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The map label for this gene is betA

Identifier: 13476322

GI number: 13476322

Start: 6300310

End: 6301962

Strand: Reverse

Name: betA

Synonym: mll7609

Alternate gene names: 13476322

Gene position: 6301962-6300310 (Counterclockwise)

Preceding gene: 13476323

Following gene: 13476321

Centisome position: 89.57

GC content: 63.04

Gene sequence:

>1653_bases
ATGCTTGAAGCGGATTTCGTTATCATCGGCTCCGGCTCCGCCGGCTCGGCCATGGCCTATCGCCTGTCGGAAGACGGCAA
GCATTCGGTCATTGTCATCGAATTCGGCGGCAGCGATATCGGGCCGCTGATCCAGATGCCGTCGGCGCTGTCGATCCCGC
TCAATATGAGCCTTTACGACTGGGGCTTTGCCAGCGAACCGGAGCCGCATCTCGGCGGCCGCGTGCTGGCGACGCCGCGC
GGCAAGGTGATCGGCGGTTCGTCCTCGATCAACGGCATGGTCTATGTGCGCGGCCATGCCCGCGACTTTGACCATTGGGC
CGAAGAAGGTGCAACGGGTTGGGGCTTCGCCGACGTACTCCCCTACTTCAAGCGCATGGAGGACAATGACGGCGGCGAGG
ACGGCTGGCGCGGCCATGGCGGGCCGCTGCATGTGCAGCGTGGCTCGCGTAAAAATCCACTCTACGGCGCCTTCGTCGAA
GCGGGCCGCCAGGCTGGGTTCGAACTGACCGACGACTACAACGGCTCCAAGCAGGAAGGTTTTGGGCCGATGGAACAGAC
CATAAGCGGCGGCCGCCGCTGGTCGGCGGCATCAGCCTATCTGAAGCCGGCGCTCAAGCGGAAAAACGTGAGTCTGGTCA
AGGGCTTTGCCCGTCGGGTGATCATCGAGAATCAACGCGCTATCGGCGTCGAGATCGAAGCTCACAAACAGATTCAAGTT
GTTAAGGCGCGACGTGAGGTGATCGTCGCCGCGTCGTCGATCAATTCGCCCAAGATCCTGATGCTGTCCGGCATCGGCCC
GGCCGAGCATTTGCGCGAAAACGGTATCGCCGTGGTGGCCGACCGGCCCGGCGTCGGCCGCAATCTGCAGGATCACATGG
AGCTTTATATCCAGCAGGAATCCACCAAGCCGATCACGCTGAATTCGGTGCTCAACCCGTTCTCGAAAGCGTTGATCGGA
GCACAGTGGCTGTTCTTCAAGTCCGGCCTCGGCGCCACCAACCATTTCGAGGCCGCCGCCTTCGTGCGCTCGCGCGCCGG
CGTCGATTATCCAGACATTCAGTACCACTTCATCCCGGCGGCGGTGCGCTATGACGGCAAGGCGGCGGCGAAGTCGCACG
GCTTCCAGGCGCATGTCGGGCCGATGCGGTCAAAGTCGCGCGGCTCGGTGACGCTGCGTTCGCCCGATCCGAAAGCGAAG
CCGGTGATCCGCTTCAACTACATGTCGCATCCGGACGACTGGACCGAGTTCCGCCACTGCATCCGGCTGACCCGCGAAAT
CTTCGGCCAGTCGGCCTTCGACGCTTTTCGCGGCCAGGAAATCTCGCCGGGCAGCCATGTGCAGTCGGACGATGATCTCG
ACGTCTTCATCCGCGACCATGCCGAGAGCGCCTACCACCCCTGCGGCACCTGCAAGATGGGCCGCGCCGACGATGTGACG
AGCGTTGTCGATCCGGAATGCCGGGTCATCGGCGTCGACGGGCTGCGGGTCGCCGATTCCTCGATTTTCCCGCGTGTCAC
CAACGGCAATCTCAATGCGCCATCGATCATGACCGGCGAGAAGGCGTCCGACCATATTCTTGGCCGCACGCCGCTGGCGC
CGTCCAACCAGGAGCCATGGATCAATCCGCGCTGGCAGGTGTCGGACAGATAG

Upstream 100 bases:

>100_bases
GCATTGCTCGGTGGCAAGGTGGATGTGACTGATAAAACCGTCCTTGTTGTGGCTACCGGCGGCAATGTCTCGCTCGCCGA
TTTTATGGCGCATATGAACC

Downstream 100 bases:

