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The map label for this gene is purK [H]

Identifier: 13473269

GI number: 13473269

Start: 3058192

End: 3059268

Strand: Direct

Name: purK [H]

Synonym: mlr3811

Alternate gene names: 13473269

Gene position: 3058192-3059268 (Clockwise)

Preceding gene: 13473268

Following gene: 13473271

Centisome position: 43.46

GC content: 65.18

Gene sequence:

>1077_bases
GTGAGCCTGCCCGCCGGATCGACCATCGGCATTATCGGCGGCGGCCAGCTCGGCCGCATGCTGGCAATGGCCGCCGCCCG
CCTCGGTTATCGCACCATCGTGCTGGAGCCGCAGCCGGATTGTCCGGCGGCACAAGTCGCCAACCGGCAGATTACATCAG
CCTATGACGACCCGGCCGCCCTTGCTGAACTGGCGGCGGCAAGTACCGTCGTCACCTACGAGTTCGAGAATGTTCCCGTT
GCCGCCGCAGAAGCGCTTGCCGCCGAGGTTGCAGTCTACCCGCCGGCGCGCGCGCTCGACGTGGCGCAGGACCGGGTGAG
CGAAAAAACATTCCTCAATGGCATCGGCATTGCCACCGCCGATTTTTGTCCGGTCGACACGGACGCGGAACTGACAGCGG
CGCTGAAGAGATTCGGCGGCAGCGGCATCCTGAAGACGCGGCGCATGGGCTATGACGGCAAGGGCCAGCGCGTCTTTCGC
AACATGGAAGCGGGCGGCTTCGCCGGCACTTGCGAGGCGATGGGCAATGTGCCGCTGATCCTGGAAAGCTTTGTCCCCTT
CGAGCGCGAGATCTCGGTGATTGCAGCGCGCGGCTTGGATGGCGCCGTGGCCGCCTACGACCCGGCCGAGAATGTCCACC
GCCACGGCATTCTCCACACCTCGACCCTGCCGGCGGGCGTCAAACTTGAAACGGCTGAAGCGGCACGAACGGCTGCGGCA
AAAATCCTGTCGGCGCTCGATTATGTCGGCGTCATCGGTGTCGAGTTCTTCGTGCTTTCCGACGGTTCGCTGCTGGCCAA
CGAGATTGCGCCGCGCGTCCACAATTCCGGCCATTGGACCGAGGCCGCCTGCATCGTTTCGCAGTTCGAGCAGCATATCC
GCGCGGTTGCTGGCTTGCCGCTGGGCAACCCTGGCCGCCACTCTGATTGCGTGATGGAGAACCTGATCGGCGACGACGTG
CTGCGCGTGCCGGCCCTGCTCGCCGAGCCCGATCTGATGCTGCATCTCTATGGCAAGGCGGAGGCGCGCCCTGGCCGCAA
GATGGGCCATTTCACCCGCATCAGCCGCCGCGTTTAA

Upstream 100 bases:

>100_bases
CCGCCGTGCTGGCGCTCAACGACGACAAGCTTGCCCAGCGCCTCGACGCCTGGCGCGCCTCGCAGACCGCCAAGGTCGCC
GACGAACCGACGGACACGCC

Downstream 100 bases:

>100_bases
TAGCCAGAAGCGACCCTATTGCACCTCGTCGCTGTCCTGGTTGGGACTGGCGCAACTCGCATCGCCTTCCTGGCAATTGG
CCGAGGCGGCGAGTTGCTTG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSLPAGSTIGIIGGGQLGRMLAMAAARLGYRTIVLEPQPDCPAAQVANRQITSAYDDPAALAELAAASTVVTYEFENVPV
AAAEALAAEVAVYPPARALDVAQDRVSEKTFLNGIGIATADFCPVDTDAELTAALKRFGGSGILKTRRMGYDGKGQRVFR
NMEAGGFAGTCEAMGNVPLILESFVPFEREISVIAARGLDGAVAAYDPAENVHRHGILHTSTLPAGVKLETAEAARTAAA
KILSALDYVGVIGVEFFVLSDGSLLANEIAPRVHNSGHWTEAACIVSQFEQHIRAVAGLPLGNPGRHSDCVMENLIGDDV
LRVPALLAEPDLMLHLYGKAEARPGRKMGHFTRISRRV

Sequences:

>Translated_358_residues
MSLPAGSTIGIIGGGQLGRMLAMAAARLGYRTIVLEPQPDCPAAQVANRQITSAYDDPAALAELAAASTVVTYEFENVPV
AAAEALAAEVAVYPPARALDVAQDRVSEKTFLNGIGIATADFCPVDTDAELTAALKRFGGSGILKTRRMGYDGKGQRVFR
NMEAGGFAGTCEAMGNVPLILESFVPFEREISVIAARGLDGAVAAYDPAENVHRHGILHTSTLPAGVKLETAEAARTAAA
KILSALDYVGVIGVEFFVLSDGSLLANEIAPRVHNSGHWTEAACIVSQFEQHIRAVAGLPLGNPGRHSDCVMENLIGDDV
LRVPALLAEPDLMLHLYGKAEARPGRKMGHFTRISRRV
>Mature_357_residues
SLPAGSTIGIIGGGQLGRMLAMAAARLGYRTIVLEPQPDCPAAQVANRQITSAYDDPAALAELAAASTVVTYEFENVPVA
AAEALAAEVAVYPPARALDVAQDRVSEKTFLNGIGIATADFCPVDTDAELTAALKRFGGSGILKTRRMGYDGKGQRVFRN
MEAGGFAGTCEAMGNVPLILESFVPFEREISVIAARGLDGAVAAYDPAENVHRHGILHTSTLPAGVKLETAEAARTAAAK
ILSALDYVGVIGVEFFVLSDGSLLANEIAPRVHNSGHWTEAACIVSQFEQHIRAVAGLPLGNPGRHSDCVMENLIGDDVL
RVPALLAEPDLMLHLYGKAEARPGRKMGHFTRISRRV

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=347, Percent_Identity=36.3112391930836, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1788155, Length=369, Percent_Identity=27.3712737127371, Blast_Score=101, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=366, Percent_Identity=34.4262295081967, Blast_Score=211, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 37781; Mature: 37649

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPAGSTIGIIGGGQLGRMLAMAAARLGYRTIVLEPQPDCPAAQVANRQITSAYDDPAA
CCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCHHHHCCCCHHH
LAELAAASTVVTYEFENVPVAAAEALAAEVAVYPPARALDVAQDRVSEKTFLNGIGIATA
HHHHHHHHEEEEEEECCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
DFCPVDTDAELTAALKRFGGSGILKTRRMGYDGKGQRVFRNMEAGGFAGTCEAMGNVPLI
CCCCCCCCHHHHHHHHHHCCCCCEEHHHCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCH
LESFVPFEREISVIAARGLDGAVAAYDPAENVHRHGILHTSTLPAGVKLETAEAARTAAA
HHHHCCCHHHEEEEEECCCCCCEECCCCHHHHHHCCCEEECCCCCCCEEEHHHHHHHHHH
KILSALDYVGVIGVEFFVLSDGSLLANEIAPRVHNSGHWTEAACIVSQFEQHIRAVAGLP
HHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
LGNPGRHSDCVMENLIGDDVLRVPALLAEPDLMLHLYGKAEARPGRKMGHFTRISRRV
CCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLPAGSTIGIIGGGQLGRMLAMAAARLGYRTIVLEPQPDCPAAQVANRQITSAYDDPAA
CCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCHHHHCCCCHHH
LAELAAASTVVTYEFENVPVAAAEALAAEVAVYPPARALDVAQDRVSEKTFLNGIGIATA
HHHHHHHHEEEEEEECCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
DFCPVDTDAELTAALKRFGGSGILKTRRMGYDGKGQRVFRNMEAGGFAGTCEAMGNVPLI
CCCCCCCCHHHHHHHHHHCCCCCEEHHHCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCH
LESFVPFEREISVIAARGLDGAVAAYDPAENVHRHGILHTSTLPAGVKLETAEAARTAAA
HHHHCCCHHHEEEEEECCCCCCEECCCCHHHHHHCCCEEECCCCCCCEEEHHHHHHHHHH
KILSALDYVGVIGVEFFVLSDGSLLANEIAPRVHNSGHWTEAACIVSQFEQHIRAVAGLP
HHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
LGNPGRHSDCVMENLIGDDVLRVPALLAEPDLMLHLYGKAEARPGRKMGHFTRISRRV
CCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]