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The map label for this gene is deoA [H]

Identifier: 13507803

GI number: 13507803

Start: 80414

End: 81679

Strand: Direct

Name: deoA [H]

Synonym: MPN064

Alternate gene names: 13507803

Gene position: 80414-81679 (Clockwise)

Preceding gene: 13507802

Following gene: 13507804

Centisome position: 9.85

GC content: 42.81

Gene sequence:

>1266_bases
ATGAACATCGTTAACCTTATTAGTAAAAAGCAACGCGGCAAGGCGTTAACGGAAACAGAAATTAACTGGTTTGTCCATTC
CGTTAATAACAAAAGCTTGGCCGATTATCAGGTCAGTGCCTTTTTAATGGCAGTGTGATTTCAGGGGATGAATTCCAAGG
AGTTGTTTTGTCTCACCAAAGCGATGGTGAAATCAGGAGAGAGCCTCCACTTTAACCACCACAGCAAGTTAAGTGTTGAC
AAACACTCCACTGGTGGTATTGGTGACAAGGTTTCCATTGCTTTAATTCCAATCTTAACTGCCTTAGATTACAGTGTCGC
AAAACTGTCGGGTCGTGGTTTGGGCTACACTGGTGGCACAATTGACAAATTGGAAGCAGTGGGAGTAAAAACAGATTTTA
CACCAACAGAGGCGCAGAACTTACTAGACCAAAATGACTGCTTTATTATTGGTCAAAGTGAGGGCATTGCTCCCGTAGAC
AAGGTGTTGTATGCACTACGCGATACTACGGCAACTGTGGACAGTCTGCCCTTAATTGCTTCCAGTGTCATGTCGAAGAA
GTTGGCAATTAACAACGACTACATCTTCATTGACCTTAAGTACGGTAAGGGCGCTTTCTGTAAAACGAAGACGATGGCTA
AAGAGCTAGCGCAGTACATGTACAGTATTGCCAAGCAGTTTAAGCGCAAACTCTACATTAAACTAAGTGACATGAACCAG
GTTTTGGGTAAAACGATTGGTAATGCGTTAGAGGTCTTGGAAGTAGTGCACTTCTTAAAACGGAATTGAACTGAAGTGGG
TGCTGACTTTATTCAGTTGATGGAGCAAATAGTCACTGAAATCCTTATAGAAACAAAACGTGCACCAAACAAACGGGCAG
CTGTAGCACTTTACCACGCTACATTAGAGGGCGAAAAACCATGGCAGCGTTTTTTAAAATTTATTGAGCTGCAAGGTAGT
AGTTGGGAACGTTTTTTGGATTTAAAAGAGCTGTTTAATCCCCAGTATAAAGCGCCAGTGTTAGCATCTCAAAGTGGTAC
TTTGAGCTATACCAGTCCGGTGGATTTAGCCATGGTCTCGATTAGCTTAGGTGCTGGTCGAATGGTTAAAACAGATCTGA
TTGACCCAATGGCGGGGATTAAGTTAGTGAAACAAGCTAACGAAGTGGTAAAAGCTGGGGACACAGTCTTAGAACTTTAC
AGCTCCAAACCAATTACGCCTGCCCACATAGAAGCTGCGCAGCACACCATTATTATTAAGCAGTAA

Upstream 100 bases:

>100_bases
ACAGCGCAGCAATTCCTTGACTTCTTTAATGCTGGAGTTAGTCGGATTGGCACTTCCAATGCGGTCAAGATTATGGAAGA
ATTGCACAAACTAGAAAGCC

Downstream 100 bases:

>100_bases
ATAAACCTCAATGAAAGTTGATTTAGATTGAGTCCACCACAAGTTACAGGAGGTGGTCAATCATGCCTACACGCCTTTTT
CAAAGTTTAAGGTAGCTTGT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNIVNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAVWFQGMNSKELFCLTKAMVKSGESLHFNHHSKLSVD
KHSTGGIGDKVSIALIPILTALDYSVAKLSGRGLGYTGGTIDKLEAVGVKTDFTPTEAQNLLDQNDCFIIGQSEGIAPVD
KVLYALRDTTATVDSLPLIASSVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQ
VLGKTIGNALEVLEVVHFLKRNWTEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHATLEGEKPWQRFLKFIELQGS
SWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVDLAMVSISLGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELY
SSKPITPAHIEAAQHTIIIKQ

Sequences:

>Translated_421_residues
MNIVNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAV*FQGMNSKELFCLTKAMVKSGESLHFNHHSKLSVD
KHSTGGIGDKVSIALIPILTALDYSVAKLSGRGLGYTGGTIDKLEAVGVKTDFTPTEAQNLLDQNDCFIIGQSEGIAPVD
KVLYALRDTTATVDSLPLIASSVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQ
VLGKTIGNALEVLEVVHFLKRN*TEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHATLEGEKPWQRFLKFIELQGS
SWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVDLAMVSISLGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELY
SSKPITPAHIEAAQHTIIIKQ
>Mature_421_residues
MNIVNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAV*FQGMNSKELFCLTKAMVKSGESLHFNHHSKLSVD
KHSTGGIGDKVSIALIPILTALDYSVAKLSGRGLGYTGGTIDKLEAVGVKTDFTPTEAQNLLDQNDCFIIGQSEGIAPVD
KVLYALRDTTATVDSLPLIASSVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQ
VLGKTIGNALEVLEVVHFLKRN*TEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHATLEGEKPWQRFLKFIELQGS
SWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVDLAMVSISLGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELY
SSKPITPAHIEAAQHTIIIKQ

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=432, Percent_Identity=33.7962962962963, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI4503445, Length=432, Percent_Identity=33.7962962962963, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI166158922, Length=432, Percent_Identity=33.7962962962963, Blast_Score=218, Evalue=8e-57,
Organism=Escherichia coli, GI1790842, Length=402, Percent_Identity=35.0746268656716, Blast_Score=207, Evalue=9e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 46220; Mature: 46220

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00061 ADH_SHORT ; PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAVFQGMNSKELFCLTKA
CCHHHHHHHHHCCCCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
MVKSGESLHFNHHSKLSVDKHSTGGIGDKVSIALIPILTALDYSVAKLSGRGLGYTGGTI
HHHCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
DKLEAVGVKTDFTPTEAQNLLDQNDCFIIGQSEGIAPVDKVLYALRDTTATVDSLPLIAS
HHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
SVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQV
HHHHHHEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHH
LGKTIGNALEVLEVVHFLKRNTEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHATL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEC
EGEKPWQRFLKFIELQGSSWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVDLAMVSIS
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCEEEEEEE
LGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELYSSKPITPAHIEAAQHTIIIKQ
CCCCCEEHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHCCCEEEEEEC
>Mature Secondary Structure
MNIVNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAVFQGMNSKELFCLTKA
CCHHHHHHHHHCCCCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
MVKSGESLHFNHHSKLSVDKHSTGGIGDKVSIALIPILTALDYSVAKLSGRGLGYTGGTI
HHHCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
DKLEAVGVKTDFTPTEAQNLLDQNDCFIIGQSEGIAPVDKVLYALRDTTATVDSLPLIAS
HHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
SVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQV
HHHHHHEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHH
LGKTIGNALEVLEVVHFLKRNTEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHATL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEC
EGEKPWQRFLKFIELQGSSWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVDLAMVSIS
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCEEEEEEE
LGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELYSSKPITPAHIEAAQHTIIIKQ
CCCCCEEHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]