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The map label for this gene is yqjC [H]

Identifier: 138895934

GI number: 138895934

Start: 2413840

End: 2414316

Strand: Reverse

Name: yqjC [H]

Synonym: GTNG_2293

Alternate gene names: 138895934

Gene position: 2414316-2413840 (Counterclockwise)

Preceding gene: 138895936

Following gene: 138895933

Centisome position: 68.0

GC content: 50.52

Gene sequence:

>477_bases
ATGGCGAATATACATTACGATTCAGAATTATTTCGCAGCAAAGGGGACGAAATCATGCATGTAAAAAAAGTCGATCATAT
TGGCATTGCCGTCCGCTCAATCGAGAAAGCGCTTCCGTTTTATACGGATGTGCTCAGGCTGCCGTTTCTCGGCATTGAAG
AAGTCGAATCGGAGCAGGTGAAAGTAGCGTTTTTGCAGGCTGGGGAAGCGAAAATTGAACTGCTTGAGCCGCTGTCGCCA
GAGAGCGCGATAGCGAAATTTATCGAAAAGAGAGGGGAAGGCATCCATCACGTGGCGCTTGGTGTCGATGACATCACTGA
GCGCATCCGTGAGCTGAAGGAGCATGGCATCCGTATGATTCAAGAAATGCCAAAACGCGGCGCCGGCGGGGCATGGGTGG
CGTTTATGCATCCGAAGTCGACTGGCGGCGTTTTATACGAACTTTGCGAACGGTCGAACATGGAGGGACAACAATGA

Upstream 100 bases:

>100_bases
ACAACGGTTTTTCCTCCTCCCCGTCCGCTGTTCTGTTTTTATTGTAACCGCACGCGGCGGAGCGGACAAGGAAAAACAAA
AAGAAGGATTTTTTGTCGAA

Downstream 100 bases:

>100_bases
GCGACATGTATGACAAAATTAATGAGTTGTACGACCGCCGCCGTGAAATCGAGCTGGGCGGCGGCGATAAGAAAATTGAA
CAGCAGCACGCGAAAGGGAA

Product: lactoylglutathione lyase and related lyase

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MANIHYDSELFRSKGDEIMHVKKVDHIGIAVRSIEKALPFYTDVLRLPFLGIEEVESEQVKVAFLQAGEAKIELLEPLSP
ESAIAKFIEKRGEGIHHVALGVDDITERIRELKEHGIRMIQEMPKRGAGGAWVAFMHPKSTGGVLYELCERSNMEGQQ

Sequences:

>Translated_158_residues
MANIHYDSELFRSKGDEIMHVKKVDHIGIAVRSIEKALPFYTDVLRLPFLGIEEVESEQVKVAFLQAGEAKIELLEPLSP
ESAIAKFIEKRGEGIHHVALGVDDITERIRELKEHGIRMIQEMPKRGAGGAWVAFMHPKSTGGVLYELCERSNMEGQQ
>Mature_157_residues
ANIHYDSELFRSKGDEIMHVKKVDHIGIAVRSIEKALPFYTDVLRLPFLGIEEVESEQVKVAFLQAGEAKIELLEPLSPE
SAIAKFIEKRGEGIHHVALGVDDITERIRELKEHGIRMIQEMPKRGAGGAWVAFMHPKSTGGVLYELCERSNMEGQQ

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI188035928, Length=133, Percent_Identity=38.3458646616541, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17506387, Length=127, Percent_Identity=37.7952755905512, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR018146
- InterPro:   IPR017515 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 17765; Mature: 17634

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIHYDSELFRSKGDEIMHVKKVDHIGIAVRSIEKALPFYTDVLRLPFLGIEEVESEQV
CCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHH
KVAFLQAGEAKIELLEPLSPESAIAKFIEKRGEGIHHVALGVDDITERIRELKEHGIRMI
HHHEECCCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHH
QEMPKRGAGGAWVAFMHPKSTGGVLYELCERSNMEGQQ
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ANIHYDSELFRSKGDEIMHVKKVDHIGIAVRSIEKALPFYTDVLRLPFLGIEEVESEQV
CCCCCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHH
KVAFLQAGEAKIELLEPLSPESAIAKFIEKRGEGIHHVALGVDDITERIRELKEHGIRMI
HHHEECCCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHH
QEMPKRGAGGAWVAFMHPKSTGGVLYELCERSNMEGQQ
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]