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The map label for this gene is ndk [H]

Identifier: 138895787

GI number: 138895787

Start: 2274422

End: 2275006

Strand: Reverse

Name: ndk [H]

Synonym: GTNG_2143

Alternate gene names: 138895787

Gene position: 2275006-2274422 (Counterclockwise)

Preceding gene: 138895788

Following gene: 138895786

Centisome position: 64.08

GC content: 48.89

Gene sequence:

>585_bases
ATGATCTCGCCCTCTACATCGGGAAAAGGGATTATTAACGCTTTCAAGGACATTATTGCCAATGACGCGAAACGATGGTA
CTATGATGAGGGGAACCCGTTTCCTAGTACATACGACAGTAGGGGTGGAGAGTCAATGAAAGAACGGACATTTTTAATGG
TAAAGCCAGACGGGGTTCAGCGCAATTTAATCGGTGAAATTGTCTCCCGCTTTGAAAAAAAGGGATTCCAGCTTGTCGGC
GCCAAGCTGATGCAAGTGTCGCGTGAGCTGGCTGAGCAGCATTACGCCGAACATAAAGAGCGTCCGTTTTTTGGCGAGCT
TGTTGATTTCATTACGTCCGGACCGGTATTCGCGATGGTGTGGGAAGGTGAAAACGTGATCGCTGCCGCCCGGCAAATGA
TGGGGAAAACGAATCCACAAGACGCCGCACCGGGGACGATTCGCGGAGATTTCGGCTTGACGGTCGGCAAAAACGTCATT
CACGGTTCCGATTCGCCGCAAAGCGCGGAACGCGAGATCAACTTGTTCTTCAAAGAAGAAGAGCTCATTACATATACAAA
ACTGATGAACGAATGGCTATATTAA

Upstream 100 bases:

>100_bases
GATGCCATTGACCAGTCGTACGCATTAAGCGACCGCTACCTCGAAAAAGCGCTCCGTCTGCTCGGTGAATTGCCCGCCAA
TAAGGCGCGCACCTTGTTGC

Downstream 100 bases:

>100_bases
TGTGAAGACCGGCCACAACTTGGCCGGTTTTTGCCATTTTATGAGGACGACACGATAACGGGAGAGGGGGCAGTACCGAT
GGATGATTATGCACAATTTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MISPSTSGKGIINAFKDIIANDAKRWYYDEGNPFPSTYDSRGGESMKERTFLMVKPDGVQRNLIGEIVSRFEKKGFQLVG
AKLMQVSRELAEQHYAEHKERPFFGELVDFITSGPVFAMVWEGENVIAAARQMMGKTNPQDAAPGTIRGDFGLTVGKNVI
HGSDSPQSAEREINLFFKEEELITYTKLMNEWLY

Sequences:

>Translated_194_residues
MISPSTSGKGIINAFKDIIANDAKRWYYDEGNPFPSTYDSRGGESMKERTFLMVKPDGVQRNLIGEIVSRFEKKGFQLVG
AKLMQVSRELAEQHYAEHKERPFFGELVDFITSGPVFAMVWEGENVIAAARQMMGKTNPQDAAPGTIRGDFGLTVGKNVI
HGSDSPQSAEREINLFFKEEELITYTKLMNEWLY
>Mature_194_residues
MISPSTSGKGIINAFKDIIANDAKRWYYDEGNPFPSTYDSRGGESMKERTFLMVKPDGVQRNLIGEIVSRFEKKGFQLVG
AKLMQVSRELAEQHYAEHKERPFFGELVDFITSGPVFAMVWEGENVIAAARQMMGKTNPQDAAPGTIRGDFGLTVGKNVI
HGSDSPQSAEREINLFFKEEELITYTKLMNEWLY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI38045913, Length=168, Percent_Identity=55.3571428571429, Blast_Score=201, Evalue=4e-52,
Organism=Homo sapiens, GI37693993, Length=164, Percent_Identity=56.7073170731707, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI4557797, Length=147, Percent_Identity=59.8639455782313, Blast_Score=198, Evalue=2e-51,
Organism=Homo sapiens, GI66392227, Length=147, Percent_Identity=58.5034013605442, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI66392205, Length=147, Percent_Identity=58.5034013605442, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI4505409, Length=147, Percent_Identity=58.5034013605442, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI66392192, Length=147, Percent_Identity=58.5034013605442, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI66392203, Length=147, Percent_Identity=58.5034013605442, Blast_Score=193, Evalue=7e-50,
Organism=Homo sapiens, GI4826862, Length=157, Percent_Identity=47.7707006369427, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI7019465, Length=143, Percent_Identity=38.4615384615385, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI37574614, Length=143, Percent_Identity=38.4615384615385, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=38.0597014925373, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI148839372, Length=139, Percent_Identity=30.2158273381295, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=140, Percent_Identity=47.1428571428571, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=151, Percent_Identity=49.6688741721854, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6322783, Length=150, Percent_Identity=57.3333333333333, Blast_Score=192, Evalue=4e-50,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=59.4594594594595, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=32.5925925925926, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 21881; Mature: 21881

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPSTSGKGIINAFKDIIANDAKRWYYDEGNPFPSTYDSRGGESMKERTFLMVKPDGVQ
CCCCCCCCCHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCCCCCHHHCEEEEECCCCCH
RNLIGEIVSRFEKKGFQLVGAKLMQVSRELAEQHYAEHKERPFFGELVDFITSGPVFAMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
WEGENVIAAARQMMGKTNPQDAAPGTIRGDFGLTVGKNVIHGSDSPQSAEREINLFFKEE
ECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEECCCCCCCCHHHHHHEEECCH
ELITYTKLMNEWLY
HHHHHHHHHHHHCC
>Mature Secondary Structure
MISPSTSGKGIINAFKDIIANDAKRWYYDEGNPFPSTYDSRGGESMKERTFLMVKPDGVQ
CCCCCCCCCHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCCCCCHHHCEEEEECCCCCH
RNLIGEIVSRFEKKGFQLVGAKLMQVSRELAEQHYAEHKERPFFGELVDFITSGPVFAMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
WEGENVIAAARQMMGKTNPQDAAPGTIRGDFGLTVGKNVIHGSDSPQSAEREINLFFKEE
ECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEECCCCCCCCHHHHHHEEECCH
ELITYTKLMNEWLY
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA