Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 13475931

GI number: 13475931

Start: 5878313

End: 5879677

Strand: Direct

Name: gyaR [H]

Synonym: mlr7122

Alternate gene names: 13475931

Gene position: 5878313-5879677 (Clockwise)

Preceding gene: 13475930

Following gene: 13475938

Centisome position: 83.55

GC content: 64.62

Gene sequence:

>1365_bases
TTGGTCGGCCTGCGCTTCGGACCTGACGGCAAGCCTGATCCCAGCGAAGTGCGCGCCTATATCGAAGCCAAGGGCGGCCG
CTTCCACCTGTCCGCGCTTGGCGACAAAGCGGGCCTCGAGCGGGGCCGGGTGCATTTCTTCTACCAGCCGGATCTCAGCA
CCCGCGAGGAGCTGATCGAAGCCGCCGGCGACGGACGCTATGACGCCGTCATTGCCGCGGCGACCTTCCTGCCCCCCGAA
ACCGTCTTTGCGCTCGCCGGCGTGCGGATCGGCGCCGGCACCGGCAATATGGGCTCGCGCTCCTGGGGCGGCGGCAGCGG
CGAGGGCGGCAGCGCGGTGCTGATGAACACGCCCGGCATCAACAGCCGCGCCACCGCACAGATGGTGATGAAGGCGATCC
TGAAAGTCCTGCCGGATCTGCCGGTCGGCTTGCTTCACGACCGGGTGGCGCGCGCCGATTTCGACACCGGCAGGGAGCTG
CGCGATTTCCCGACCGAAAAGCTCGAAGGCAAGACCATCGCGATCATCGGCTACGGCAATATCGGCCGTGAGGTCGCTAA
GCTCGCTCGCGCCTTCGGCATGCGCGTGGTGATCCATGCACGGCCACGGCACCGCGACTGGATCGAAGCCGAGGGCTTTG
CCTTCGCGGCGGATCTCGCCGATGCGGCTGAAGGCGCCGATGTGCTCAGCGTCCATGTCGGCCTCGGCAAGCAGGACGCG
CAGACCGGCCGCTACGCCAATGCCGGGCTCATCGGCGCCGAGGTCTTGTCCCGCATGAACAAGGGCGCCGTGCTGGTCAA
TTACGATCGCGGCGAGCTTGTCGACGTCGCAGCGCTTGGCGACGCCCTCGATACAGGGCAGATGCGCCATGCCGCCATCG
ATGCGGACCTGTTCAGAGATGCCTCGACCGGGCGCCTTTCCGGCCCGATGCTGCCCTATCTCGACCTCGTCGAGAGGCAT
GGCGAAAAACTTGAACTTCTGCCGCATGCTGCAGCCGATACGGACCATCCGTCGCGCGTCGCCGGCGCCAAACAGGCCGT
CGACCAGCTGTTTGATGTCATCTGTCGCAAATCGGTGACCAATGCCAAAGGCACCGTGCCGCCGGGTTATCTCTCGCTTG
GGGCGACAACGCCCCCAGGCATTGGACCGGTGACGGCGGATCATTTTTTGAAATTGACTGCCAGCGACTGCTCAGAACTG
GCGGATGTCTGTGATCGGCAAAGCCGGTTGTGGAAGGCTTTGTCGGATGCGCCGCTCACCAAGCGTGGGGCGATTGTCGG
CGAACGAGGCGAAGAACTTGTCCGGCTGATCGACCGCTTCTGCCATCTGGCTGAGAAACTCAACCTCAGAGGTCCTTATC
AATAA

Upstream 100 bases:

>100_bases
TCCGTTCTTGCATGGGGGAAACGACGTGACCGCAAACACCAACACACAGGCCGTTGAGCCGATCGATCCGCAGGGGATGT
ACACCGTGCTGATCTGCGAT

Downstream 100 bases:

>100_bases
CATCACGCTGTCGCCGCGGGTTGTCACGGCAGCAGGTCTGAGCGAGACACTCCGCCGCAATCTTCAATATTTAACCCACC
GCAGGCTCGATCCGATATCG

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MVGLRFGPDGKPDPSEVRAYIEAKGGRFHLSALGDKAGLERGRVHFFYQPDLSTREELIEAAGDGRYDAVIAAATFLPPE
TVFALAGVRIGAGTGNMGSRSWGGGSGEGGSAVLMNTPGINSRATAQMVMKAILKVLPDLPVGLLHDRVARADFDTGREL
RDFPTEKLEGKTIAIIGYGNIGREVAKLARAFGMRVVIHARPRHRDWIEAEGFAFAADLADAAEGADVLSVHVGLGKQDA
QTGRYANAGLIGAEVLSRMNKGAVLVNYDRGELVDVAALGDALDTGQMRHAAIDADLFRDASTGRLSGPMLPYLDLVERH
GEKLELLPHAAADTDHPSRVAGAKQAVDQLFDVICRKSVTNAKGTVPPGYLSLGATTPPGIGPVTADHFLKLTASDCSEL
ADVCDRQSRLWKALSDAPLTKRGAIVGERGEELVRLIDRFCHLAEKLNLRGPYQ

Sequences:

>Translated_454_residues
MVGLRFGPDGKPDPSEVRAYIEAKGGRFHLSALGDKAGLERGRVHFFYQPDLSTREELIEAAGDGRYDAVIAAATFLPPE
TVFALAGVRIGAGTGNMGSRSWGGGSGEGGSAVLMNTPGINSRATAQMVMKAILKVLPDLPVGLLHDRVARADFDTGREL
RDFPTEKLEGKTIAIIGYGNIGREVAKLARAFGMRVVIHARPRHRDWIEAEGFAFAADLADAAEGADVLSVHVGLGKQDA
QTGRYANAGLIGAEVLSRMNKGAVLVNYDRGELVDVAALGDALDTGQMRHAAIDADLFRDASTGRLSGPMLPYLDLVERH
GEKLELLPHAAADTDHPSRVAGAKQAVDQLFDVICRKSVTNAKGTVPPGYLSLGATTPPGIGPVTADHFLKLTASDCSEL
ADVCDRQSRLWKALSDAPLTKRGAIVGERGEELVRLIDRFCHLAEKLNLRGPYQ
>Mature_454_residues
MVGLRFGPDGKPDPSEVRAYIEAKGGRFHLSALGDKAGLERGRVHFFYQPDLSTREELIEAAGDGRYDAVIAAATFLPPE
TVFALAGVRIGAGTGNMGSRSWGGGSGEGGSAVLMNTPGINSRATAQMVMKAILKVLPDLPVGLLHDRVARADFDTGREL
RDFPTEKLEGKTIAIIGYGNIGREVAKLARAFGMRVVIHARPRHRDWIEAEGFAFAADLADAAEGADVLSVHVGLGKQDA
QTGRYANAGLIGAEVLSRMNKGAVLVNYDRGELVDVAALGDALDTGQMRHAAIDADLFRDASTGRLSGPMLPYLDLVERH
GEKLELLPHAAADTDHPSRVAGAKQAVDQLFDVICRKSVTNAKGTVPPGYLSLGATTPPGIGPVTADHFLKLTASDCSEL
ADVCDRQSRLWKALSDAPLTKRGAIVGERGEELVRLIDRFCHLAEKLNLRGPYQ

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=211, Percent_Identity=32.2274881516588, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4557497, Length=211, Percent_Identity=32.2274881516588, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI23308577, Length=249, Percent_Identity=28.9156626506024, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI145580578, Length=210, Percent_Identity=31.9047619047619, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4557499, Length=210, Percent_Identity=31.9047619047619, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI145580575, Length=210, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789279, Length=181, Percent_Identity=30.939226519337, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=231, Percent_Identity=31.1688311688312, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=289, Percent_Identity=26.2975778546713, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=146, Percent_Identity=31.5068493150685, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI62472511, Length=211, Percent_Identity=33.175355450237, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646446, Length=212, Percent_Identity=33.0188679245283, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646448, Length=212, Percent_Identity=33.0188679245283, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646452, Length=212, Percent_Identity=33.0188679245283, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646450, Length=212, Percent_Identity=33.0188679245283, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=274, Percent_Identity=28.1021897810219, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 48415; Mature: 48415

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGLRFGPDGKPDPSEVRAYIEAKGGRFHLSALGDKAGLERGRVHFFYQPDLSTREELIE
CCCCCCCCCCCCCHHHHHHHEEECCCEEEEEECCCHHCCCCCCEEEEECCCCCHHHHHHH
AAGDGRYDAVIAAATFLPPETVFALAGVRIGAGTGNMGSRSWGGGSGEGGSAVLMNTPGI
HCCCCCHHHEEEHHHCCCHHHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
NSRATAQMVMKAILKVLPDLPVGLLHDRVARADFDTGRELRDFPTEKLEGKTIAIIGYGN
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHCCCEEEEEECCC
IGREVAKLARAFGMRVVIHARPRHRDWIEAEGFAFAADLADAAEGADVLSVHVGLGKQDA
CCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHCCCCEEEEEECCCCCCC
QTGRYANAGLIGAEVLSRMNKGAVLVNYDRGELVDVAALGDALDTGQMRHAAIDADLFRD
CCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHCCHHCCCCHHHHHHHHHHHCC
ASTGRLSGPMLPYLDLVERHGEKLELLPHAAADTDHPSRVAGAKQAVDQLFDVICRKSVT
CCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
NAKGTVPPGYLSLGATTPPGIGPVTADHFLKLTASDCSELADVCDRQSRLWKALSDAPLT
CCCCCCCCCCEECCCCCCCCCCCCCHHHHEEECHHHHHHHHHHHHHHHHHHHHHHCCCCC
KRGAIVGERGEELVRLIDRFCHLAEKLNLRGPYQ
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVGLRFGPDGKPDPSEVRAYIEAKGGRFHLSALGDKAGLERGRVHFFYQPDLSTREELIE
CCCCCCCCCCCCCHHHHHHHEEECCCEEEEEECCCHHCCCCCCEEEEECCCCCHHHHHHH
AAGDGRYDAVIAAATFLPPETVFALAGVRIGAGTGNMGSRSWGGGSGEGGSAVLMNTPGI
HCCCCCHHHEEEHHHCCCHHHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
NSRATAQMVMKAILKVLPDLPVGLLHDRVARADFDTGRELRDFPTEKLEGKTIAIIGYGN
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHCCCEEEEEECCC
IGREVAKLARAFGMRVVIHARPRHRDWIEAEGFAFAADLADAAEGADVLSVHVGLGKQDA
CCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHCCCCEEEEEECCCCCCC
QTGRYANAGLIGAEVLSRMNKGAVLVNYDRGELVDVAALGDALDTGQMRHAAIDADLFRD
CCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHCCHHCCCCHHHHHHHHHHHCC
ASTGRLSGPMLPYLDLVERHGEKLELLPHAAADTDHPSRVAGAKQAVDQLFDVICRKSVT
CCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
NAKGTVPPGYLSLGATTPPGIGPVTADHFLKLTASDCSELADVCDRQSRLWKALSDAPLT
CCCCCCCCCCEECCCCCCCCCCCCCHHHHEEECHHHHHHHHHHHHHHHHHHHHHHCCCCC
KRGAIVGERGEELVRLIDRFCHLAEKLNLRGPYQ
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]