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The map label for this gene is ubiE [H]

Identifier: 138895789

GI number: 138895789

Start: 2275948

End: 2276655

Strand: Reverse

Name: ubiE [H]

Synonym: GTNG_2145

Alternate gene names: 138895789

Gene position: 2276655-2275948 (Counterclockwise)

Preceding gene: 138895790

Following gene: 138895788

Centisome position: 64.13

GC content: 51.84

Gene sequence:

>708_bases
ATGATGCATCAATCAAAGGAAGAGCGAGTTCATCGTGTGTTTGAAAAAATCTCCACTCATTATGATCGGATGAACTCCGT
CATCAGCTTCCGTCGCCATTTAAAATGGCGCGAAGACGTGATGCGACGGATGAATGTGCAAAAAGGGAAAAAAGCGCTCG
ATGTTTGCTGCGGGACGGCCGACTGGGCGATCGCCTTAGCCGAGGCGGTCGGGCCAGAGGGGGAAGTGTATGGCCTCGAT
TTCAGCGAAAACATGTTAAAAGTCGGCGAGCAAAAGGTGAAAGAGCGCAGCTTGCACAATGTGAAGCTCATTCATGGCAA
CGCCATGCAGCTGCCGTTTCCTGACAATTCGTTCGATTACGTGACCATTGGTTTCGGCTTGCGCAACGTCCCTGATTATA
TGACGGTGCTGAAAGAAATGCACCGGGTCACGAAACCGGGCGGCATGACTGTCTGTTTGGAAACGTCGCAGCCGACGCTA
TTTGGCTTCCGCCAGCTTTACTATTTTTATTTCCGGTTTATTATGCCGCTGTTTGGCAAACTATTGGCCAAAAGCTATGA
GGAGTATTCGTGGTTGCAAGAGTCCGCGCGCGAGTTCCCGGGGCGGGATGAGCTGGCGGAAATGTTTCGCGCCGCTGGCT
TTGTCGATGTCGAGGTCAAACCGTACACGTTCGGCGTGGCGGCGATGCATTTAGGTTACAAACGATGA

Upstream 100 bases:

>100_bases
ACGGCGAAATTGCTGCCAAACGACGTGCTGGCGCTCCGCGTGACTGAGCTTTCCGGTGGATTTTCAGCCATCGCCAAAAA
GACGGTGGAAGAAGGGTAGA

Downstream 100 bases:

>100_bases
GTCAAGGTGAACATTCATGAAGTTAAAGGCGATGTATTCGTTTTTAAGCAAGGATTTGGCGGCGGTCGAACAAGAGCTCG
AGCGGACGGTTCAGTCGGAA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MMHQSKEERVHRVFEKISTHYDRMNSVISFRRHLKWREDVMRRMNVQKGKKALDVCCGTADWAIALAEAVGPEGEVYGLD
FSENMLKVGEQKVKERSLHNVKLIHGNAMQLPFPDNSFDYVTIGFGLRNVPDYMTVLKEMHRVTKPGGMTVCLETSQPTL
FGFRQLYYFYFRFIMPLFGKLLAKSYEEYSWLQESAREFPGRDELAEMFRAAGFVDVEVKPYTFGVAAMHLGYKR

Sequences:

>Translated_235_residues
MMHQSKEERVHRVFEKISTHYDRMNSVISFRRHLKWREDVMRRMNVQKGKKALDVCCGTADWAIALAEAVGPEGEVYGLD
FSENMLKVGEQKVKERSLHNVKLIHGNAMQLPFPDNSFDYVTIGFGLRNVPDYMTVLKEMHRVTKPGGMTVCLETSQPTL
FGFRQLYYFYFRFIMPLFGKLLAKSYEEYSWLQESAREFPGRDELAEMFRAAGFVDVEVKPYTFGVAAMHLGYKR
>Mature_235_residues
MMHQSKEERVHRVFEKISTHYDRMNSVISFRRHLKWREDVMRRMNVQKGKKALDVCCGTADWAIALAEAVGPEGEVYGLD
FSENMLKVGEQKVKERSLHNVKLIHGNAMQLPFPDNSFDYVTIGFGLRNVPDYMTVLKEMHRVTKPGGMTVCLETSQPTL
FGFRQLYYFYFRFIMPLFGKLLAKSYEEYSWLQESAREFPGRDELAEMFRAAGFVDVEVKPYTFGVAAMHLGYKR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=265, Percent_Identity=32.4528301886792, Blast_Score=140, Evalue=8e-34,
Organism=Escherichia coli, GI48994983, Length=232, Percent_Identity=38.7931034482759, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17557039, Length=232, Percent_Identity=34.9137931034483, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323526, Length=254, Percent_Identity=29.9212598425197, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641702, Length=243, Percent_Identity=35.8024691358025, Blast_Score=148, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014122
- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 27363; Mature: 27363

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHQSKEERVHRVFEKISTHYDRMNSVISFRRHLKWREDVMRRMNVQKGKKALDVCCGTA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DWAIALAEAVGPEGEVYGLDFSENMLKVGEQKVKERSLHNVKLIHGNAMQLPFPDNSFDY
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCCCE
VTIGFGLRNVPDYMTVLKEMHRVTKPGGMTVCLETSQPTLFGFRQLYYFYFRFIMPLFGK
EEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LLAKSYEEYSWLQESAREFPGRDELAEMFRAAGFVDVEVKPYTFGVAAMHLGYKR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCC
>Mature Secondary Structure
MMHQSKEERVHRVFEKISTHYDRMNSVISFRRHLKWREDVMRRMNVQKGKKALDVCCGTA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DWAIALAEAVGPEGEVYGLDFSENMLKVGEQKVKERSLHNVKLIHGNAMQLPFPDNSFDY
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCCCE
VTIGFGLRNVPDYMTVLKEMHRVTKPGGMTVCLETSQPTLFGFRQLYYFYFRFIMPLFGK
EEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LLAKSYEEYSWLQESAREFPGRDELAEMFRAAGFVDVEVKPYTFGVAAMHLGYKR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA