Click here to switch to the map view.

The map label for this gene is flhA [H]

Identifier: 13472610

GI number: 13472610

Start: 2379913

End: 2382000

Strand: Direct

Name: flhA [H]

Synonym: mlr2957

Alternate gene names: 13472610

Gene position: 2379913-2382000 (Clockwise)

Preceding gene: 13472599

Following gene: 13472611

Centisome position: 33.82

GC content: 63.75

Gene sequence:

>2088_bases
ATGGCGATCAGCGAAAGCATCCAGCCCGGCGCGGTGGCCAAGAATGGCCGCGACATCTTCTTCGCGCTCGGCATCGTCAT
CATCCTGGCCGTGCTGTTCCTGCCGATCCCGGCCTTCCTCATCGACATCGGCCTCGCCTTCTCGATCGCGCTGTCGGTGC
TGATCCTGATGGTGGCGCTGTGGATCCAGCGGCCGCTCGATTTCTCCTCGTTCCCGACCGTGCTGCTCATCGCCACGATG
CTGCGGCTGTCCCTCAACATCGCCACCACGCGCATGATCCTGTCGCATGGCAATGAGGGCACGCACGCCGCCGGTTATGT
CATTGCAGGCTTCTCCAAGCTGGTGATGGCCAGCGACTTCGTCATCGGCCTCATCGTCTTCATGATCCTGATCGTGGTAA
ACTTCATCGTCATCACCAAGGGCGCCACGCGTATCGCCGAAGTCGGCGCCCGTTTCACCCTCGACGCCATCCCCGGCAAG
CAGATGTCGATCGACGCCGACCTCTCCGCCGGCATGATCGACGACAAGACCGCGCAATTGCGCCGCCGCGAACTGGAAGA
AGAATCCTCCTTCTTCGGCTCGATGGACGGTGCCTCGAAATTCGTGCGCGGCGACGCCATCGCCGGCCTCATCATCACCG
CCATCAACATCATCGGCGGCATCGCCATCGGCTACATCAGGCATGGCATGGGCATGGGCGAGGCCGCCGACGTGTTCATC
AAGCTGTCGGTCGGCGACGGTCTGGTCACCCAGATCCCGGCGCTGATCGTTTCGCTCGCCGCCGGCCTGCTGGTTTCCAA
GGGCGGCACCCGCGGCTCGACCAACCAGGCGGTGTTCGGCCAGCTCGGCGCCCATCCGCGCGCGCTTTACGTGGCGGCGG
CACTGCTGGTGCTGCTCGGCCTGATGCCCGGCCTGCCGCTGTTCCCCTTCTTTGCGCTGGCCGGCGGCATGGCCGGCCTC
GGCTACGTCATCCCGATGCGCGCCAACCGCGTCCTCGCCGCGGCCGAGGCGCTGAAGACCCAGGAAAAGGCGACCAAGGC
CGAGGAAGAAAAGAACTCGGTCAAGGCCTCGCTCGCCACCGCCGAGATCGAACTGCTGATCGGCAAGCAGCTATCGACCA
GGCTCCTGGTCTCGCATCAGGAACTGGTCTTCCGCATGGGCAAGATGCGCAAGAAATTCGCGCAGCAATACGGCTTCGTC
GTGCCGGAAGTGCGCGTTGCCGACGATTTCGCCATCCCTCCGAAAAGCTACCAGATCAAGGTGCATGGCACGGTGGTCGC
CGAATATTCGATGCGCGTCGGCGAGATCATGGTGCTGCTCGGCAGCCGCGACGTGCCCGAAATTCCGGGCGAGGAGATCC
GCGAGCCGGCCTTCGGCATGCGCGCCTATTCCGTCATGGAAACTTTCGCCGAGGATTTGAAGCGCGAGAACTACACCTTC
GCCGACAACATGTCGGTGCTGCTCACCCATCTCTCGGAAGTCATCCGCAACAACCTGCCGCAGCTTCTGTCCTACAAGGA
CATGAAGGCGCTGCTCGAACGCCAGGACCAGGAATACCGCAAGCTCGCCGACGAGATCTGCACCACGCACATCTCGTATC
CCGGCCTGCAGGCGGTGCTGAAGCTGCTGCTCGCCGAGCGCGTCTCGATCCGCAATCTGCACCTGATCATCGAGGCCATC
GCCGAGATCGCGCCGCATGTGCGCCGCACCGAGCAGATCGTCGAACATGTCCGCATCCGCATGGCCCAGCAGATCTGCGG
CGATCTCTCGGAAGGCGGCGTGCTCAAGGTGCTGCGCCTCGGCAACCGCTGGGACCTCGCCTTCCATCAAAGCCTCAAGC
GCGACGCCAAGGGCGAGGTGCGCGAGTTCGACATTGATCCGCGCCAGCTCGAGGAATTCGGCCAGGACGCCACCAAGGCG
ATCAAGAAATTCCTCGAAGCCGGCGAGCGCTTCGTCCTCGTCACCGCGCCCGACGCCCGCCCCTATGTGCGCATGATCAT
CGAGCGCCTGTTCACCACGCTGCCGGTGCTCTCCCATGTCGAAATCGCCAAGGGCGTCGAGATCAGGGTGCTCGGGACCA
TATCGTGA

Upstream 100 bases:

>100_bases
ACGACATGCATAAAACAAAGTCTCCCACCCTCGCGCAAGCTTGGCCAACTACCCTCGCCGGGCTGTCCTATGCGCGACAG
TCTATGGTTCGAGGACTTAT

Downstream 100 bases:

>100_bases
GCGTTCTTTCGCAGAGCGTCGTCATCGCGGCGTTCCTCGCCTTCTGCCGCATCGGCGCCTGCTTCATGCTGATGCCGGGC
CTGTCCAGCGCCCGTGTGCC

Product: flagellar biosynthesis protein FlhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MAISESIQPGAVAKNGRDIFFALGIVIILAVLFLPIPAFLIDIGLAFSIALSVLILMVALWIQRPLDFSSFPTVLLIATM
LRLSLNIATTRMILSHGNEGTHAAGYVIAGFSKLVMASDFVIGLIVFMILIVVNFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGMIDDKTAQLRRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINIIGGIAIGYIRHGMGMGEAADVFI
KLSVGDGLVTQIPALIVSLAAGLLVSKGGTRGSTNQAVFGQLGAHPRALYVAAALLVLLGLMPGLPLFPFFALAGGMAGL
GYVIPMRANRVLAAAEALKTQEKATKAEEEKNSVKASLATAEIELLIGKQLSTRLLVSHQELVFRMGKMRKKFAQQYGFV
VPEVRVADDFAIPPKSYQIKVHGTVVAEYSMRVGEIMVLLGSRDVPEIPGEEIREPAFGMRAYSVMETFAEDLKRENYTF
ADNMSVLLTHLSEVIRNNLPQLLSYKDMKALLERQDQEYRKLADEICTTHISYPGLQAVLKLLLAERVSIRNLHLIIEAI
AEIAPHVRRTEQIVEHVRIRMAQQICGDLSEGGVLKVLRLGNRWDLAFHQSLKRDAKGEVREFDIDPRQLEEFGQDATKA
IKKFLEAGERFVLVTAPDARPYVRMIIERLFTTLPVLSHVEIAKGVEIRVLGTIS

Sequences:

>Translated_695_residues
MAISESIQPGAVAKNGRDIFFALGIVIILAVLFLPIPAFLIDIGLAFSIALSVLILMVALWIQRPLDFSSFPTVLLIATM
LRLSLNIATTRMILSHGNEGTHAAGYVIAGFSKLVMASDFVIGLIVFMILIVVNFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGMIDDKTAQLRRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINIIGGIAIGYIRHGMGMGEAADVFI
KLSVGDGLVTQIPALIVSLAAGLLVSKGGTRGSTNQAVFGQLGAHPRALYVAAALLVLLGLMPGLPLFPFFALAGGMAGL
GYVIPMRANRVLAAAEALKTQEKATKAEEEKNSVKASLATAEIELLIGKQLSTRLLVSHQELVFRMGKMRKKFAQQYGFV
VPEVRVADDFAIPPKSYQIKVHGTVVAEYSMRVGEIMVLLGSRDVPEIPGEEIREPAFGMRAYSVMETFAEDLKRENYTF
ADNMSVLLTHLSEVIRNNLPQLLSYKDMKALLERQDQEYRKLADEICTTHISYPGLQAVLKLLLAERVSIRNLHLIIEAI
AEIAPHVRRTEQIVEHVRIRMAQQICGDLSEGGVLKVLRLGNRWDLAFHQSLKRDAKGEVREFDIDPRQLEEFGQDATKA
IKKFLEAGERFVLVTAPDARPYVRMIIERLFTTLPVLSHVEIAKGVEIRVLGTIS
>Mature_694_residues
AISESIQPGAVAKNGRDIFFALGIVIILAVLFLPIPAFLIDIGLAFSIALSVLILMVALWIQRPLDFSSFPTVLLIATML
RLSLNIATTRMILSHGNEGTHAAGYVIAGFSKLVMASDFVIGLIVFMILIVVNFIVITKGATRIAEVGARFTLDAIPGKQ
MSIDADLSAGMIDDKTAQLRRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINIIGGIAIGYIRHGMGMGEAADVFIK
LSVGDGLVTQIPALIVSLAAGLLVSKGGTRGSTNQAVFGQLGAHPRALYVAAALLVLLGLMPGLPLFPFFALAGGMAGLG
YVIPMRANRVLAAAEALKTQEKATKAEEEKNSVKASLATAEIELLIGKQLSTRLLVSHQELVFRMGKMRKKFAQQYGFVV
PEVRVADDFAIPPKSYQIKVHGTVVAEYSMRVGEIMVLLGSRDVPEIPGEEIREPAFGMRAYSVMETFAEDLKRENYTFA
DNMSVLLTHLSEVIRNNLPQLLSYKDMKALLERQDQEYRKLADEICTTHISYPGLQAVLKLLLAERVSIRNLHLIIEAIA
EIAPHVRRTEQIVEHVRIRMAQQICGDLSEGGVLKVLRLGNRWDLAFHQSLKRDAKGEVREFDIDPRQLEEFGQDATKAI
KKFLEAGERFVLVTAPDARPYVRMIIERLFTTLPVLSHVEIAKGVEIRVLGTIS

Specific function: Required for formation of the rod structure of the flagellar apparatus. May constitute the export apparatus of flagellin. The flagellum is required to cause a persistent disease in a murine model of infection [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=676, Percent_Identity=37.2781065088757, Blast_Score=423, Evalue=1e-119,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006301
- InterPro:   IPR001712 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 76011; Mature: 75879

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISESIQPGAVAKNGRDIFFALGIVIILAVLFLPIPAFLIDIGLAFSIALSVLILMVAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIQRPLDFSSFPTVLLIATMLRLSLNIATTRMILSHGNEGTHAAGYVIAGFSKLVMASDF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VIGLIVFMILIVVNFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGMIDDKTAQL
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCCHHHHH
RRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINIIGGIAIGYIRHGMGMGEAADVFI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
KLSVGDGLVTQIPALIVSLAAGLLVSKGGTRGSTNQAVFGQLGAHPRALYVAAALLVLLG
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
LMPGLPLFPFFALAGGMAGLGYVIPMRANRVLAAAEALKTQEKATKAEEEKNSVKASLAT
HCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEIELLIGKQLSTRLLVSHQELVFRMGKMRKKFAQQYGFVVPEVRVADDFAIPPKSYQIK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEE
VHGTVVAEYSMRVGEIMVLLGSRDVPEIPGEEIREPAFGMRAYSVMETFAEDLKRENYTF
EEEEEEEHHHHHHHHHEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
ADNMSVLLTHLSEVIRNNLPQLLSYKDMKALLERQDQEYRKLADEICTTHISYPGLQAVL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
KLLLAERVSIRNLHLIIEAIAEIAPHVRRTEQIVEHVRIRMAQQICGDLSEGGVLKVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHC
GNRWDLAFHQSLKRDAKGEVREFDIDPRQLEEFGQDATKAIKKFLEAGERFVLVTAPDAR
CCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCC
PYVRMIIERLFTTLPVLSHVEIAKGVEIRVLGTIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure 
AISESIQPGAVAKNGRDIFFALGIVIILAVLFLPIPAFLIDIGLAFSIALSVLILMVAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIQRPLDFSSFPTVLLIATMLRLSLNIATTRMILSHGNEGTHAAGYVIAGFSKLVMASDF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VIGLIVFMILIVVNFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGMIDDKTAQL
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCCHHHHH
RRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINIIGGIAIGYIRHGMGMGEAADVFI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
KLSVGDGLVTQIPALIVSLAAGLLVSKGGTRGSTNQAVFGQLGAHPRALYVAAALLVLLG
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
LMPGLPLFPFFALAGGMAGLGYVIPMRANRVLAAAEALKTQEKATKAEEEKNSVKASLAT
HCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEIELLIGKQLSTRLLVSHQELVFRMGKMRKKFAQQYGFVVPEVRVADDFAIPPKSYQIK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEE
VHGTVVAEYSMRVGEIMVLLGSRDVPEIPGEEIREPAFGMRAYSVMETFAEDLKRENYTF
EEEEEEEHHHHHHHHHEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
ADNMSVLLTHLSEVIRNNLPQLLSYKDMKALLERQDQEYRKLADEICTTHISYPGLQAVL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
KLLLAERVSIRNLHLIIEAIAEIAPHVRRTEQIVEHVRIRMAQQICGDLSEGGVLKVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHC
GNRWDLAFHQSLKRDAKGEVREFDIDPRQLEEFGQDATKAIKKFLEAGERFVLVTAPDAR
CCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCC
PYVRMIIERLFTTLPVLSHVEIAKGVEIRVLGTIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]