BacMap

Definition	Mesorhizobium loti MAFF303099 chromosome, complete genome.
Accession	NC_002678
Length	7,036,071

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The map label for this gene is hdhA [C]

Identifier: 13475326

GI number: 13475326

Start: 5190504

End: 5191628

Strand: Direct

Name: hdhA [C]

Synonym: mlr6366

Alternate gene names: 13475326

Gene position: 5190504-5191628 (Clockwise)

Preceding gene: 13475325

Following gene: 13475327

Centisome position: 73.77

GC content: 70.58

Gene sequence:

>1125_bases
ATGCGCGTCGTGATCGATCAGGATCTATGCGGAACCACCGGGCAGTGTGTGCTGACGCTGCCGGGCACCTTTCGCCAGCG
CGAACCGGACGGCGTGGCGGAAGTGTGCGTGGCGACGGTCCCGCAGGCGCTGCACGCCGCCGCGCGGCTCGCGGCCAGCC
AGTGTCCGGTCGCCGCCATTCGGGTCATCGAAAGCGACGCTGGCGAGCGCGCCAGCGCCGACCCTGCGCCTTCTCCGGCG
CAGGCTGAGCGGCATGCCGCGAAAGACCAACGCAACCCAGGAGGACGGTTTGAAGGCAAGGTGGCCGTGGTGACCGGCGC
CGGCGCCGGCATCGGCAAGGCATGCGCCCTCGCCATCGCGCGCGAGGGCGGCAGAGTGGTGGTGGCCGACATTGATGGCT
CGGCGGCCGTCGCCTGCACCGCGCAGATCGCGGCCGAAGCGGGCCACGCGCTGGCCCTGGCCATGGACATCGCCGATGCG
CAGGCGGTGGCAGCGCTGTTCGAGACGGCGGAGCGGCACTTCGGTGGGGTCGACCTGCTGGTGAACAACGCGAGCGCCAT
GCATCTGACACCGCGCGACCGCACGATCCTCGACCTGGACCTGGCGGTCTGGGATCAGACCATGGCGACCAATCTGCGCG
GCACGCTGCTCTGCTGCCGGCAGGCCATCCCACGAATGATCGCCCGCGGCGGTGGCGCGATCGTCAACATGTCGTCGTGC
CAGGGGCTCAGCGGTGACACCGCGCAGACGTCCTACGCCGCGTCGAAGGCGGCGATGAACATGCTGTCGGCCTCGCTCGC
CACCCAGTACGGTCATGCGCAGATCCGCTGCAACGCGGTTGCGCCGGGTCTCATCATGACCGAGCGTCTCCTCGCCAAGC
TGGACGAGTGCATGCAACGGCATCTGAGCCGGCACCAACTCCTGCAGCGCGTCGGCCGCCCCGAGGACGTGGCCGCGCTG
GTGGCGTTCCTGCTCTCCGACGATGCTGCGTTCATCACCGGCCAGGTCCTGTGCATCGACGGCGGCATGCTGGCGCATGT
GCCGACGTACGCCGACGGTGGCAACAGCCGCGCCGCGCGGCCTGCCGGCGACACCGCCAAAGCGGCCGCGGGGCCGCGCT
GCTGA

Upstream 100 bases:

>100_bases
CCCACGCTGGCATTGGCCGAGCAGCCGACCCGGGAGCCATCCGCGTTCCTCAGGACGTTCCGCGCGCTGCCGGTGCGACT
GCATGCTCAGGGGGGCTGAG

Downstream 100 bases:

>100_bases
TGGACATGCTGCTCAACCCGCTGGACCGTCGGCACCGGCTGCGGGACGACATCCCGGTCGTGCCCGGCGCTTTCCCCCTG
GTCGGACATCTTCCCGCCAT

Product: short-chain type dehydrogenase/reductase

Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MRVVIDQDLCGTTGQCVLTLPGTFRQREPDGVAEVCVATVPQALHAAARLAASQCPVAAIRVIESDAGERASADPAPSPA
QAERHAAKDQRNPGGRFEGKVAVVTGAGAGIGKACALAIAREGGRVVVADIDGSAAVACTAQIAAEAGHALALAMDIADA
QAVAALFETAERHFGGVDLLVNNASAMHLTPRDRTILDLDLAVWDQTMATNLRGTLLCCRQAIPRMIARGGGAIVNMSSC
QGLSGDTAQTSYAASKAAMNMLSASLATQYGHAQIRCNAVAPGLIMTERLLAKLDECMQRHLSRHQLLQRVGRPEDVAAL
VAFLLSDDAAFITGQVLCIDGGMLAHVPTYADGGNSRAARPAGDTAKAAAGPRC

Sequences:

>Translated_374_residues
MRVVIDQDLCGTTGQCVLTLPGTFRQREPDGVAEVCVATVPQALHAAARLAASQCPVAAIRVIESDAGERASADPAPSPA
QAERHAAKDQRNPGGRFEGKVAVVTGAGAGIGKACALAIAREGGRVVVADIDGSAAVACTAQIAAEAGHALALAMDIADA
QAVAALFETAERHFGGVDLLVNNASAMHLTPRDRTILDLDLAVWDQTMATNLRGTLLCCRQAIPRMIARGGGAIVNMSSC
QGLSGDTAQTSYAASKAAMNMLSASLATQYGHAQIRCNAVAPGLIMTERLLAKLDECMQRHLSRHQLLQRVGRPEDVAAL
VAFLLSDDAAFITGQVLCIDGGMLAHVPTYADGGNSRAARPAGDTAKAAAGPRC
>Mature_374_residues
MRVVIDQDLCGTTGQCVLTLPGTFRQREPDGVAEVCVATVPQALHAAARLAASQCPVAAIRVIESDAGERASADPAPSPA
QAERHAAKDQRNPGGRFEGKVAVVTGAGAGIGKACALAIAREGGRVVVADIDGSAAVACTAQIAAEAGHALALAMDIADA
QAVAALFETAERHFGGVDLLVNNASAMHLTPRDRTILDLDLAVWDQTMATNLRGTLLCCRQAIPRMIARGGGAIVNMSSC
QGLSGDTAQTSYAASKAAMNMLSASLATQYGHAQIRCNAVAPGLIMTERLLAKLDECMQRHLSRHQLLQRVGRPEDVAAL
VAFLLSDDAAFITGQVLCIDGGMLAHVPTYADGGNSRAARPAGDTAKAAAGPRC

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=35.7723577235772, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=33.0739299610895, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI19923817, Length=278, Percent_Identity=29.8561151079137, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=31.2, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI66933014, Length=255, Percent_Identity=32.9411764705882, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4504505, Length=241, Percent_Identity=33.6099585062241, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI10190704, Length=258, Percent_Identity=31.3953488372093, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=31.8897637795276, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI126723750, Length=260, Percent_Identity=27.6923076923077, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI40254986, Length=198, Percent_Identity=33.8383838383838, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI31542939, Length=267, Percent_Identity=29.5880149812734, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=28.3464566929134, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI209862901, Length=219, Percent_Identity=30.1369863013699, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI19923983, Length=219, Percent_Identity=30.1369863013699, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI20149619, Length=194, Percent_Identity=30.4123711340206, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=30.9278350515464, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI126723191, Length=189, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI224922801, Length=164, Percent_Identity=34.1463414634146, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI59889578, Length=254, Percent_Identity=32.6771653543307, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI40807363, Length=201, Percent_Identity=28.8557213930348, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=29.0697674418605, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI157739938, Length=194, Percent_Identity=28.8659793814433, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4502601, Length=146, Percent_Identity=34.2465753424658, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI7657478, Length=203, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=35.2226720647773, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=34.1176470588235, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=34.2412451361868, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=34.8178137651822, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=28.8, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=30.6772908366534, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=29.5275590551181, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786812, Length=260, Percent_Identity=32.3076923076923, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=29.3650793650794, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=29.3436293436293, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=31.4516129032258, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787820, Length=187, Percent_Identity=25.1336898395722, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=31.4176245210728, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=34.2741935483871, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=31.2, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=31.9838056680162, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=32.0754716981132, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=31.4741035856574, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17561402, Length=261, Percent_Identity=31.4176245210728, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=31.2267657992565, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=31.5589353612167, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=30, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17568967, Length=283, Percent_Identity=30.3886925795053, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=30.9433962264151, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=31.5589353612167, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17536025, Length=266, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=29.2307692307692, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=30.6818181818182, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=29.3893129770992, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=28.1368821292776, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=30.1587301587302, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=27.6923076923077, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17565030, Length=262, Percent_Identity=27.8625954198473, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=29.2592592592593, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538182, Length=260, Percent_Identity=29.2307692307692, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=27.6923076923077, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71982365, Length=197, Percent_Identity=29.4416243654822, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=28.6259541984733, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17558628, Length=198, Percent_Identity=31.8181818181818, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=27.0992366412214, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=27.6923076923077, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=257, Percent_Identity=30.3501945525292, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=162, Percent_Identity=28.3950617283951, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17555612, Length=204, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=164, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=256, Percent_Identity=26.953125, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997099, Length=205, Percent_Identity=28.2926829268293, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=194, Percent_Identity=23.7113402061856, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=24.0837696335079, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=166, Percent_Identity=25.9036144578313, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=265, Percent_Identity=29.0566037735849, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324126, Length=267, Percent_Identity=26.5917602996255, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=33.9920948616601, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=30.6772908366534, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=30.3149606299213, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI18859837, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=32.9457364341085, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644339, Length=261, Percent_Identity=31.8007662835249, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574402, Length=204, Percent_Identity=31.3725490196078, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24584744, Length=204, Percent_Identity=31.3725490196078, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=29.5275590551181, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24644337, Length=263, Percent_Identity=31.9391634980989, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=29.4820717131474, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=30.3030303030303, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358495, Length=267, Percent_Identity=27.3408239700375, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI161076933, Length=191, Percent_Identity=28.7958115183246, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584748, Length=191, Percent_Identity=28.7958115183246, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24665243, Length=254, Percent_Identity=27.1653543307087, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221331218, Length=254, Percent_Identity=27.1653543307087, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24665247, Length=255, Percent_Identity=27.0588235294118, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221331216, Length=255, Percent_Identity=27.0588235294118, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24641232, Length=217, Percent_Identity=27.6497695852535, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640492, Length=200, Percent_Identity=25.5, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24663911, Length=220, Percent_Identity=28.6363636363636, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281364892, Length=179, Percent_Identity=28.4916201117318, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24581726, Length=194, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.159 [C]

Molecular weight: Translated: 38547; Mature: 38547

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVIDQDLCGTTGQCVLTLPGTFRQREPDGVAEVCVATVPQALHAAARLAASQCPVAAI
CEEEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVIESDAGERASADPAPSPAQAERHAAKDQRNPGGRFEGKVAVVTGAGAGIGKACALAIA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHC
REGGRVVVADIDGSAAVACTAQIAAEAGHALALAMDIADAQAVAALFETAERHFGGVDLL
CCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEE
VNNASAMHLTPRDRTILDLDLAVWDQTMATNLRGTLLCCRQAIPRMIARGGGAIVNMSSC
EECCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
QGLSGDTAQTSYAASKAAMNMLSASLATQYGHAQIRCNAVAPGLIMTERLLAKLDECMQR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
HLSRHQLLQRVGRPEDVAALVAFLLSDDAAFITGQVLCIDGGMLAHVPTYADGGNSRAAR
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHEEEEEEEECCEEEECCCCCCCCCCCCCC
PAGDTAKAAAGPRC
CCCCCHHCCCCCCC
>Mature Secondary Structure
MRVVIDQDLCGTTGQCVLTLPGTFRQREPDGVAEVCVATVPQALHAAARLAASQCPVAAI
CEEEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVIESDAGERASADPAPSPAQAERHAAKDQRNPGGRFEGKVAVVTGAGAGIGKACALAIA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHC
REGGRVVVADIDGSAAVACTAQIAAEAGHALALAMDIADAQAVAALFETAERHFGGVDLL
CCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEE
VNNASAMHLTPRDRTILDLDLAVWDQTMATNLRGTLLCCRQAIPRMIARGGGAIVNMSSC
EECCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
QGLSGDTAQTSYAASKAAMNMLSASLATQYGHAQIRCNAVAPGLIMTERLLAKLDECMQR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
HLSRHQLLQRVGRPEDVAALVAFLLSDDAAFITGQVLCIDGGMLAHVPTYADGGNSRAAR
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHEEEEEEEECCEEEECCCCCCCCCCCCCC
PAGDTAKAAAGPRC
CCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]

Metal ions: CaCl2; KCl; MnCl2; NaCl [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]

Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]

Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]

General reaction: Redox reaction [C]

Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]