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The map label for this gene is mutSB [H]

Identifier: 138896257

GI number: 138896257

Start: 2726205

End: 2728559

Strand: Reverse

Name: mutSB [H]

Synonym: GTNG_2620

Alternate gene names: 138896257

Gene position: 2728559-2726205 (Counterclockwise)

Preceding gene: 138896258

Following gene: 138896256

Centisome position: 76.85

GC content: 55.46

Gene sequence:

>2355_bases
GTGCAGCAAAAAATGCTTCGTATCCTAGAGTTCGATAAAGTGAAAGAACAGTTGGCCGAGCATGCGTCATCCGCGCTCGG
TTTAGAGAAAATCGCCGCTCTCGTTCCATCGTCTGATTTGGATGAAGTGGCGGTTTGGCTTGAGGAAACAGATGAGGCGG
CTGCGGTGTTGCGGCTGCGCGGCTACGTTCCGCTGGACGGGGTGGTCGACATCCGTTCGCATTTGAAACGGGCGGCCATC
GGCGGTGTGCTCAGTCCGATTGAGCTGTTGGAAGTCGCGGCGACGGCTGCCGCAAGCCGCCAAATGAAGCAGTTGATCAT
GTCGCTTCACGATGAGCACGGCGGGCTCGCGCGGCTGGCCGACTATGCGGATGAGCTTGCCGAGGTGCCGGCGCTTGAAG
AGGACATCCGCCGCTCGATCGATGATCACGGCGAGGTGTTGGACACAGCCAGCGACCGTCTTCGTTCGCTGCGCGGGCAA
ATCCGGGCGGCTGAAGCGCGCATCCGCGAGAAGCTTGAAAGCATTATCCGCTCGCCATCAGCGCAAAAGCGGCTGTCGGA
CGCGATCATTACGATCCGCAACGATCGGTATGTCATCCCGGTCAAGCAAGAATACCGCAGCGCTTACGGCGGCATCGTCC
ATGACCAGTCAGCCTCCGGAGCGACTCTGTTTATCGAGCCGCAGGTGGTCGTTGAGCTGAATAATGCACTGCGCGAGGCG
CGGGCGAAAGAAAAGCAAGAAATCGAACGCATTTTGCGCGAACTCTCAGCCAAAGTGGCTGAACACGATGAACCGCTCAA
ACGAGCTGTGGAGGCGCTTGCCCATTTTGATTTCTTATTTGCCAAGGCGAAATACGCGCGCCGGCTGCAAGCGGCAAAGC
CAGCGGTCAACAACCGCGGCTACCTCCGCTTTTTGCAAGCGCGCCATCCGCTTATTGACCAAGATAAAGCGGTGCCGAAT
GATATTGTGTTGGGCGGCGATTACACGACGATCGTTATTACCGGGCCGAACACCGGTGGGAAAACGGTGACGTTAAAAAC
AGTCGGCCTGTTGACCATCATGGCGCAAGCCGGGCTGTTTATCCCGGCGGCGGACGGGTCGGAGGCAGCAGTGTTCCGCT
CTGTTTTCGCCGATATCGGTGACGAGCAGTCAATCGAACAAAGTTTGAGTACGTTCTCTTCCCATATGGTGAATATTGTT
GATATTTTGCGTCATGTTGATGAGGAAAGCCTCGTGCTCTTTGATGAGCTGGGGGCCGGTACCGATCCACAAGAGGGAGC
CGCGCTGGCTATCGCTATTTTGGATGAAGTACACGGACGCGGGGCGCGGACGGTAGCGACGACGCATTATCCGGAGTTGA
AAGCGTACGGTTACAATCGCCCCGGAGTGGTAAATGCCAGCGTCGAATTTGACACCGAAACGCTTCGTCCGACGTATAAA
TTGTTGATCGGCATTCCCGGCCGCAGCAACGCCTTTGACATCTCGCGCCGTCTTGGGCTCGATGAGCGGATTATCGAGCG
GGCGAAAGTGCAAGTAAGCGCAGAAAGCCATAGCGTGGAAAACATGATCGCTTCACTGGAACGAAGCAAAAAGCAAGCCG
AGGAAGATGAGGCAAGAGCGCACTCGGCACGTGAAGAAGCGGAACGATTGCGTGCTGAGTGGGAACAAAAACTTGAAGAG
CTGGAAGACAAAAAAGCAGAGCAGCTCGCGGAAGCGGCGCAAAAGGCAACCGACATCATCCGCGCTGCCGAGCGCGAGGC
TGAGCGGATTATCAACGAGTTGCGTCGTCTGCAAAAAGAAAAGCAGGCAGAAGTGAAGGAGCATGAGCTCATTGCCGCGA
AACAGCGACTTGCTGCCGCTGTGCCCGTAGTTGAAAAACGGAAAAAAACAAAAAAAGCGACTGCACGCCATGCGTTCCAA
TCGGGTGATGAAGTGAAAGTGACAAGCTTAAACCAAAAGGGGTATTTGCTCGAAAAAGTGTCAGAGGATGAATGGCAAGT
GCAGCTTGGCATTTTAAAAATGAAAATTCATGAGCGCGACTTGGAGTATATTGGCAGCGCACCGGCCAAAGAAGTGACGC
CGATTGCGACTGTAAAAGGCAAGGACGCCCACGTCAGCCTAGAGCTTGATTTGCGCGGTGAGCGCTACGAAGACGCCCTT
GTCCGACTGGAAAAATATATTGATGACGCCGTGCTTGCCGGCTATCCGCGCGTCTCGATCATCCACGGTAAAGGAACAGG
CGCGCTTCGCCAAGGAGTCCAGCAGTTTTTAAAACAGCACCGGGCGGTAAAAAGCTTCCGGTTCGGTGCGGCGAATGAGG
GCGGTACCGGGGTGACGGTCGTCGAACTGAAATGA

Upstream 100 bases:

>100_bases
AAAAAAGAGACGGTGATCAATACATGGCCGCTTGAGAAGTTACAACAGTTTTTGCGCGACAAACGAAAGCAAACATGATG
AGGCATGGGGGTTTGAATAC

Downstream 100 bases:

>100_bases
TAGGGGAGAGAGCGATGATGCCGTTTTGGGAGCACGACATGGTGAGGACGGCAGCCAATTTTAGCGTCGCAGTATTGTGC
ATCGTCGTGTTTTTAGCCTT

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MQQKMLRILEFDKVKEQLAEHASSALGLEKIAALVPSSDLDEVAVWLEETDEAAAVLRLRGYVPLDGVVDIRSHLKRAAI
GGVLSPIELLEVAATAAASRQMKQLIMSLHDEHGGLARLADYADELAEVPALEEDIRRSIDDHGEVLDTASDRLRSLRGQ
IRAAEARIREKLESIIRSPSAQKRLSDAIITIRNDRYVIPVKQEYRSAYGGIVHDQSASGATLFIEPQVVVELNNALREA
RAKEKQEIERILRELSAKVAEHDEPLKRAVEALAHFDFLFAKAKYARRLQAAKPAVNNRGYLRFLQARHPLIDQDKAVPN
DIVLGGDYTTIVITGPNTGGKTVTLKTVGLLTIMAQAGLFIPAADGSEAAVFRSVFADIGDEQSIEQSLSTFSSHMVNIV
DILRHVDEESLVLFDELGAGTDPQEGAALAIAILDEVHGRGARTVATTHYPELKAYGYNRPGVVNASVEFDTETLRPTYK
LLIGIPGRSNAFDISRRLGLDERIIERAKVQVSAESHSVENMIASLERSKKQAEEDEARAHSAREEAERLRAEWEQKLEE
LEDKKAEQLAEAAQKATDIIRAAEREAERIINELRRLQKEKQAEVKEHELIAAKQRLAAAVPVVEKRKKTKKATARHAFQ
SGDEVKVTSLNQKGYLLEKVSEDEWQVQLGILKMKIHERDLEYIGSAPAKEVTPIATVKGKDAHVSLELDLRGERYEDAL
VRLEKYIDDAVLAGYPRVSIIHGKGTGALRQGVQQFLKQHRAVKSFRFGAANEGGTGVTVVELK

Sequences:

>Translated_784_residues
MQQKMLRILEFDKVKEQLAEHASSALGLEKIAALVPSSDLDEVAVWLEETDEAAAVLRLRGYVPLDGVVDIRSHLKRAAI
GGVLSPIELLEVAATAAASRQMKQLIMSLHDEHGGLARLADYADELAEVPALEEDIRRSIDDHGEVLDTASDRLRSLRGQ
IRAAEARIREKLESIIRSPSAQKRLSDAIITIRNDRYVIPVKQEYRSAYGGIVHDQSASGATLFIEPQVVVELNNALREA
RAKEKQEIERILRELSAKVAEHDEPLKRAVEALAHFDFLFAKAKYARRLQAAKPAVNNRGYLRFLQARHPLIDQDKAVPN
DIVLGGDYTTIVITGPNTGGKTVTLKTVGLLTIMAQAGLFIPAADGSEAAVFRSVFADIGDEQSIEQSLSTFSSHMVNIV
DILRHVDEESLVLFDELGAGTDPQEGAALAIAILDEVHGRGARTVATTHYPELKAYGYNRPGVVNASVEFDTETLRPTYK
LLIGIPGRSNAFDISRRLGLDERIIERAKVQVSAESHSVENMIASLERSKKQAEEDEARAHSAREEAERLRAEWEQKLEE
LEDKKAEQLAEAAQKATDIIRAAEREAERIINELRRLQKEKQAEVKEHELIAAKQRLAAAVPVVEKRKKTKKATARHAFQ
SGDEVKVTSLNQKGYLLEKVSEDEWQVQLGILKMKIHERDLEYIGSAPAKEVTPIATVKGKDAHVSLELDLRGERYEDAL
VRLEKYIDDAVLAGYPRVSIIHGKGTGALRQGVQQFLKQHRAVKSFRFGAANEGGTGVTVVELK
>Mature_784_residues
MQQKMLRILEFDKVKEQLAEHASSALGLEKIAALVPSSDLDEVAVWLEETDEAAAVLRLRGYVPLDGVVDIRSHLKRAAI
GGVLSPIELLEVAATAAASRQMKQLIMSLHDEHGGLARLADYADELAEVPALEEDIRRSIDDHGEVLDTASDRLRSLRGQ
IRAAEARIREKLESIIRSPSAQKRLSDAIITIRNDRYVIPVKQEYRSAYGGIVHDQSASGATLFIEPQVVVELNNALREA
RAKEKQEIERILRELSAKVAEHDEPLKRAVEALAHFDFLFAKAKYARRLQAAKPAVNNRGYLRFLQARHPLIDQDKAVPN
DIVLGGDYTTIVITGPNTGGKTVTLKTVGLLTIMAQAGLFIPAADGSEAAVFRSVFADIGDEQSIEQSLSTFSSHMVNIV
DILRHVDEESLVLFDELGAGTDPQEGAALAIAILDEVHGRGARTVATTHYPELKAYGYNRPGVVNASVEFDTETLRPTYK
LLIGIPGRSNAFDISRRLGLDERIIERAKVQVSAESHSVENMIASLERSKKQAEEDEARAHSAREEAERLRAEWEQKLEE
LEDKKAEQLAEAAQKATDIIRAAEREAERIINELRRLQKEKQAEVKEHELIAAKQRLAAAVPVVEKRKKTKKATARHAFQ
SGDEVKVTSLNQKGYLLEKVSEDEWQVQLGILKMKIHERDLEYIGSAPAKEVTPIATVKGKDAHVSLELDLRGERYEDAL
VRLEKYIDDAVLAGYPRVSIIHGKGTGALRQGVQQFLKQHRAVKSFRFGAANEGGTGVTVVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=388, Percent_Identity=29.1237113402062, Blast_Score=136, Evalue=1e-31,
Organism=Homo sapiens, GI4504191, Length=289, Percent_Identity=30.7958477508651, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI4557761, Length=349, Percent_Identity=27.2206303724928, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI36949366, Length=272, Percent_Identity=27.5735294117647, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI26638666, Length=292, Percent_Identity=30.4794520547945, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4505253, Length=292, Percent_Identity=30.4794520547945, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI26638664, Length=293, Percent_Identity=30.3754266211604, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI262231786, Length=218, Percent_Identity=32.5688073394495, Blast_Score=97, Evalue=7e-20,
Organism=Escherichia coli, GI1789089, Length=328, Percent_Identity=28.6585365853659, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17534743, Length=193, Percent_Identity=35.2331606217617, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17508445, Length=287, Percent_Identity=26.4808362369338, Blast_Score=110, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17508447, Length=219, Percent_Identity=28.7671232876712, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17539736, Length=273, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=289, Percent_Identity=30.4498269896194, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324482, Length=346, Percent_Identity=26.5895953757225, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321109, Length=242, Percent_Identity=30.1652892561983, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6321912, Length=255, Percent_Identity=26.2745098039216, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=305, Percent_Identity=26.8852459016393, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320047, Length=267, Percent_Identity=26.2172284644195, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664545, Length=277, Percent_Identity=30.3249097472924, Blast_Score=120, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24584320, Length=284, Percent_Identity=26.4084507042254, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86844; Mature: 86844

