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The map label for this gene is degS [H]

Identifier: 138896713

GI number: 138896713

Start: 3170558

End: 3171742

Strand: Reverse

Name: degS [H]

Synonym: GTNG_3076

Alternate gene names: 138896713

Gene position: 3171742-3170558 (Counterclockwise)

Preceding gene: 138896716

Following gene: 138896712

Centisome position: 89.34

GC content: 49.62

Gene sequence:

>1185_bases
ATGGCAGGGGAAAAACGTTGGGATGAGAAGTATTTAGATAAAATTGTCGAAAAAATGATCGACACCGTTCAACATAGCAA
AGACGAAATTTTTCGTATCGGCGAGCAGTCACGCCAAGAGCAAGACTGTTTGTTGCGCGAGTTGGAGGAAGTGAAGTGGT
TGACTGTAAGAGTGATCGAAGAGGTCGATCAGCTTGAAGTCAAAGCGCGTCAGGCGCGCCGCCGCTTGTCGGAAGTGAGC
CAACACTTTTCGTCCCACTCGGAACAAGATATTCGCGAGGCGTATGAAGTTGCACATGAGCTGCACATGAAGCTGGCGAT
GGTGCGCGAGCAGGAGAAGCAGCTGCGCCTGCGCCGCGATGAGCTTGAGCGGCGGCTGGCCAGCCTGATACAAATCATCG
AGCGCTCCGATCATTTGGTCGGTCAAATTACGGTTGTGCTCAACTATTTAAACAGCGATTTCCGCCAAGTAAGCGAGATC
ATTGAAGGGGCGAAACAAAAACAAGAATTCGGTCTCAAAATCATTGAAGCACAAGAAGAAGAACGGCGTCGGTTGTCGCG
GGAAATTCATGACGGTCCAGCGCAGCTCCTTGCCCATGTGCTCCTTCGGTCGGATCTCGTTGAAAAAGTGATGAAAGACC
GAGGGACTGAAGCAGCGATTGCCGAAATTCGCGATTTTCGCAAAATGGTACGCTCCGCCTTATCCGAGGTGCGACGCATT
ATTTATGACTTACGGCCGATGGCGCTTGATGATTTAGGATTAGTTCCAACACTTAAAAAATACCTACAAACGACCGAAGA
ATATAATAAGGGAGTCCATATTTCCTTTGTACATATGGGTGAGGAGACTCGATTGCCGTCTCGGATGGAGGTGGCGGTGT
TTCGGCTTGTCCAAGAGTCAGTGCAAAACGCCCTAAAACACGCTGAAGCGAGTCAAATTGATGTCAAAATGGAAGTGACA
TGCCGTGAGTTGCTTGTCAGTGTGAAAGACAATGGCAAAGGGTTCGACCCATCTGTCAAAAAAGAAAATGCATTCGGTTT
GATCGGGATGCGGGAGCGGGTCGAGCTGCTTGGAGGCACGTTGACGATCCGCTCAACAATCGGCGGCGGTACCATTGTGT
TCATCCGTGTCCCGATTGACCGTTCAGTCCTAGAAACAGCAAACAAGGAGGAGAGGAAATCATGA

Upstream 100 bases:

>100_bases
GGGTATGCTTTTACTATTATAAATCGACAACTTTTTTCCTTCAAATAAATTTTGTTGGCGCTCATGCATACTGCTTGGCA
GCGCTGCTGGAGGTTGGCAG

Downstream 100 bases:

>100_bases
CAACACGCATTGCCATTATTGATGACCACCAACTGTTCCGTGAAGGTATCAAACGTATTTTAGAGTTTGATGGTGATTTT
GAAGTCGTGGCCGAAGGGAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MAGEKRWDEKYLDKIVEKMIDTVQHSKDEIFRIGEQSRQEQDCLLRELEEVKWLTVRVIEEVDQLEVKARQARRRLSEVS
QHFSSHSEQDIREAYEVAHELHMKLAMVREQEKQLRLRRDELERRLASLIQIIERSDHLVGQITVVLNYLNSDFRQVSEI
IEGAKQKQEFGLKIIEAQEEERRRLSREIHDGPAQLLAHVLLRSDLVEKVMKDRGTEAAIAEIRDFRKMVRSALSEVRRI
IYDLRPMALDDLGLVPTLKKYLQTTEEYNKGVHISFVHMGEETRLPSRMEVAVFRLVQESVQNALKHAEASQIDVKMEVT
CRELLVSVKDNGKGFDPSVKKENAFGLIGMRERVELLGGTLTIRSTIGGGTIVFIRVPIDRSVLETANKEERKS

Sequences:

>Translated_394_residues
MAGEKRWDEKYLDKIVEKMIDTVQHSKDEIFRIGEQSRQEQDCLLRELEEVKWLTVRVIEEVDQLEVKARQARRRLSEVS
QHFSSHSEQDIREAYEVAHELHMKLAMVREQEKQLRLRRDELERRLASLIQIIERSDHLVGQITVVLNYLNSDFRQVSEI
IEGAKQKQEFGLKIIEAQEEERRRLSREIHDGPAQLLAHVLLRSDLVEKVMKDRGTEAAIAEIRDFRKMVRSALSEVRRI
IYDLRPMALDDLGLVPTLKKYLQTTEEYNKGVHISFVHMGEETRLPSRMEVAVFRLVQESVQNALKHAEASQIDVKMEVT
CRELLVSVKDNGKGFDPSVKKENAFGLIGMRERVELLGGTLTIRSTIGGGTIVFIRVPIDRSVLETANKEERKS
>Mature_393_residues
AGEKRWDEKYLDKIVEKMIDTVQHSKDEIFRIGEQSRQEQDCLLRELEEVKWLTVRVIEEVDQLEVKARQARRRLSEVSQ
HFSSHSEQDIREAYEVAHELHMKLAMVREQEKQLRLRRDELERRLASLIQIIERSDHLVGQITVVLNYLNSDFRQVSEII
EGAKQKQEFGLKIIEAQEEERRRLSREIHDGPAQLLAHVLLRSDLVEKVMKDRGTEAAIAEIRDFRKMVRSALSEVRRII
YDLRPMALDDLGLVPTLKKYLQTTEEYNKGVHISFVHMGEETRLPSRMEVAVFRLVQESVQNALKHAEASQIDVKMEVTC
RELLVSVKDNGKGFDPSVKKENAFGLIGMRERVELLGGTLTIRSTIGGGTIVFIRVPIDRSVLETANKEERKS

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=245, Percent_Identity=30.2040816326531, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787474, Length=202, Percent_Identity=26.7326732673267, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082311, Length=212, Percent_Identity=29.2452830188679, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45713; Mature: 45582

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEEEECCCCEEEEEEECCCHHHHHHCCHHHCCC
>Mature Secondary Structure 
AGEKRWDEKYLDKIVEKMIDTVQHSKDEIFRIGEQSRQEQDCLLRELEEVKWLTVRVIE
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
EVDQLEVKARQARRRLSEVSQHFSSHSEQDIREAYEVAHELHMKLAMVREQEKQLRLRRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELERRLASLIQIIERSDHLVGQITVVLNYLNSDFRQVSEIIEGAKQKQEFGLKIIEAQEE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHH
ERRRLSREIHDGPAQLLAHVLLRSDLVEKVMKDRGTEAAIAEIRDFRKMVRSALSEVRRI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYDLRPMALDDLGLVPTLKKYLQTTEEYNKGVHISFVHMGEETRLPSRMEVAVFRLVQES
HHHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
VQNALKHAEASQIDVKMEVTCRELLVSVKDNGKGFDPSVKKENAFGLIGMRERVELLGGT
HHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
LTIRSTIGGGTIVFIRVPIDRSVLETANKEERKS
EEEEEECCCCEEEEEEECCCHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]