Click here to switch to the map view.

The map label for this gene is yqjD [H]

Identifier: 138895933

GI number: 138895933

Start: 2412293

End: 2413843

Strand: Reverse

Name: yqjD [H]

Synonym: GTNG_2292

Alternate gene names: 138895933

Gene position: 2413843-2412293 (Counterclockwise)

Preceding gene: 138895934

Following gene: 138895932

Centisome position: 67.99

GC content: 52.1

Gene sequence:

>1551_bases
ATGAGCGACATGTATGACAAAATTAATGAGTTGTACGACCGCCGCCGTGAAATCGAGCTGGGCGGCGGCGATAAGAAAAT
TGAACAGCAGCACGCGAAAGGGAAGCTGACGGCGCGTGAGCGGATTGACTTGCTTTTAGACGAGGGGACGTTTGTCGAAC
TCAATCCGTTCATCGAGCATCGCTGCACTGATTTTGGTCTTGGCGAAAAAAAGGGGCCGGGGGATGGGGTCGTTACCGGC
TACGGGAAGATCAACGGACGCACCGTCTTTGTATTCTCACAAGATTTCACGGTCTTTGGCGGCGCACTCGGGGAAATGCA
CGCGAAAAAAATTACGAACATTATGGATTTGGCGGCGAAAACCGGAGCCCCGGTCATCGGCTTGAACGATTCGGGCGGTG
CCCGCATTCAAGAAGGGGTGTTGTCGCTTGATGGATACGGGCATATTTTTTATCGCAACGCCATCTATTCTGGGGTGATC
CCGCAAATCTCCGTTATTATGGGGCCGTGCGCAGGCGGGGCTGTCTATTCGCCGGCCATCACCGATTTTGTGTTCATGGT
CGAAAAAACGAGCCAAATGTTCATCACCGGGCCGAAGGTGATTGAGGCAGTGACCGGTGAGAAAATCAGCGCTGAAGATT
TAGGGGGTGCACGCGTTCATAATACGATTAGCGGCAACGCCCATTTTGCGGCGGCGAGTGAAGAAGAAGCGCTCGCTAAC
GTGCGGCTGTTGCTGAGTTATTTGCCGTCAAATAATAACGAAAAACCGCCGCTTGGCCCTGTTCCCGACGGGGATGACTA
CCGTCCTGATTTGGCTGACGTCGTGCCGATTGACGCCGTCCGTCCGTACGATGTGCGCCACGTCATTGCTCAAGTCGTCG
ATGACGGATCGTTTATGGAAGTGCAAAAAGATTTCGCTAAAAACATTGTCATCGGCTTTGCCCGCATTAAAGGGGAAGTC
GTTGGGCTTGTGTGCAACCAACCGAAATTTATGGCGGGTGGACTTGACATCGATTCGTCAGATAAAGCCGCGCGCTTTAT
TCGCTTTTGCGATTCGTTCAACATCCCGATCATTACATTTGAGGACGTCACCGGATTTTTCCCGGGCGTCAAGCAAGAGC
ACGGCGGCATCATCCGCCATGGGGCGAAAATTTTGTACGCCTACTCGGAGGCGACAGTGCCCAAAATTACTGTCATTTTG
CGTAAAGCTTACGGTGGTGCGTACGTCGCCTTAAACAGCAAGTCGATTGGAGCCGATGTCGTTTATGCATGGCCGAACGC
TGAAGTGGCGGTCATGGGGCCGCAAGGGGCGGCGAACATCATTTTTGCAAGCGAAATTGCAAACAGCCCAAATCCGGAAG
AAACGCGGGCGCAAAAAATTGAAGAATATCGTGAAAAATTCGCCAACCCGTACGTCGCTGCCAAATACGGCATGATCGAT
GACGTCATCGACCCGCGTGACACTCGAATAAAACTTATTCAAGCGCTCGAAATGCTCCGCTGTAAACACGAAGAGCGGCC
GAAGAAAAAACATGGCAACATTCCGTTGTAA

Upstream 100 bases:

>100_bases
AACGCGGCGCCGGCGGGGCATGGGTGGCGTTTATGCATCCGAAGTCGACTGGCGGCGTTTTATACGAACTTTGCGAACGG
TCGAACATGGAGGGACAACA

Downstream 100 bases:

>100_bases
GCGATAGAAGGCGCCTAACAAGCAATGGGCGCCTTTTTCGCAGCAAATAATCATTGAGACGGGAGTCGTGTTGCTCGGCC
TTTCATCACGCCAAGGTGTG

Product: methylmalonyl-CoA decarboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSDMYDKINELYDRRREIELGGGDKKIEQQHAKGKLTARERIDLLLDEGTFVELNPFIEHRCTDFGLGEKKGPGDGVVTG
YGKINGRTVFVFSQDFTVFGGALGEMHAKKITNIMDLAAKTGAPVIGLNDSGGARIQEGVLSLDGYGHIFYRNAIYSGVI
PQISVIMGPCAGGAVYSPAITDFVFMVEKTSQMFITGPKVIEAVTGEKISAEDLGGARVHNTISGNAHFAAASEEEALAN
VRLLLSYLPSNNNEKPPLGPVPDGDDYRPDLADVVPIDAVRPYDVRHVIAQVVDDGSFMEVQKDFAKNIVIGFARIKGEV
VGLVCNQPKFMAGGLDIDSSDKAARFIRFCDSFNIPIITFEDVTGFFPGVKQEHGGIIRHGAKILYAYSEATVPKITVIL
RKAYGGAYVALNSKSIGADVVYAWPNAEVAVMGPQGAANIIFASEIANSPNPEETRAQKIEEYREKFANPYVAAKYGMID
DVIDPRDTRIKLIQALEMLRCKHEERPKKKHGNIPL

Sequences:

>Translated_516_residues
MSDMYDKINELYDRRREIELGGGDKKIEQQHAKGKLTARERIDLLLDEGTFVELNPFIEHRCTDFGLGEKKGPGDGVVTG
YGKINGRTVFVFSQDFTVFGGALGEMHAKKITNIMDLAAKTGAPVIGLNDSGGARIQEGVLSLDGYGHIFYRNAIYSGVI
PQISVIMGPCAGGAVYSPAITDFVFMVEKTSQMFITGPKVIEAVTGEKISAEDLGGARVHNTISGNAHFAAASEEEALAN
VRLLLSYLPSNNNEKPPLGPVPDGDDYRPDLADVVPIDAVRPYDVRHVIAQVVDDGSFMEVQKDFAKNIVIGFARIKGEV
VGLVCNQPKFMAGGLDIDSSDKAARFIRFCDSFNIPIITFEDVTGFFPGVKQEHGGIIRHGAKILYAYSEATVPKITVIL
RKAYGGAYVALNSKSIGADVVYAWPNAEVAVMGPQGAANIIFASEIANSPNPEETRAQKIEEYREKFANPYVAAKYGMID
DVIDPRDTRIKLIQALEMLRCKHEERPKKKHGNIPL
>Mature_515_residues
SDMYDKINELYDRRREIELGGGDKKIEQQHAKGKLTARERIDLLLDEGTFVELNPFIEHRCTDFGLGEKKGPGDGVVTGY
GKINGRTVFVFSQDFTVFGGALGEMHAKKITNIMDLAAKTGAPVIGLNDSGGARIQEGVLSLDGYGHIFYRNAIYSGVIP
QISVIMGPCAGGAVYSPAITDFVFMVEKTSQMFITGPKVIEAVTGEKISAEDLGGARVHNTISGNAHFAAASEEEALANV
RLLLSYLPSNNNEKPPLGPVPDGDDYRPDLADVVPIDAVRPYDVRHVIAQVVDDGSFMEVQKDFAKNIVIGFARIKGEVV
GLVCNQPKFMAGGLDIDSSDKAARFIRFCDSFNIPIITFEDVTGFFPGVKQEHGGIIRHGAKILYAYSEATVPKITVILR
KAYGGAYVALNSKSIGADVVYAWPNAEVAVMGPQGAANIIFASEIANSPNPEETRAQKIEEYREKFANPYVAAKYGMIDD
VIDPRDTRIKLIQALEMLRCKHEERPKKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=514, Percent_Identity=56.8093385214008, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI295821216, Length=534, Percent_Identity=54.6816479400749, Blast_Score=576, Evalue=1e-164,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=35.7285429141717, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI38679977, Length=396, Percent_Identity=24.7474747474747, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679967, Length=396, Percent_Identity=24.7474747474747, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679971, Length=396, Percent_Identity=24.7474747474747, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679974, Length=396, Percent_Identity=24.7474747474747, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679960, Length=396, Percent_Identity=24.7474747474747, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI134142062, Length=395, Percent_Identity=23.5443037974684, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1788655, Length=251, Percent_Identity=29.0836653386454, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=57.9567779960707, Blast_Score=594, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=57.9567779960707, Blast_Score=594, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17552936, Length=517, Percent_Identity=34.2359767891683, Blast_Score=274, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI71997163, Length=310, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323863, Length=292, Percent_Identity=23.972602739726, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24586065, Length=518, Percent_Identity=34.3629343629344, Blast_Score=266, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56275; Mature: 56144

