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The map label for this gene is nadC [H]

Identifier: 13488070

GI number: 13488070

Start: 80320

End: 81174

Strand: Reverse

Name: nadC [H]

Synonym: mll9102

Alternate gene names: 13488070

Gene position: 81174-80320 (Counterclockwise)

Preceding gene: 13488071

Following gene: 13488069

Centisome position: 23.07

GC content: 63.86

Gene sequence:

>855_bases
ATGAACCTCGCGCCCCTGCCCGCAATCATGCTCGAGCCCCTGGTCCGGGCAGCCCTTCTGGAAGATCTCGGCCGGGCGGG
TGATCTGACCACCGACGCCATCGTGCCGAAGGACCTTCGGGCAACGACCGTGCTTTCGGCGCGGCAGACTGGGGTTGTCG
CCGGGCTCGATCTGGCGATACTCGCTTTCAGGCTGATCGATGAGAGGATCGAGACTACGCCGGTGTGCCCGGACGGCAGC
GAGGTGACGCCAGGACAGACCATAGCGTTGGTGAGCGGGCCAGCCCGAGCCATTCTCACCGCCGAACGCACCGCGCTTAA
TTTTCTCAGCCATCTGAGCGGCATCGCCACGGCGACGGCATCGATCGTCAATGCAATCCGCGACCACAAGGCGAAGATCG
TCTGCACGCGCAAGACGACACCCGGCTTGCGGGCCGTCGAAAAATACGCCGTGCGCGCCGGTGGCGGCGGCAATCACCGT
TTCGGCCTCGACGATGCCATCCTGATCAAGGACAACCATATCGCCATGGCCGGCGGAATCCGCCCGGCCATCGAGCGAAC
GCGTGCGAGTGTAGGCCATCTCATCAAAATCGAAGTCGAGGTCGATACGCTGGCCCAGCTGGAAGAGGCCCTGGCTCTCG
CCCCGGACGCCGTGCTGCTCGACAACATGTCGCTCGACGAATTGCGCCATGCGGTATCGATGGTCGCCGGTCGATGCATC
ACCGAAGCATCGGGCAGGATCACCACCTCAACAGTGCCGGCGGTCGCCGCGACCGGCGTCGATCTGATCTCCATCGGCTG
GCTGACCCACAGCGCGCCGATCCTCGATATTGGCCTTGATTATCGGGACACATGA

Upstream 100 bases:

>100_bases
ATCGTGCTGCCATCGCCCGCCGCTCCAGGCTCAGGCTTGATGAAGCCTTAGCGGCAGCCGACGAACTGGCATGTTCGCCA
ACGCTTGAAGAGGTCGAGCC

Downstream 100 bases:

>100_bases
TCGCCTGACGAACGCACGGCAGCGCGTCGACACCTTTCCAGTCGCCGTGAACCCGCTAGAAAAGAAGCCGTAACGCCGGA
ACCCCAGGGAACAGGACAGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNLAPLPAIMLEPLVRAALLEDLGRAGDLTTDAIVPKDLRATTVLSARQTGVVAGLDLAILAFRLIDERIETTPVCPDGS
EVTPGQTIALVSGPARAILTAERTALNFLSHLSGIATATASIVNAIRDHKAKIVCTRKTTPGLRAVEKYAVRAGGGGNHR
FGLDDAILIKDNHIAMAGGIRPAIERTRASVGHLIKIEVEVDTLAQLEEALALAPDAVLLDNMSLDELRHAVSMVAGRCI
TEASGRITTSTVPAVAATGVDLISIGWLTHSAPILDIGLDYRDT

Sequences:

>Translated_284_residues
MNLAPLPAIMLEPLVRAALLEDLGRAGDLTTDAIVPKDLRATTVLSARQTGVVAGLDLAILAFRLIDERIETTPVCPDGS
EVTPGQTIALVSGPARAILTAERTALNFLSHLSGIATATASIVNAIRDHKAKIVCTRKTTPGLRAVEKYAVRAGGGGNHR
FGLDDAILIKDNHIAMAGGIRPAIERTRASVGHLIKIEVEVDTLAQLEEALALAPDAVLLDNMSLDELRHAVSMVAGRCI
TEASGRITTSTVPAVAATGVDLISIGWLTHSAPILDIGLDYRDT
>Mature_284_residues
MNLAPLPAIMLEPLVRAALLEDLGRAGDLTTDAIVPKDLRATTVLSARQTGVVAGLDLAILAFRLIDERIETTPVCPDGS
EVTPGQTIALVSGPARAILTAERTALNFLSHLSGIATATASIVNAIRDHKAKIVCTRKTTPGLRAVEKYAVRAGGGGNHR
FGLDDAILIKDNHIAMAGGIRPAIERTRASVGHLIKIEVEVDTLAQLEEALALAPDAVLLDNMSLDELRHAVSMVAGRCI
TEASGRITTSTVPAVAATGVDLISIGWLTHSAPILDIGLDYRDT

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=279, Percent_Identity=36.2007168458781, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1786299, Length=273, Percent_Identity=39.1941391941392, Blast_Score=167, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6321162, Length=260, Percent_Identity=33.4615384615385, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29832; Mature: 29832

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAPLPAIMLEPLVRAALLEDLGRAGDLTTDAIVPKDLRATTVLSARQTGVVAGLDLAI
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEHHHHHH
LAFRLIDERIETTPVCPDGSEVTPGQTIALVSGPARAILTAERTALNFLSHLSGIATATA
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHH
SIVNAIRDHKAKIVCTRKTTPGLRAVEKYAVRAGGGGNHRFGLDDAILIKDNHIAMAGGI
HHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECCC
RPAIERTRASVGHLIKIEVEVDTLAQLEEALALAPDAVLLDNMSLDELRHAVSMVAGRCI
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
TEASGRITTSTVPAVAATGVDLISIGWLTHSAPILDIGLDYRDT
HCCCCCEEECCCCHHHHCCCCEEEEEHHHCCCCEEEECCCCCCC
>Mature Secondary Structure
MNLAPLPAIMLEPLVRAALLEDLGRAGDLTTDAIVPKDLRATTVLSARQTGVVAGLDLAI
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEHHHHHH
LAFRLIDERIETTPVCPDGSEVTPGQTIALVSGPARAILTAERTALNFLSHLSGIATATA
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHH
SIVNAIRDHKAKIVCTRKTTPGLRAVEKYAVRAGGGGNHRFGLDDAILIKDNHIAMAGGI
HHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECCC
RPAIERTRASVGHLIKIEVEVDTLAQLEEALALAPDAVLLDNMSLDELRHAVSMVAGRCI
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
TEASGRITTSTVPAVAATGVDLISIGWLTHSAPILDIGLDYRDT
HCCCCCEEECCCCHHHHCCCCEEEEEHHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]