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The map label for this gene is deoC

Identifier: 13507802

GI number: 13507802

Start: 79753

End: 80427

Strand: Direct

Name: deoC

Synonym: MPN063

Alternate gene names: 13507802

Gene position: 79753-80427 (Clockwise)

Preceding gene: 13507801

Following gene: 13507803

Centisome position: 9.77

GC content: 41.93

Gene sequence:

>675_bases
ATGAAATTAGAATACAACCGCATTATTGACAGTACACTACTTAAAGCTGATACCTTACCCCACGAAATTGATGCTTTATG
TGCTGATGCTCATAAGTACCAGTTTTACGCAGTTTGTGTCAATCCTAGCTATGTGCGGTATGCCAAAAATATCCTTAAGG
GTACGGGGGTGAAACTGTGCACTGTCGTTGGTTTTCCCTTAGGACAAACAACACAACGCCAGAAGGTGTATGAAACTAAG
ATTGCCATTAAGGAAGGTGCGGATGAAATTGACATGGTAATGAACATTGCCGAGTTCAAAAAGCGCTGTGCCTGTGTCAT
TAGTGAAATAAGGGCAGTCAAAAAGGTTTGTGGTAAGCGAACGCTCAAAGTCATTATTGAAACGGCTTTGTTAAACCAGG
ACGAAATTCGTGATGCCGTTAATGTCTGTATTGATGGTAACGCTGACTTTGTCAAAACTTCTACCGGGTTTTCCATGCGT
GGTGCATCATTGGAAGATATCACAATTATGCGCGAAGCTAGTGGTAATCTCATTAAGATCAAAGCATCGGGTGGGGTTCA
AACAGCGCAGCAATTCCTTGACTTCTTTAATGCTGGAGTTAGTCGGATTGGCACTTCCAATGCGGTCAAGATTATGGAAG
AATTGCACAAACTAGAAAGCCATGAACATCGTTAA

Upstream 100 bases:

>100_bases
TTTGGTAACCCATGCTGCTCTACCAGCGGAACAACGCCAAGCCACCTTTAAGAACATGGCTATCTTATCCTTGGAAATGG
CTAGCCAACTCGTTTAAACA

Downstream 100 bases:

>100_bases
CCTTATTAGTAAAAAGCAACGCGGCAAGGCGTTAACGGAAACAGAAATTAACTGGTTTGTCCATTCCGTTAATAACAAAA
GCTTGGCCGATTATCAGGTC

Product: deoxyribose-phosphate aldolase

Products: NA

Alternate protein names: Phosphodeoxyriboaldolase; DERA; Deoxyriboaldolase

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKLEYNRIIDSTLLKADTLPHEIDALCADAHKYQFYAVCVNPSYVRYAKNILKGTGVKLCTVVGFPLGQTTQRQKVYETK
IAIKEGADEIDMVMNIAEFKKRCACVISEIRAVKKVCGKRTLKVIIETALLNQDEIRDAVNVCIDGNADFVKTSTGFSMR
GASLEDITIMREASGNLIKIKASGGVQTAQQFLDFFNAGVSRIGTSNAVKIMEELHKLESHEHR

Sequences:

>Translated_224_residues
MKLEYNRIIDSTLLKADTLPHEIDALCADAHKYQFYAVCVNPSYVRYAKNILKGTGVKLCTVVGFPLGQTTQRQKVYETK
IAIKEGADEIDMVMNIAEFKKRCACVISEIRAVKKVCGKRTLKVIIETALLNQDEIRDAVNVCIDGNADFVKTSTGFSMR
GASLEDITIMREASGNLIKIKASGGVQTAQQFLDFFNAGVSRIGTSNAVKIMEELHKLESHEHR
>Mature_224_residues
MKLEYNRIIDSTLLKADTLPHEIDALCADAHKYQFYAVCVNPSYVRYAKNILKGTGVKLCTVVGFPLGQTTQRQKVYETK
IAIKEGADEIDMVMNIAEFKKRCACVISEIRAVKKVCGKRTLKVIIETALLNQDEIRDAVNVCIDGNADFVKTSTGFSMR
GASLEDITIMREASGNLIKIKASGGVQTAQQFLDFFNAGVSRIGTSNAVKIMEELHKLESHEHR

Specific function: Nucleotide and deoxyribonucleotide catabolism. [C]

COG id: COG0274

COG function: function code F; Deoxyribose-phosphate aldolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily

Homologues:

Organism=Homo sapiens, GI116063554, Length=219, Percent_Identity=30.1369863013699, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1790841, Length=205, Percent_Identity=32.6829268292683, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17533015, Length=195, Percent_Identity=30.2564102564103, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEOC_MYCPN (P09924)

Other databases:

- EMBL:   X13544
- EMBL:   U00089
- PIR:   S02216
- RefSeq:   NP_109751.1
- ProteinModelPortal:   P09924
- SMR:   P09924
- IntAct:   P09924
- GeneID:   876837
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN063
- HOGENOM:   HBG636421
- OMA:   GANTPEV
- ProtClustDB:   PRK00507
- BioCyc:   MetaCyc:MONOMER-641
- BioCyc:   MPNE272634:MPN063-MONOMER
- BRENDA:   4.1.2.4
- GO:   GO:0005737
- HAMAP:   MF_00114
- InterPro:   IPR013785
- InterPro:   IPR011343
- InterPro:   IPR002915
- InterPro:   IPR022979
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR10889
- PIRSF:   PIRSF001357
- TIGRFAMs:   TIGR00126

Pfam domain/function: PF01791 DeoC

EC number: =4.1.2.4

Molecular weight: Translated: 24878; Mature: 24878

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: ACT_SITE 152-152 ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEYNRIIDSTLLKADTLPHEIDALCADAHKYQFYAVCVNPSYVRYAKNILKGTGVKLC
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHCCCCEEE
TVVGFPLGQTTQRQKVYETKIAIKEGADEIDMVMNIAEFKKRCACVISEIRAVKKVCGKR
EEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLKVIIETALLNQDEIRDAVNVCIDGNADFVKTSTGFSMRGASLEDITIMREASGNLIKI
HHHHHHHHHHCCHHHHHHHHHEEECCCCCEEEECCCCEECCCCCHHHEEEEECCCCEEEE
KASGGVQTAQQFLDFFNAGVSRIGTSNAVKIMEELHKLESHEHR
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLEYNRIIDSTLLKADTLPHEIDALCADAHKYQFYAVCVNPSYVRYAKNILKGTGVKLC
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHCCCCEEE
TVVGFPLGQTTQRQKVYETKIAIKEGADEIDMVMNIAEFKKRCACVISEIRAVKKVCGKR
EEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLKVIIETALLNQDEIRDAVNVCIDGNADFVKTSTGFSMRGASLEDITIMREASGNLIKI
HHHHHHHHHHCCHHHHHHHHHEEECCCCCEEEECCCCEECCCCCHHHEEEEECCCCEEEE
KASGGVQTAQQFLDFFNAGVSRIGTSNAVKIMEELHKLESHEHR
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492658; 8948633