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMYDKINELYDRRREIELGGGDKKIEQQHAKGKLTARERIDLLLDEGTFVELNPFIEH
CCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCHHHHEEEEECCCCEEEECHHHHH
RCTDFGLGEKKGPGDGVVTGYGKINGRTVFVFSQDFTVFGGALGEMHAKKITNIMDLAAK
CCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHH
TGAPVIGLNDSGGARIQEGVLSLDGYGHIFYRNAIYSGVIPQISVIMGPCAGGAVYSPAI
CCCCEEEECCCCCCHHHHCCEEECCCCEEEEHHHHHHCCCCEEEHEEECCCCCCCCCHHH
TDFVFMVEKTSQMFITGPKVIEAVTGEKISAEDLGGARVHNTISGNAHFAAASEEEALAN
HHHHHHEECCCEEEEECHHHHHHHCCCCCCHHHCCCCEEEEECCCCEEEECCCHHHHHHH
VRLLLSYLPSNNNEKPPLGPVPDGDDYRPDLADVVPIDAVRPYDVRHVIAQVVDDGSFME
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCHHH
VQKDFAKNIVIGFARIKGEVVGLVCNQPKFMAGGLDIDSSDKAARFIRFCDSFNIPIITF
HHHHHHHHHEEEEEEECCEEEEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCCCCEEEE
EDVTGFFPGVKQEHGGIIRHGAKILYAYSEATVPKITVILRKAYGGAYVALNSKSIGADV
CCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCCCEE
VYAWPNAEVAVMGPQGAANIIFASEIANSPNPEETRAQKIEEYREKFANPYVAAKYGMID
EEECCCCCEEEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHH
DVIDPRDTRIKLIQALEMLRCKHEERPKKKHGNIPL
HCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SDMYDKINELYDRRREIELGGGDKKIEQQHAKGKLTARERIDLLLDEGTFVELNPFIEH
CHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCHHHHEEEEECCCCEEEECHHHHH
RCTDFGLGEKKGPGDGVVTGYGKINGRTVFVFSQDFTVFGGALGEMHAKKITNIMDLAAK
CCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHH
TGAPVIGLNDSGGARIQEGVLSLDGYGHIFYRNAIYSGVIPQISVIMGPCAGGAVYSPAI
CCCCEEEECCCCCCHHHHCCEEECCCCEEEEHHHHHHCCCCEEEHEEECCCCCCCCCHHH
TDFVFMVEKTSQMFITGPKVIEAVTGEKISAEDLGGARVHNTISGNAHFAAASEEEALAN
HHHHHHEECCCEEEEECHHHHHHHCCCCCCHHHCCCCEEEEECCCCEEEECCCHHHHHHH
VRLLLSYLPSNNNEKPPLGPVPDGDDYRPDLADVVPIDAVRPYDVRHVIAQVVDDGSFME
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCHHH
VQKDFAKNIVIGFARIKGEVVGLVCNQPKFMAGGLDIDSSDKAARFIRFCDSFNIPIITF
HHHHHHHHHEEEEEEECCEEEEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCCCCEEEE
EDVTGFFPGVKQEHGGIIRHGAKILYAYSEATVPKITVILRKAYGGAYVALNSKSIGADV
CCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCCCEE
VYAWPNAEVAVMGPQGAANIIFASEIANSPNPEETRAQKIEEYREKFANPYVAAKYGMID
EEECCCCCEEEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHH
DVIDPRDTRIKLIQALEMLRCKHEERPKKKHGNIPL
HCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]