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The map label for this gene is hemH

Identifier: 13472652

GI number: 13472652

Start: 2422345

End: 2423406

Strand: Direct

Name: hemH

Synonym: mlr3019

Alternate gene names: 13472652

Gene position: 2422345-2423406 (Clockwise)

Preceding gene: 13472651

Following gene: 13472653

Centisome position: 34.43

GC content: 62.05

Gene sequence:

>1062_bases
ATGACGTCTGCCATCGCTGTCGATCCCAAAGCCGCCAAGCCGGTTGGCGTGACGGCGGGGCACGCACCGGCCGGGGCCGG
CAAGGTCGGCGTCCTGCTGGTCAATCTCGGCACGCCTGACGGCACCGAGTTCAAGCCGATGTGGCGATATCTCAGGGAAT
TCCTGTCCGATCCGCGTGTCATCGAGCTCAACAAGGCGATCTGGTATCCGATCCTCTACGGCCTGGTGCTTACTACGCGG
CCGAAGAAGTCGGGCGCCAACTATGCCCGGATCTGGAACCAGGAGAGGAACGAGTCGCCGCTGCGCACCTACACGCGCGC
GCAGTCTGAAAAGCTGGCCGAGGCGCTGGGCGACCTGCCCGATGTCACCGTCGATTGGGCCATGCGCTACGGCAACCCTT
CGACGGCGAGCGTCGCCGAAAGACTGGTCGCGCAAGGCTGCGACCGCATTCTTTCGTTTCCGCTCTATCCGCAATACTCC
GCAACAACGACGGCCACCGCCAACGACCAGTTGTTTCGCGCGCTGATGAAGCTGCGCCGCGCGCCGGCCATCCGCAGCGT
GCCGCCCTATTATGCCGAGCCCGTTTACATCGAAGCGCTCGCCAGTTCGATCGAACGGCATCTGGCAACGCTCGATTTCG
AGCCGGAAGTGGTCATCACCTCCTACCACGGCATCCCGAAACCCTATTCCGACAAGGGCGATCCCTATCAGGCGCATTGC
CTGGAAACGACGCGGCTGCTGCGCGAAAAACTTGGTTGGGATGAGAAGAAGCTGATCACCACCTTCCAGTCTCGCTTCGG
CGCACAGGAATGGCTGCAGCCCTACACCGACAAGACCGTGGAGAAGCTGGGCAAGGACGGAGTGAAATCGATCGCCATCG
TCAATCCCGGTTTTTCAGTCGACTGCATCGAGACGCTAGACGAAATCGGCCGCGAGGCCGCCGAGACCTTTCATCACGCC
GGGGGCAAGAATTTCGCTCACATCCCTTGTCTCAACGACAGCGCCGAAGGCATGACGGTGATCGAGGCGATGGTGCGGCG
CGAACTGTCCGGCTGGGTCTAG

Upstream 100 bases:

>100_bases
AACCGGGCGGGTTTTGCGTTTTCGGGCTAAGGTGCGGCCAGACGCGGCATTGAAAACCGGCGCGCCTTCGCTAGTTTCAC
GCCGTGCCCGGAGAACCCTT

Downstream 100 bases:

>100_bases
GAGAAATTCCAGGAAAAGTGTGAAACGGTTTTCCCGGGAAAAGCGCACAGCGCTTTCCCTTGGGAATTTCGTCAACCAAA
GAGTCGTCAACCAAAGAGTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTSAIAVDPKAAKPVGVTAGHAPAGAGKVGVLLVNLGTPDGTEFKPMWRYLREFLSDPRVIELNKAIWYPILYGLVLTTR
PKKSGANYARIWNQERNESPLRTYTRAQSEKLAEALGDLPDVTVDWAMRYGNPSTASVAERLVAQGCDRILSFPLYPQYS
ATTTATANDQLFRALMKLRRAPAIRSVPPYYAEPVYIEALASSIERHLATLDFEPEVVITSYHGIPKPYSDKGDPYQAHC
LETTRLLREKLGWDEKKLITTFQSRFGAQEWLQPYTDKTVEKLGKDGVKSIAIVNPGFSVDCIETLDEIGREAAETFHHA
GGKNFAHIPCLNDSAEGMTVIEAMVRRELSGWV

Sequences:

>Translated_353_residues
MTSAIAVDPKAAKPVGVTAGHAPAGAGKVGVLLVNLGTPDGTEFKPMWRYLREFLSDPRVIELNKAIWYPILYGLVLTTR
PKKSGANYARIWNQERNESPLRTYTRAQSEKLAEALGDLPDVTVDWAMRYGNPSTASVAERLVAQGCDRILSFPLYPQYS
ATTTATANDQLFRALMKLRRAPAIRSVPPYYAEPVYIEALASSIERHLATLDFEPEVVITSYHGIPKPYSDKGDPYQAHC
LETTRLLREKLGWDEKKLITTFQSRFGAQEWLQPYTDKTVEKLGKDGVKSIAIVNPGFSVDCIETLDEIGREAAETFHHA
GGKNFAHIPCLNDSAEGMTVIEAMVRRELSGWV
>Mature_352_residues
TSAIAVDPKAAKPVGVTAGHAPAGAGKVGVLLVNLGTPDGTEFKPMWRYLREFLSDPRVIELNKAIWYPILYGLVLTTRP
KKSGANYARIWNQERNESPLRTYTRAQSEKLAEALGDLPDVTVDWAMRYGNPSTASVAERLVAQGCDRILSFPLYPQYSA
TTTATANDQLFRALMKLRRAPAIRSVPPYYAEPVYIEALASSIERHLATLDFEPEVVITSYHGIPKPYSDKGDPYQAHCL
ETTRLLREKLGWDEKKLITTFQSRFGAQEWLQPYTDKTVEKLGKDGVKSIAIVNPGFSVDCIETLDEIGREAAETFHHAG
GKNFAHIPCLNDSAEGMTVIEAMVRRELSGWV

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=245, Percent_Identity=27.7551020408163, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI60499021, Length=245, Percent_Identity=27.7551020408163, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=41.8238993710692, Blast_Score=247, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6324750, Length=291, Percent_Identity=25.085910652921, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17864156, Length=300, Percent_Identity=23.6666666666667, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_RHILO (Q98H61)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104219.1
- ProteinModelPortal:   Q98H61
- SMR:   Q98H61
- GeneID:   1226880
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr3019
- NMPDR:   fig|266835.1.peg.2323
- HOGENOM:   HBG697135
- OMA:   IRPAKSA
- ProtClustDB:   PRK00035
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 39201; Mature: 39070

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAIAVDPKAAKPVGVTAGHAPAGAGKVGVLLVNLGTPDGTEFKPMWRYLREFLSDPRV
CCCCEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
IELNKAIWYPILYGLVLTTRPKKSGANYARIWNQERNESPLRTYTRAQSEKLAEALGDLP
EEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
DVTVDWAMRYGNPSTASVAERLVAQGCDRILSFPLYPQYSATTTATANDQLFRALMKLRR
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
APAIRSVPPYYAEPVYIEALASSIERHLATLDFEPEVVITSYHGIPKPYSDKGDPYQAHC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHH
LETTRLLREKLGWDEKKLITTFQSRFGAQEWLQPYTDKTVEKLGKDGVKSIAIVNPGFSV
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
DCIETLDEIGREAAETFHHAGGKNFAHIPCLNDSAEGMTVIEAMVRRELSGWV
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSAIAVDPKAAKPVGVTAGHAPAGAGKVGVLLVNLGTPDGTEFKPMWRYLREFLSDPRV
CCCEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
IELNKAIWYPILYGLVLTTRPKKSGANYARIWNQERNESPLRTYTRAQSEKLAEALGDLP
EEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
DVTVDWAMRYGNPSTASVAERLVAQGCDRILSFPLYPQYSATTTATANDQLFRALMKLRR
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
APAIRSVPPYYAEPVYIEALASSIERHLATLDFEPEVVITSYHGIPKPYSDKGDPYQAHC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHH
LETTRLLREKLGWDEKKLITTFQSRFGAQEWLQPYTDKTVEKLGKDGVKSIAIVNPGFSV
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
DCIETLDEIGREAAETFHHAGGKNFAHIPCLNDSAEGMTVIEAMVRRELSGWV
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968