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The map label for this gene is hepT [H]

Identifier: 138895788

GI number: 138895788

Start: 2274969

End: 2275931

Strand: Reverse

Name: hepT [H]

Synonym: GTNG_2144

Alternate gene names: 138895788

Gene position: 2275931-2274969 (Counterclockwise)

Preceding gene: 138895789

Following gene: 138895787

Centisome position: 64.1

GC content: 54.93

Gene sequence:

>963_bases
ATGAAGTTAAAGGCGATGTATTCGTTTTTAAGCAAGGATTTGGCGGCGGTCGAACAAGAGCTCGAGCGGACGGTTCAGTC
GGAATATGGGCCGCTTGGGGAAGCGGCGCTGCATTTATTGCAGGCGGGCGGAAAGCGGATCCGTCCCGTTTTTGTCTTGC
TTGCCGCCCGCTTTGGCCATTATGATCTCGAGCGGATCAAGCATGTAGCTGTAGCGCTCGAACTCATTCACATGGCATCG
CTCGTCCATGACGATGTGATCGACGATGCCGACTTGCGCCGCGGCCGACCGACGATCAAAGCGAAATGGAGCAATCGGTT
TGCCATGTACACGGGCGATTATTTGTTTGCCCGTTCGCTCGAACGGATGGCGGAACTTGACGACCCACGCGCTCACCAAG
TACTCGCGAAAACGATTGTCGAAGTGTGCCGCGGGGAAATTGAGCAAATTAAAGACAAATACTGGTTTGAACAACCACTC
CGCACGTATTTGCGGCGCATCCGCCGGAAAACGGCGCTGCTGATCGCTGCTAGCTGCCAGCTTGGCGCTCTGGCCGCTGG
CGCCCCGGAATCGGTGGCTAAACGTCTGTATTGGTTTGGCCATTATGTCGGCATGTCGTTTCAAATTACGGATGATATCC
TCGATTTTACAGGCACGGAAGAGCAATTGGGCAAGCCGGCGGGAAGCGACTTGCTGCAAGGAAACATCACCCTCCCGGTG
CTGTACGCGCTTCGTGATGAACGGTTGAAAGCGGCGATCACCGCTGTCAGCCCGGAAACCAATGCGGATGAGATGGCAGC
TGTCATTTCCGCCATTAAGCGAACGGATGCCATTGACCAGTCGTACGCATTAAGCGACCGCTACCTCGAAAAAGCGCTCC
GTCTGCTCGGTGAATTGCCCGCCAATAAGGCGCGCACCTTGTTGCATGATCTCGCCCTCTACATCGGGAAAAGGGATTAT
TAA

Upstream 100 bases:

>100_bases
TTTCGCGCCGCTGGCTTTGTCGATGTCGAGGTCAAACCGTACACGTTCGGCGTGGCGGCGATGCATTTAGGTTACAAACG
ATGAGTCAAGGTGAACATTC

Downstream 100 bases:

>100_bases
CGCTTTCAAGGACATTATTGCCAATGACGCGAAACGATGGTACTATGATGAGGGGAACCCGTTTCCTAGTACATACGACA
GTAGGGGTGGAGAGTCAATG

Product: heptaprenyl diphosphate synthase subunit II

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKLKAMYSFLSKDLAAVEQELERTVQSEYGPLGEAALHLLQAGGKRIRPVFVLLAARFGHYDLERIKHVAVALELIHMAS
LVHDDVIDDADLRRGRPTIKAKWSNRFAMYTGDYLFARSLERMAELDDPRAHQVLAKTIVEVCRGEIEQIKDKYWFEQPL
RTYLRRIRRKTALLIAASCQLGALAAGAPESVAKRLYWFGHYVGMSFQITDDILDFTGTEEQLGKPAGSDLLQGNITLPV
LYALRDERLKAAITAVSPETNADEMAAVISAIKRTDAIDQSYALSDRYLEKALRLLGELPANKARTLLHDLALYIGKRDY

Sequences:

>Translated_320_residues
MKLKAMYSFLSKDLAAVEQELERTVQSEYGPLGEAALHLLQAGGKRIRPVFVLLAARFGHYDLERIKHVAVALELIHMAS
LVHDDVIDDADLRRGRPTIKAKWSNRFAMYTGDYLFARSLERMAELDDPRAHQVLAKTIVEVCRGEIEQIKDKYWFEQPL
RTYLRRIRRKTALLIAASCQLGALAAGAPESVAKRLYWFGHYVGMSFQITDDILDFTGTEEQLGKPAGSDLLQGNITLPV
LYALRDERLKAAITAVSPETNADEMAAVISAIKRTDAIDQSYALSDRYLEKALRLLGELPANKARTLLHDLALYIGKRDY
>Mature_320_residues
MKLKAMYSFLSKDLAAVEQELERTVQSEYGPLGEAALHLLQAGGKRIRPVFVLLAARFGHYDLERIKHVAVALELIHMAS
LVHDDVIDDADLRRGRPTIKAKWSNRFAMYTGDYLFARSLERMAELDDPRAHQVLAKTIVEVCRGEIEQIKDKYWFEQPL
RTYLRRIRRKTALLIAASCQLGALAAGAPESVAKRLYWFGHYVGMSFQITDDILDFTGTEEQLGKPAGSDLLQGNITLPV
LYALRDERLKAAITAVSPETNADEMAAVISAIKRTDAIDQSYALSDRYLEKALRLLGELPANKARTLLHDLALYIGKRDY

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=325, Percent_Identity=31.0769230769231, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4758430, Length=231, Percent_Identity=26.4069264069264, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI83700220, Length=231, Percent_Identity=26.4069264069264, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789578, Length=322, Percent_Identity=30.1242236024845, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786623, Length=222, Percent_Identity=33.7837837837838, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17505681, Length=352, Percent_Identity=29.2613636363636, Blast_Score=147, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319475, Length=301, Percent_Identity=30.2325581395349, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6325188, Length=226, Percent_Identity=25.6637168141593, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651612, Length=294, Percent_Identity=31.2925170068027, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281365769, Length=218, Percent_Identity=27.9816513761468, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24660002, Length=218, Percent_Identity=27.9816513761468, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36034; Mature: 36034

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKAMYSFLSKDLAAVEQELERTVQSEYGPLGEAALHLLQAGGKRIRPVFVLLAARFGH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
YDLERIKHVAVALELIHMASLVHDDVIDDADLRRGRPTIKAKWSNRFAMYTGDYLFARSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCEEEEEECHHHHHHHH
ERMAELDDPRAHQVLAKTIVEVCRGEIEQIKDKYWFEQPLRTYLRRIRRKTALLIAASCQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
LGALAAGAPESVAKRLYWFGHYVGMSFQITDDILDFTGTEEQLGKPAGSDLLQGNITLPV
CCHHCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCHHHHCCCCCCHHHCCCCHHHH
LYALRDERLKAAITAVSPETNADEMAAVISAIKRTDAIDQSYALSDRYLEKALRLLGELP
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ANKARTLLHDLALYIGKRDY
CHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLKAMYSFLSKDLAAVEQELERTVQSEYGPLGEAALHLLQAGGKRIRPVFVLLAARFGH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
YDLERIKHVAVALELIHMASLVHDDVIDDADLRRGRPTIKAKWSNRFAMYTGDYLFARSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCEEEEEECHHHHHHHH
ERMAELDDPRAHQVLAKTIVEVCRGEIEQIKDKYWFEQPLRTYLRRIRRKTALLIAASCQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
LGALAAGAPESVAKRLYWFGHYVGMSFQITDDILDFTGTEEQLGKPAGSDLLQGNITLPV
CCHHCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCHHHHCCCCCCHHHCCCCHHHH
LYALRDERLKAAITAVSPETNADEMAAVISAIKRTDAIDQSYALSDRYLEKALRLLGELP
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ANKARTLLHDLALYIGKRDY
CHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]