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The map label for this gene is CYP117A2 [H]

Identifier: 13475327

GI number: 13475327

Start: 5191628

End: 5192971

Strand: Direct

Name: CYP117A2 [H]

Synonym: mlr6367

Alternate gene names: 13475327

Gene position: 5191628-5192971 (Clockwise)

Preceding gene: 13475326

Following gene: 13475328

Centisome position: 73.79

GC content: 67.56

Gene sequence:

>1344_bases
ATGGACATGCTGCTCAACCCGCTGGACCGTCGGCACCGGCTGCGGGACGACATCCCGGTCGTGCCCGGCGCTTTCCCCCT
GGTCGGACATCTTCCCGCCATCGTATGCGACCTGCCGCGCCTGCTGCGGCGCGCGGAACGGACGTTGGGCAGCCACTTCT
GGCTGGATTTCGGCCCTGCCGGACACCTGATGACCTGCGTGGATCCGGATGCGTTTGCACTGCTCCGGCACAAGGACGTG
TCCTCGGCGCTGATCGAAGAGATCGCGCCCGAATTGCTTGGCGGAACGTTGGTCGCCCAGGACGGCGGCGCGCACCGGCA
GGCGCGCGACGCGATCAAGGCGGCGTTCCTGCCCAAGGGGCTGACCCAAGCCGGCATCGGCAACCTGTTCGCGCCCGTCA
TCCAGGCGCGGGTGCAGGCGTGGCGCGACCGCGGCGACGTAACCATCCTGCGCGAAACCGGCGACCTGATGCTCAAGCTC
ATCTTCAGCCTCATGGGAATCCCAGCGCAGGACCTGCCGGGATGGCATCGCAAATACCGGCAACTGCTGCAGTTGATCGT
CGCGCCCCCGGTCGACCTGCCTGGACTGCCCTTGCGGCGCGGCCGCGCCGCCCGCGACTGGATCGACGCGCAGTTGCGCC
AGTTCGTCCGCGACGCGCGCGCACATGCCGCGCGCACTGGGTTGATCAATGACATGGTGAGCTCCTTCGATCGCGGCGAC
GATGCGCTCTCCGACGACGTCCTGGTCGCCAATATCCGCCTGCTGCTGCTTGCCGGTCACGACACCACCGCCTCGACGAT
GGCCTGGATGGTGATCGAGCTGGCGCGGCAGCCTGGGCTATGGGACGCCCTGGTCGAGGAGGCGCAACGCGTGGGCGCGG
TGCCGACCCGGCACGCGGACCTGGCGCAGTGTCCGGTCGCCGAGGCGCTGTTCCGCGAGACGCTGCGCGTGCATCCGGCG
ACCACGCTCCTGCCGCGTCGCGCGCTGCAGGAATTGCAACTCGGCCAACGGCGCATTCCTGCGGGCACCCCTCTGTGCAT
CCCGCTGCTGCATTTCTCGACCTCTGCGCTGCTGCACGAGGCGCCTGATCAGTTCCGCCTGGCACGGTGGCTGCAACGCA
CGGAGCCGATCCGGCCGGTGGACATGCTGCAGTTCGGTACCGGCCCACACGTCTGCATCGGTTACCACCTGGTATGGCTG
GAAATGGTGCAGTTCTGCATCGCCTTGGCACTGACCATGCACAAGGCCGGGGTGCGGCCGCGGTTGCTGAGCGCCGTCGA
AAAAGGTCGGCGCTATTTCCCGACCGCACATCCGTCCATGAAAATCCGCATCGGATTCTCATGA

Upstream 100 bases:

>100_bases
GCATGCTGGCGCATGTGCCGACGTACGCCGACGGTGGCAACAGCCGCGCCGCGCGGCCTGCCGGCGACACCGCCAAAGCG
GCCGCGGGGCCGCGCTGCTG

Downstream 100 bases:

>100_bases
GCTGGCATCGCATGCCCCGTGTGGCGAGGCAGCTACTCGGCGCGCGCGCTCGGTGCGACCCCGCCAACACCGCGGCGGCT
CGGACGCTCGCCGTGGCCGT

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDMLLNPLDRRHRLRDDIPVVPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTCVDPDAFALLRHKDV
SSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPKGLTQAGIGNLFAPVIQARVQAWRDRGDVTILRETGDLMLKL
IFSLMGIPAQDLPGWHRKYRQLLQLIVAPPVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSSFDRGD
DALSDDVLVANIRLLLLAGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHADLAQCPVAEALFRETLRVHPA
TTLLPRRALQELQLGQRRIPAGTPLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWL
EMVQFCIALALTMHKAGVRPRLLSAVEKGRRYFPTAHPSMKIRIGFS

Sequences:

>Translated_447_residues
MDMLLNPLDRRHRLRDDIPVVPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTCVDPDAFALLRHKDV
SSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPKGLTQAGIGNLFAPVIQARVQAWRDRGDVTILRETGDLMLKL
IFSLMGIPAQDLPGWHRKYRQLLQLIVAPPVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSSFDRGD
DALSDDVLVANIRLLLLAGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHADLAQCPVAEALFRETLRVHPA
TTLLPRRALQELQLGQRRIPAGTPLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWL
EMVQFCIALALTMHKAGVRPRLLSAVEKGRRYFPTAHPSMKIRIGFS
>Mature_447_residues
MDMLLNPLDRRHRLRDDIPVVPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTCVDPDAFALLRHKDV
SSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPKGLTQAGIGNLFAPVIQARVQAWRDRGDVTILRETGDLMLKL
IFSLMGIPAQDLPGWHRKYRQLLQLIVAPPVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSSFDRGD
DALSDDVLVANIRLLLLAGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHADLAQCPVAEALFRETLRVHPA
TTLLPRRALQELQLGQRRIPAGTPLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWL
EMVQFCIALALTMHKAGVRPRLLSAVEKGRRYFPTAHPSMKIRIGFS

Specific function: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI55770850, Length=165, Percent_Identity=33.9393939393939, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI153218654, Length=175, Percent_Identity=30.8571428571429, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4503231, Length=200, Percent_Identity=28, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI153218646, Length=175, Percent_Identity=30.8571428571429, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4503211, Length=176, Percent_Identity=30.1136363636364, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI167466231, Length=211, Percent_Identity=33.6492890995261, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI16933530, Length=426, Percent_Identity=23.943661971831, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4503213, Length=188, Percent_Identity=32.4468085106383, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI6005737, Length=210, Percent_Identity=29.0476190476191, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI150036266, Length=224, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI193083180, Length=200, Percent_Identity=28, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI193083178, Length=200, Percent_Identity=28, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI13435386, Length=178, Percent_Identity=27.5280898876405, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI16933533, Length=186, Percent_Identity=26.3440860215054, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI262290932, Length=212, Percent_Identity=24.5283018867925, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI13435391, Length=239, Percent_Identity=25.5230125523013, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI16933528, Length=345, Percent_Identity=24.0579710144928, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI12383060, Length=189, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI119220562, Length=239, Percent_Identity=26.3598326359833, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4503195, Length=164, Percent_Identity=33.5365853658537, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI61743918, Length=157, Percent_Identity=31.2101910828025, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71998720, Length=202, Percent_Identity=25.7425742574257, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536187, Length=202, Percent_Identity=27.2277227722772, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72001484, Length=218, Percent_Identity=24.3119266055046, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17536177, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536183, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17553062, Length=202, Percent_Identity=29.2079207920792, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17933518, Length=164, Percent_Identity=28.6585365853659, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639289, Length=191, Percent_Identity=26.7015706806283, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24639287, Length=191, Percent_Identity=26.7015706806283, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45552577, Length=370, Percent_Identity=25.1351351351351, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656064, Length=169, Percent_Identity=28.9940828402367, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642101, Length=164, Percent_Identity=26.219512195122, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24943083, Length=370, Percent_Identity=25.1351351351351, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330299, Length=196, Percent_Identity=26.0204081632653, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21355669, Length=165, Percent_Identity=27.8787878787879, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24660171, Length=169, Percent_Identity=26.6272189349112, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641483, Length=158, Percent_Identity=30.379746835443, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28571357, Length=168, Percent_Identity=29.7619047619048, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR017972
- InterPro:   IPR002403 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 49729; Mature: 49729

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMLLNPLDRRHRLRDDIPVVPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPA
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GHLMTCVDPDAFALLRHKDVSSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPKG
CCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCC
LTQAGIGNLFAPVIQARVQAWRDRGDVTILRETGDLMLKLIFSLMGIPAQDLPGWHRKYR
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QLLQLIVAPPVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSSFDRGD
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DALSDDVLVANIRLLLLAGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHAD
CCCCCCCHHEEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCH
LAQCPVAEALFRETLRVHPATTLLPRRALQELQLGQRRIPAGTPLCIPLLHFSTSALLHE
HHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
APDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWLEMVQFCIALALTMHKAGVRP
CCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
RLLSAVEKGRRYFPTAHPSMKIRIGFS
HHHHHHHHCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MDMLLNPLDRRHRLRDDIPVVPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPA
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GHLMTCVDPDAFALLRHKDVSSALIEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPKG
CCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCC
LTQAGIGNLFAPVIQARVQAWRDRGDVTILRETGDLMLKLIFSLMGIPAQDLPGWHRKYR
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QLLQLIVAPPVDLPGLPLRRGRAARDWIDAQLRQFVRDARAHAARTGLINDMVSSFDRGD
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DALSDDVLVANIRLLLLAGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHAD
CCCCCCCHHEEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCH
LAQCPVAEALFRETLRVHPATTLLPRRALQELQLGQRRIPAGTPLCIPLLHFSTSALLHE
HHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
APDQFRLARWLQRTEPIRPVDMLQFGTGPHVCIGYHLVWLEMVQFCIALALTMHKAGVRP
CCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
RLLSAVEKGRRYFPTAHPSMKIRIGFS
HHHHHHHHCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]