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKMLRILEFDKVKEQLAEHASSALGLEKIAALVPSSDLDEVAVWLEETDEAAAVLRLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHC
GYVPLDGVVDIRSHLKRAAIGGVLSPIELLEVAATAAASRQMKQLIMSLHDEHGGLARLA
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DYADELAEVPALEEDIRRSIDDHGEVLDTASDRLRSLRGQIRAAEARIREKLESIIRSPS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AQKRLSDAIITIRNDRYVIPVKQEYRSAYGGIVHDQSASGATLFIEPQVVVELNNALREA
HHHHHHHCEEEEECCEEEEECHHHHHHHHCCCEECCCCCCCEEEECCHHEEHHHHHHHHH
RAKEKQEIERILRELSAKVAEHDEPLKRAVEALAHFDFLFAKAKYARRLQAAKPAVNNRG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YLRFLQARHPLIDQDKAVPNDIVLGGDYTTIVITGPNTGGKTVTLKTVGLLTIMAQAGLF
HHHHHHHCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCEE
IPAADGSEAAVFRSVFADIGDEQSIEQSLSTFSSHMVNIVDILRHVDEESLVLFDELGAG
EECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCC
TDPQEGAALAIAILDEVHGRGARTVATTHYPELKAYGYNRPGVVNASVEFDTETLRPTYK
CCCCCCCEEHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCEEEEEEECCCHHHCCEEE
LLIGIPGRSNAFDISRRLGLDERIIERAKVQVSAESHSVENMIASLERSKKQAEEDEARA
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
HSAREEAERLRAEWEQKLEELEDKKAEQLAEAAQKATDIIRAAEREAERIINELRRLQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQAEVKEHELIAAKQRLAAAVPVVEKRKKTKKATARHAFQSGDEVKVTSLNQKGYLLEKV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHC
SEDEWQVQLGILKMKIHERDLEYIGSAPAKEVTPIATVKGKDAHVSLELDLRGERYEDAL
CCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCCCHHHHHH
VRLEKYIDDAVLAGYPRVSIIHGKGTGALRQGVQQFLKQHRAVKSFRFGAANEGGTGVTV
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
VELK
EEEC
>Mature Secondary Structure
MQQKMLRILEFDKVKEQLAEHASSALGLEKIAALVPSSDLDEVAVWLEETDEAAAVLRLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHC
GYVPLDGVVDIRSHLKRAAIGGVLSPIELLEVAATAAASRQMKQLIMSLHDEHGGLARLA
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DYADELAEVPALEEDIRRSIDDHGEVLDTASDRLRSLRGQIRAAEARIREKLESIIRSPS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AQKRLSDAIITIRNDRYVIPVKQEYRSAYGGIVHDQSASGATLFIEPQVVVELNNALREA
HHHHHHHCEEEEECCEEEEECHHHHHHHHCCCEECCCCCCCEEEECCHHEEHHHHHHHHH
RAKEKQEIERILRELSAKVAEHDEPLKRAVEALAHFDFLFAKAKYARRLQAAKPAVNNRG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YLRFLQARHPLIDQDKAVPNDIVLGGDYTTIVITGPNTGGKTVTLKTVGLLTIMAQAGLF
HHHHHHHCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCEE
IPAADGSEAAVFRSVFADIGDEQSIEQSLSTFSSHMVNIVDILRHVDEESLVLFDELGAG
EECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCC
TDPQEGAALAIAILDEVHGRGARTVATTHYPELKAYGYNRPGVVNASVEFDTETLRPTYK
CCCCCCCEEHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCEEEEEEECCCHHHCCEEE
LLIGIPGRSNAFDISRRLGLDERIIERAKVQVSAESHSVENMIASLERSKKQAEEDEARA
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
HSAREEAERLRAEWEQKLEELEDKKAEQLAEAAQKATDIIRAAEREAERIINELRRLQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQAEVKEHELIAAKQRLAAAVPVVEKRKKTKKATARHAFQSGDEVKVTSLNQKGYLLEKV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHC
SEDEWQVQLGILKMKIHERDLEYIGSAPAKEVTPIATVKGKDAHVSLELDLRGERYEDAL
CCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCCCHHHHHH
VRLEKYIDDAVLAGYPRVSIIHGKGTGALRQGVQQFLKQHRAVKSFRFGAANEGGTGVTV
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
VELK
EEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA