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The map label for this gene is murQ

Identifier: 138895528

GI number: 138895528

Start: 2004427

End: 2005314

Strand: Reverse

Name: murQ

Synonym: GTNG_1878

Alternate gene names: 138895528

Gene position: 2005314-2004427 (Counterclockwise)

Preceding gene: 138895529

Following gene: 138895527

Centisome position: 56.48

GC content: 50.45

Gene sequence:

>888_bases
TTGCTTGAGCATCTTGCGACAGAACAACGAAATGAAAAGACGAAACATTTGGATGGAATGACGACAAGAGAAATTTTACA
CGTCATGAACGAGGAAGACCGAGCCGCGGTCATCGCGGTATCCAAGCAGCTTGATTGTATTGAAAAAATCGTTCATCTTG
TCATCGCCGCATTTCGGCGTGGGGGGCGATTGATTTATGTTGGGGCGGGTACGAGCGGCCGGCTCGGATTGCTTGATGCG
GTAGAATGCCCACCAACGTTTGGAACCGAACCGTCCATGGTGCAGGCGATTCTTGCCGGAGGATTGAAAGCGATTTCGGA
GGCCGTGGAAGGAGCCGAAGATGATGAAGAGGCCGCTGTTCGCGATCTGCAGGCAGTGGGCTTGACGAAAAACGATGTCG
TTATTGGCATTGCAGCGAGCGGCCGAACGCCATATGTAGTCAGCGCACTTCGCTATGCCAAACAAATCGGTGCGGCGACA
GGAAGCATTGCCTGCAATAAAGGAGCCGTCATTAGCCAGTATGCCGATGCGGCGGTGGAAATTGAAACAGGACCGGAAGT
GCTGGCTGGTTCAACGAGGTTAAAAGCTGGGACAGCCCAAAAAATGGTACTCAACATGATTTCTACTGCATCGATGGTCG
GTATTGGCAAAGTGTATGGAAACTGGATGGTCGATGTACAGGCGACAAACGAAAAGTTAAAAGAGCGGGCAAAGCGCATT
TTAATAGAGGCGACAGGAGTCAGCGCCGAAGAAGCGTCCCGCTATTATGAACAAGCAAAAGGGGAGGTGAAAACAGCGAT
CGTTATGATTTTGCGCCAATGCGGTTATGAAGAAGCAAAAGAACGACTGCAGCAAGCCGAAGGGTTTGTACGTAAAGCGC
TTGAATAA

Upstream 100 bases:

>100_bases
TTGTAGGAATGTTTCAAATGAAAAAAGAATAGATTGATATTTTATTTCATAAATTTATAATATAATTATGAAACATAATT
TCGTTAAAGAGGTGACCAGA

Downstream 100 bases:

>100_bases
CGAATAAGGGGGAGAGAAATATCATGACTCGAGAACAACAAATAGCAGCATCGATACTTCAGTATGTTGGGGGGAAAGAA
AACATCACCCGCGTTGCCCA

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLEHLATEQRNEKTKHLDGMTTREILHVMNEEDRAAVIAVSKQLDCIEKIVHLVIAAFRRGGRLIYVGAGTSGRLGLLDA
VECPPTFGTEPSMVQAILAGGLKAISEAVEGAEDDEEAAVRDLQAVGLTKNDVVIGIAASGRTPYVVSALRYAKQIGAAT
GSIACNKGAVISQYADAAVEIETGPEVLAGSTRLKAGTAQKMVLNMISTASMVGIGKVYGNWMVDVQATNEKLKERAKRI
LIEATGVSAEEASRYYEQAKGEVKTAIVMILRQCGYEEAKERLQQAEGFVRKALE

Sequences:

>Translated_295_residues
MLEHLATEQRNEKTKHLDGMTTREILHVMNEEDRAAVIAVSKQLDCIEKIVHLVIAAFRRGGRLIYVGAGTSGRLGLLDA
VECPPTFGTEPSMVQAILAGGLKAISEAVEGAEDDEEAAVRDLQAVGLTKNDVVIGIAASGRTPYVVSALRYAKQIGAAT
GSIACNKGAVISQYADAAVEIETGPEVLAGSTRLKAGTAQKMVLNMISTASMVGIGKVYGNWMVDVQATNEKLKERAKRI
LIEATGVSAEEASRYYEQAKGEVKTAIVMILRQCGYEEAKERLQQAEGFVRKALE
>Mature_295_residues
MLEHLATEQRNEKTKHLDGMTTREILHVMNEEDRAAVIAVSKQLDCIEKIVHLVIAAFRRGGRLIYVGAGTSGRLGLLDA
VECPPTFGTEPSMVQAILAGGLKAISEAVEGAEDDEEAAVRDLQAVGLTKNDVVIGIAASGRTPYVVSALRYAKQIGAAT
GSIACNKGAVISQYADAAVEIETGPEVLAGSTRLKAGTAQKMVLNMISTASMVGIGKVYGNWMVDVQATNEKLKERAKRI
LIEATGVSAEEASRYYEQAKGEVKTAIVMILRQCGYEEAKERLQQAEGFVRKALE

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=294, Percent_Identity=50, Blast_Score=286, Evalue=8e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_GEOTN (A4IPI2)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125981.1
- ProteinModelPortal:   A4IPI2
- SMR:   A4IPI2
- STRING:   A4IPI2
- GeneID:   4966810
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1878
- NMPDR:   fig|420246.5.peg.1808
- eggNOG:   COG2103
- HOGENOM:   HBG703490
- OMA:   HLLTEQI
- PhylomeDB:   A4IPI2
- ProtClustDB:   PRK05441
- BioCyc:   GTHE420246:GTNG_1878-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 31621; Mature: 31621

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 82-82 ACT_SITE 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHLATEQRNEKTKHLDGMTTREILHVMNEEDRAAVIAVSKQLDCIEKIVHLVIAAFRR
CCCHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHC
GGRLIYVGAGTSGRLGLLDAVECPPTFGTEPSMVQAILAGGLKAISEAVEGAEDDEEAAV
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RDLQAVGLTKNDVVIGIAASGRTPYVVSALRYAKQIGAATGSIACNKGAVISQYADAAVE
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEE
IETGPEVLAGSTRLKAGTAQKMVLNMISTASMVGIGKVYGNWMVDVQATNEKLKERAKRI
ECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
LIEATGVSAEEASRYYEQAKGEVKTAIVMILRQCGYEEAKERLQQAEGFVRKALE
HHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLEHLATEQRNEKTKHLDGMTTREILHVMNEEDRAAVIAVSKQLDCIEKIVHLVIAAFRR
CCCHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHC
GGRLIYVGAGTSGRLGLLDAVECPPTFGTEPSMVQAILAGGLKAISEAVEGAEDDEEAAV
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RDLQAVGLTKNDVVIGIAASGRTPYVVSALRYAKQIGAATGSIACNKGAVISQYADAAVE
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEE
IETGPEVLAGSTRLKAGTAQKMVLNMISTASMVGIGKVYGNWMVDVQATNEKLKERAKRI
ECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
LIEATGVSAEEASRYYEQAKGEVKTAIVMILRQCGYEEAKERLQQAEGFVRKALE
HHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA