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The map label for this gene is fsr [H]

Identifier: 13472402

GI number: 13472402

Start: 2161847

End: 2163118

Strand: Direct

Name: fsr [H]

Synonym: mlr2687

Alternate gene names: 13472402

Gene position: 2161847-2163118 (Clockwise)

Preceding gene: 13472400

Following gene: 13472404

Centisome position: 30.73

GC content: 63.52

Gene sequence:

>1272_bases
GTGCCCGCCAAAAAGACCACGGAGCCTGCCTTGACCGATACGACAGCCGCCAGCGTCGCGTCACCAGCGACCGCCAGTCA
CGCCTCAGCTCAGGCGACGGCCTTCACCGTCATCCTGGCGGTGAGCTTCTGCCATTGCATCAACGACATCATGCAATCGC
TGCTGTCGGCCATTTATCCGCTTCTGAAACAGAATTACGGCCTCGATTTCTGGCAGATTGGCCTGCTGACCTTCACCTTC
CAGGTGACGGCGTCCTTGCTGCAGCCGGTGATCGGCATGATCACCGACAAGCGGCCGATGCCCTATTCCCTGCCCTACGG
CATGGCCTCGTCTCTGATCGGCCTGGTCGTGCTGGCCTACGCCGGGCACTATTATCTGCTGCTGATCGGCGCCTCGCTGA
TCGGCATCGGCTCGGCGATCTTCCATCCCGAATCCTCGCGCATCGCGCGCTTTGCTTCCGGCGGCCGGTTTGGCCTGGCG
CAGTCGCTGTTCCAGGTCGGCGGCAATTTCGGCCAGTCCATGGGGCCGCTGCTGGCCGCCTTCATCGTCGTGCCGTTTGG
CCAGACCAGCATCGCCTGGTTCGCCGTCGGCTCGCTGATCGGCATCGTCGTTTTGTGGCAGGTCGGCGGCTGGTACAGTC
GCCTGCGCGCCGCGCAAGGCACCCGCAAGGCGGTAAGCTTCGTCTCGCCCTTCCCGCGCCGCAAAGTCATGAGCGCGCTG
ATCGTACTGACGCTGCTGGTGCTGAGCAAGAACGCCTACATCGCCAGCCTCGCCAGCTACTACACCTTCTACTCCATCCA
TAAATTCGGGGTGTCCGTGCAGATGAGCCAGGTGATGCTGTTCCTGTTCCTCGGCGCCTCGGCGCTGGGCATCCTGCTCG
GCGGGCCGTTCGGCGACCGCTACGGACAGAAAGCGATGATCTGGTTCTCGATCGTCGGCGTGCTGCCCTTCACGCTGGCG
CTGCCCTACGCCAATCTGGAATGGACGATGGTGCTGACCGTGCTGATCGGGCTGATCCTGTCGTCGGCCTTCTCCAACAT
CGTCGTCTTCGCGCAGGAACTGGTGCCGGGCCGCGTCGGCATGATCGCCGGCATCTTCTTCGGCTTCGCCTTCGGCATGG
GCGGCATCGCGGCGGCCGTGCTCGGCGTCGTCGCCGACATGAAGGGCATCGATTTCGTCTTCCAGGTCTGCTCGTATCTG
CCGCTCCTGGGCCTGCTGACGGTATTCCTGCCCAACATGAAGGAAGCACGGAAGGCGCAGGCTGTGGCCTAA

Upstream 100 bases:

>100_bases
ACTATTGGACCAAACCACGAAAGAAGTTGCGCGGCAAGCGGCCTATAAGGCAACCGTCCCTAAGGCGGCCGCGGGAGCGT
CCGCTAGATTGCCCGCGGGC

Downstream 100 bases:

