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The map label for this gene is cyoB [H]

Identifier: 13475707

GI number: 13475707

Start: 5636920

End: 5638917

Strand: Direct

Name: cyoB [H]

Synonym: mlr6847

Alternate gene names: 13475707

Gene position: 5636920-5638917 (Clockwise)

Preceding gene: 13475706

Following gene: 13475708

Centisome position: 80.11

GC content: 61.66

Gene sequence:

>1998_bases
ATGCCCGATACGCTGACCAAATTCATTTTCGGCCGTCTTACCTGGGACTCGCTGCCGCTGCACGAGCCGATCGTGGTGGC
AACCTTCGTCGCGGTGGCGCTCGGCGGCATCGCGCTTCTCGGCGTCGTCACCTATTTCAAGCTCTGGACCTACCTGTGGC
GCGAGTGGTTCACCAGCGTCGACCACAAGAAGATCGGCATCATGTACATGGTGCTCGGCCTGGTCATGCTGCTGCGCGGC
TTCTCCGATGCCATCATGATGCGCCTGCAGCAGGCCATGGCGTTCAACGGTTCCGAGGGCTACCTCAATTCGCATCACTA
CGACCAGATCTTCACCGCGCACGGCGTGATCATGATCTTCTTCGTGGCGATGCCTTTCGTCACCGGGCTGATGAATTTCG
TCGTGCCGCTGCAGATCGGCGCGCGCGATGTCTCCTTCCCGTTCCTCAACAATTTCAGCTTCTGGATGACGGTCGGCGGC
GCCATCCTGGTCATGGCGTCGCTGTTCGTCGGCGAATTCGCCCGCACCGGCTGGCTCGCCTATCCGCCACTCTCCGGCAT
CGGCTACAGTCCGGATGTCGGCGTCGATTATTACATCTGGGCGCTGCAGGTGGCGGGCGTCGGCACCACACTGTCGGGCA
TCAACCTGATCTGCACGATCATCAAGATGCGCGCGCCCGGCATGACCATGATGCGCATGCCTGTCTTCACCTGGACGTCG
CTCTGCACCAACGTGCTGATCGTGGCGTCCTTCCCGGTGCTGACGGCGGTGCTCTCGCTCTTGGCGCTCGACCGCTATGT
CGGCACCAATTTCTTCACCAACGACTTCGGCGGCAACCCGATGATGTACGTGAACCTCATCTGGATATGGGGTCACCCGG
AAGTCTACATCCTCATCCTGCCGCTTTTCGGCGTCTTTTCCGAGGTCACTTCCACCTTCTCCGGCAAGCGCCTGTTCGGC
TACACCTCGATGGTCTATGCCACGGTGGTCATCACCATCCTGTCGTACCTGGTCTGGCTGCACCACTTCTTCACCATGGG
CTCCGGCGCCAGCGTCAATTCCTTCTTCGGCATCACCACGATGATCATCTCGATCCCGACCGGAGCGAAGATCTTCAACT
GGCTGTTCACCATGTATCGCGGCCGCATCCGCTTCGAACTCCCGATGATGTGGACGATGGCCTTCATGCTCACCTTCGTC
GTCGGCGGCATGACCGGCGTGCTGCTCGCCGTGCCGCCGGCGGACTTCGTGCTGCACAACAGCCTGTTCCTGATCGCGCA
CTTCCACAACGTCATCATCGGCGGCGTGCTGTTCGGCCTGTTTGCCGGCATCGCCTACTGGTGGCCCAAGGCCTTCGGCT
TCAAGCTCGATCCGTTCTGGGGCAAGGTGTCGTTCTGGTGCTGGGTGGTCGGCTTCTGGTTCGCCTTCATGCCGCTCTAC
ATACTCGGCCTGATGGGCGTGACGCGCCGCATGCGTGTCTTCGACGATCCCTCGCTGCAGATATGGTTCGTCATCGCCGC
CTTCGGCGCGGTGCTGATCGCCTTCGGCATCGCCGCCTTCCTGATCCAGATCTTCGTCTCCATTCGCAAGCGCGAGGCTC
TGACCGATCCGACCGGCGATCCTTGGGACGGCCGCACGCTCGAATGGTCGACCTCTTCGCCGCCGCCGGCCTATAATTTC
GCCTTCACGCCGGTCGTACGCGACAACGACGCCTGGTGGGACATGAAGAAGGCCGGCTACACCAGGCCGCTCTCAGGTTT
CAAGCCGATCCATATGCCCAGCAATACCGGCACCGGCGTCATCCTGGCCGCCTTCAGCGTGGCGCTCGGCTTCGGCCTGA
TCTGGTACATCTGGTGGCTGGCGGCGTTGAGCTTCGTCTGCCTGATCGCCACCGCGATCGGCCACACTTTCAACTATCAC
CGCGACTTCCACATTCCGGCTGCCGAGGTCACACAAACGGAGGTGGCGAGGACGACGCTCCTTGCCGCCCAGGGCTAG

Upstream 100 bases:

>100_bases
CGCGGGGCGGGGCTGCTGAGGCCCGGGACCGAGAGCCGTCGCGCCGCGGCGGATACGCCGTCGCTCGGCCTGCTGCGGCG
CGAATTGTGAGAGACAGCCG

Downstream 100 bases:

>100_bases
GGTTTAAGCATGGATTCGATAGCGACCACGGCCGGCACCGAACCGGTCTTCCACCTGGAAGAAGAGCATGTGCATGCCGA
AGGCAGCAGCACCATGCTCG

Product: cytochrome o ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MPDTLTKFIFGRLTWDSLPLHEPIVVATFVAVALGGIALLGVVTYFKLWTYLWREWFTSVDHKKIGIMYMVLGLVMLLRG
FSDAIMMRLQQAMAFNGSEGYLNSHHYDQIFTAHGVIMIFFVAMPFVTGLMNFVVPLQIGARDVSFPFLNNFSFWMTVGG
AILVMASLFVGEFARTGWLAYPPLSGIGYSPDVGVDYYIWALQVAGVGTTLSGINLICTIIKMRAPGMTMMRMPVFTWTS
LCTNVLIVASFPVLTAVLSLLALDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILILPLFGVFSEVTSTFSGKRLFG
YTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKIFNWLFTMYRGRIRFELPMMWTMAFMLTFV
VGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGLFAGIAYWWPKAFGFKLDPFWGKVSFWCWVVGFWFAFMPLY
ILGLMGVTRRMRVFDDPSLQIWFVIAAFGAVLIAFGIAAFLIQIFVSIRKREALTDPTGDPWDGRTLEWSTSSPPPAYNF
AFTPVVRDNDAWWDMKKAGYTRPLSGFKPIHMPSNTGTGVILAAFSVALGFGLIWYIWWLAALSFVCLIATAIGHTFNYH
RDFHIPAAEVTQTEVARTTLLAAQG

Sequences:

>Translated_665_residues
MPDTLTKFIFGRLTWDSLPLHEPIVVATFVAVALGGIALLGVVTYFKLWTYLWREWFTSVDHKKIGIMYMVLGLVMLLRG
FSDAIMMRLQQAMAFNGSEGYLNSHHYDQIFTAHGVIMIFFVAMPFVTGLMNFVVPLQIGARDVSFPFLNNFSFWMTVGG
AILVMASLFVGEFARTGWLAYPPLSGIGYSPDVGVDYYIWALQVAGVGTTLSGINLICTIIKMRAPGMTMMRMPVFTWTS
LCTNVLIVASFPVLTAVLSLLALDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILILPLFGVFSEVTSTFSGKRLFG
YTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKIFNWLFTMYRGRIRFELPMMWTMAFMLTFV
VGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGLFAGIAYWWPKAFGFKLDPFWGKVSFWCWVVGFWFAFMPLY
ILGLMGVTRRMRVFDDPSLQIWFVIAAFGAVLIAFGIAAFLIQIFVSIRKREALTDPTGDPWDGRTLEWSTSSPPPAYNF
AFTPVVRDNDAWWDMKKAGYTRPLSGFKPIHMPSNTGTGVILAAFSVALGFGLIWYIWWLAALSFVCLIATAIGHTFNYH
RDFHIPAAEVTQTEVARTTLLAAQG
>Mature_664_residues
PDTLTKFIFGRLTWDSLPLHEPIVVATFVAVALGGIALLGVVTYFKLWTYLWREWFTSVDHKKIGIMYMVLGLVMLLRGF
SDAIMMRLQQAMAFNGSEGYLNSHHYDQIFTAHGVIMIFFVAMPFVTGLMNFVVPLQIGARDVSFPFLNNFSFWMTVGGA
ILVMASLFVGEFARTGWLAYPPLSGIGYSPDVGVDYYIWALQVAGVGTTLSGINLICTIIKMRAPGMTMMRMPVFTWTSL
CTNVLIVASFPVLTAVLSLLALDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILILPLFGVFSEVTSTFSGKRLFGY
TSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKIFNWLFTMYRGRIRFELPMMWTMAFMLTFVV
GGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGLFAGIAYWWPKAFGFKLDPFWGKVSFWCWVVGFWFAFMPLYI
LGLMGVTRRMRVFDDPSLQIWFVIAAFGAVLIAFGIAAFLIQIFVSIRKREALTDPTGDPWDGRTLEWSTSSPPPAYNFA
FTPVVRDNDAWWDMKKAGYTRPLSGFKPIHMPSNTGTGVILAAFSVALGFGLIWYIWWLAALSFVCLIATAIGHTFNYHR
DFHIPAAEVTQTEVARTTLLAAQG

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=515, Percent_Identity=39.0291262135922, Blast_Score=332, Evalue=6e-91,
Organism=Escherichia coli, GI1786634, Length=648, Percent_Identity=67.9012345679012, Blast_Score=915, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=36.3128491620112, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6226524, Length=327, Percent_Identity=42.2018348623853, Blast_Score=239, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6226523, Length=252, Percent_Identity=34.9206349206349, Blast_Score=134, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74518; Mature: 74387

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDTLTKFIFGRLTWDSLPLHEPIVVATFVAVALGGIALLGVVTYFKLWTYLWREWFTSV
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DHKKIGIMYMVLGLVMLLRGFSDAIMMRLQQAMAFNGSEGYLNSHHYDQIFTAHGVIMIF
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
FVAMPFVTGLMNFVVPLQIGARDVSFPFLNNFSFWMTVGGAILVMASLFVGEFARTGWLA
HHHHHHHHHHHHHHHHHEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
YPPLSGIGYSPDVGVDYYIWALQVAGVGTTLSGINLICTIIKMRAPGMTMMRMPVFTWTS
CCCCCCCCCCCCCCCHHEEEEEEHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LCTNVLIVASFPVLTAVLSLLALDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEHHH
PLFGVFSEVTSTFSGKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MIISIPTGAKIFNWLFTMYRGRIRFELPMMWTMAFMLTFVVGGMTGVLLAVPPADFVLHN
HEEECCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCHHCEEEEECCHHHHHHC
SLFLIAHFHNVIIGGVLFGLFAGIAYWWPKAFGFKLDPFWGKVSFWCWVVGFWFAFMPLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHH
ILGLMGVTRRMRVFDDPSLQIWFVIAAFGAVLIAFGIAAFLIQIFVSIRKREALTDPTGD
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PWDGRTLEWSTSSPPPAYNFAFTPVVRDNDAWWDMKKAGYTRPLSGFKPIHMPSNTGTGV
CCCCCEEEECCCCCCCCCCEEECCEEECCCCCCCHHHCCCCCCCCCCCCEECCCCCCCHH
ILAAFSVALGFGLIWYIWWLAALSFVCLIATAIGHTFNYHRDFHIPAAEVTQTEVARTTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LAAQG
HCCCC
>Mature Secondary Structure 
PDTLTKFIFGRLTWDSLPLHEPIVVATFVAVALGGIALLGVVTYFKLWTYLWREWFTSV
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DHKKIGIMYMVLGLVMLLRGFSDAIMMRLQQAMAFNGSEGYLNSHHYDQIFTAHGVIMIF
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
FVAMPFVTGLMNFVVPLQIGARDVSFPFLNNFSFWMTVGGAILVMASLFVGEFARTGWLA
HHHHHHHHHHHHHHHHHEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
YPPLSGIGYSPDVGVDYYIWALQVAGVGTTLSGINLICTIIKMRAPGMTMMRMPVFTWTS
CCCCCCCCCCCCCCCHHEEEEEEHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LCTNVLIVASFPVLTAVLSLLALDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEHHH
PLFGVFSEVTSTFSGKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MIISIPTGAKIFNWLFTMYRGRIRFELPMMWTMAFMLTFVVGGMTGVLLAVPPADFVLHN
HEEECCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCHHCEEEEECCHHHHHHC
SLFLIAHFHNVIIGGVLFGLFAGIAYWWPKAFGFKLDPFWGKVSFWCWVVGFWFAFMPLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHH
ILGLMGVTRRMRVFDDPSLQIWFVIAAFGAVLIAFGIAAFLIQIFVSIRKREALTDPTGD
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PWDGRTLEWSTSSPPPAYNFAFTPVVRDNDAWWDMKKAGYTRPLSGFKPIHMPSNTGTGV
CCCCCEEEECCCCCCCCCCEEECCEEECCCCCCCHHHCCCCCCCCCCCCEECCCCCCCHH
ILAAFSVALGFGLIWYIWWLAALSFVCLIATAIGHTFNYHRDFHIPAAEVTQTEVARTTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LAAQG
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]