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The map label for this gene is tdcB [H]

Identifier: 13476323

GI number: 13476323

Start: 6301955

End: 6302959

Strand: Reverse

Name: tdcB [H]

Synonym: mll7611

Alternate gene names: 13476323

Gene position: 6302959-6301955 (Counterclockwise)

Preceding gene: 13476324

Following gene: 13476322

Centisome position: 89.58

GC content: 65.77

Gene sequence:

>1005_bases
ATGATGGCAGACCTTCTCGTCCCCTCGCTGGCCCATCTCAAACAGGCCTATGCCGTCACCTCCAGGGCGACGCAGATCAC
GCCGCTGCTGGAATCGACCGCACTCGCCAGGGAGACCGGTGCTGCCCGTGTCTTCATCAAGCCGGAATCGCTGCAATGGG
CCGGATCGTTCAAGATCCGCGGCGCCTATTGGCGGTTGAAGCGGCTGTCGGCCGACGAAGCGAGGAAAGGAGTCGTCGCC
TACTCCTCCGGCAATTTCGCGCAAGGCCTGGCGGCAGCCGGCCAAGCGCTCGGCATTCCCGTCACCATCGTCATGCCGAT
CGACGCACCCGCCGCCAAGCGTGACGCGACGGCGGGCTATGGCGCGCGTGTCGTGTTGACCGACCATGGCGAGCGCGCGC
GAGAAGAGGTTGCCGCTGCCAAGGCGCGCGAGATCGCCGAGACGGAAGGGCTGGCCCTGCTGCATCCCTTCGACGATCCG
GAGATCGTCGCCGGCCAGGCTGGCGCCGGGCTCGAAGCGCTCGACCAGCTTGAGGCCAAGGACGCCAGCGCCGACCTGTT
GTTCTGCTCGGTCGGCGGCGGCGGGCTGATCGGCGGCGTTTCGCTCGCCTTCCACTATCTGTCGCCGGCGACGGAGATCA
TCGGCGTCGAGCCGGAAGGCTTCAATGGCATGGGCTCGTCGCTGGCGCATGGCAGCATCGAGACCATGCCGATCGGGCCG
AAATCGATTTGCGACGGGCTGATGTCGCGGCGGCCGGGCGATGCGCCGTTCGCGGCGGTCAAGACCGCTGGCGTTCGCGG
AATCACCGTCGATGATCAATCGGTGCGGCGTGCCATGCGGATCGCCTTCGAGCGGATGAAGCTGGTGCTGGAGCCGTCCG
GGGCTGCGTCGCTGGCAGCATTGCTCGGTGGCAAGGTGGATGTGACTGATAAAACCGTCCTTGTTGTGGCTACCGGCGGC
AATGTCTCGCTCGCCGATTTTATGGCGCATATGAACCATGCTTGA

Upstream 100 bases:

>100_bases
CCTGGGAGTTCCAGCCGCTGCAGAAGGCCTCGGAACGCTACATGCGCAACCACATGGATCTCAACGTGCTCGAAGAGCAA
AAACGCTTTCCGCGAGGCGA

Downstream 100 bases:

>100_bases
AGCGGATTTCGTTATCATCGGCTCCGGCTCCGCCGGCTCGGCCATGGCCTATCGCCTGTCGGAAGACGGCAAGCATTCGG
TCATTGTCATCGAATTCGGC

Product: serine/threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MMADLLVPSLAHLKQAYAVTSRATQITPLLESTALARETGAARVFIKPESLQWAGSFKIRGAYWRLKRLSADEARKGVVA
YSSGNFAQGLAAAGQALGIPVTIVMPIDAPAAKRDATAGYGARVVLTDHGERAREEVAAAKAREIAETEGLALLHPFDDP
EIVAGQAGAGLEALDQLEAKDASADLLFCSVGGGGLIGGVSLAFHYLSPATEIIGVEPEGFNGMGSSLAHGSIETMPIGP
KSICDGLMSRRPGDAPFAAVKTAGVRGITVDDQSVRRAMRIAFERMKLVLEPSGAASLAALLGGKVDVTDKTVLVVATGG
NVSLADFMAHMNHA

Sequences:

>Translated_334_residues
MMADLLVPSLAHLKQAYAVTSRATQITPLLESTALARETGAARVFIKPESLQWAGSFKIRGAYWRLKRLSADEARKGVVA
YSSGNFAQGLAAAGQALGIPVTIVMPIDAPAAKRDATAGYGARVVLTDHGERAREEVAAAKAREIAETEGLALLHPFDDP
EIVAGQAGAGLEALDQLEAKDASADLLFCSVGGGGLIGGVSLAFHYLSPATEIIGVEPEGFNGMGSSLAHGSIETMPIGP
KSICDGLMSRRPGDAPFAAVKTAGVRGITVDDQSVRRAMRIAFERMKLVLEPSGAASLAALLGGKVDVTDKTVLVVATGG
NVSLADFMAHMNHA
>Mature_334_residues
MMADLLVPSLAHLKQAYAVTSRATQITPLLESTALARETGAARVFIKPESLQWAGSFKIRGAYWRLKRLSADEARKGVVA
YSSGNFAQGLAAAGQALGIPVTIVMPIDAPAAKRDATAGYGARVVLTDHGERAREEVAAAKAREIAETEGLALLHPFDDP
EIVAGQAGAGLEALDQLEAKDASADLLFCSVGGGGLIGGVSLAFHYLSPATEIIGVEPEGFNGMGSSLAHGSIETMPIGP
KSICDGLMSRRPGDAPFAAVKTAGVRGITVDDQSVRRAMRIAFERMKLVLEPSGAASLAALLGGKVDVTDKTVLVVATGG
NVSLADFMAHMNHA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=332, Percent_Identity=32.8313253012048, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI19923959, Length=323, Percent_Identity=26.9349845201238, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789505, Length=290, Percent_Identity=37.9310344827586, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790207, Length=280, Percent_Identity=36.4285714285714, Blast_Score=124, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=319, Percent_Identity=29.7805642633229, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71991565, Length=301, Percent_Identity=35.5481727574751, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17537387, Length=285, Percent_Identity=34.7368421052632, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322631, Length=323, Percent_Identity=37.4613003095975, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320930, Length=289, Percent_Identity=32.5259515570934, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319788, Length=327, Percent_Identity=26.9113149847095, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=36.6771159874608, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24645328, Length=227, Percent_Identity=35.6828193832599, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34642; Mature: 34642

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMADLLVPSLAHLKQAYAVTSRATQITPLLESTALARETGAARVFIKPESLQWAGSFKIR
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCEEEE
GAYWRLKRLSADEARKGVVAYSSGNFAQGLAAAGQALGIPVTIVMPIDAPAAKRDATAGY
HHHHEEECCCHHHHHCCEEEECCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCC
GARVVLTDHGERAREEVAAAKAREIAETEGLALLHPFDDPEIVAGQAGAGLEALDQLEAK
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCCCHHHHHHHHCC
DASADLLFCSVGGGGLIGGVSLAFHYLSPATEIIGVEPEGFNGMGSSLAHGSIETMPIGP
CCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCH
KSICDGLMSRRPGDAPFAAVKTAGVRGITVDDQSVRRAMRIAFERMKLVLEPSGAASLAA
HHHHHHHHHCCCCCCCCHHHHHCCEEEEEECHHHHHHHHHHHHHHHHEEECCCCHHHHHH
LLGGKVDVTDKTVLVVATGGNVSLADFMAHMNHA
HHCCEEEECCCEEEEEEECCCEEHHHHHHHHCCC
>Mature Secondary Structure
MMADLLVPSLAHLKQAYAVTSRATQITPLLESTALARETGAARVFIKPESLQWAGSFKIR
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCEEEE
GAYWRLKRLSADEARKGVVAYSSGNFAQGLAAAGQALGIPVTIVMPIDAPAAKRDATAGY
HHHHEEECCCHHHHHCCEEEECCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCC
GARVVLTDHGERAREEVAAAKAREIAETEGLALLHPFDDPEIVAGQAGAGLEALDQLEAK
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCCCHHHHHHHHCC
DASADLLFCSVGGGGLIGGVSLAFHYLSPATEIIGVEPEGFNGMGSSLAHGSIETMPIGP
CCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCH
KSICDGLMSRRPGDAPFAAVKTAGVRGITVDDQSVRRAMRIAFERMKLVLEPSGAASLAA
HHHHHHHHHCCCCCCCCHHHHHCCEEEEEECHHHHHHHHHHHHHHHHEEECCCCHHHHHH
LLGGKVDVTDKTVLVVATGGNVSLADFMAHMNHA
HHCCEEEECCCEEEEEEECCCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA