGGCGGCTCATACTTGCATCCGAAAGTGACGCACAATT
TGATCCGTGAATACCGCCGTCTGACAACGGAAACAAATAGCAATGTAATGGTCCAACAAGAAGTGCGCCGTCCGCTTCAT
TTATTGACACGGCGTGAATGTGAAGTACTTCAGCTGTTGGCGGACGGTAAAAGCAACCGCGCGATTGGTGAAACGCTCTA
CATTAGCGAGAAAACGGTAAAAAACCATGTCAGCAGCATCTTACAAAAATTGAACGTCAATGACCGAACACAAGCGGTCG
TAGTGGCGATCAAAAACGGTTGGGTCGAAGTGCGCTGA

Upstream 100 bases:

>100_bases
TGACGATCCGCTCAACAATCGGCGGCGGTACCATTGTGTTCATCCGTGTCCCGATTGACCGTTCAGTCCTAGAAACAGCA
AACAAGGAGGAGAGGAAATC

Downstream 100 bases:

>100_bases
TCGTAGGTCTTCCCCCTTACTGGATGACAGGTGAAACTGCTTTGACGTCAATAGTGGCTAGCATCCGCTGCGGCGATGGT
TCATCTTTCATCCGCTCACG

Product: two-component response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTTRIAIIDDHQLFREGIKRILEFDGDFEVVAEGSDGREALSIVEEHRPDLVLMDINMPDTNGVEATKQLIETYPDTKVV
VLSIHDDENYVMRALQTGATGYLLKEMDADTLIEAVRIVAEGGSYLHPKVTHNLIREYRRLTTETNSNVMVQQEVRRPLH
LLTRRECEVLQLLADGKSNRAIGETLYISEKTVKNHVSSILQKLNVNDRTQAVVVAIKNGWVEVR

Sequences:

>Translated_225_residues
MTTRIAIIDDHQLFREGIKRILEFDGDFEVVAEGSDGREALSIVEEHRPDLVLMDINMPDTNGVEATKQLIETYPDTKVV
VLSIHDDENYVMRALQTGATGYLLKEMDADTLIEAVRIVAEGGSYLHPKVTHNLIREYRRLTTETNSNVMVQQEVRRPLH
LLTRRECEVLQLLADGKSNRAIGETLYISEKTVKNHVSSILQKLNVNDRTQAVVVAIKNGWVEVR
>Mature_224_residues
TTRIAIIDDHQLFREGIKRILEFDGDFEVVAEGSDGREALSIVEEHRPDLVLMDINMPDTNGVEATKQLIETYPDTKVVV
LSIHDDENYVMRALQTGATGYLLKEMDADTLIEAVRIVAEGGSYLHPKVTHNLIREYRRLTTETNSNVMVQQEVRRPLHL
LTRRECEVLQLLADGKSNRAIGETLYISEKTVKNHVSSILQKLNVNDRTQAVVVAIKNGWVEVR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=215, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=29.4930875576037, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790102, Length=217, Percent_Identity=33.1797235023041, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1787473, Length=220, Percent_Identity=36.8181818181818, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=29.7560975609756, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1788712, Length=198, Percent_Identity=28.7878787878788, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787277, Length=167, Percent_Identity=31.1377245508982, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082052, Length=105, Percent_Identity=31.4285714285714, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=33.0275229357798, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25520; Mature: 25388

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRIAIIDDHQLFREGIKRILEFDGDFEVVAEGSDGREALSIVEEHRPDLVLMDINMPD
CCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCC
TNGVEATKQLIETYPDTKVVVLSIHDDENYVMRALQTGATGYLLKEMDADTLIEAVRIVA
CCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHH
EGGSYLHPKVTHNLIREYRRLTTETNSNVMVQQEVRRPLHLLTRRECEVLQLLADGKSNR
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AIGETLYISEKTVKNHVSSILQKLNVNDRTQAVVVAIKNGWVEVR
CCCCEEEECHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEC
>Mature Secondary Structure 
TTRIAIIDDHQLFREGIKRILEFDGDFEVVAEGSDGREALSIVEEHRPDLVLMDINMPD
CEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCC
TNGVEATKQLIETYPDTKVVVLSIHDDENYVMRALQTGATGYLLKEMDADTLIEAVRIVA
CCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHH
EGGSYLHPKVTHNLIREYRRLTTETNSNVMVQQEVRRPLHLLTRRECEVLQLLADGKSNR
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AIGETLYISEKTVKNHVSSILQKLNVNDRTQAVVVAIKNGWVEVR
CCCCEEEECHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]