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The map label for this gene is udg [H]

Identifier: 13474390

GI number: 13474390

Start: 4194545

End: 4195876

Strand: Direct

Name: udg [H]

Synonym: mlr5265

Alternate gene names: 13474390

Gene position: 4194545-4195876 (Clockwise)

Preceding gene: 13474389

Following gene: 13474391

Centisome position: 59.61

GC content: 61.94

Gene sequence:

>1332_bases
ATGAACTTGACGGTGTTTGGAATTGGCTATGTCGGCCTCGTGCAGGCGGCGGTGCTTGCCGAGGTTGGCCACCAGGTTGT
TTGCGTCGATATCGACGAAAACAAGGTGGAGCGCCTCAACCAGGGCTTCGTCCCGATCTTCGAGCCAGGCCTAGAAAGCC
TCGTCCGGGAGAACCACGCCGCCGGCCGCATCAAATTCACCACCGATGCCGCAGCCGCCGTCCGGCATGGTGAAATCCAG
ATGATCGCGGTCGGCACGCCGCCCGGCGAAGACGGTTCGGCCGACCTCAAATATGTGCTGGCGGTCGCCGAGACCATCGG
CCGTGAAATGGACACCGCCAAGATCGTCGTCGGAAAGTCGACCGTGCCGGTCGGCACCTGCGAAAAGGTGAAGGCCAAGA
TCGCCGAGACGCTGAAGAAGAGAGGGCGTGAAGACCTGAGCTTCGACGTCGCCTCCAATCCCGAATTCCTCAAGGAAGGC
TCGGCCGTGGCCGACTGCATGAGGCCCGACCGTATCATCGTCGGCACTTCGAGCGAGGGGACCGAGGCGGTGATGCGCGA
ACTCTACGCGCCCTTCAACCGCAACCATGAAAAGATGATCGTGATGGACGTGCGCAGCGCCGAATTCACGAAATACGCCG
CCAACTGCATGCTGGCCACCAAGATCAGCTTCATGAACGAGATGGCCAACCTGGCCGAGCAGCTCGGCGCCGACATCGAG
GAGGTGCGCAAGGGCATCGGCAGCGATCCGCGCATCGGCTACCACTTTATCTATCCGGGTCTCGGCTATGGCGGCTCCTG
CTTTCCCAAGGACGTCCGCGCCCTGATCAAGACCGCCGAGGGCGTCAAGTTCGACGCCAAGCTGCTGCGCGCCGTCGAGG
AGCGCAACAACGACCAGAAATCCGTGCTGTTCGACAAGGTGAACCGCTATTTCAAGGGCAGTCTCAAGGGCAAGACCTTT
GCGCTCTGGGGTCTGGCCTTCAAGCCCAACACCGACGACATGCGCGAGGCGCCGGCGCGTGTCCTGATGGAAGCGCTATG
GAAGGCCGGAGCAACCGTGCAGGCCTATGACCCCGAGGCTATGCAGGAATGCCAGGCCATCTACGGCCTGCGCGACGACC
TGCTTTTGTGCGGCACCAAGGAAGCGGCACTGCGCGGCGCCGATGCACTGCTCATCGCCACCGAATGGAAGAGTTTTCGA
GCCCCGTCGTTCGATGCGTTGAAGGACGCGCTGACCACGCCGGTCATCTTCGACGGCCGCAACCTCTATGACCCCAAGGT
CGTGGCGCGTTACGGCATCGAATATCACTCGATCGGCAGAATGGCGGCATGA

Upstream 100 bases:

>100_bases
TTTCCGGAATCGCTCGTATGCAGCGTAAAAGAGTTGGGAAAGACGAATTGAACCGGCCGGATCGAAAACAGGTCGCGGCC
ATGGATGGGAATGAAACCGA

Downstream 100 bases:

>100_bases
GAGCGAGCGCGGGAAGCAAGCGGAGTTTGGCACGCGCGCCCGGCGCGGAAAGGAGTTGCAGCTGATGGTGCTGGACGTAA
AGCCCGAGCAAATCACCAAG

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNLTVFGIGYVGLVQAAVLAEVGHQVVCVDIDENKVERLNQGFVPIFEPGLESLVRENHAAGRIKFTTDAAAAVRHGEIQ
MIAVGTPPGEDGSADLKYVLAVAETIGREMDTAKIVVGKSTVPVGTCEKVKAKIAETLKKRGREDLSFDVASNPEFLKEG
SAVADCMRPDRIIVGTSSEGTEAVMRELYAPFNRNHEKMIVMDVRSAEFTKYAANCMLATKISFMNEMANLAEQLGADIE
EVRKGIGSDPRIGYHFIYPGLGYGGSCFPKDVRALIKTAEGVKFDAKLLRAVEERNNDQKSVLFDKVNRYFKGSLKGKTF
ALWGLAFKPNTDDMREAPARVLMEALWKAGATVQAYDPEAMQECQAIYGLRDDLLLCGTKEAALRGADALLIATEWKSFR
APSFDALKDALTTPVIFDGRNLYDPKVVARYGIEYHSIGRMAA

Sequences:

>Translated_443_residues
MNLTVFGIGYVGLVQAAVLAEVGHQVVCVDIDENKVERLNQGFVPIFEPGLESLVRENHAAGRIKFTTDAAAAVRHGEIQ
MIAVGTPPGEDGSADLKYVLAVAETIGREMDTAKIVVGKSTVPVGTCEKVKAKIAETLKKRGREDLSFDVASNPEFLKEG
SAVADCMRPDRIIVGTSSEGTEAVMRELYAPFNRNHEKMIVMDVRSAEFTKYAANCMLATKISFMNEMANLAEQLGADIE
EVRKGIGSDPRIGYHFIYPGLGYGGSCFPKDVRALIKTAEGVKFDAKLLRAVEERNNDQKSVLFDKVNRYFKGSLKGKTF
ALWGLAFKPNTDDMREAPARVLMEALWKAGATVQAYDPEAMQECQAIYGLRDDLLLCGTKEAALRGADALLIATEWKSFR
APSFDALKDALTTPVIFDGRNLYDPKVVARYGIEYHSIGRMAA
>Mature_443_residues
MNLTVFGIGYVGLVQAAVLAEVGHQVVCVDIDENKVERLNQGFVPIFEPGLESLVRENHAAGRIKFTTDAAAAVRHGEIQ
MIAVGTPPGEDGSADLKYVLAVAETIGREMDTAKIVVGKSTVPVGTCEKVKAKIAETLKKRGREDLSFDVASNPEFLKEG
SAVADCMRPDRIIVGTSSEGTEAVMRELYAPFNRNHEKMIVMDVRSAEFTKYAANCMLATKISFMNEMANLAEQLGADIE
EVRKGIGSDPRIGYHFIYPGLGYGGSCFPKDVRALIKTAEGVKFDAKLLRAVEERNNDQKSVLFDKVNRYFKGSLKGKTF
ALWGLAFKPNTDDMREAPARVLMEALWKAGATVQAYDPEAMQECQAIYGLRDDLLLCGTKEAALRGADALLIATEWKSFR
APSFDALKDALTTPVIFDGRNLYDPKVVARYGIEYHSIGRMAA

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=468, Percent_Identity=32.6923076923077, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI296040438, Length=375, Percent_Identity=33.6, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI296040443, Length=320, Percent_Identity=34.0625, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=30.6629834254144, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI48994968, Length=446, Percent_Identity=28.0269058295964, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560350, Length=460, Percent_Identity=35.4347826086957, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI17136908, Length=473, Percent_Identity=32.1353065539112, Blast_Score=229, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48508; Mature: 48508

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTVFGIGYVGLVQAAVLAEVGHQVVCVDIDENKVERLNQGFVPIFEPGLESLVRENHA
CCEEEEECHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCC
AGRIKFTTDAAAAVRHGEIQMIAVGTPPGEDGSADLKYVLAVAETIGREMDTAKIVVGKS
CCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCC
TVPVGTCEKVKAKIAETLKKRGREDLSFDVASNPEFLKEGSAVADCMRPDRIIVGTSSEG
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHHCCCCEEEEECCCCC
TEAVMRELYAPFNRNHEKMIVMDVRSAEFTKYAANCMLATKISFMNEMANLAEQLGADIE
HHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVRKGIGSDPRIGYHFIYPGLGYGGSCFPKDVRALIKTAEGVKFDAKLLRAVEERNNDQK
HHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
SVLFDKVNRYFKGSLKGKTFALWGLAFKPNTDDMREAPARVLMEALWKAGATVQAYDPEA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHH
MQECQAIYGLRDDLLLCGTKEAALRGADALLIATEWKSFRAPSFDALKDALTTPVIFDGR
HHHHHHHHCCCCCEEEECCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEECCC
NLYDPKVVARYGIEYHSIGRMAA
CCCCCHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure
MNLTVFGIGYVGLVQAAVLAEVGHQVVCVDIDENKVERLNQGFVPIFEPGLESLVRENHA
CCEEEEECHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCC
AGRIKFTTDAAAAVRHGEIQMIAVGTPPGEDGSADLKYVLAVAETIGREMDTAKIVVGKS
CCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCC
TVPVGTCEKVKAKIAETLKKRGREDLSFDVASNPEFLKEGSAVADCMRPDRIIVGTSSEG
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHHCCCCEEEEECCCCC
TEAVMRELYAPFNRNHEKMIVMDVRSAEFTKYAANCMLATKISFMNEMANLAEQLGADIE
HHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVRKGIGSDPRIGYHFIYPGLGYGGSCFPKDVRALIKTAEGVKFDAKLLRAVEERNNDQK
HHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
SVLFDKVNRYFKGSLKGKTFALWGLAFKPNTDDMREAPARVLMEALWKAGATVQAYDPEA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHH
MQECQAIYGLRDDLLLCGTKEAALRGADALLIATEWKSFRAPSFDALKDALTTPVIFDGR
HHHHHHHHCCCCCEEEECCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEECCC
NLYDPKVVARYGIEYHSIGRMAA
CCCCCHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]