Click here to switch to the map view.

The map label for this gene is bioF [C]

Identifier: 13488068

GI number: 13488068

Start: 78084

End: 79223

Strand: Reverse

Name: bioF [C]

Synonym: mll9099

Alternate gene names: 13488068

Gene position: 79223-78084 (Counterclockwise)

Preceding gene: 13488069

Following gene: 13488067

Centisome position: 22.51

GC content: 64.56

Gene sequence:

>1140_bases
ATGAGCGCAAGGCCCCTCGCCCGCTATGACGCGACCTTGCGCGGACTGGCGCGCAACGACCGGCTGCGGACGCTGTCGCC
GCGCGCCGGCCTCGACTTCTCGTCGAACGACTATCTCGGGCTTGCCAGATCACAGAGGCTAGCCAATGCCATCAGCGCAG
CGCTTGCTCGTGGCACGCCAGTCGGAGCAAGCGGTTCGCGACTGCTCCGAGGCAATGCGCCCGAACATGAGGCGCTTGAG
GCAAACGCAGCGGCGTTCTTCCGTGCCGAGCGCGCCCTGTTTTTCGGCGGCGGTTATATCGCCAATTTCGCTCTTCTCAC
AACACTGCCGCAGAAAGGCGATCTTCTCGTCCTCGACGAACTTGTGCATGCCAGCGCCCATGAAGGCGCCCGTGCTGGCC
GGGCGCAAATTGCCGTCGCGGCTCACAATGATGCGGACGCTTTTGCAAGCGTCATCGAGGAGTGGCGCCAATCCGGCGGT
GTTGGGCACGTGTGGATCGGTGTCGAAAGCCTGTACAGTATGGATGGCGACCGCGCACCGCTCAAAGACCTCATGGTGCT
GGCCGATCGCCATGACGGGTTCTTGCTCATCGATGAAGCGCATGCCACCGGCGTCTACGGGCCGAATGGGCGCGGCCTTG
CCGCCGCGTTCGAGGGACGCGAGAATGTGGTGACGCTGCATACATGCGGCAAGGCTCTTGGAGCGTCCGGCGCGCTCGTA
ACCGGACCGCGAACGCTGTGCGACTATCTTGTCAACCGATGCCGGCCATTTATCTATGCAACGGCGCCATCGCCGTTAAT
GGCCGTCGCGGCCCAGGAAGCGCTCGCTGTCCTGCAGGAGGAGCCTGATCGCCGCGACCGTCTGGCCGACCTGGTGAGCT
TTGCCGCCCAGGAACTGATGAAACGCTGCGGCGTTGCGGCCAGCGGTTCGCAGATTCTCCCGGTCATCGTTGGCGACAAC
AGGCGCACCATGGCGCTGGCGGCCGCACTGCAGGCGCGCGGCTTCGACATACGCGGCATTCGTCCGCCGACCGTGCCGGA
AGGCTCCTCGCGCCTGCGCATCTCGCTGACGCTCAACGTCGACGAAGCCGCCATTTCGGCCATGATCGAGGCGCTCGTCG
AAGTGTTGGCCCAAACATGA

Upstream 100 bases:

>100_bases
TCGTCGGCGACACGCTGCTGACGGCGGACAATCCCGGCGAGGACGAAGATACCGCGCTGTTCCGGCGTCTCGGCATCCAG
CGCATGGAACGTGAAACATA

Downstream 100 bases:

>100_bases
CCGGAGGCGACATGACCAAGCGCGTTGTCGTCGCCGGAACCGATACCGGCATCGGCAAAACGGTGTTTTCGGCGGGATTG
GCCGGCCTGCTCGACGGCTT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSARPLARYDATLRGLARNDRLRTLSPRAGLDFSSNDYLGLARSQRLANAISAALARGTPVGASGSRLLRGNAPEHEALE
ANAAAFFRAERALFFGGGYIANFALLTTLPQKGDLLVLDELVHASAHEGARAGRAQIAVAAHNDADAFASVIEEWRQSGG
VGHVWIGVESLYSMDGDRAPLKDLMVLADRHDGFLLIDEAHATGVYGPNGRGLAAAFEGRENVVTLHTCGKALGASGALV
TGPRTLCDYLVNRCRPFIYATAPSPLMAVAAQEALAVLQEEPDRRDRLADLVSFAAQELMKRCGVAASGSQILPVIVGDN
RRTMALAAALQARGFDIRGIRPPTVPEGSSRLRISLTLNVDEAAISAMIEALVEVLAQT

Sequences:

>Translated_379_residues
MSARPLARYDATLRGLARNDRLRTLSPRAGLDFSSNDYLGLARSQRLANAISAALARGTPVGASGSRLLRGNAPEHEALE
ANAAAFFRAERALFFGGGYIANFALLTTLPQKGDLLVLDELVHASAHEGARAGRAQIAVAAHNDADAFASVIEEWRQSGG
VGHVWIGVESLYSMDGDRAPLKDLMVLADRHDGFLLIDEAHATGVYGPNGRGLAAAFEGRENVVTLHTCGKALGASGALV
TGPRTLCDYLVNRCRPFIYATAPSPLMAVAAQEALAVLQEEPDRRDRLADLVSFAAQELMKRCGVAASGSQILPVIVGDN
RRTMALAAALQARGFDIRGIRPPTVPEGSSRLRISLTLNVDEAAISAMIEALVEVLAQT
>Mature_378_residues
SARPLARYDATLRGLARNDRLRTLSPRAGLDFSSNDYLGLARSQRLANAISAALARGTPVGASGSRLLRGNAPEHEALEA
NAAAFFRAERALFFGGGYIANFALLTTLPQKGDLLVLDELVHASAHEGARAGRAQIAVAAHNDADAFASVIEEWRQSGGV
GHVWIGVESLYSMDGDRAPLKDLMVLADRHDGFLLIDEAHATGVYGPNGRGLAAAFEGRENVVTLHTCGKALGASGALVT
GPRTLCDYLVNRCRPFIYATAPSPLMAVAAQEALAVLQEEPDRRDRLADLVSFAAQELMKRCGVAASGSQILPVIVGDNR
RTMALAAALQARGFDIRGIRPPTVPEGSSRLRISLTLNVDEAAISAMIEALVEVLAQT

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=32.8611898016997, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI7657118, Length=353, Percent_Identity=32.8611898016997, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI83977444, Length=349, Percent_Identity=28.9398280802292, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI83977442, Length=349, Percent_Identity=28.9398280802292, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI83977440, Length=349, Percent_Identity=28.9398280802292, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4758668, Length=353, Percent_Identity=26.9121813031161, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=25.8152173913043, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4502025, Length=353, Percent_Identity=28.6118980169972, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI40316939, Length=353, Percent_Identity=28.6118980169972, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI5454084, Length=264, Percent_Identity=25.3787878787879, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=37.6436781609195, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1790046, Length=379, Percent_Identity=31.1345646437995, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=362, Percent_Identity=31.4917127071823, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=24.390243902439, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=295, Percent_Identity=25.4237288135593, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982617, Length=295, Percent_Identity=25.4237288135593, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560912, Length=300, Percent_Identity=25, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17560914, Length=300, Percent_Identity=25, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=353, Percent_Identity=28.6118980169972, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=24.2506811989101, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=24.1635687732342, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24662918, Length=359, Percent_Identity=29.5264623955432, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17137420, Length=357, Percent_Identity=31.0924369747899, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=26.4462809917355, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40184; Mature: 40053

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARPLARYDATLRGLARNDRLRTLSPRAGLDFSSNDYLGLARSQRLANAISAALARGTP
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
VGASGSRLLRGNAPEHEALEANAAAFFRAERALFFGGGYIANFALLTTLPQKGDLLVLDE
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCCCEEEHHH
LVHASAHEGARAGRAQIAVAAHNDADAFASVIEEWRQSGGVGHVWIGVESLYSMDGDRAP
HHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCC
LKDLMVLADRHDGFLLIDEAHATGVYGPNGRGLAAAFEGRENVVTLHTCGKALGASGALV
HHHHHHHEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCHHHCCCCCEE
TGPRTLCDYLVNRCRPFIYATAPSPLMAVAAQEALAVLQEEPDRRDRLADLVSFAAQELM
ECHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KRCGVAASGSQILPVIVGDNRRTMALAAALQARGFDIRGIRPPTVPEGSSRLRISLTLNV
HHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEEEECC
DEAAISAMIEALVEVLAQT
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SARPLARYDATLRGLARNDRLRTLSPRAGLDFSSNDYLGLARSQRLANAISAALARGTP
CCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
VGASGSRLLRGNAPEHEALEANAAAFFRAERALFFGGGYIANFALLTTLPQKGDLLVLDE
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCCCEEEHHH
LVHASAHEGARAGRAQIAVAAHNDADAFASVIEEWRQSGGVGHVWIGVESLYSMDGDRAP
HHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCC
LKDLMVLADRHDGFLLIDEAHATGVYGPNGRGLAAAFEGRENVVTLHTCGKALGASGALV
HHHHHHHEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCHHHCCCCCEE
TGPRTLCDYLVNRCRPFIYATAPSPLMAVAAQEALAVLQEEPDRRDRLADLVSFAAQELM
ECHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KRCGVAASGSQILPVIVGDNRRTMALAAALQARGFDIRGIRPPTVPEGSSRLRISLTLNV
HHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEEEECC
DEAAISAMIEALVEVLAQT
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA