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The map label for this gene is aphA [H]

Identifier: 13472559

GI number: 13472559

Start: 2331992

End: 2333023

Strand: Direct

Name: aphA [H]

Synonym: mlr2893

Alternate gene names: 13472559

Gene position: 2331992-2333023 (Clockwise)

Preceding gene: 13472558

Following gene: 13472561

Centisome position: 33.14

GC content: 65.21

Gene sequence:

>1032_bases
ATGAAGACTGTCTATTCGCCGCTTCATGCTGGCCATGCCGGCCAGATGGAACTGGTCACCTCAGCCATCGTGCCGGGTTT
TGAAAAGCCCTCGCGGGCCGAATTCATCAAGGCACGGGTCGAAAGCGAGAACCTCGGTCCGATCGTCCTGCCGCTCGAGC
ACGACCTTGCCGCCGCCAAGCGCATCCACAAATCAGACTATGTCGACTTCCTGCCGACGGTCTGGCCGCAATGGGTGGCC
TCCGGTCACGAGGGCACGGCCATGCCCTTCACCTGGCCGACGCGCGGCCTGCGCGGCGACGTGCCGCCAAAGCGCGTCGA
CGCGCTGCTCGGCTACTATTCCTTCGACGCCGGCGCCACCTTCGTCGAAGGCACCTGGGCCGCGATCAAATCGTCCTATG
ACGTGGCGCTGACCGCGGCCGGCCTGGTCAAGGGCGGCGAGAGGTCGGCCTTCGCGCTCTGCCGCCCGCCGGGCCACCAT
GCCGGCGCCGGCTTCATGGGCGGCTACTGCTACATCAACAACGCCGCCGTCGCCGCGCAGTGGTTCCTCGACCAGGGCGC
CAAACGCATCTCCATCCTCGATGTCGACTACCACCATGGCAACGGCACGCAGGAAATCTTCTACGACCGCGCCGACGTGC
AGGTCCTCAACCTGCATGGTGATCCCCTGGTCGAATACCCGTTCTTCCTCGGCCATGCCGATGAACGCGGCGCGGGCGAC
GGCGAAGGCTTCAACATCAACTATCCCATGCCGTTCGGCACCGACTGGGACGCCTGGAACGCCTCGCTGGAGGATGCCTG
CGGCAAGCTCGCCGCCTACGCGCCCGACATCGTCATCGTCTCGCTCGGCGTCGACACCTTCGAGAAGGACCCGATCAGCC
AGTTCAAGCTGACAAGCCCTGACTATCCCAAGATCGGCCGCCGCATCGCCAAGCTCGGCCTGCCGACCTTGTTCGTCATG
GAAGGCGGCTATGCCGTCGAGGAGATCGGCATCAACGCCGTCGGCGTGCTGACCGGTTTCGAGGACCGCTAG

Upstream 100 bases:

>100_bases
AGGACATACAACCTCATCGAGGACGATGTCGAAGCCATGTGGCTCGCCCTTGTGAACCCCTATCTCAACCTTGACTGATT
GCGCATTTCGAGAGGAATTT

Downstream 100 bases:

>100_bases
GCCTGCTCGCAAACCCAGAGCGGAAAAAAGGGCGGCATATCAGCCCTTTTTTGCAAACTATGTTGCGGTGCCGGTGCTCG
GCGTGGCCATCGGTGCGGCT

Product: acetylpolyamine aminohydolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKTVYSPLHAGHAGQMELVTSAIVPGFEKPSRAEFIKARVESENLGPIVLPLEHDLAAAKRIHKSDYVDFLPTVWPQWVA
SGHEGTAMPFTWPTRGLRGDVPPKRVDALLGYYSFDAGATFVEGTWAAIKSSYDVALTAAGLVKGGERSAFALCRPPGHH
AGAGFMGGYCYINNAAVAAQWFLDQGAKRISILDVDYHHGNGTQEIFYDRADVQVLNLHGDPLVEYPFFLGHADERGAGD
GEGFNINYPMPFGTDWDAWNASLEDACGKLAAYAPDIVIVSLGVDTFEKDPISQFKLTSPDYPKIGRRIAKLGLPTLFVM
EGGYAVEEIGINAVGVLTGFEDR

Sequences:

>Translated_343_residues
MKTVYSPLHAGHAGQMELVTSAIVPGFEKPSRAEFIKARVESENLGPIVLPLEHDLAAAKRIHKSDYVDFLPTVWPQWVA
SGHEGTAMPFTWPTRGLRGDVPPKRVDALLGYYSFDAGATFVEGTWAAIKSSYDVALTAAGLVKGGERSAFALCRPPGHH
AGAGFMGGYCYINNAAVAAQWFLDQGAKRISILDVDYHHGNGTQEIFYDRADVQVLNLHGDPLVEYPFFLGHADERGAGD
GEGFNINYPMPFGTDWDAWNASLEDACGKLAAYAPDIVIVSLGVDTFEKDPISQFKLTSPDYPKIGRRIAKLGLPTLFVM
EGGYAVEEIGINAVGVLTGFEDR
>Mature_343_residues
MKTVYSPLHAGHAGQMELVTSAIVPGFEKPSRAEFIKARVESENLGPIVLPLEHDLAAAKRIHKSDYVDFLPTVWPQWVA
SGHEGTAMPFTWPTRGLRGDVPPKRVDALLGYYSFDAGATFVEGTWAAIKSSYDVALTAAGLVKGGERSAFALCRPPGHH
AGAGFMGGYCYINNAAVAAQWFLDQGAKRISILDVDYHHGNGTQEIFYDRADVQVLNLHGDPLVEYPFFLGHADERGAGD
GEGFNINYPMPFGTDWDAWNASLEDACGKLAAYAPDIVIVSLGVDTFEKDPISQFKLTSPDYPKIGRRIAKLGLPTLFVM
EGGYAVEEIGINAVGVLTGFEDR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795202, Length=202, Percent_Identity=32.1782178217822, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI30795204, Length=211, Percent_Identity=31.2796208530806, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI17158039, Length=202, Percent_Identity=32.1782178217822, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI153085395, Length=199, Percent_Identity=35.678391959799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI169234807, Length=223, Percent_Identity=33.6322869955157, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI148539870, Length=223, Percent_Identity=33.6322869955157, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI13128860, Length=286, Percent_Identity=25.5244755244755, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI20070354, Length=214, Percent_Identity=31.7757009345794, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI13128864, Length=222, Percent_Identity=31.0810810810811, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI62750347, Length=213, Percent_Identity=29.5774647887324, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI62750349, Length=213, Percent_Identity=29.5774647887324, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI13128862, Length=281, Percent_Identity=25.2669039145907, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI293336691, Length=249, Percent_Identity=25.7028112449799, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI8923769, Length=169, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI262073088, Length=160, Percent_Identity=30, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI226529806, Length=130, Percent_Identity=35.3846153846154, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17540332, Length=208, Percent_Identity=35.0961538461538, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540334, Length=208, Percent_Identity=35.0961538461538, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=208, Percent_Identity=35.0961538461538, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17537347, Length=221, Percent_Identity=28.9592760180996, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193209491, Length=250, Percent_Identity=28.4, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17534739, Length=333, Percent_Identity=24.6246246246246, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508561, Length=285, Percent_Identity=24.5614035087719, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25154020, Length=244, Percent_Identity=25, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561978, Length=287, Percent_Identity=24.0418118466899, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25154022, Length=212, Percent_Identity=25.4716981132075, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=206, Percent_Identity=36.4077669902913, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321244, Length=303, Percent_Identity=27.3927392739274, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323999, Length=273, Percent_Identity=26.007326007326, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325141, Length=91, Percent_Identity=38.4615384615385, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281360899, Length=216, Percent_Identity=35.1851851851852, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642146, Length=216, Percent_Identity=35.1851851851852, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642144, Length=225, Percent_Identity=35.1111111111111, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24642142, Length=225, Percent_Identity=35.1111111111111, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281360799, Length=212, Percent_Identity=34.4339622641509, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24641720, Length=212, Percent_Identity=34.4339622641509, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281360801, Length=212, Percent_Identity=34.4339622641509, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24657891, Length=276, Percent_Identity=26.4492753623188, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644244, Length=310, Percent_Identity=23.8709677419355, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37222; Mature: 37222

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVYSPLHAGHAGQMELVTSAIVPGFEKPSRAEFIKARVESENLGPIVLPLEHDLAAAK
CCCCCCCHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHH
RIHKSDYVDFLPTVWPQWVASGHEGTAMPFTWPTRGLRGDVPPKRVDALLGYYSFDAGAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCCE
FVEGTWAAIKSSYDVALTAAGLVKGGERSAFALCRPPGHHAGAGFMGGYCYINNAAVAAQ
EECCHHHHHHCCCCEEEEEEHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHH
WFLDQGAKRISILDVDYHHGNGTQEIFYDRADVQVLNLHGDPLVEYPFFLGHADERGAGD
HHHHCCCCEEEEEEEEEECCCCCHHEEEECCCEEEEEECCCCCEECCEEECCCCCCCCCC
GEGFNINYPMPFGTDWDAWNASLEDACGKLAAYAPDIVIVSLGVDTFEKDPISQFKLTSP
CCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEECCC
DYPKIGRRIAKLGLPTLFVMEGGYAVEEIGINAVGVLTGFEDR
CCHHHHHHHHHHCCCEEEEEECCEEEECCCCCEEEEECCCCCC
>Mature Secondary Structure
MKTVYSPLHAGHAGQMELVTSAIVPGFEKPSRAEFIKARVESENLGPIVLPLEHDLAAAK
CCCCCCCHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHH
RIHKSDYVDFLPTVWPQWVASGHEGTAMPFTWPTRGLRGDVPPKRVDALLGYYSFDAGAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCCE
FVEGTWAAIKSSYDVALTAAGLVKGGERSAFALCRPPGHHAGAGFMGGYCYINNAAVAAQ
EECCHHHHHHCCCCEEEEEEHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHH
WFLDQGAKRISILDVDYHHGNGTQEIFYDRADVQVLNLHGDPLVEYPFFLGHADERGAGD
HHHHCCCCEEEEEEEEEECCCCCHHEEEECCCEEEEEECCCCCEECCEEECCCCCCCCCC
GEGFNINYPMPFGTDWDAWNASLEDACGKLAAYAPDIVIVSLGVDTFEKDPISQFKLTSP
CCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEECCC
DYPKIGRRIAKLGLPTLFVMEGGYAVEEIGINAVGVLTGFEDR
CCHHHHHHHHHHCCCEEEEEECCEEEECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]