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The map label for this gene is hssR [H]

Identifier: 138894462

GI number: 138894462

Start: 866076

End: 866756

Strand: Reverse

Name: hssR [H]

Synonym: GTNG_0792

Alternate gene names: 138894462

Gene position: 866756-866076 (Counterclockwise)

Preceding gene: 138894463

Following gene: 138894461

Centisome position: 24.41

GC content: 48.02

Gene sequence:

>681_bases
ATGACAATGGCCCGAATTTTAGTTGTCGATGATGATGCACATATCCGCGAACTCGTCAGCCATTTTTTAAGTTTGGAAGG
ATTGACAATCCACGAAGCAGCTAATGGAAAAGAAGCACTTGACGTGCTAGAAACGACGAAAGTGGATTTGGTCATTATGG
ATATTATGATGCCGGAAATGGATGGGTGGGAACTATGCCGTGAACTGCGCGACTATGACGATGTTCCCATTCTGATGTTG
ACCGCTAAAGGGGAAACGAGGGAAAAAGTGAAAGGATTTTCTCTTGGGGCAGACGACTATCTCGTCAAACCGTTTGACCC
CCTTGAACTTGTCGCCCGTGTCAAAGCATTGCTTAAACGGTATCGTATCGCCACCTCGCAAATCGTGCAAATTGGCCATT
TGTCGTTAAACCGCAAGACGTACGAATGCCGTTTGGGAGACGTGGAAGTCCCTTTGCCACCAAAAGAATTCGAACTGCTT
TTTCAACTGGCCAGCTATCCCGGTAAAACGTTCACGCGCGACGAATTGATTGAACAGATTTGGGGTTACGATTATGAAGG
AGATGAGCGAACCGTTGATGTTCATATCAAGCGGCTGCGTGAACGGTTCGCTCAGCCGAACGTTCCCTTTTTCATCCGCA
CGATTCGTGGACTCGGCTATCGGCTGGAGGCACGCCAATGA

Upstream 100 bases:

>100_bases
AACATCGGACGAATAGCGATGAATGGCGAGCAATACGCCCGCTACATTGACGGGGACGAACGAAAACGGCACAATGGAAA
AGAGAACGCGTGGAGGGAAG

Downstream 100 bases:

>100_bases
AACGATTATGGTTTGTGTTTAAATCCATCTTGACCGTGATCGCTGTGATGTCAATCATCTGCCTCTTTTGGTCTGCGGCA
TATTTCATCACAGAAGCGAT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTMARILVVDDDAHIRELVSHFLSLEGLTIHEAANGKEALDVLETTKVDLVIMDIMMPEMDGWELCRELRDYDDVPILML
TAKGETREKVKGFSLGADDYLVKPFDPLELVARVKALLKRYRIATSQIVQIGHLSLNRKTYECRLGDVEVPLPPKEFELL
FQLASYPGKTFTRDELIEQIWGYDYEGDERTVDVHIKRLRERFAQPNVPFFIRTIRGLGYRLEARQ

Sequences:

>Translated_226_residues
MTMARILVVDDDAHIRELVSHFLSLEGLTIHEAANGKEALDVLETTKVDLVIMDIMMPEMDGWELCRELRDYDDVPILML
TAKGETREKVKGFSLGADDYLVKPFDPLELVARVKALLKRYRIATSQIVQIGHLSLNRKTYECRLGDVEVPLPPKEFELL
FQLASYPGKTFTRDELIEQIWGYDYEGDERTVDVHIKRLRERFAQPNVPFFIRTIRGLGYRLEARQ
>Mature_225_residues
TMARILVVDDDAHIRELVSHFLSLEGLTIHEAANGKEALDVLETTKVDLVIMDIMMPEMDGWELCRELRDYDDVPILMLT
AKGETREKVKGFSLGADDYLVKPFDPLELVARVKALLKRYRIATSQIVQIGHLSLNRKTYECRLGDVEVPLPPKEFELLF
QLASYPGKTFTRDELIEQIWGYDYEGDERTVDVHIKRLRERFAQPNVPFFIRTIRGLGYRLEARQ

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36.8888888888889, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=38.6666666666667, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=36.3636363636364, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=36.9369369369369, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=35.4260089686099, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=34.2105263157895, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=34.3347639484979, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=33.1838565022422, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=34.703196347032, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.0807174887892, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.6491228070175, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.4372294372294, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=32.4324324324324, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=31.6017316017316, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788550, Length=146, Percent_Identity=34.9315068493151, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790299, Length=118, Percent_Identity=36.4406779661017, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788713, Length=131, Percent_Identity=35.1145038167939, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788905, Length=125, Percent_Identity=36, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788222, Length=136, Percent_Identity=33.8235294117647, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=106, Percent_Identity=35.8490566037736, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790437, Length=168, Percent_Identity=31.547619047619, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=36, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=101, Percent_Identity=35.6435643564356, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26155; Mature: 26023

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00230 MAP1B_NEURAXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMARILVVDDDAHIRELVSHFLSLEGLTIHEAANGKEALDVLETTKVDLVIMDIMMPEM
CCEEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCHHEEEEEHHCCCC
DGWELCRELRDYDDVPILMLTAKGETREKVKGFSLGADDYLVKPFDPLELVARVKALLKR
CHHHHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
YRIATSQIVQIGHLSLNRKTYECRLGDVEVPLPPKEFELLFQLASYPGKTFTRDELIEQI
HHHHHHHHHHHHHEEECCEEEEEEECCEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
WGYDYEGDERTVDVHIKRLRERFAQPNVPFFIRTIRGLGYRLEARQ
CCCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEECCC
>Mature Secondary Structure 
TMARILVVDDDAHIRELVSHFLSLEGLTIHEAANGKEALDVLETTKVDLVIMDIMMPEM
CEEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCHHEEEEEHHCCCC
DGWELCRELRDYDDVPILMLTAKGETREKVKGFSLGADDYLVKPFDPLELVARVKALLKR
CHHHHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
YRIATSQIVQIGHLSLNRKTYECRLGDVEVPLPPKEFELLFQLASYPGKTFTRDELIEQI
HHHHHHHHHHHHHEEECCEEEEEEECCEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
WGYDYEGDERTVDVHIKRLRERFAQPNVPFFIRTIRGLGYRLEARQ
CCCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA