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The map label for this gene is alr

Identifier: 13475189

GI number: 13475189

Start: 5030901

End: 5032094

Strand: Reverse

Name: alr

Synonym: mll6211

Alternate gene names: 13475189

Gene position: 5032094-5030901 (Counterclockwise)

Preceding gene: 13475190

Following gene: 13475186

Centisome position: 71.52

GC content: 53.52

Gene sequence:

>1194_bases
ATGATGTTGTCCATAGTGCGGTCAGTCGACGTCGTATTGGAAATCGATCTAGCGGCTATTCGGGCGAATTTCCAGAAGAT
CTCGACACTTGTTGGGGATAAGGTGAAGGTAGCTGCAGTCGTCAAAAGTGATGCGTACGGACTTGGTCTTGTAGACATTG
CCAGGACGCTCATAGATGCCGGCTGCGACCTACTGTTTGTTGCCAATTTGGATGAGGCCCTGCTTCTAAGATCTTCCTTT
AGTCGAGTTGCAATTGCGGTCTTTCGTGATGAGTTTGATAGGTTTGGCACATGGTACCGGTCGCATGGCCTGATACCTGT
GGTGAACAACTGCAAGGAATTGCATGCAGTTGGCACAGCCGGAGAGCCGCAATCATACTTTCTCAATGTGGAAACTGGAT
TCTCTCGCTTTGGGCTCAGCGTTGGCGATATCCAGCGCGAGTATCTGCTACGCACCTTCGAAAGGTATCGCCCTTCGATC
GTGCTCAGCCACCTCGCATGCGGCGAATGCATTTCGGACCCAATGAATCAATTGCAGAGGGACCGTTTTCGGACAGTCTA
TGATCTTCTTAAACCCACGCGCGGCAGTCTCTCTGCCTCCGCCGGTGTATGGCTCGGAAAGTCCTACCACTTTGACATGG
TGCGTGTAGGATCGGCGCTGTACGGGATCCATAACGCTGGCGTGCAAACAAATCCCCTGAAGCCCGTGGTCAAACTCAGA
GCAAGAATACTTGACGTGCGGAGCGTTCCGGCGGGGGAAGCCGTTGGATATGGTGCAACGTTTCGTACGGACCGAGCCAG
CCGAGTAGCAATCGTCGGGATCGGGTACAAGCACGGGCTTCCATGGTCCTGCGCGAACAAGATATTCGTTCGGTTGGCGG
AATATTCAGCGCCTTCAATAGGAAGAATCTCCATGGAATATATGATAATTGATATAACGGACGTTCCGGCGAGACGTTGC
AGCCCGGGCACCTTTGCGGAATTGCTAAGTGAAGACTTCACCGTCAATGACCTCGGAGCGGCCGCTGGGGTTAGTCCACA
GGAGGCACTGACGCGGCTTGGTGCCGGGTGCACACGGAAGTATCTGAATTTATTCCCTCCATCTGCAGCGTTCACAGCAA
ACCGCCCGACGGAGGCGATGAGTAACCCATCGAGAGCAAAGAGCCGACCGATGGACAAGCAAGCGCTCATCTAG

Upstream 100 bases:

>100_bases
GGGGGTACAATAGCCGGTGTTTGCTAACATGACAAACAATGGGTCGCGTCGCCGCGCTTCGAAATAAGAAACTGTACTCT
AGACAGTTTTTAGAGAGTTG

Downstream 100 bases:

>100_bases
CGGTTAGGCTATCTGGCAGGCCGCCCGGCTGCCAACCTTGCGCAGTGCTCGGCTAGAAGGTCCACGAACCCGATTGACGA
GCTCGACCCGATCTGCAACC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MMLSIVRSVDVVLEIDLAAIRANFQKISTLVGDKVKVAAVVKSDAYGLGLVDIARTLIDAGCDLLFVANLDEALLLRSSF
SRVAIAVFRDEFDRFGTWYRSHGLIPVVNNCKELHAVGTAGEPQSYFLNVETGFSRFGLSVGDIQREYLLRTFERYRPSI
VLSHLACGECISDPMNQLQRDRFRTVYDLLKPTRGSLSASAGVWLGKSYHFDMVRVGSALYGIHNAGVQTNPLKPVVKLR
ARILDVRSVPAGEAVGYGATFRTDRASRVAIVGIGYKHGLPWSCANKIFVRLAEYSAPSIGRISMEYMIIDITDVPARRC
SPGTFAELLSEDFTVNDLGAAAGVSPQEALTRLGAGCTRKYLNLFPPSAAFTANRPTEAMSNPSRAKSRPMDKQALI

Sequences:

>Translated_397_residues
MMLSIVRSVDVVLEIDLAAIRANFQKISTLVGDKVKVAAVVKSDAYGLGLVDIARTLIDAGCDLLFVANLDEALLLRSSF
SRVAIAVFRDEFDRFGTWYRSHGLIPVVNNCKELHAVGTAGEPQSYFLNVETGFSRFGLSVGDIQREYLLRTFERYRPSI
VLSHLACGECISDPMNQLQRDRFRTVYDLLKPTRGSLSASAGVWLGKSYHFDMVRVGSALYGIHNAGVQTNPLKPVVKLR
ARILDVRSVPAGEAVGYGATFRTDRASRVAIVGIGYKHGLPWSCANKIFVRLAEYSAPSIGRISMEYMIIDITDVPARRC
SPGTFAELLSEDFTVNDLGAAAGVSPQEALTRLGAGCTRKYLNLFPPSAAFTANRPTEAMSNPSRAKSRPMDKQALI
>Mature_397_residues
MMLSIVRSVDVVLEIDLAAIRANFQKISTLVGDKVKVAAVVKSDAYGLGLVDIARTLIDAGCDLLFVANLDEALLLRSSF
SRVAIAVFRDEFDRFGTWYRSHGLIPVVNNCKELHAVGTAGEPQSYFLNVETGFSRFGLSVGDIQREYLLRTFERYRPSI
VLSHLACGECISDPMNQLQRDRFRTVYDLLKPTRGSLSASAGVWLGKSYHFDMVRVGSALYGIHNAGVQTNPLKPVVKLR
ARILDVRSVPAGEAVGYGATFRTDRASRVAIVGIGYKHGLPWSCANKIFVRLAEYSAPSIGRISMEYMIIDITDVPARRC
SPGTFAELLSEDFTVNDLGAAAGVSPQEALTRLGAGCTRKYLNLFPPSAAFTANRPTEAMSNPSRAKSRPMDKQALI

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=359, Percent_Identity=30.6406685236769, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787439, Length=350, Percent_Identity=28.8571428571429, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR1_RHILO (Q98A05)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106753.1
- ProteinModelPortal:   Q98A05
- GeneID:   1229408
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll6211
- NMPDR:   fig|266835.1.peg.4854
- HOGENOM:   HBG712172
- OMA:   CANSAVF
- ProtClustDB:   CLSK250252
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 43463; Mature: 43463

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 42-42 ACT_SITE 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLSIVRSVDVVLEIDLAAIRANFQKISTLVGDKVKVAAVVKSDAYGLGLVDIARTLIDA
CHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHC
GCDLLFVANLDEALLLRSSFSRVAIAVFRDEFDRFGTWYRSHGLIPVVNNCKELHAVGTA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCC
GEPQSYFLNVETGFSRFGLSVGDIQREYLLRTFERYRPSIVLSHLACGECISDPMNQLQR
CCCCEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
DRFRTVYDLLKPTRGSLSASAGVWLGKSYHFDMVRVGSALYGIHNAGVQTNPLKPVVKLR
HHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
ARILDVRSVPAGEAVGYGATFRTDRASRVAIVGIGYKHGLPWSCANKIFVRLAEYSAPSI
HHHHHHCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
GRISMEYMIIDITDVPARRCSPGTFAELLSEDFTVNDLGAAAGVSPQEALTRLGAGCTRK
CEEEEEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHH
YLNLFPPSAAFTANRPTEAMSNPSRAKSRPMDKQALI
HHHCCCCCCCCCCCCCHHHHCCCHHHHCCCCCHHCCC
>Mature Secondary Structure
MMLSIVRSVDVVLEIDLAAIRANFQKISTLVGDKVKVAAVVKSDAYGLGLVDIARTLIDA
CHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHC
GCDLLFVANLDEALLLRSSFSRVAIAVFRDEFDRFGTWYRSHGLIPVVNNCKELHAVGTA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCC
GEPQSYFLNVETGFSRFGLSVGDIQREYLLRTFERYRPSIVLSHLACGECISDPMNQLQR
CCCCEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
DRFRTVYDLLKPTRGSLSASAGVWLGKSYHFDMVRVGSALYGIHNAGVQTNPLKPVVKLR
HHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
ARILDVRSVPAGEAVGYGATFRTDRASRVAIVGIGYKHGLPWSCANKIFVRLAEYSAPSI
HHHHHHCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
GRISMEYMIIDITDVPARRCSPGTFAELLSEDFTVNDLGAAAGVSPQEALTRLGAGCTRK
CEEEEEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHH
YLNLFPPSAAFTANRPTEAMSNPSRAKSRPMDKQALI
HHHCCCCCCCCCCCCCHHHHCCCHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968