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The map label for this gene is dxs

Identifier: 138895963

GI number: 138895963

Start: 2444827

End: 2446719

Strand: Reverse

Name: dxs

Synonym: GTNG_2322

Alternate gene names: 138895963

Gene position: 2446719-2444827 (Counterclockwise)

Preceding gene: 138895964

Following gene: 138895962

Centisome position: 68.92

GC content: 53.41

Gene sequence:

>1893_bases
TTGGACTTAACGAAAATTGAACATCCGCGCGTGGTAAAAACCATGTCGATTCCCCAGCTGAAACAGTTAAGCGCCGATAT
CCGGCGATTTTTAATTGAAAAGCTGTCGAAAACAGGCGGACATATCGGTCCAAATTTAGGGGTCGTCGAGCTGACGATCG
CCCTTCATCGGGAGTTTGACAGCCCGAAAGATAAGCTCATTTGGGACGTCGGCCATCAGTCGTACGTGCATAAAATTTTG
ACCGGGCGCGCCGCCGAGTTTGATACGCTTCGGCAATATAAAGGGCTGTCGGGGTTTCCGAAGCGGAGCGAAAGCGAGCA
TGATGTCTGGGAAACCGGTCATAGCTCGACATCGCTGTCGGCAGCGATGGGAATGGCGATCGCCCGCGATTTGAAAGGGA
CGGATGAATACATTGTGCCGATTATCGGCGATGGAGCGTTGACCGGTGGGATGGCGCTTGAGGCGCTCAACCATATCGGT
CATGAAAAAACGGATATGATCGTGATCTTAAACGATAATGAAATGTCCATCGCCCCGAACGTCGGAGCGTTGCACAACAT
TCTTGGCCGACTGCGCACCGCCGGCAAATACCAATGGGTCAAGGACGAGCTCGAACTGTTGCTCAAACGCATTCCGGCGG
TCGGTGGCAAGTTGGCGGCGACCGCTGAGCGGTTGAAGGACAGTTTAAAGTACTTGCTCGTTTCCGGCGTGTTTTTTGAG
GAGCTTGGGTTTACGTATTTAGGTCCGGTTGACGGCCACGATTTTGAGGATTTGCTTGAAAACTTGCGCTATGCGAAGAA
GGTGAAAGGCCCGGTTCTTGTGCACGTGATCACGAAAAAAGGGAAAGGCTACAGCCCGGCAGAAAATGACAAAGTCGGCA
CGTGGCACGGCACAGGGCCATACAAAATCGAAACTGGTACCTTTGTCAAGACAAAAGAAGGGGGACCGTCATGGAGCGGG
CTGGTCAGTGAAACAGTACGCCGGATTGCCCGCACTGACCCGCGCATTGTCGCCATTACACCGGCGATGCCGGTTGGTTC
GAAGCTTGAAGGGTTTGCGAGCGAATTTCCGGATCGGATGTTTGATGTCGGCATCGCCGAACAGCATGCGACGACGCTTG
CGGCCGGACTGGCGACGCAAGGGATGAAACCGTTTTTGGCCATTTACTCGACGTTTTTGCAGCGGGCATATGATCAAGTG
GTTCATGACGTATGCCGGCAAAATTTAAACGTCTTTTTCGCCATTGACCGCGCCGGACTTGTCGGTGCTGACGGCGAAAC
ACATCAAGGGGTGTTTGACATCGCCTTTTTGCGCCATGTGCCGAACCTTGTTTTGATGATGCCAAAGGATGAAAACGAAG
GCCAGCATATGGTGTACACTGCCCTCCGCTATGATGACGGGCCGATCGCCATGCGTTTTCCGCGCGGTAACGGACTTGGC
GTTCCGCTTGATGAGGAACTGAAAGAAATTCCGATCGGCACATGGGAGGTGCTGCGCGACGGCAGCGATGCGGTGATTTT
AACGTTTGGGACGACGATTTCGATGGCGCTTGAGGCGGCTGAACAGTTGGCGAGAGACGGCGTGTCGGTGAAAGTCGTCA
ATGCCCGCTTTCTGAAGCCGATGGATGAAGCGATGCTTCACGAATTGCTCGAGAGCCGTCTGCCGATATTAACGATTGAA
GAGGCGGTCTTGCAAGGCGGTTTTGGCAGTTCCGTGCTTGAATTTGCCCATGACCATGGCTACCACCAGGCGGTCATTGA
ACGGATGGGCATTCCTGATCGCTTTATCGAGCATGGAAGTGTCAGCGAGCTGCTGGACGAAATCGGGCTGACGGCAGCCC
ATGTCGCTGATCGCATCAAAACGATTATGCCAAGAAAACAGAAAAGGGCTTGA

Upstream 100 bases:

>100_bases
GGCAAAAGTCGATTTTTCGTGCCGAATCATGTATAATAATACTACCTGTATCATGGGAGAACCGGCTCGGAGAACGACCA
AATGAAAGCGAGTGATCTTG

Downstream 100 bases:

>100_bases
GAAAGATGAAAGGAAAGAAAGAACGGCTCGATGTGTTGCTTGTTGAACGCGGGTTGGTAGAAACGCGGGAAAAGGCGAAG
CGGGCCATCATGGCCGGGCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MDLTKIEHPRVVKTMSIPQLKQLSADIRRFLIEKLSKTGGHIGPNLGVVELTIALHREFDSPKDKLIWDVGHQSYVHKIL
TGRAAEFDTLRQYKGLSGFPKRSESEHDVWETGHSSTSLSAAMGMAIARDLKGTDEYIVPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNILGRLRTAGKYQWVKDELELLLKRIPAVGGKLAATAERLKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDFEDLLENLRYAKKVKGPVLVHVITKKGKGYSPAENDKVGTWHGTGPYKIETGTFVKTKEGGPSWSG
LVSETVRRIARTDPRIVAITPAMPVGSKLEGFASEFPDRMFDVGIAEQHATTLAAGLATQGMKPFLAIYSTFLQRAYDQV
VHDVCRQNLNVFFAIDRAGLVGADGETHQGVFDIAFLRHVPNLVLMMPKDENEGQHMVYTALRYDDGPIAMRFPRGNGLG
VPLDEELKEIPIGTWEVLRDGSDAVILTFGTTISMALEAAEQLARDGVSVKVVNARFLKPMDEAMLHELLESRLPILTIE
EAVLQGGFGSSVLEFAHDHGYHQAVIERMGIPDRFIEHGSVSELLDEIGLTAAHVADRIKTIMPRKQKRA

Sequences:

>Translated_630_residues
MDLTKIEHPRVVKTMSIPQLKQLSADIRRFLIEKLSKTGGHIGPNLGVVELTIALHREFDSPKDKLIWDVGHQSYVHKIL
TGRAAEFDTLRQYKGLSGFPKRSESEHDVWETGHSSTSLSAAMGMAIARDLKGTDEYIVPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNILGRLRTAGKYQWVKDELELLLKRIPAVGGKLAATAERLKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDFEDLLENLRYAKKVKGPVLVHVITKKGKGYSPAENDKVGTWHGTGPYKIETGTFVKTKEGGPSWSG
LVSETVRRIARTDPRIVAITPAMPVGSKLEGFASEFPDRMFDVGIAEQHATTLAAGLATQGMKPFLAIYSTFLQRAYDQV
VHDVCRQNLNVFFAIDRAGLVGADGETHQGVFDIAFLRHVPNLVLMMPKDENEGQHMVYTALRYDDGPIAMRFPRGNGLG
VPLDEELKEIPIGTWEVLRDGSDAVILTFGTTISMALEAAEQLARDGVSVKVVNARFLKPMDEAMLHELLESRLPILTIE
EAVLQGGFGSSVLEFAHDHGYHQAVIERMGIPDRFIEHGSVSELLDEIGLTAAHVADRIKTIMPRKQKRA
>Mature_630_residues
MDLTKIEHPRVVKTMSIPQLKQLSADIRRFLIEKLSKTGGHIGPNLGVVELTIALHREFDSPKDKLIWDVGHQSYVHKIL
TGRAAEFDTLRQYKGLSGFPKRSESEHDVWETGHSSTSLSAAMGMAIARDLKGTDEYIVPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNILGRLRTAGKYQWVKDELELLLKRIPAVGGKLAATAERLKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDFEDLLENLRYAKKVKGPVLVHVITKKGKGYSPAENDKVGTWHGTGPYKIETGTFVKTKEGGPSWSG
LVSETVRRIARTDPRIVAITPAMPVGSKLEGFASEFPDRMFDVGIAEQHATTLAAGLATQGMKPFLAIYSTFLQRAYDQV
VHDVCRQNLNVFFAIDRAGLVGADGETHQGVFDIAFLRHVPNLVLMMPKDENEGQHMVYTALRYDDGPIAMRFPRGNGLG
VPLDEELKEIPIGTWEVLRDGSDAVILTFGTTISMALEAAEQLARDGVSVKVVNARFLKPMDEAMLHELLESRLPILTIE
EAVLQGGFGSSVLEFAHDHGYHQAVIERMGIPDRFIEHGSVSELLDEIGLTAAHVADRIKTIMPRKQKRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI225637459, Length=433, Percent_Identity=26.5588914549654, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI225637463, Length=433, Percent_Identity=26.5588914549654, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI225637461, Length=433, Percent_Identity=26.5588914549654, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI133778974, Length=425, Percent_Identity=28, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI205277463, Length=619, Percent_Identity=23.2633279483037, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4507521, Length=619, Percent_Identity=23.2633279483037, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156564403, Length=229, Percent_Identity=24.0174672489083, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI291084858, Length=221, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=46.8497576736672, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1788808, Length=266, Percent_Identity=26.6917293233083, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI48994911, Length=266, Percent_Identity=25.187969924812, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=434, Percent_Identity=23.0414746543779, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538422, Length=235, Percent_Identity=24.6808510638298, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=229, Percent_Identity=24.8908296943231, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24666278, Length=594, Percent_Identity=23.9057239057239, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24645119, Length=628, Percent_Identity=23.8853503184713, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551847, Length=627, Percent_Identity=23.9234449760766, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45550715, Length=627, Percent_Identity=23.9234449760766, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21358145, Length=228, Percent_Identity=22.8070175438596, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650940, Length=228, Percent_Identity=22.8070175438596, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_GEOTN (A4IQR7)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126416.1
- ProteinModelPortal:   A4IQR7
- SMR:   A4IQR7
- STRING:   A4IQR7
- GeneID:   4967249
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2322
- NMPDR:   fig|420246.5.peg.2228
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- PhylomeDB:   A4IQR7
- ProtClustDB:   PRK05444
- BioCyc:   GTHE420246:GTNG_2322-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69398; Mature: 69398

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTKIEHPRVVKTMSIPQLKQLSADIRRFLIEKLSKTGGHIGPNLGVVELTIALHREFD
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCC
SPKDKLIWDVGHQSYVHKILTGRAAEFDTLRQYKGLSGFPKRSESEHDVWETGHSSTSLS
CCHHHEEEECCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHH
AAMGMAIARDLKGTDEYIVPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPN
HHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGALHNILGRLRTAGKYQWVKDELELLLKRIPAVGGKLAATAERLKDSLKYLLVSGVFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHDFEDLLENLRYAKKVKGPVLVHVITKKGKGYSPAENDKVGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCC
YKIETGTFVKTKEGGPSWSGLVSETVRRIARTDPRIVAITPAMPVGSKLEGFASEFPDRM
EEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCHHH
FDVGIAEQHATTLAAGLATQGMKPFLAIYSTFLQRAYDQVVHDVCRQNLNVFFAIDRAGL
HHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCE
VGADGETHQGVFDIAFLRHVPNLVLMMPKDENEGQHMVYTALRYDDGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCCC
VPLDEELKEIPIGTWEVLRDGSDAVILTFGTTISMALEAAEQLARDGVSVKVVNARFLKP
CCCHHHHHHCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHCCC
MDEAMLHELLESRLPILTIEEAVLQGGFGSSVLEFAHDHGYHQAVIERMGIPDRFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCC
VSELLDEIGLTAAHVADRIKTIMPRKQKRA
HHHHHHHHCCHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MDLTKIEHPRVVKTMSIPQLKQLSADIRRFLIEKLSKTGGHIGPNLGVVELTIALHREFD
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCC
SPKDKLIWDVGHQSYVHKILTGRAAEFDTLRQYKGLSGFPKRSESEHDVWETGHSSTSLS
CCHHHEEEECCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHH
AAMGMAIARDLKGTDEYIVPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPN
HHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGALHNILGRLRTAGKYQWVKDELELLLKRIPAVGGKLAATAERLKDSLKYLLVSGVFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHDFEDLLENLRYAKKVKGPVLVHVITKKGKGYSPAENDKVGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCC
YKIETGTFVKTKEGGPSWSGLVSETVRRIARTDPRIVAITPAMPVGSKLEGFASEFPDRM
EEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCHHH
FDVGIAEQHATTLAAGLATQGMKPFLAIYSTFLQRAYDQVVHDVCRQNLNVFFAIDRAGL
HHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCE
VGADGETHQGVFDIAFLRHVPNLVLMMPKDENEGQHMVYTALRYDDGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCCC
VPLDEELKEIPIGTWEVLRDGSDAVILTFGTTISMALEAAEQLARDGVSVKVVNARFLKP
CCCHHHHHHCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHCCC
MDEAMLHELLESRLPILTIEEAVLQGGFGSSVLEFAHDHGYHQAVIERMGIPDRFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCC
VSELLDEIGLTAAHVADRIKTIMPRKQKRA
HHHHHHHHCCHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA