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The map label for this gene is drrB [H]

Identifier: 138894463

GI number: 138894463

Start: 866981

End: 867772

Strand: Reverse

Name: drrB [H]

Synonym: GTNG_0793

Alternate gene names: 138894463

Gene position: 867772-866981 (Counterclockwise)

Preceding gene: 138894464

Following gene: 138894462

Centisome position: 24.44

GC content: 51.52

Gene sequence:

>792_bases
ATGAACACTCGCCAACTGAACAGCCGCACGAGCATTTCCCAAGCGGTGCGAAACTCGTTTACAATGGCCTACCGCGGTTT
GCTGAAGGTACGGCGTACGCCGGAACAACTATTTGACGTCACTTTCCAGCCGATCATTTTCACGTTGATGTTTACTTATA
TCTTTGGTGGAGCCATCGCCGGAAATGTGGACAACTACCTGCCAATGATTATTCCCGGCATTCTCATCCAAACATTGATC
GGCGCCTCTGTCGCTTCAGGAGTCCAACTTCGGGATGATATGGACAAAGGTGTGTTCGACCGCTTTAAATCATTGCCGAT
CGCCCGCATCGCGCCGTTGGCAGGGGCGTTATTAGCCGATGTCGTTCGCTATGTCATTGCCGCTGTGCTGACGTTTACCA
TCGGATTTCTCATCGGCTATCGTCCGGAAGGAGGTGTCGCCAGTGTGGCGCTTGCCATCGTGTTCTCCATCGGGTGCACG
TGGGCTGTCAGCTGGATATTTGCCTTCTTCGGCGTCATTGCCCGCAATGCAGCTAGCGTACAAGGAATTTCCATGTTGGC
GCTGTTTCCGCTTATGTTTCTTTCAAATGCGTTCGTGCCAGTCAAGACAATGCCTGACTGGCTGCAATGGATTGCCAAAG
CCAATCCTCTTTCCCATATGATCACGGCCGTTCGCGAACTAACGAACCATGGCACGATTGGCACTGATTTTATTATTTCT
TTAATCGGCGCAGGAGCGATTGTCGCGATTTTTGCCCCGATCACGGTTCGTGTCTATATACGCCGCGCATAA

Upstream 100 bases:

>100_bases
GTCCAAAAACCGACCCTTGATGAAGTCTTTTTAGCCATTACCGGCCATGGAACGAAAAAAGATGAAGAAGAATTCAGCGT
TCTAAGGGAGGTTCGATAGA

Downstream 100 bases:

>100_bases
TCATGGGGGATGTCTGACACTTATCCCCCGAACAGCCAAAACCAACAAACAGATTCATTCACGATCTGACGTCAGGATGA
AAATAAGGAACAGATGGGCT

Product: ABC transporter transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNTRQLNSRTSISQAVRNSFTMAYRGLLKVRRTPEQLFDVTFQPIIFTLMFTYIFGGAIAGNVDNYLPMIIPGILIQTLI
GASVASGVQLRDDMDKGVFDRFKSLPIARIAPLAGALLADVVRYVIAAVLTFTIGFLIGYRPEGGVASVALAIVFSIGCT
WAVSWIFAFFGVIARNAASVQGISMLALFPLMFLSNAFVPVKTMPDWLQWIAKANPLSHMITAVRELTNHGTIGTDFIIS
LIGAGAIVAIFAPITVRVYIRRA

Sequences:

>Translated_263_residues
MNTRQLNSRTSISQAVRNSFTMAYRGLLKVRRTPEQLFDVTFQPIIFTLMFTYIFGGAIAGNVDNYLPMIIPGILIQTLI
GASVASGVQLRDDMDKGVFDRFKSLPIARIAPLAGALLADVVRYVIAAVLTFTIGFLIGYRPEGGVASVALAIVFSIGCT
WAVSWIFAFFGVIARNAASVQGISMLALFPLMFLSNAFVPVKTMPDWLQWIAKANPLSHMITAVRELTNHGTIGTDFIIS
LIGAGAIVAIFAPITVRVYIRRA
>Mature_263_residues
MNTRQLNSRTSISQAVRNSFTMAYRGLLKVRRTPEQLFDVTFQPIIFTLMFTYIFGGAIAGNVDNYLPMIIPGILIQTLI
GASVASGVQLRDDMDKGVFDRFKSLPIARIAPLAGALLADVVRYVIAAVLTFTIGFLIGYRPEGGVASVALAIVFSIGCT
WAVSWIFAFFGVIARNAASVQGISMLALFPLMFLSNAFVPVKTMPDWLQWIAKANPLSHMITAVRELTNHGTIGTDFIIS
LIGAGAIVAIFAPITVRVYIRRA

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 28637; Mature: 28637

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHEEEEECC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]