>100_bases
AGCATGATCCACCTGTCAGATTGAGCCGTCCCTAGATTGAGCCGTCCCTTTTGGGGGCGCAGACATTCGGAGACTACCCA
TGCGCGCCCAGCCCACGGCA

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MLEADFVIIGSGSAGSAMAYRLSEDGKHSVIVIEFGGSDIGPLIQMPSALSIPLNMSLYDWGFASEPEPHLGGRVLATPR
GKVIGGSSSINGMVYVRGHARDFDHWAEEGATGWGFADVLPYFKRMEDNDGGEDGWRGHGGPLHVQRGSRKNPLYGAFVE
AGRQAGFELTDDYNGSKQEGFGPMEQTISGGRRWSAASAYLKPALKRKNVSLVKGFARRVIIENQRAIGVEIEAHKQIQV
VKARREVIVAASSINSPKILMLSGIGPAEHLRENGIAVVADRPGVGRNLQDHMELYIQQESTKPITLNSVLNPFSKALIG
AQWLFFKSGLGATNHFEAAAFVRSRAGVDYPDIQYHFIPAAVRYDGKAAAKSHGFQAHVGPMRSKSRGSVTLRSPDPKAK
PVIRFNYMSHPDDWTEFRHCIRLTREIFGQSAFDAFRGQEISPGSHVQSDDDLDVFIRDHAESAYHPCGTCKMGRADDVT
SVVDPECRVIGVDGLRVADSSIFPRVTNGNLNAPSIMTGEKASDHILGRTPLAPSNQEPWINPRWQVSDR

Sequences:

>Translated_550_residues
MLEADFVIIGSGSAGSAMAYRLSEDGKHSVIVIEFGGSDIGPLIQMPSALSIPLNMSLYDWGFASEPEPHLGGRVLATPR
GKVIGGSSSINGMVYVRGHARDFDHWAEEGATGWGFADVLPYFKRMEDNDGGEDGWRGHGGPLHVQRGSRKNPLYGAFVE
AGRQAGFELTDDYNGSKQEGFGPMEQTISGGRRWSAASAYLKPALKRKNVSLVKGFARRVIIENQRAIGVEIEAHKQIQV
VKARREVIVAASSINSPKILMLSGIGPAEHLRENGIAVVADRPGVGRNLQDHMELYIQQESTKPITLNSVLNPFSKALIG
AQWLFFKSGLGATNHFEAAAFVRSRAGVDYPDIQYHFIPAAVRYDGKAAAKSHGFQAHVGPMRSKSRGSVTLRSPDPKAK
PVIRFNYMSHPDDWTEFRHCIRLTREIFGQSAFDAFRGQEISPGSHVQSDDDLDVFIRDHAESAYHPCGTCKMGRADDVT
SVVDPECRVIGVDGLRVADSSIFPRVTNGNLNAPSIMTGEKASDHILGRTPLAPSNQEPWINPRWQVSDR
>Mature_550_residues
MLEADFVIIGSGSAGSAMAYRLSEDGKHSVIVIEFGGSDIGPLIQMPSALSIPLNMSLYDWGFASEPEPHLGGRVLATPR
GKVIGGSSSINGMVYVRGHARDFDHWAEEGATGWGFADVLPYFKRMEDNDGGEDGWRGHGGPLHVQRGSRKNPLYGAFVE
AGRQAGFELTDDYNGSKQEGFGPMEQTISGGRRWSAASAYLKPALKRKNVSLVKGFARRVIIENQRAIGVEIEAHKQIQV
VKARREVIVAASSINSPKILMLSGIGPAEHLRENGIAVVADRPGVGRNLQDHMELYIQQESTKPITLNSVLNPFSKALIG
AQWLFFKSGLGATNHFEAAAFVRSRAGVDYPDIQYHFIPAAVRYDGKAAAKSHGFQAHVGPMRSKSRGSVTLRSPDPKAK
PVIRFNYMSHPDDWTEFRHCIRLTREIFGQSAFDAFRGQEISPGSHVQSDDDLDVFIRDHAESAYHPCGTCKMGRADDVT
SVVDPECRVIGVDGLRVADSSIFPRVTNGNLNAPSIMTGEKASDHILGRTPLAPSNQEPWINPRWQVSDR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=556, Percent_Identity=48.9208633093525, Blast_Score=542, Evalue=1e-154,
Organism=Escherichia coli, GI1786503, Length=543, Percent_Identity=49.5395948434622, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17532301, Length=550, Percent_Identity=45.2727272727273, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24642042, Length=586, Percent_Identity=38.5665529010239, Blast_Score=342, Evalue=5e-94,
Organism=Drosophila melanogaster, GI45551458, Length=564, Percent_Identity=38.1205673758865, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI45549471, Length=564, Percent_Identity=38.2978723404255, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24642048, Length=566, Percent_Identity=35.6890459363958, Blast_Score=312, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24650267, Length=580, Percent_Identity=37.0689655172414, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24642055, Length=567, Percent_Identity=35.0970017636684, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24642059, Length=564, Percent_Identity=34.5744680851064, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI17137792, Length=560, Percent_Identity=33.75, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24642039, Length=562, Percent_Identity=34.5195729537367, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24642037, Length=567, Percent_Identity=33.1569664902998, Blast_Score=255, Evalue=6e-68,
Organism=Drosophila melanogaster, GI18859995, Length=575, Percent_Identity=31.8260869565217, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642035, Length=578, Percent_Identity=32.5259515570934, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24642051, Length=563, Percent_Identity=30.550621669627, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI18859993, Length=562, Percent_Identity=31.4946619217082, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24645930, Length=574, Percent_Identity=28.2229965156794, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24642057, Length=597, Percent_Identity=26.1306532663317, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETA_RHILO (Q985M5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107892.1
- ProteinModelPortal:   Q985M5
- SMR:   Q985M5
- GeneID:   1230547
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll7609
- NMPDR:   fig|266835.1.peg.5993
- HOGENOM:   HBG734713
- OMA:   DNRRMHC
- ProtClustDB:   PRK02106
- BRENDA:   1.1.99.1
- HAMAP:   MF_00750
- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137
- TIGRFAMs:   TIGR01810

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: =1.1.99.1

Molecular weight: Translated: 60125; Mature: 60125

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 466-466

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEADFVIIGSGSAGSAMAYRLSEDGKHSVIVIEFGGSDIGPLIQMPSALSIPLNMSLYD
CCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHCCCCEECCEECEEEE
WGFASEPEPHLGGRVLATPRGKVIGGSSSINGMVYVRGHARDFDHWAEEGATGWGFADVL
CCCCCCCCCCCCCEEEECCCCCEEECCCCCCEEEEEEECCCCHHHHHHCCCCCCCHHHHH
PYFKRMEDNDGGEDGWRGHGGPLHVQRGSRKNPLYGAFVEAGRQAGFELTDDYNGSKQEG
HHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
FGPMEQTISGGRRWSAASAYLKPALKRKNVSLVKGFARRVIIENQRAIGVEIEAHKQIQV
CCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCEEEEEEECCCHHHH
VKARREVIVAASSINSPKILMLSGIGPAEHLRENGIAVVADRPGVGRNLQDHMELYIQQE
HHHCEEEEEEECCCCCCEEEEEECCCHHHHHHHCCEEEEECCCCCCCCHHHHHHEEEEEC
STKPITLNSVLNPFSKALIGAQWLFFKSGLGATNHFEAAAFVRSRAGVDYPDIQYHFIPA
CCCCEEHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEE
AVRYDGKAAAKSHGFQAHVGPMRSKSRGSVTLRSPDPKAKPVIRFNYMSHPDDWTEFRHC
EEEECCCHHHHCCCCEEECCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
IRLTREIFGQSAFDAFRGQEISPGSHVQSDDDLDVFIRDHAESAYHPCGTCKMGRADDVT
HHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCH
SVVDPECRVIGVDGLRVADSSIFPRVTNGNLNAPSIMTGEKASDHILGRTPLAPSNQEPW
HHCCCCEEEEECCCCEECCCCCCCEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
INPRWQVSDR
CCCCEECCCC
>Mature Secondary Structure
MLEADFVIIGSGSAGSAMAYRLSEDGKHSVIVIEFGGSDIGPLIQMPSALSIPLNMSLYD
CCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHCCCCEECCEECEEEE
WGFASEPEPHLGGRVLATPRGKVIGGSSSINGMVYVRGHARDFDHWAEEGATGWGFADVL
CCCCCCCCCCCCCEEEECCCCCEEECCCCCCEEEEEEECCCCHHHHHHCCCCCCCHHHHH
PYFKRMEDNDGGEDGWRGHGGPLHVQRGSRKNPLYGAFVEAGRQAGFELTDDYNGSKQEG
HHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
FGPMEQTISGGRRWSAASAYLKPALKRKNVSLVKGFARRVIIENQRAIGVEIEAHKQIQV
CCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCEEEEEEECCCHHHH
VKARREVIVAASSINSPKILMLSGIGPAEHLRENGIAVVADRPGVGRNLQDHMELYIQQE
HHHCEEEEEEECCCCCCEEEEEECCCHHHHHHHCCEEEEECCCCCCCCHHHHHHEEEEEC
STKPITLNSVLNPFSKALIGAQWLFFKSGLGATNHFEAAAFVRSRAGVDYPDIQYHFIPA
CCCCEEHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEE
AVRYDGKAAAKSHGFQAHVGPMRSKSRGSVTLRSPDPKAKPVIRFNYMSHPDDWTEFRHC
EEEECCCHHHHCCCCEEECCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
IRLTREIFGQSAFDAFRGQEISPGSHVQSDDDLDVFIRDHAESAYHPCGTCKMGRADDVT
HHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCH
SVVDPECRVIGVDGLRVADSSIFPRVTNGNLNAPSIMTGEKASDHILGRTPLAPSNQEPW
HHCCCCEEEEECCCCEECCCCCCCEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
INPRWQVSDR
CCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968