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The map label for this gene is polX [H]

Identifier: 138896258

GI number: 138896258

Start: 2728582

End: 2730309

Strand: Reverse

Name: polX [H]

Synonym: GTNG_2621

Alternate gene names: 138896258

Gene position: 2730309-2728582 (Counterclockwise)

Preceding gene: 138896259

Following gene: 138896257

Centisome position: 76.9

GC content: 52.72

Gene sequence:

>1728_bases
ATGAACGTGAACAAAAAAGATGTCATCCGCCTGTTAGAGACGATCGCCTTATATATGGAGATCAAAGGAGAAAATCCGTT
TAAAGTGACAGCGTTTCGCAAGGCGGCGGCCGCGCTGGAAACAGATGAACGGAGTTTGTCGGAAATCGAAGAGTTCACTG
CCATCCCGGGCATCGGCAAAAGCACGGCGGCGATTATCACCGAGTTTGTCCAAACCGGTTCATCGTCGGTGCTAGAGGAA
TTAAGGCGCGACATTCCGGAGACATTGCTTGCTTTGCTTAAGCTCCCGGGGCTTGGCGGCAAAAAAATCGCGAAGCTGCA
TCAGGAGCTTGGCATTGTGGATATGAATGGATTGAAGGAAGCATGTCTTTCCGGAAAGGTGCGGGAGCTTCCTGGATTTG
GGGTGAAAACGGAAGAGAAGCTGCTTATGGCTCTCGAAGAGGCGGGAAAACGTCCTGAGCGGCTGCCGCTCGCTCGGGTA
TTGCCGCTCGCCGAGGACATTGAACGTCAACTGCAAGAGATCGATGGCATCATCCGCTTCGCGCGAGCAGGCAGTTTGCG
GCGTTTGAAAGAAACGGTGAAAGATTTGGATTATGTCATCGCTACCGATCGCCCGGCCGAGGTGCGCGAGGCACTCCTTC
GTCTTTCGCGCATCCGTGAAGTCATCGCTGCCGGGGAAACGAAAGTGTCGCTTCTTTTCAAGTATGAGGATGAAATCGCC
GCCGACTTCCGGCTCGTCAGTGCGGCTGAGTTTGCGACAGCGCTTCATCATTTCACTGGATCGAAAGAACATAATGTCCG
CATGCGCCAGCTTGCCAAAGAACGTGGGGAGAAAATTAGCGAATACGGCGTTGAAGACCAAACAACAGGGGATGTAAAAA
CGTTCTCGGATGAACCGGCGTTTTATGCTTACTTCGGGTTGCCGTACATTCCGCCTGAACTGCGCGAAGACGGCACGGAA
GTTGAGCGATATTCTTCGGATTATCCGCTTGTCCATCTTGACGATATCCGAGGCGATTTGCATATGCACTCGGCATGGAG
CGACGGGGCGTGTTCGCTCGAGGAGCTCGCTGAGGCGTGCCGTCGCCGCGGCTACCAGTATATGGCCATTACGGATCATT
CTCAATATTTGAAAGTCGCCAACGGCTTGACGCCAGATCGATTGCGGCGTCAACGCGAGGAGATTGAGCGGTTGAATGCA
CGCTATTCTGATTTTACGATCTTAGCTGGCATCGAGATGGATATTTTGCCTGACGGGACGCTCGATTACGATGATGACGT
GCTCAAGGAGCTTGATTTTGTCATTGCCGCCATTCATTCTGCGTTCAAACAGCCGCGCGAGGTAATTATGAAGCGGCTCG
AAGCGGCGCTTCGCCACCCGTATGTGGATGTCATCGCCCATCCGACCGGCCGGCTCATCGGCCAGCGTGACGGCTATGAC
GTCGACGTTGAACGATTAATCGAGTTGGCGGTCGAGACGAACACGGTGCTCGAGCTCAACGCGAATCCGAACCGCCTCGA
TTTGTCGGCTGTTTACGTGAAAAAAGCGCAAGAAGCAGGTGCTTATATTGCCATTCATACGGACGCCCACCATTTGGACA
TGCTTGATGATATGGTCATTGGTGTGACGACGGCAAGGAAAGGATGGATCAAAAAAGAGACGGTGATCAATACATGGCCG
CTTGAGAAGTTACAACAGTTTTTGCGCGACAAACGAAAGCAAACATGA

Upstream 100 bases:

>100_bases
ACATACACCAATCTTGTCGGAGATGCTTAGCAACTGGTGGATTCATGGCCGCATCTAACGGAGCGCGGCCCGCGGTGTTT
CGGAAAAGGGAGGGGACGGC

Downstream 100 bases:

>100_bases
TGAGGCATGGGGGTTTGAATACGTGCAGCAAAAAATGCTTCGTATCCTAGAGTTCGATAAAGTGAAAGAACAGTTGGCCG
AGCATGCGTCATCCGCGCTC

Product: hypothetical protein

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MNVNKKDVIRLLETIALYMEIKGENPFKVTAFRKAAAALETDERSLSEIEEFTAIPGIGKSTAAIITEFVQTGSSSVLEE
LRRDIPETLLALLKLPGLGGKKIAKLHQELGIVDMNGLKEACLSGKVRELPGFGVKTEEKLLMALEEAGKRPERLPLARV
LPLAEDIERQLQEIDGIIRFARAGSLRRLKETVKDLDYVIATDRPAEVREALLRLSRIREVIAAGETKVSLLFKYEDEIA
ADFRLVSAAEFATALHHFTGSKEHNVRMRQLAKERGEKISEYGVEDQTTGDVKTFSDEPAFYAYFGLPYIPPELREDGTE
VERYSSDYPLVHLDDIRGDLHMHSAWSDGACSLEELAEACRRRGYQYMAITDHSQYLKVANGLTPDRLRRQREEIERLNA
RYSDFTILAGIEMDILPDGTLDYDDDVLKELDFVIAAIHSAFKQPREVIMKRLEAALRHPYVDVIAHPTGRLIGQRDGYD
VDVERLIELAVETNTVLELNANPNRLDLSAVYVKKAQEAGAYIAIHTDAHHLDMLDDMVIGVTTARKGWIKKETVINTWP
LEKLQQFLRDKRKQT

Sequences:

>Translated_575_residues
MNVNKKDVIRLLETIALYMEIKGENPFKVTAFRKAAAALETDERSLSEIEEFTAIPGIGKSTAAIITEFVQTGSSSVLEE
LRRDIPETLLALLKLPGLGGKKIAKLHQELGIVDMNGLKEACLSGKVRELPGFGVKTEEKLLMALEEAGKRPERLPLARV
LPLAEDIERQLQEIDGIIRFARAGSLRRLKETVKDLDYVIATDRPAEVREALLRLSRIREVIAAGETKVSLLFKYEDEIA
ADFRLVSAAEFATALHHFTGSKEHNVRMRQLAKERGEKISEYGVEDQTTGDVKTFSDEPAFYAYFGLPYIPPELREDGTE
VERYSSDYPLVHLDDIRGDLHMHSAWSDGACSLEELAEACRRRGYQYMAITDHSQYLKVANGLTPDRLRRQREEIERLNA
RYSDFTILAGIEMDILPDGTLDYDDDVLKELDFVIAAIHSAFKQPREVIMKRLEAALRHPYVDVIAHPTGRLIGQRDGYD
VDVERLIELAVETNTVLELNANPNRLDLSAVYVKKAQEAGAYIAIHTDAHHLDMLDDMVIGVTTARKGWIKKETVINTWP
LEKLQQFLRDKRKQT
>Mature_575_residues
MNVNKKDVIRLLETIALYMEIKGENPFKVTAFRKAAAALETDERSLSEIEEFTAIPGIGKSTAAIITEFVQTGSSSVLEE
LRRDIPETLLALLKLPGLGGKKIAKLHQELGIVDMNGLKEACLSGKVRELPGFGVKTEEKLLMALEEAGKRPERLPLARV
LPLAEDIERQLQEIDGIIRFARAGSLRRLKETVKDLDYVIATDRPAEVREALLRLSRIREVIAAGETKVSLLFKYEDEIA
ADFRLVSAAEFATALHHFTGSKEHNVRMRQLAKERGEKISEYGVEDQTTGDVKTFSDEPAFYAYFGLPYIPPELREDGTE
VERYSSDYPLVHLDDIRGDLHMHSAWSDGACSLEELAEACRRRGYQYMAITDHSQYLKVANGLTPDRLRRQREEIERLNA
RYSDFTILAGIEMDILPDGTLDYDDDVLKELDFVIAAIHSAFKQPREVIMKRLEAALRHPYVDVIAHPTGRLIGQRDGYD
VDVERLIELAVETNTVLELNANPNRLDLSAVYVKKAQEAGAYIAIHTDAHHLDMLDDMVIGVTTARKGWIKKETVINTWP
LEKLQQFLRDKRKQT

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1796

COG function: function code L; DNA polymerase IV (family X)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

Organism=Homo sapiens, GI4505931, Length=281, Percent_Identity=26.6903914590747, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64964; Mature: 64964

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVNKKDVIRLLETIALYMEIKGENPFKVTAFRKAAAALETDERSLSEIEEFTAIPGIGK
CCCCHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
STAAIITEFVQTGSSSVLEELRRDIPETLLALLKLPGLGGKKIAKLHQELGIVDMNGLKE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHH
ACLSGKVRELPGFGVKTEEKLLMALEEAGKRPERLPLARVLPLAEDIERQLQEIDGIIRF
HHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARAGSLRRLKETVKDLDYVIATDRPAEVREALLRLSRIREVIAAGETKVSLLFKYEDEIA
HHCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECHHHH
ADFRLVSAAEFATALHHFTGSKEHNVRMRQLAKERGEKISEYGVEDQTTGDVKTFSDEPA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCEECCCCCC
FYAYFGLPYIPPELREDGTEVERYSSDYPLVHLDDIRGDLHMHSAWSDGACSLEELAEAC
EEEEECCCCCCHHHHCCCCHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHH
RRRGYQYMAITDHSQYLKVANGLTPDRLRRQREEIERLNARYSDFTILAGIEMDILPDGT
HHCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCC
LDYDDDVLKELDFVIAAIHSAFKQPREVIMKRLEAALRHPYVDVIAHPTGRLIGQRDGYD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCC
VDVERLIELAVETNTVLELNANPNRLDLSAVYVKKAQEAGAYIAIHTDAHHLDMLDDMVI
CCHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
GVTTARKGWIKKETVINTWPLEKLQQFLRDKRKQT
HHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVNKKDVIRLLETIALYMEIKGENPFKVTAFRKAAAALETDERSLSEIEEFTAIPGIGK
CCCCHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
STAAIITEFVQTGSSSVLEELRRDIPETLLALLKLPGLGGKKIAKLHQELGIVDMNGLKE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHH
ACLSGKVRELPGFGVKTEEKLLMALEEAGKRPERLPLARVLPLAEDIERQLQEIDGIIRF
HHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARAGSLRRLKETVKDLDYVIATDRPAEVREALLRLSRIREVIAAGETKVSLLFKYEDEIA
HHCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECHHHH
ADFRLVSAAEFATALHHFTGSKEHNVRMRQLAKERGEKISEYGVEDQTTGDVKTFSDEPA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCEECCCCCC
FYAYFGLPYIPPELREDGTEVERYSSDYPLVHLDDIRGDLHMHSAWSDGACSLEELAEAC
EEEEECCCCCCHHHHCCCCHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHH
RRRGYQYMAITDHSQYLKVANGLTPDRLRRQREEIERLNARYSDFTILAGIEMDILPDGT
HHCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCC
LDYDDDVLKELDFVIAAIHSAFKQPREVIMKRLEAALRHPYVDVIAHPTGRLIGQRDGYD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCC
VDVERLIELAVETNTVLELNANPNRLDLSAVYVKKAQEAGAYIAIHTDAHHLDMLDDMVI
CCHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
GVTTARKGWIKKETVINTWPLEKLQQFLRDKRKQT
HHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]