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The map label for this gene is mtlA [H]

Identifier: 13508390

GI number: 13508390

Start: 776337

End: 777476

Strand: Direct

Name: mtlA [H]

Synonym: MPN651

Alternate gene names: 13508390

Gene position: 776337-777476 (Clockwise)

Preceding gene: 13508377

Following gene: 13508391

Centisome position: 95.09

GC content: 34.65

Gene sequence:

>1140_bases
ATGTTTTTAGGTGTGATGATATTCGGCCCAATTGCAGCGCTAATCTTAAAACACACTGAAAAGTTTTGAATTCACCGTAT
TAAAAGTGGCTTTGAAATGCTGGTAAATAATTTTTACCTTGGCTTTTTAGGTTTCGCCTTAATATTTCCTAGTTTTTACC
TATCAATTTACTTAATTGGTTACATTCAATTAGGTTTAAAACTGCTTGTTGAAATAATGCAACAGTACAAACTTTATCCA
ATAGCTGCCATTGTGATAGAGCCGGCCAAAGTTTTATTCCTAAATAATGCCATTAACCATGGCGTGCTAACTCCATTAGG
CTTACAACAAGTAAGAGACAGTGGTAAATCAATTCTTTTCTTATTGGAATCAAATCCTGGTCCAGGTTTGGGTCTCCTTG
TTGCTTTCTTAATCTTTTTCTTTAAACGTGATAAAAAGCTTTCTAGTAATGCGGCATCTTCTAGTCCTATTCACCTCTTT
GGTGGTATCCATGAAGTTTACTTTCCGTTTGTGCTATTAAAACCTGTGTTAATTCTGGCCACAATTGCTGTTGGTGTTGT
GGGAAACGGCATTTTGCAAATATTTAATGCTGGGACAATTGCACCAGTGTCACCTGGTTCTGTTATTGCTGGTTTTCTCC
AAATTAATAAAACACCTTTAGATGTAGCTGGTTATGCTTTGGCACTCGTTTTATCAGCTGTAACTTCGTTGTTAATTTCG
CTTTTATTACTTTCTTTAACACGTAAAAAACAATTGAAAACACTGCAAGAAGCGCAAGCACAAGTTGCAGAAATGAAGCA
AACGCCTGCAAAAAAACCAAGACAAAAAGATACTCCAGCAATTGCTACAAAGATAGACTTTTCCCAAGTTACCTTTGTTT
GCGATGCAGGTATGGGTTCTTCTACTATGGGAGCAGCTATATTTAGAAAAGAACTAAAAAATCAAAATATTGAAGACATT
ACAGTGATTAATAAAGCAATAGTTGATTTAAAAGATGAAAAGGTAATTATTACCATTTCCCAACTTTATGATCGCGTAAA
AGCGAAGCGTGCAGACGCTACGATTTATACCATCAATCAGTTCTTAGATAAACAAGGCTATTTAACTATTATTGAAAAGA
TTAAAAATGAAAAGAATTAA

Upstream 100 bases:

>100_bases
TGAAATACGTGGTGGTGTGATTGCTGTCATTATTGCCATTGCTGTAATAGCTGCTGGTCAAACCGAAGCATTTACAAAAA
TTGTTGGTCAAAAATCAGTA

Downstream 100 bases:

>100_bases
TGTATTGCACTTTGGCGCTGGTAATATAGGTAGAGGTGTTATATTACCGATTTACCAACAAAATGACTTTTCCATTGATT
TAGTGGAATTGAATCAAAAT

Product: mannitol-specific PRS EIIBC

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MFLGVMIFGPIAALILKHTEKFWIHRIKSGFEMLVNNFYLGFLGFALIFPSFYLSIYLIGYIQLGLKLLVEIMQQYKLYP
IAAIVIEPAKVLFLNNAINHGVLTPLGLQQVRDSGKSILFLLESNPGPGLGLLVAFLIFFFKRDKKLSSNAASSSPIHLF
GGIHEVYFPFVLLKPVLILATIAVGVVGNGILQIFNAGTIAPVSPGSVIAGFLQINKTPLDVAGYALALVLSAVTSLLIS
LLLLSLTRKKQLKTLQEAQAQVAEMKQTPAKKPRQKDTPAIATKIDFSQVTFVCDAGMGSSTMGAAIFRKELKNQNIEDI
TVINKAIVDLKDEKVIITISQLYDRVKAKRADATIYTINQFLDKQGYLTIIEKIKNEKN

Sequences:

>Translated_379_residues
MFLGVMIFGPIAALILKHTEKF*IHRIKSGFEMLVNNFYLGFLGFALIFPSFYLSIYLIGYIQLGLKLLVEIMQQYKLYP
IAAIVIEPAKVLFLNNAINHGVLTPLGLQQVRDSGKSILFLLESNPGPGLGLLVAFLIFFFKRDKKLSSNAASSSPIHLF
GGIHEVYFPFVLLKPVLILATIAVGVVGNGILQIFNAGTIAPVSPGSVIAGFLQINKTPLDVAGYALALVLSAVTSLLIS
LLLLSLTRKKQLKTLQEAQAQVAEMKQTPAKKPRQKDTPAIATKIDFSQVTFVCDAGMGSSTMGAAIFRKELKNQNIEDI
TVINKAIVDLKDEKVIITISQLYDRVKAKRADATIYTINQFLDKQGYLTIIEKIKNEKN
>Mature_379_residues
MFLGVMIFGPIAALILKHTEKF*IHRIKSGFEMLVNNFYLGFLGFALIFPSFYLSIYLIGYIQLGLKLLVEIMQQYKLYP
IAAIVIEPAKVLFLNNAINHGVLTPLGLQQVRDSGKSILFLLESNPGPGLGLLVAFLIFFFKRDKKLSSNAASSSPIHLF
GGIHEVYFPFVLLKPVLILATIAVGVVGNGILQIFNAGTIAPVSPGSVIAGFLQINKTPLDVAGYALALVLSAVTSLLIS
LLLLSLTRKKQLKTLQEAQAQVAEMKQTPAKKPRQKDTPAIATKIDFSQVTFVCDAGMGSSTMGAAIFRKELKNQNIEDI
TVINKAIVDLKDEKVIITISQLYDRVKAKRADATIYTINQFLDKQGYLTIIEKIKNEKN

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=382, Percent_Identity=38.4816753926702, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1789301, Length=385, Percent_Identity=36.8831168831169, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 41511; Mature: 41511

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLGVMIFGPIAALILKHTEKFIHRIKSGFEMLVNNFYLGFLGFALIFPSFYLSIYLIGY
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQLGLKLLVEIMQQYKLYPIAAIVIEPAKVLFLNNAINHGVLTPLGLQQVRDSGKSILFL
HHHHHHHHHHHHHHHCCCHHHHEEECCHHHEEECCCCCCCCCCCCCHHHHHCCCCEEEEE
LESNPGPGLGLLVAFLIFFFKRDKKLSSNAASSSPIHLFGGIHEVYFPFVLLKPVLILAT
EECCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
IAVGVVGNGILQIFNAGTIAPVSPGSVIAGFLQINKTPLDVAGYALALVLSAVTSLLISL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLLSLTRKKQLKTLQEAQAQVAEMKQTPAKKPRQKDTPAIATKIDFSQVTFVCDAGMGSS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHEEEEEECCCCCC
TMGAAIFRKELKNQNIEDITVINKAIVDLKDEKVIITISQLYDRVKAKRADATIYTINQF
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCEEEHHHH
LDKQGYLTIIEKIKNEKN
HCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MFLGVMIFGPIAALILKHTEKFIHRIKSGFEMLVNNFYLGFLGFALIFPSFYLSIYLIGY
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQLGLKLLVEIMQQYKLYPIAAIVIEPAKVLFLNNAINHGVLTPLGLQQVRDSGKSILFL
HHHHHHHHHHHHHHHCCCHHHHEEECCHHHEEECCCCCCCCCCCCCHHHHHCCCCEEEEE
LESNPGPGLGLLVAFLIFFFKRDKKLSSNAASSSPIHLFGGIHEVYFPFVLLKPVLILAT
EECCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
IAVGVVGNGILQIFNAGTIAPVSPGSVIAGFLQINKTPLDVAGYALALVLSAVTSLLISL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLLSLTRKKQLKTLQEAQAQVAEMKQTPAKKPRQKDTPAIATKIDFSQVTFVCDAGMGSS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHEEEEEECCCCCC
TMGAAIFRKELKNQNIEDITVINKAIVDLKDEKVIITISQLYDRVKAKRADATIYTINQF
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCEEEHHHH
LDKQGYLTIIEKIKNEKN
HCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]