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The map label for this gene is betC [H]

Identifier: 13476324

GI number: 13476324

Start: 6302956

End: 6304485

Strand: Reverse

Name: betC [H]

Synonym: mll7612

Alternate gene names: 13476324

Gene position: 6304485-6302956 (Counterclockwise)

Preceding gene: 13476325

Following gene: 13476323

Centisome position: 89.6

GC content: 63.33

Gene sequence:

>1530_bases
GTGACAGCGAAGCGACCCAATTTCCTGATCGTCATGGTCGATCAGCTCAACGGGACTTTTTTTCCCGATGGGCCTGCCGC
GTTTCTGCACGCGCCGCATCTGAAGGCACTCGCGGCGCGTTCGGCCCGATTCAGGAACAACTACACCGCCTCGCCGCTCT
GCGCGCCGGGCCGCGCCTCGTTCATGAGCGGCCAGTTGCCGTCGCGCACCGAGGTCTATGACAACGCCGCCGAATTCGCC
TCGTCGATCCCGACCTTTGCCCATCATCTGCGCGCCGACGGCTATCACACCGTACTGTCGGGCAAGATGCATTTCGTCGG
GCCGGACCAGTTGCACGGCTTCGAGGAGCGGCTGACCACGGACATCTATCCCGCCGATTTCGGCTGGACACCGGACTACC
GCAAGCCCGGCGAGCGCATCGACTGGTGGTATCACAATCTGGGCTCGGTAAGCGGCGCCGGCGTCGCCGAGATCTCAAAC
CAGATGGAGTATGACGACGAGGTCGCCTTCCACGCGGTGCAAAAACTCTACGACTTCGCCCGCGTCTCCGACGATGCGGC
GCACCGGCCCTGGTGCCTGACGGTTTCCTTCACCCATCCGCACGACCCCTATGTGGCGCGGCGGCAGTACTGGGATCTTT
ATGAGGATTGCCCAGCGCTAGAACCCGAAGTGGGCTTCATCCCCTGCGACAGCCAGGACCCGCATTCGCAGCGGCTCTAC
AAGGCTTCCGACTACAACAGTTTCGACATCACGGCAGAGCAAATCCGCCGCTCGCGGCGCGGCTATTTCGCCAACATCTC
CTATCTCGACGACAAGGTCGGCGAGTTGCTGTCGGTGCTTGAGCGCACGCGCATGCTCGACGACACGATCATCCTGTTCT
GCTCGGACCATGGCGACATGCTCGGCGAGCGCGGCCTGTGGTTCAAGATGTGCTTCTTCGAGGGCTCGGCACGGGTGCCG
CTGATGATCGCCGGCAAGGACATTCCCGCTGGCCTGATCAAGGCGCCGGTCTCTAATCTCGACGTGACGCCGACGCTGTG
CGACCTCGCCGGCATCGACATGAGCGCGATCGCGCCATGGACCGACGGCCAGTCGCTGCTGCCGCTGCTGGAGGGCAAGC
AGCGCTACGCGCCCGTATTGATGGAGTATGCGGCCGAAGGCTCCAACGCGCCGTTGGTGGCGATCCGCGACGGCCGCTAC
AAATTCGTCCATTGCGAGATCGATCCGCCGCAACTCTATGATATCGAAGCCGACCCGCATGAGCTGAGCAATCTTGCCAC
CGATCCGGCGCATGCCGATCTGGTGGCGGCTTTCCTGGAAAAGGTGCGCGCACGCTGGGACATGGCGGCCTTCGATACCG
CCGTGCGCGCCAACCAGGCGCGGCGCTGGGTGGTCTACCCGGCGCTGCGCAACGGCACGCATTACCCCTGGGAGTTCCAG
CCGCTGCAGAAGGCCTCGGAACGCTACATGCGCAACCACATGGATCTCAACGTGCTCGAAGAGCAAAAACGCTTTCCGCG
AGGCGAATGA

Upstream 100 bases:

