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The map label for this gene is dxs [C]

Identifier: 13474796

GI number: 13474796

Start: 4645089

End: 4646111

Strand: Reverse

Name: dxs [C]

Synonym: mll5764

Alternate gene names: 13474796

Gene position: 4646111-4645089 (Counterclockwise)

Preceding gene: 13474797

Following gene: 13474795

Centisome position: 66.03

GC content: 63.15

Gene sequence:

>1023_bases
GTGAGGCAGTCAAAATTCGCGCCGCGCCACGCCGTCAACGCGGGTGAGCGCAAGACCACCTCGGCGATGATCGCCTCGAT
CGCGCCCAATGGCGTTCCGACGCGCAGTGCTCCGTTCGGACACACGCTTGCAAGGCTAGCCCATCAGCGGCCCGGGATCG
TGGGTTTGACGGCTGATCTTGCGAAATACACCGACCTTCATGTGTTCGCACAGGAACATCCGGATCGCTTCTATCAAATG
GGCATGGCCGAGCAGGTGCTGATGAGTGCCGCCGCCGGCCTGGCGCGGGAGGGTTTCACGCCCTTCGCCACGACCTACGC
TGTCTTTGCCTCCCGACGGGCCTACGATTTCATCTGCATGGCGATTGCCGAGGAGAAGCTCGACGTCAAGATCGTCTGCG
CCCTGCCGGGGCTGACCACCGGCTACGGCCCCAGCCACCAGGCGACAGAAGACATCGCGATCTTCCGCGGCATGCCGAAC
CTGACGATCATCGACCCTTGCGACGCGCTCGACATCGAACAGGCCACGGAGGCAATCGCGGACTACAAGGGCCCGGTCTA
CATGCGGCTTTTGCGCGGCAAAGTTCCTGTCGTGCTCGACGAATACGACTACACGTTCGAGATCGGCAAGGCGCGGCTGT
TGCGCGATGGGGCGGACGTGCTGTTCATTTCCAGCGGCCTGATGACCATGCGAGTGCTGGAGGCCGCGAAGGCGCTTGAA
GCAGACCGCATCGACTGCGCGGTGCTGCACGTGCCGACGATCAAACCTCTGGACACGCAGGCGATACTTGATGGCGCGCG
CCGTCCGGGACGGCTGGTGGTGGTGGCGGAGAATCACACCATCATTGGTGGCCTAGGCGAAGGCGTTGCCGCGTTGCTGA
TGCGGGAGGGCGTGGCCCCAGTCTTTCGCCAGATTGCCCTGCCCGACGAGTTCCTCGATGCTGGCGCACTGCTGACGCTT
CATGATCGCTACGGGATCTCATCGTCCGAGCTCGTGCGTCGTGTCCGCAAATGGACAGAGTAA

Upstream 100 bases:

>100_bases
GTGTGCCGTTCCTGGAGGCTCGCGACATCACGCATTTCATCCGCGTCGAGCCCTATGAGTGGGCTCTGGCGCTCGAGGCT
CTGGAAAAGGGACGTCCGCA

Downstream 100 bases:

>100_bases
AAGCAAAGCAGGAGCTCGAGCTAATTCTTCGCGGTCGCATGTCCGCTTTCGGCAACGGGCCAGAATTGGTGTTGATCACC
GACATGCTGCGCAAAGCTGC

Product: transketolase

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRQSKFAPRHAVNAGERKTTSAMIASIAPNGVPTRSAPFGHTLARLAHQRPGIVGLTADLAKYTDLHVFAQEHPDRFYQM
GMAEQVLMSAAAGLAREGFTPFATTYAVFASRRAYDFICMAIAEEKLDVKIVCALPGLTTGYGPSHQATEDIAIFRGMPN
LTIIDPCDALDIEQATEAIADYKGPVYMRLLRGKVPVVLDEYDYTFEIGKARLLRDGADVLFISSGLMTMRVLEAAKALE
ADRIDCAVLHVPTIKPLDTQAILDGARRPGRLVVVAENHTIIGGLGEGVAALLMREGVAPVFRQIALPDEFLDAGALLTL
HDRYGISSSELVRRVRKWTE

Sequences:

>Translated_340_residues
MRQSKFAPRHAVNAGERKTTSAMIASIAPNGVPTRSAPFGHTLARLAHQRPGIVGLTADLAKYTDLHVFAQEHPDRFYQM
GMAEQVLMSAAAGLAREGFTPFATTYAVFASRRAYDFICMAIAEEKLDVKIVCALPGLTTGYGPSHQATEDIAIFRGMPN
LTIIDPCDALDIEQATEAIADYKGPVYMRLLRGKVPVVLDEYDYTFEIGKARLLRDGADVLFISSGLMTMRVLEAAKALE
ADRIDCAVLHVPTIKPLDTQAILDGARRPGRLVVVAENHTIIGGLGEGVAALLMREGVAPVFRQIALPDEFLDAGALLTL
HDRYGISSSELVRRVRKWTE
>Mature_340_residues
MRQSKFAPRHAVNAGERKTTSAMIASIAPNGVPTRSAPFGHTLARLAHQRPGIVGLTADLAKYTDLHVFAQEHPDRFYQM
GMAEQVLMSAAAGLAREGFTPFATTYAVFASRRAYDFICMAIAEEKLDVKIVCALPGLTTGYGPSHQATEDIAIFRGMPN
LTIIDPCDALDIEQATEAIADYKGPVYMRLLRGKVPVVLDEYDYTFEIGKARLLRDGADVLFISSGLMTMRVLEAAKALE
ADRIDCAVLHVPTIKPLDTQAILDGARRPGRLVVVAENHTIIGGLGEGVAALLMREGVAPVFRQIALPDEFLDAGALLTL
HDRYGISSSELVRRVRKWTE

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=269, Percent_Identity=35.3159851301115, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI4507521, Length=269, Percent_Identity=35.3159851301115, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI133778974, Length=300, Percent_Identity=32.6666666666667, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI225637463, Length=312, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI225637461, Length=312, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI225637459, Length=312, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786622, Length=310, Percent_Identity=29.0322580645161, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=312, Percent_Identity=36.8589743589744, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45551847, Length=312, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI45550715, Length=312, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24645119, Length=312, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24666278, Length=302, Percent_Identity=32.7814569536424, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 37062; Mature: 37062

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSKFAPRHAVNAGERKTTSAMIASIAPNGVPTRSAPFGHTLARLAHQRPGIVGLTADL
CCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEHHHH
AKYTDLHVFAQEHPDRFYQMGMAEQVLMSAAAGLAREGFTPFATTYAVFASRRAYDFICM
HHHHHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
AIAEEKLDVKIVCALPGLTTGYGPSHQATEDIAIFRGMPNLTIIDPCDALDIEQATEAIA
HHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHH
DYKGPVYMRLLRGKVPVVLDEYDYTFEIGKARLLRDGADVLFISSGLMTMRVLEAAKALE
HCCCHHHHHHHCCCCCEEECCCCCEEECCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHC
ADRIDCAVLHVPTIKPLDTQAILDGARRPGRLVVVAENHTIIGGLGEGVAALLMREGVAP
CCCCCEEEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHCHHH
VFRQIALPDEFLDAGALLTLHDRYGISSSELVRRVRKWTE
HHHHHCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRQSKFAPRHAVNAGERKTTSAMIASIAPNGVPTRSAPFGHTLARLAHQRPGIVGLTADL
CCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEHHHH
AKYTDLHVFAQEHPDRFYQMGMAEQVLMSAAAGLAREGFTPFATTYAVFASRRAYDFICM
HHHHHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
AIAEEKLDVKIVCALPGLTTGYGPSHQATEDIAIFRGMPNLTIIDPCDALDIEQATEAIA
HHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHH
DYKGPVYMRLLRGKVPVVLDEYDYTFEIGKARLLRDGADVLFISSGLMTMRVLEAAKALE
HCCCHHHHHHHCCCCCEEECCCCCEEECCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHC
ADRIDCAVLHVPTIKPLDTQAILDGARRPGRLVVVAENHTIIGGLGEGVAALLMREGVAP
CCCCCEEEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHCHHH
VFRQIALPDEFLDAGALLTLHDRYGISSSELVRRVRKWTE
HHHHHCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]