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The map label for this gene is mco [H]

Identifier: 13473095

GI number: 13473095

Start: 2889260

End: 2890768

Strand: Reverse

Name: mco [H]

Synonym: mll3586

Alternate gene names: 13473095

Gene position: 2890768-2889260 (Counterclockwise)

Preceding gene: 13473097

Following gene: 13473094

Centisome position: 41.08

GC content: 65.67

Gene sequence:

>1509_bases
ATGCATCGGCGAGGTTTTCTGGCGGCAGGTCTTGCGGCGGTTCTTGTGAGCGAGCGCGCCGTTGCCCAGATGAAGATGGA
CGACATGCCGGGCATGGATATGGGCGGTCACGCGGGCCACGACATGGGCGCCGCGCCGCAAGGCACGGTCGTTGTGCCCG
AGGGCGAGGTGTTGCGCGAATTGCCCCTGCTGGCGAACGAAGCCAGCAGGCCGGGTCTGTTCAAGGCGACGCTGACGGCC
GGGTCCGCTACGGCGCGTTTTGCGAAGGGACTGGACACGCCGATCCTCGCTTACAACGGCACCAGCCCCGGGCCGCTGAT
CGAGGCAGTCGAGGGCGACCGCGTCGAAATCACCTTCGCCAACCGGATCGCGAACGAGGCAAGCACCATCCACTGGCACG
GCATGCCGGTGCCGGCCGATCAGGACGGCAACCCAATGGACCCGGTCGCCACCGGCACCGATCGTACCTACAGTTTCGAT
CTGCCGGAAGCCAGCGCCGGCTCTTATTGGTATCACCCGCATCCGCACGGCAAGACCGCCGAGCAGGTCTATCGTGGCCT
TGCCGGCGCGTTCGTGGTTAAGCCGAAGGCCGATCCGATCCCGGCCGCCTATGGCGATACCGTGCTGGTGTTCACCGACC
TGCGCCTTGCGGCCGATGGCACCTTGCCCGACAACACGATGACGGACCTGATGAACGGGCGCGTCGGCGACCATGTGCTG
GTCAACGGCCAAAAGAATCCCACACTGACGGTGCCCTTTGGCGCGAAGCGGCGCTTCCGGTTCTACAATGCGACCAACGC
GCGCTTTCTGCGGCTCTCCTTCGACGGCGCGTCGATGACAATCATCGGAACGGATGGCGGTCTGCTAGAAGCCCCGGTCG
CGGCCGGCGACATCCTGCTCAGCCCGGCGGAACGGCTTGAACTGGTCGTCTCGTTCGATAAGCCCGGCGCGGCCGCGCTT
ACGACGCTCGACTATGACCGCGGCTGGATGGGTCCCGGGCGACCAGCCGATGCCGGACTGACGCTGCTGACGGTCAATGT
TTCGCAGACCGAGGCGGACCCTGTTCCGCCACTGCCCGACAGGCTGCGGCCGATCGCACAACTCGGCGCCCCGGCCGTCA
GCCGCCGCTTCGTCTTCACCGAAACCATGGCCATGAACGCCAGCGGCATGGAGATGGGCTTCCTGATCAACGGCGCCGCC
TTCGACATGCAGCGCATCGACGTCGTCGCCAAGGCTGGGCAGGTCGAACTCTGGGAGATCGTCAACGAGGCGGACATGGA
TCATCCATTCCATGTGCACGGGACGCAGTTCCAGGTGGTCGAGCACGAACGCGGCGGCAACATATCAAAGCCGGCCTATC
GCGCCTGGAAAGACACCGTCAATGTCGCGCGCGGGGAGGCGGTGCGGCTGCTGCTTCGGCAGGACCGGCCGGGGCCGAGG
ATGTATCACTGCCACATCCTCGAGCACGAGCAGCTCGGCATGATGGGCGTAGTCGACGTGCAGGCATAG

Upstream 100 bases:

>100_bases
GAACCGATCAGGCGGCCCAAACGCCGCATTGACCTGGCCGGCCATCGGCAGTCTCCTAGGGGCGCCCTTGGTGTTCAACG
CCTGATCGAGGAAATGACAG

Downstream 100 bases:

>100_bases
TCCGGCGTGGTGGCGCTCTATGGCGCATTGTTCATCAGTGCCTTCCTCGCCGCAACCGTCCTGCCGGTTTCGTCGGAGGC
TGTGCTCGCTGGCATGATCG

Product: putative periplasmic oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MHRRGFLAAGLAAVLVSERAVAQMKMDDMPGMDMGGHAGHDMGAAPQGTVVVPEGEVLRELPLLANEASRPGLFKATLTA
GSATARFAKGLDTPILAYNGTSPGPLIEAVEGDRVEITFANRIANEASTIHWHGMPVPADQDGNPMDPVATGTDRTYSFD
LPEASAGSYWYHPHPHGKTAEQVYRGLAGAFVVKPKADPIPAAYGDTVLVFTDLRLAADGTLPDNTMTDLMNGRVGDHVL
VNGQKNPTLTVPFGAKRRFRFYNATNARFLRLSFDGASMTIIGTDGGLLEAPVAAGDILLSPAERLELVVSFDKPGAAAL
TTLDYDRGWMGPGRPADAGLTLLTVNVSQTEADPVPPLPDRLRPIAQLGAPAVSRRFVFTETMAMNASGMEMGFLINGAA
FDMQRIDVVAKAGQVELWEIVNEADMDHPFHVHGTQFQVVEHERGGNISKPAYRAWKDTVNVARGEAVRLLLRQDRPGPR
MYHCHILEHEQLGMMGVVDVQA

Sequences:

>Translated_502_residues
MHRRGFLAAGLAAVLVSERAVAQMKMDDMPGMDMGGHAGHDMGAAPQGTVVVPEGEVLRELPLLANEASRPGLFKATLTA
GSATARFAKGLDTPILAYNGTSPGPLIEAVEGDRVEITFANRIANEASTIHWHGMPVPADQDGNPMDPVATGTDRTYSFD
LPEASAGSYWYHPHPHGKTAEQVYRGLAGAFVVKPKADPIPAAYGDTVLVFTDLRLAADGTLPDNTMTDLMNGRVGDHVL
VNGQKNPTLTVPFGAKRRFRFYNATNARFLRLSFDGASMTIIGTDGGLLEAPVAAGDILLSPAERLELVVSFDKPGAAAL
TTLDYDRGWMGPGRPADAGLTLLTVNVSQTEADPVPPLPDRLRPIAQLGAPAVSRRFVFTETMAMNASGMEMGFLINGAA
FDMQRIDVVAKAGQVELWEIVNEADMDHPFHVHGTQFQVVEHERGGNISKPAYRAWKDTVNVARGEAVRLLLRQDRPGPR
MYHCHILEHEQLGMMGVVDVQA
>Mature_502_residues
MHRRGFLAAGLAAVLVSERAVAQMKMDDMPGMDMGGHAGHDMGAAPQGTVVVPEGEVLRELPLLANEASRPGLFKATLTA
GSATARFAKGLDTPILAYNGTSPGPLIEAVEGDRVEITFANRIANEASTIHWHGMPVPADQDGNPMDPVATGTDRTYSFD
LPEASAGSYWYHPHPHGKTAEQVYRGLAGAFVVKPKADPIPAAYGDTVLVFTDLRLAADGTLPDNTMTDLMNGRVGDHVL
VNGQKNPTLTVPFGAKRRFRFYNATNARFLRLSFDGASMTIIGTDGGLLEAPVAAGDILLSPAERLELVVSFDKPGAAAL
TTLDYDRGWMGPGRPADAGLTLLTVNVSQTEADPVPPLPDRLRPIAQLGAPAVSRRFVFTETMAMNASGMEMGFLINGAA
FDMQRIDVVAKAGQVELWEIVNEADMDHPFHVHGTQFQVVEHERGGNISKPAYRAWKDTVNVARGEAVRLLLRQDRPGPR
MYHCHILEHEQLGMMGVVDVQA

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=487, Percent_Identity=30.8008213552361, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1789394, Length=474, Percent_Identity=31.0126582278481, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323703, Length=476, Percent_Identity=24.1596638655462, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=263, Percent_Identity=24.3346007604563, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859919, Length=257, Percent_Identity=31.1284046692607, Blast_Score=89, Evalue=9e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 53996; Mature: 53996

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRRGFLAAGLAAVLVSERAVAQMKMDDMPGMDMGGHAGHDMGAAPQGTVVVPEGEVLRE
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHH
LPLLANEASRPGLFKATLTAGSATARFAKGLDTPILAYNGTSPGPLIEAVEGDRVEITFA
CCHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEH
NRIANEASTIHWHGMPVPADQDGNPMDPVATGTDRTYSFDLPEASAGSYWYHPHPHGKTA
HHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCH
EQVYRGLAGAFVVKPKADPIPAAYGDTVLVFTDLRLAADGTLPDNTMTDLMNGRVGDHVL
HHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCHHHHHHCCCCCCEEE
VNGQKNPTLTVPFGAKRRFRFYNATNARFLRLSFDGASMTIIGTDGGLLEAPVAAGDILL
ECCCCCCEEEEECCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCEEECCCCCCCEEE
SPAERLELVVSFDKPGAAALTTLDYDRGWMGPGRPADAGLTLLTVNVSQTEADPVPPLPD
CCHHHEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHH
RLRPIAQLGAPAVSRRFVFTETMAMNASGMEMGFLINGAAFDMQRIDVVAKAGQVELWEI
HHHHHHHHCCCHHHCEEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEHHH
VNEADMDHPFHVHGTQFQVVEHERGGNISKPAYRAWKDTVNVARGEAVRLLLRQDRPGPR
HHHCCCCCCEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCCCCC
MYHCHILEHEQLGMMGVVDVQA
EEEEEEECCCCCCCEEEEEECC
>Mature Secondary Structure
MHRRGFLAAGLAAVLVSERAVAQMKMDDMPGMDMGGHAGHDMGAAPQGTVVVPEGEVLRE
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHH
LPLLANEASRPGLFKATLTAGSATARFAKGLDTPILAYNGTSPGPLIEAVEGDRVEITFA
CCHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEH
NRIANEASTIHWHGMPVPADQDGNPMDPVATGTDRTYSFDLPEASAGSYWYHPHPHGKTA
HHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCH
EQVYRGLAGAFVVKPKADPIPAAYGDTVLVFTDLRLAADGTLPDNTMTDLMNGRVGDHVL
HHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCHHHHHHCCCCCCEEE
VNGQKNPTLTVPFGAKRRFRFYNATNARFLRLSFDGASMTIIGTDGGLLEAPVAAGDILL
ECCCCCCEEEEECCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCEEECCCCCCCEEE
SPAERLELVVSFDKPGAAALTTLDYDRGWMGPGRPADAGLTLLTVNVSQTEADPVPPLPD
CCHHHEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHH
RLRPIAQLGAPAVSRRFVFTETMAMNASGMEMGFLINGAAFDMQRIDVVAKAGQVELWEI
HHHHHHHHCCCHHHCEEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEHHH
VNEADMDHPFHVHGTQFQVVEHERGGNISKPAYRAWKDTVNVARGEAVRLLLRQDRPGPR
HHHCCCCCCEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCCCCC
MYHCHILEHEQLGMMGVVDVQA
EEEEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]