>100_bases
ACATCAGGCGGGCGCTGAAGGACGGCGTGCCCAACGCCGCGACCGCGATCGCGCTGGTCGAGGACTATCTCGAAACCAAA
CTCGGCGAGCGGCAAAAGCA

Downstream 100 bases:

>100_bases
TGGCAGACCTTCTCGTCCCCTCGCTGGCCCATCTCAAACAGGCCTATGCCGTCACCTCCAGGGCGACGCAGATCACGCCG
CTGCTGGAATCGACCGCACT

Product: choline sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTAKRPNFLIVMVDQLNGTFFPDGPAAFLHAPHLKALAARSARFRNNYTASPLCAPGRASFMSGQLPSRTEVYDNAAEFA
SSIPTFAHHLRADGYHTVLSGKMHFVGPDQLHGFEERLTTDIYPADFGWTPDYRKPGERIDWWYHNLGSVSGAGVAEISN
QMEYDDEVAFHAVQKLYDFARVSDDAAHRPWCLTVSFTHPHDPYVARRQYWDLYEDCPALEPEVGFIPCDSQDPHSQRLY
KASDYNSFDITAEQIRRSRRGYFANISYLDDKVGELLSVLERTRMLDDTIILFCSDHGDMLGERGLWFKMCFFEGSARVP
LMIAGKDIPAGLIKAPVSNLDVTPTLCDLAGIDMSAIAPWTDGQSLLPLLEGKQRYAPVLMEYAAEGSNAPLVAIRDGRY
KFVHCEIDPPQLYDIEADPHELSNLATDPAHADLVAAFLEKVRARWDMAAFDTAVRANQARRWVVYPALRNGTHYPWEFQ
PLQKASERYMRNHMDLNVLEEQKRFPRGE

Sequences:

>Translated_509_residues
MTAKRPNFLIVMVDQLNGTFFPDGPAAFLHAPHLKALAARSARFRNNYTASPLCAPGRASFMSGQLPSRTEVYDNAAEFA
SSIPTFAHHLRADGYHTVLSGKMHFVGPDQLHGFEERLTTDIYPADFGWTPDYRKPGERIDWWYHNLGSVSGAGVAEISN
QMEYDDEVAFHAVQKLYDFARVSDDAAHRPWCLTVSFTHPHDPYVARRQYWDLYEDCPALEPEVGFIPCDSQDPHSQRLY
KASDYNSFDITAEQIRRSRRGYFANISYLDDKVGELLSVLERTRMLDDTIILFCSDHGDMLGERGLWFKMCFFEGSARVP
LMIAGKDIPAGLIKAPVSNLDVTPTLCDLAGIDMSAIAPWTDGQSLLPLLEGKQRYAPVLMEYAAEGSNAPLVAIRDGRY
KFVHCEIDPPQLYDIEADPHELSNLATDPAHADLVAAFLEKVRARWDMAAFDTAVRANQARRWVVYPALRNGTHYPWEFQ
PLQKASERYMRNHMDLNVLEEQKRFPRGE
>Mature_508_residues
TAKRPNFLIVMVDQLNGTFFPDGPAAFLHAPHLKALAARSARFRNNYTASPLCAPGRASFMSGQLPSRTEVYDNAAEFAS
SIPTFAHHLRADGYHTVLSGKMHFVGPDQLHGFEERLTTDIYPADFGWTPDYRKPGERIDWWYHNLGSVSGAGVAEISNQ
MEYDDEVAFHAVQKLYDFARVSDDAAHRPWCLTVSFTHPHDPYVARRQYWDLYEDCPALEPEVGFIPCDSQDPHSQRLYK
ASDYNSFDITAEQIRRSRRGYFANISYLDDKVGELLSVLERTRMLDDTIILFCSDHGDMLGERGLWFKMCFFEGSARVPL
MIAGKDIPAGLIKAPVSNLDVTPTLCDLAGIDMSAIAPWTDGQSLLPLLEGKQRYAPVLMEYAAEGSNAPLVAIRDGRYK
FVHCEIDPPQLYDIEADPHELSNLATDPAHADLVAAFLEKVRARWDMAAFDTAVRANQARRWVVYPALRNGTHYPWEFQP
LQKASERYMRNHMDLNVLEEQKRFPRGE

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI39930577, Length=462, Percent_Identity=26.6233766233766, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI4557659, Length=345, Percent_Identity=27.8260869565217, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4504061, Length=474, Percent_Identity=23.8396624472574, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI5360208, Length=323, Percent_Identity=26.625386996904, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI189571643, Length=396, Percent_Identity=24.4949494949495, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI189571641, Length=396, Percent_Identity=24.4949494949495, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI189571638, Length=396, Percent_Identity=24.4949494949495, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI189571636, Length=396, Percent_Identity=24.4949494949495, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI240255478, Length=378, Percent_Identity=25.1322751322751, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI240255483, Length=378, Percent_Identity=25.1322751322751, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI29789100, Length=378, Percent_Identity=25.1322751322751, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262118210, Length=285, Percent_Identity=27.3684210526316, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1790112, Length=465, Percent_Identity=26.4516129032258, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24656835, Length=438, Percent_Identity=26.027397260274, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 57662; Mature: 57530

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKRPNFLIVMVDQLNGTFFPDGPAAFLHAPHLKALAARSARFRNNYTASPLCAPGRAS
CCCCCCCEEEEEEECCCCCCCCCCCHHHEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
FMSGQLPSRTEVYDNAAEFASSIPTFAHHLRADGYHTVLSGKMHFVGPDQLHGFEERLTT
HHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCEEEEEECEEEECCCHHHCCHHHHHHC
DIYPADFGWTPDYRKPGERIDWWYHNLGSVSGAGVAEISNQMEYDDEVAFHAVQKLYDFA
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
RVSDDAAHRPWCLTVSFTHPHDPYVARRQYWDLYEDCPALEPEVGFIPCDSQDPHSQRLY
HCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHCE
KASDYNSFDITAEQIRRSRRGYFANISYLDDKVGELLSVLERTRMLDDTIILFCSDHGDM
ECCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
LGERGLWFKMCFFEGSARVPLMIAGKDIPAGLIKAPVSNLDVTPTLCDLAGIDMSAIAPW
CCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCCCHHHHHCCCCHHHCCCC
TDGQSLLPLLEGKQRYAPVLMEYAAEGSNAPLVAIRDGRYKFVHCEIDPPQLYDIEADPH
CCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCEEECCCCHH
ELSNLATDPAHADLVAAFLEKVRARWDMAAFDTAVRANQARRWVVYPALRNGTHYPWEFQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
PLQKASERYMRNHMDLNVLEEQKRFPRGE
HHHHHHHHHHHHCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TAKRPNFLIVMVDQLNGTFFPDGPAAFLHAPHLKALAARSARFRNNYTASPLCAPGRAS
CCCCCCEEEEEEECCCCCCCCCCCHHHEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
FMSGQLPSRTEVYDNAAEFASSIPTFAHHLRADGYHTVLSGKMHFVGPDQLHGFEERLTT
HHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCEEEEEECEEEECCCHHHCCHHHHHHC
DIYPADFGWTPDYRKPGERIDWWYHNLGSVSGAGVAEISNQMEYDDEVAFHAVQKLYDFA
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
RVSDDAAHRPWCLTVSFTHPHDPYVARRQYWDLYEDCPALEPEVGFIPCDSQDPHSQRLY
HCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHCE
KASDYNSFDITAEQIRRSRRGYFANISYLDDKVGELLSVLERTRMLDDTIILFCSDHGDM
ECCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
LGERGLWFKMCFFEGSARVPLMIAGKDIPAGLIKAPVSNLDVTPTLCDLAGIDMSAIAPW
CCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCCCHHHHHCCCCHHHCCCC
TDGQSLLPLLEGKQRYAPVLMEYAAEGSNAPLVAIRDGRYKFVHCEIDPPQLYDIEADPH
CCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCEEECCCCHH
ELSNLATDPAHADLVAAFLEKVRARWDMAAFDTAVRANQARRWVVYPALRNGTHYPWEFQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
PLQKASERYMRNHMDLNVLEEQKRFPRGE
HHHHHHHHHHHHCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]