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The map label for this gene is nadC [H]

Identifier: 13474857

GI number: 13474857

Start: 4705346

End: 4706227

Strand: Reverse

Name: nadC [H]

Synonym: mll5833

Alternate gene names: 13474857

Gene position: 4706227-4705346 (Counterclockwise)

Preceding gene: 13474858

Following gene: 13474856

Centisome position: 66.89

GC content: 63.83

Gene sequence:

>882_bases
ATGACTTCACTTGCACCACTTCCCCAGATCATCATGGAGCCCATCGTGCGTTCTGCCCTGCTTGAAGACCTGGGCAGAGC
CGGCGACATCACGAGCGATGCGATCATCCCCGCCGATTGCAAAGCGACGCTGGCGTTGAATGCCCGGCAGGCAGGCGTTG
TTGCCGGGCTCGACTTGGTCATGTTTGCCTTCCTGCTGGTCGATCCCGGGATCAGCATCCAGCTGCGGTGTCCTGAGGGC
GGCAAGGTTTCGGCCGGCCAGACCATCGCGATCGTAAACGGGCCGGCGCGCAGCCTGCTGACGGCGGAGCGGACGGCGCT
CAATTTCTTATGCAAACTCAGCGGCATCGCGACGGCAACGGCTACGCTCGTAAACGCGGTGAGGGGCCATAACGCAAAAA
TCGTGTGCACACGCAAAACGACGCCCGGCCTGCGTGTCCTGGAAAAGTATGCGGTACGAGCGGGCGGCGGTGCCAATCAC
CGCTTCGCGCTCGACGACGCCGTGCTGATCAAGGACAACCACATCGCCATTGCCGGCGATATCCGCACCGCAATCGAGCG
GGCGCGCCGCGCCATCGGTCACATGGTCAAGATCGAGGTCGAGGTCGACAGGCTGGACCAGTTGGAGATCGCGCTTACAG
CGGGCGTCGACGCCGTGCTCCTCGACAACATGTCGGTCGAGGACCTTGCGCAGGCTGTGGCTATGGTCGGTGGCCGCGCG
ATCACCGAGGCTTCGGGCCGGGTGACGCGGGCGAGCGCCCCGGCAATTGCGGCGACCGGCGTCGACCTCATATCGGTCGG
CTGGCTTACCCACAGCGCGCCCATCCTCGACATTGGTCTCGACATGCCGGCCGACCGAAATTGCAACAGGCATCTGAACT
GA

Upstream 100 bases:

>100_bases
GGGCGCGATGCCGCCGCCCTCCCCTCACGATTGACGCTCTGCACAGCTTTTGAGAATGCCGTCACGCTCAGATGGCAAGC
ATCCGAACGGAGCCGTTGAC

Downstream 100 bases:

>100_bases
TGGAGAGGACATGAACCGGGATCGCAGGAACTCCTTTGGTCGCAGGCTAACCTGCGTCAGCACGTCCCAGGTTCCACCAA
CAGCCGACGCAAGCCTTCTC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTSLAPLPQIIMEPIVRSALLEDLGRAGDITSDAIIPADCKATLALNARQAGVVAGLDLVMFAFLLVDPGISIQLRCPEG
GKVSAGQTIAIVNGPARSLLTAERTALNFLCKLSGIATATATLVNAVRGHNAKIVCTRKTTPGLRVLEKYAVRAGGGANH
RFALDDAVLIKDNHIAIAGDIRTAIERARRAIGHMVKIEVEVDRLDQLEIALTAGVDAVLLDNMSVEDLAQAVAMVGGRA
ITEASGRVTRASAPAIAATGVDLISVGWLTHSAPILDIGLDMPADRNCNRHLN

Sequences:

>Translated_293_residues
MTSLAPLPQIIMEPIVRSALLEDLGRAGDITSDAIIPADCKATLALNARQAGVVAGLDLVMFAFLLVDPGISIQLRCPEG
GKVSAGQTIAIVNGPARSLLTAERTALNFLCKLSGIATATATLVNAVRGHNAKIVCTRKTTPGLRVLEKYAVRAGGGANH
RFALDDAVLIKDNHIAIAGDIRTAIERARRAIGHMVKIEVEVDRLDQLEIALTAGVDAVLLDNMSVEDLAQAVAMVGGRA
ITEASGRVTRASAPAIAATGVDLISVGWLTHSAPILDIGLDMPADRNCNRHLN
>Mature_292_residues
TSLAPLPQIIMEPIVRSALLEDLGRAGDITSDAIIPADCKATLALNARQAGVVAGLDLVMFAFLLVDPGISIQLRCPEGG
KVSAGQTIAIVNGPARSLLTAERTALNFLCKLSGIATATATLVNAVRGHNAKIVCTRKTTPGLRVLEKYAVRAGGGANHR
FALDDAVLIKDNHIAIAGDIRTAIERARRAIGHMVKIEVEVDRLDQLEIALTAGVDAVLLDNMSVEDLAQAVAMVGGRAI
TEASGRVTRASAPAIAATGVDLISVGWLTHSAPILDIGLDMPADRNCNRHLN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=281, Percent_Identity=37.7224199288256, Blast_Score=151, Evalue=9e-37,
Organism=Escherichia coli, GI1786299, Length=269, Percent_Identity=41.2639405204461, Blast_Score=171, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=253, Percent_Identity=33.201581027668, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30664; Mature: 30533

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLAPLPQIIMEPIVRSALLEDLGRAGDITSDAIIPADCKATLALNARQAGVVAGLDLV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHH
MFAFLLVDPGISIQLRCPEGGKVSAGQTIAIVNGPARSLLTAERTALNFLCKLSGIATAT
HHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ATLVNAVRGHNAKIVCTRKTTPGLRVLEKYAVRAGGGANHRFALDDAVLIKDNHIAIAGD
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCEEEEHH
IRTAIERARRAIGHMVKIEVEVDRLDQLEIALTAGVDAVLLDNMSVEDLAQAVAMVGGRA
HHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHCCCC
ITEASGRVTRASAPAIAATGVDLISVGWLTHSAPILDIGLDMPADRNCNRHLN
EECCCCCEEECCCCEEEECCCHHEEECHHHCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSLAPLPQIIMEPIVRSALLEDLGRAGDITSDAIIPADCKATLALNARQAGVVAGLDLV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHH
MFAFLLVDPGISIQLRCPEGGKVSAGQTIAIVNGPARSLLTAERTALNFLCKLSGIATAT
HHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ATLVNAVRGHNAKIVCTRKTTPGLRVLEKYAVRAGGGANHRFALDDAVLIKDNHIAIAGD
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCEEEEHH
IRTAIERARRAIGHMVKIEVEVDRLDQLEIALTAGVDAVLLDNMSVEDLAQAVAMVGGRA
HHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHCCCC
ITEASGRVTRASAPAIAATGVDLISVGWLTHSAPILDIGLDMPADRNCNRHLN
EECCCCCEEECCCCEEEECCCHHEEECHHHCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]