Click here to switch to the map view.

The map label for this gene is ispA [C]

Identifier: 138895964

GI number: 138895964

Start: 2446984

End: 2447877

Strand: Reverse

Name: ispA [C]

Synonym: GTNG_2323

Alternate gene names: 138895964

Gene position: 2447877-2446984 (Counterclockwise)

Preceding gene: 138895965

Following gene: 138895963

Centisome position: 68.95

GC content: 53.13

Gene sequence:

>894_bases
GTGGCGTCGCTTGAGATTGAACAATTTTTAAACGAGCAAAAACAGGCTGTTGAGGCGGCATTGTCTCGCTACATTGCTCA
GCTTCATGGTCCGGAGACGCTGAAAAAAGCGATGGCTTACTCGCTTGAAGCCGGCGGCAAGCGCATTCGCCCGCTCTTGT
TGTTGTCAACGATTCAAGCGCTCGGTCAAAATCCGTCGCTCGGCCTGCCGGTGGCTTGCGCGATTGAAATGATCCATACG
TATTCGCTTATCCATGACGATTTGCCGAGCATGGACAATGACGATTTACGGCGCGGCAAGCCGACAAACCATAAAGTGTT
TGGTGAGGCGATGGCCATTTTGGCGGGAGATGGGCTGTTGACGTACGCGTTTCAATTGATCGCCGAGATCCATGATGAAC
GTGTGCCTGTTGATGTCCGGCTGCAGTTGATCGCAGAGCTGGCGAAAGCGGCTGGCCCGGAAGGGATGGTGGCCGGGCAA
GTCGCTGATATGGAAGGAGAAGGAAAAACACTGGCGCTCGCCGAACTGGAATACATCCACCGTCACAAAACCGGAAAAAT
GCTGCAATATAGTGTGCATGCCGGGGCGCTACTCGGTGGCGCCGATGCCCGGCAAATGCGCGAGCTTAACGAATTTGCCG
CTCATTTAGGTCTCGCCTTTCAAATTCGTGACGATATTCTTGACATTGAAGGAACGGAAGAGAAAATTGGAAAACGGGTC
GGCAGCGACCGTGAAAATCATAAGGCCACCTACCCGGCGCTGCTGTCGCTTGCCGGTGCAAAAGAAAAACTGGCGTTTCA
TATTGATGCGGCGAAGCGTCATTTACAGCAAGCTGATGTTGATGGTGCCACGCTCGCCTATATTTGCGAACTTGTCGCTG
TCCGCGACCACTAA

Upstream 100 bases:

>100_bases
ACTTTGCCATGATAAATTGCAGCACGTTGAAAAACAGCTCGAGTATATGTTGCGCGAAGACGGCGAGCTCGTTCCTTTTT
CGCCAGAGGAGGCATGACAG

Downstream 100 bases:

>100_bases
TCATGAGACAGCCGCCTTCGCTCCGCGTTTGTTTTGATTCGGAACCGAAGGCGGCTGTTTTTTGTTCTCCGTTCGACAAG
TAGGTGCCACAACTCCCCGC

Product: farnesyl diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MASLEIEQFLNEQKQAVEAALSRYIAQLHGPETLKKAMAYSLEAGGKRIRPLLLLSTIQALGQNPSLGLPVACAIEMIHT
YSLIHDDLPSMDNDDLRRGKPTNHKVFGEAMAILAGDGLLTYAFQLIAEIHDERVPVDVRLQLIAELAKAAGPEGMVAGQ
VADMEGEGKTLALAELEYIHRHKTGKMLQYSVHAGALLGGADARQMRELNEFAAHLGLAFQIRDDILDIEGTEEKIGKRV
GSDRENHKATYPALLSLAGAKEKLAFHIDAAKRHLQQADVDGATLAYICELVAVRDH

Sequences:

>Translated_297_residues
MASLEIEQFLNEQKQAVEAALSRYIAQLHGPETLKKAMAYSLEAGGKRIRPLLLLSTIQALGQNPSLGLPVACAIEMIHT
YSLIHDDLPSMDNDDLRRGKPTNHKVFGEAMAILAGDGLLTYAFQLIAEIHDERVPVDVRLQLIAELAKAAGPEGMVAGQ
VADMEGEGKTLALAELEYIHRHKTGKMLQYSVHAGALLGGADARQMRELNEFAAHLGLAFQIRDDILDIEGTEEKIGKRV
GSDRENHKATYPALLSLAGAKEKLAFHIDAAKRHLQQADVDGATLAYICELVAVRDH
>Mature_296_residues
ASLEIEQFLNEQKQAVEAALSRYIAQLHGPETLKKAMAYSLEAGGKRIRPLLLLSTIQALGQNPSLGLPVACAIEMIHTY
SLIHDDLPSMDNDDLRRGKPTNHKVFGEAMAILAGDGLLTYAFQLIAEIHDERVPVDVRLQLIAELAKAAGPEGMVAGQV
ADMEGEGKTLALAELEYIHRHKTGKMLQYSVHAGALLGGADARQMRELNEFAAHLGLAFQIRDDILDIEGTEEKIGKRVG
SDRENHKATYPALLSLAGAKEKLAFHIDAAKRHLQQADVDGATLAYICELVAVRDH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=264, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1786623, Length=276, Percent_Identity=45.2898550724638, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1789578, Length=217, Percent_Identity=32.7188940092166, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17505681, Length=262, Percent_Identity=27.4809160305344, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24651612, Length=234, Percent_Identity=29.9145299145299, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32382; Mature: 32250

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLEIEQFLNEQKQAVEAALSRYIAQLHGPETLKKAMAYSLEAGGKRIRPLLLLSTIQA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGQNPSLGLPVACAIEMIHTYSLIHDDLPSMDNDDLRRGKPTNHKVFGEAMAILAGDGLL
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCHHH
TYAFQLIAEIHDERVPVDVRLQLIAELAKAAGPEGMVAGQVADMEGEGKTLALAELEYIH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEECEEECCCCCCCEEHHHHHHHHH
RHKTGKMLQYSVHAGALLGGADARQMRELNEFAAHLGLAFQIRDDILDIEGTEEKIGKRV
HHCCCCEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHH
GSDRENHKATYPALLSLAGAKEKLAFHIDAAKRHLQQADVDGATLAYICELVAVRDH
CCCCCCCCHHHHHHHHHHCCHHHHHEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASLEIEQFLNEQKQAVEAALSRYIAQLHGPETLKKAMAYSLEAGGKRIRPLLLLSTIQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGQNPSLGLPVACAIEMIHTYSLIHDDLPSMDNDDLRRGKPTNHKVFGEAMAILAGDGLL
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCHHH
TYAFQLIAEIHDERVPVDVRLQLIAELAKAAGPEGMVAGQVADMEGEGKTLALAELEYIH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEECEEECCCCCCCEEHHHHHHHHH
RHKTGKMLQYSVHAGALLGGADARQMRELNEFAAHLGLAFQIRDDILDIEGTEEKIGKRV
HHCCCCEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHH
GSDRENHKATYPALLSLAGAKEKLAFHIDAAKRHLQQADVDGATLAYICELVAVRDH
CCCCCCCCHHHHHHHHHHCCHHHHHEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]