>100_bases
ACGCGGCGGATCGGAATTCAAATGAAAAGGCCCCCGCCGGATGGGCGCGGGCCTTGCCTATACCGCGGAAGGCTTTAAGC
CTTGAAGAAGGCCAGCAGGT

Product: fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MPAKKTTEPALTDTTAASVASPATASHASAQATAFTVILAVSFCHCINDIMQSLLSAIYPLLKQNYGLDFWQIGLLTFTF
QVTASLLQPVIGMITDKRPMPYSLPYGMASSLIGLVVLAYAGHYYLLLIGASLIGIGSAIFHPESSRIARFASGGRFGLA
QSLFQVGGNFGQSMGPLLAAFIVVPFGQTSIAWFAVGSLIGIVVLWQVGGWYSRLRAAQGTRKAVSFVSPFPRRKVMSAL
IVLTLLVLSKNAYIASLASYYTFYSIHKFGVSVQMSQVMLFLFLGASALGILLGGPFGDRYGQKAMIWFSIVGVLPFTLA
LPYANLEWTMVLTVLIGLILSSAFSNIVVFAQELVPGRVGMIAGIFFGFAFGMGGIAAAVLGVVADMKGIDFVFQVCSYL
PLLGLLTVFLPNMKEARKAQAVA

Sequences:

>Translated_423_residues
MPAKKTTEPALTDTTAASVASPATASHASAQATAFTVILAVSFCHCINDIMQSLLSAIYPLLKQNYGLDFWQIGLLTFTF
QVTASLLQPVIGMITDKRPMPYSLPYGMASSLIGLVVLAYAGHYYLLLIGASLIGIGSAIFHPESSRIARFASGGRFGLA
QSLFQVGGNFGQSMGPLLAAFIVVPFGQTSIAWFAVGSLIGIVVLWQVGGWYSRLRAAQGTRKAVSFVSPFPRRKVMSAL
IVLTLLVLSKNAYIASLASYYTFYSIHKFGVSVQMSQVMLFLFLGASALGILLGGPFGDRYGQKAMIWFSIVGVLPFTLA
LPYANLEWTMVLTVLIGLILSSAFSNIVVFAQELVPGRVGMIAGIFFGFAFGMGGIAAAVLGVVADMKGIDFVFQVCSYL
PLLGLLTVFLPNMKEARKAQAVA
>Mature_422_residues
PAKKTTEPALTDTTAASVASPATASHASAQATAFTVILAVSFCHCINDIMQSLLSAIYPLLKQNYGLDFWQIGLLTFTFQ
VTASLLQPVIGMITDKRPMPYSLPYGMASSLIGLVVLAYAGHYYLLLIGASLIGIGSAIFHPESSRIARFASGGRFGLAQ
SLFQVGGNFGQSMGPLLAAFIVVPFGQTSIAWFAVGSLIGIVVLWQVGGWYSRLRAAQGTRKAVSFVSPFPRRKVMSALI
VLTLLVLSKNAYIASLASYYTFYSIHKFGVSVQMSQVMLFLFLGASALGILLGGPFGDRYGQKAMIWFSIVGVLPFTLAL
PYANLEWTMVLTVLIGLILSSAFSNIVVFAQELVPGRVGMIAGIFFGFAFGMGGIAAAVLGVVADMKGIDFVFQVCSYLP
LLGLLTVFLPNMKEARKAQAVA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=394, Percent_Identity=56.8527918781726, Blast_Score=422, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45146; Mature: 45015

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50850 MFS ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
PAKKTTEPALTDTTAASVASPATASHASAQATAFTVILAVSFCHCINDIMQSLLSAIYP
CCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKQNYGLDFWQIGLLTFTFQVTASLLQPVIGMITDKRPMPYSLPYGMASSLIGLVVLAY
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
AGHYYLLLIGASLIGIGSAIFHPESSRIARFASGGRFGLAQSLFQVGGNFGQSMGPLLAA
HHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHH
FIVVPFGQTSIAWFAVGSLIGIVVLWQVGGWYSRLRAAQGTRKAVSFVSPFPRRKVMSAL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHH
IVLTLLVLSKNAYIASLASYYTFYSIHKFGVSVQMSQVMLFLFLGASALGILLGGPFGDR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
YGQKAMIWFSIVGVLPFTLALPYANLEWTMVLTVLIGLILSSAFSNIVVFAQELVPGRVG
HCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MIAGIFFGFAFGMGGIAAAVLGVVADMKGIDFVFQVCSYLPLLGLLTVFLPNMKEARKAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AVA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]